Can You Answer These Medications And Drugs Questions?

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| By Raneem

Raneem

Community Contributor

Quizzes Created: 1 | Total Attempts: 250

Questions: 10 | Attempts: 251 | Updated: Nov 16, 2023

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Questions and Answers

1.

All of the following are DNA polymerase inhibitors except:
- A.
  
  Cytarabine
- B.
  
  Gemcitabine
- C.
  
  Vinblastine
- D.
  
  None of the mentioned
Correct Answer
C. Vinblastine

Explanation
Vinblastine is a vinca alkaloid that acts as an anti-cancer agent by inhibiting microtubule formation during cell division. It does not directly inhibit DNA polymerase, which is an enzyme responsible for DNA replication. On the other hand, Cytarabine and Gemcitabine are nucleoside analogs that inhibit DNA polymerase by incorporating into the growing DNA chain and terminating its elongation. Therefore, the correct answer is Vinblastine.

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2.

Which of the following causes alopecia:
- A.
  
  Vinblastine
- B.
  
  Vincristine
- C.
  
  Venorelbine
- D.
  
  Etoposide
- E.
  
  All of the above
Correct Answer
E. All of the above

Explanation
The correct answer is "All of the above." This means that all of the listed medications (Vinblastine, Vincristine, Venorelbine, and Etoposide) can cause alopecia. Alopecia is a medical term used to describe hair loss, and these medications are known to have this side effect.

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3.

Dexrazoxane currently approved to prevent or reduced cardiotoxicity of:
- A.
  
  Mitomycine
- B.
  
  Imatinib
- C.
  
  Doxorubicin
- D.
  
  Cladribine
Correct Answer
C. Doxorubicin

Explanation
Dexrazoxane is currently approved to prevent or reduce cardiotoxicity caused by Doxorubicin. Doxorubicin is a chemotherapy drug that is known to cause damage to the heart muscle, leading to cardiotoxicity. Dexrazoxane works by binding to the free radicals produced by Doxorubicin, preventing them from causing damage to the heart. This helps to protect the heart from the toxic effects of Doxorubicin and reduces the risk of cardiotoxicity.

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4.

The MOA of anthracyclines is/are:
- A.
  
  Topoisomerase II inhibitor
- B.
  
  DNA intercalation
- C.
  
  Free radical killing
- D.
  
  Binding to cellular membrane
- E.
  
  All of the above
Correct Answer
E. All of the above

Explanation
The correct answer is "All of the above". Anthracyclines have multiple mechanisms of action, including being a topoisomerase II inhibitor, DNA intercalation, free radical killing, and binding to the cellular membrane. These mechanisms contribute to their ability to inhibit DNA replication and transcription, leading to cell death.

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5.

Example of Nitrosoureas is/are:
- A.
  
  BCNU
- B.
  
  Mythel-CCNU
- C.
  
  6-MP
- D.
  
  A and B
Correct Answer
D. A and B

Explanation
Nitrosoureas are a type of chemotherapy drug used to treat various types of cancer. BCNU (Carmustine) and Mythel-CCNU (Lomustine) are both examples of Nitrosoureas. These drugs work by damaging the DNA in cancer cells, preventing them from dividing and growing. 6-MP (6-Mercaptopurine) is not a Nitrosourea, but rather a different type of chemotherapy drug used to treat leukemia. Therefore, the correct answer is A and B, as both BCNU and Mythel-CCNU are examples of Nitrosoureas.

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6.

Which of the following can inhibit the metabolism of 6-MP (mercaptopurine):
- A.
  
  6-thioguanine
- B.
  
  Fludarabine
- C.
  
  Bleomycin
- D.
  
  Allopurinol
Correct Answer
D. Allopurinol

Explanation
Allopurinol is known to inhibit the metabolism of 6-MP (mercaptopurine). Allopurinol is an inhibitor of xanthine oxidase, an enzyme responsible for the metabolism of 6-MP. By inhibiting this enzyme, allopurinol reduces the breakdown of 6-MP, leading to increased levels of the drug in the body. This can result in enhanced therapeutic effects or increased toxicity of 6-MP. Therefore, allopurinol can interfere with the metabolism of 6-MP.

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7.

All of the following are true about cladribine except:
- A.
  
  Administrated as single continuous 7-day infusion
- B.
  
  Immunosuppressive is one of the side effect
- C.
  
  Inhibit DNA polymerase
- D.
  
  Inhibit tubulin polymerization
Correct Answer
D. Inhibit tubulin polymerization

Explanation
Cladribine is a medication that is administered as a single continuous 7-day infusion. It is known to have immunosuppressive effects as a side effect and it inhibits DNA polymerase. However, it does not inhibit tubulin polymerization.

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8.

Asparaginase side effect is /are:
- A.
  
  Pancreatitis
- B.
  
  Fever
- C.
  
  Confusion
- D.
  
  All of the above
Correct Answer
D. All of the above

Explanation
The correct answer is "All of the above." Asparaginase is a medication used in cancer treatment, particularly for leukemia. One of its side effects is pancreatitis, which is inflammation of the pancreas. Fever can also occur as a side effect of asparaginase treatment. Additionally, confusion can be a side effect, although this is less common. Therefore, all of these side effects are possible when taking asparaginase.

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9.

Albumin-bound paclitaxel (Abraxane) not associated with hypersensitivity reactions.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
The statement suggests that albumin-bound paclitaxel, also known as Abraxane, is not linked to hypersensitivity reactions. This implies that individuals who are administered with Abraxane are less likely to experience allergic or hypersensitivity responses compared to other forms of paclitaxel.

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10.

Pemetrexed is hepatically eliminated.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
Pemetrexed is not hepatically eliminated.

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Current Version
Nov 16, 2023

Quiz Edited by
ProProfs Editorial Team
Jan 03, 2019

Quiz Created by
Raneem

Can You Answer These Medications And Drugs Questions?

All of the following are DNA polymerase inhibitors except:

Which of the following causes alopecia:

Dexrazoxane currently approved to prevent or reduced cardiotoxicity of:

The MOA of anthracyclines is/are:

Example of Nitrosoureas is/are:

Which of the following can inhibit the metabolism of 6-MP (mercaptopurine):

All of the following are true about cladribine except:

Asparaginase side effect is /are:

Albumin-bound paclitaxel (Abraxane) not associated with hypersensitivity reactions.

Pemetrexed is hepatically eliminated.