Tumor Markers Quiz (March 24, 2020)

20 Questions | Total Attempts: 134

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Tumor Markers Quiz (March 24, 2020)


Questions and Answers
  • 1. 
    How do we diagnose cancer today?
    • A. 

      Chemotherapy

    • B. 

      Blood Tests

    • C. 

      Surgery

    • D. 

      Radiation Therapy

  • 2. 
    The characteristics of an ideal tumor marker:
    • A. 

      Non specificity for a single type of cancer

    • B. 

      High sensitivity and specificity for cancerous growth

    • C. 

      Heterogeneous (i.e., minimal post-translational modifications)

    • D. 

      Long half-life in circulation

  • 3. 
    The learning objectives in studying tumor markers except:
    • A. 

      Know the ideal characteristics of a tumor marker

    • B. 

      Understand the role of tumor markers for diagnosis and management of patients with cancer

    • C. 

      Know the emerging technologies for tumor markers

    • D. 

      Understand the role of tumor markers for therapeutic selection

    • E. 

      None of the Above

  • 4. 
    Elevated in pregnancy, liver disease (hepatitis, cirrhosis, GI tumors)
    • A. 

      AFP

    • B. 

      CEA

    • C. 

      CA 125

    • D. 

      CA 15-3

  • 5. 
    Elevated in breast, pancreatic, GI, and lung cancer
    • A. 

      CA 15-3

    • B. 

      CEA

    • C. 

      AFP

    • D. 

      CA-125

  • 6. 
    PSA range that is considered low risk:
    • A. 

      0-4 ng/ml

    • B. 

      4-10 ng/ml

    • C. 

      >10 ng/ml

    • D. 

      None of the above

  • 7. 
    Gene amplification/over expression occurs in 30% of patients & correlates with aggressive disease & shortened survival
    • A. 

      HER-2/neu

    • B. 

      KRAS

    • C. 

      BCR-ABL

    • D. 

      EGFR

  • 8. 
    Which technique is most useful for detecting gene duplication and deletions?
    • A. 

      Immunohistochemistry

    • B. 

      Comparative genomic hybridization

    • C. 

      Fluorescence in situ hybridization

    • D. 

      Real-time polymerase chain reaction

  • 9. 
    High sensitivity PSA assays are useful for:
    • A. 

      Early detection of disease recurrence after  prostatectomy

    • B. 

      Differentiation between benign prostatic hypertrophy  and prostate cancer

    • C. 

      Differentiation between aggressive vs. non-  aggressive disease

    • D. 

      All of the above

  • 10. 
    Onco fetal antigen/s
    • A. 

      CEA

    • B. 

      AFP

    • C. 

      CA-125

    • D. 

      A and C

    • E. 

      A and B

  • 11. 
    Prolactin is an example of which type of tumor marker?
    • A. 

      Receptor

    • B. 

      Protein

    • C. 

      Enzyme

    • D. 

      Hormone

  • 12. 
    Mutations/translocations are examples of genetic changes.
    • A. 

      True

    • B. 

      False

  • 13. 
    Monitor for disease recurrence or progression (most widely  used function) is one of the roles of tumor markers
    • A. 

      True

    • B. 

      False

  • 14. 
     [Blank] is considered a Germ cell tumor.
  • 15. 
    [Blank] is elevated in smokers and elderly.
  • 16. 
    Which of the following is indicative of a positive result for Her-2/neu using immunohistochemistry?
    • A. 

      Option 1

    • B. 

      Option 2

  • 17. 
    A method of comparing differences in DNA copy  number between tests (e.g. tumor) and  reference samples
    • A. 

      MRNA Microarrays

    • B. 

      Comparative genomic hybridization

  • 18. 
    Norepinephrine is an example of which type of tumor marker?
    • A. 

      Metabolite

    • B. 

      Enzyme

    • C. 

      Hormone

    • D. 

      Protein

  • 19. 
     [Blank], a tumor marker is considered as a normal protein.
  • 20. 
    CA 15-3
    • A. 

      Colorectal

    • B. 

      Ovarian

    • C. 

      Breast 

    • D. 

      Pancreatic

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