Large mines can have significant impacts on the environment, affecting the atmosphere, biosphere, and hydrosphere. Pollution is a common consequence of mining activities, as it can release harmful substances into the air, water, and soil. Vegetation removal is another consequence, as mining often requires clearing large areas of land, leading to habitat destruction and loss of biodiversity. Additionally, mining can alter water flow patterns, disrupting natural drainage systems and affecting aquatic ecosystems. Therefore, all of the above options are valid changes that can occur when large mines are dug in the ground.