Cop 2015 Pharmaceutics Lecture 08/18/2011

16 Questions | Total Attempts: 38

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Cop 2015 Pharmaceutics Lecture 08/18/2011 - Quiz

Questions and Answers
  • 1. 
    Which is the stronger acidic functional group?
    • A. 

      Phenol, pKa 9-11

    • B. 

      Sulfonic acid, pKa 0-1

    • C. 

      Sulfonimide, pKa 5-6

  • 2. 
    Acid strength increases as pKa increases.
    • A. 

      True

    • B. 

      False

  • 3. 
    Which is the stronger basic functional group?
    • A. 

      Imine, pKa 3-4

    • B. 

      Aromatic amine, pKa 5-6

    • C. 

      Guanidine, pKa 10-11

    • D. 

      Arylamine, pKa 4-5

  • 4. 
    As pKb increases, the strength of the base also increases.
    • A. 

      True

    • B. 

      False

  • 5. 
    As pKa increases, the strength of the base also increases.
    • A. 

      True

    • B. 

      False

  • 6. 
    Amphiprotic molecules are:
    • A. 

      Mostly basic

    • B. 

      Mostly acidic

    • C. 

      Neither basic nor acidic

    • D. 

      Both basic and acidic

  • 7. 
    When calculating the pH of an amphiprotic solution, which of these will factor into the equation? (Two correct answers)
    • A. 

      PKa at which the amphiprotic molecule loses a proton, pKa1

    • B. 

      PKa at which the amphiprotic molecule gains a proton, pKa2

    • C. 

      PKw

    • D. 

      Concentration

  • 8. 
    Adding a strong acid, such as HCl, to a weakly basic drug will produce the salt form of the drug. The product is:
    • A. 

      A weak base

    • B. 

      A weak acid

    • C. 

      A strong base

    • D. 

      A strong acid

    • E. 

      Neutral

  • 9. 
    Adding a strong base, such as NaOH, to a weakly acidic drug will produce the salt form of the drug. The product is:
    • A. 

      A weak base

    • B. 

      A weak acid

    • C. 

      A strong base

    • D. 

      A strong acid

    • E. 

      Neutral

  • 10. 
    If you were trying to calculate the pH of the reaction below, the pKa of which molecule would be used in the calculation?
    • A. 

      Maleic acid

    • B. 

      Chlorpheniramine

    • C. 

      Chlorpheniramine maleate

    • D. 

      Water

  • 11. 
    If you were trying to calculate the pH of the reaction below, the pKb of which molecule would be used in the calculation?
    • A. 

      Maleic acid

    • B. 

      Chlorpheniramine

    • C. 

      Chlorpheniramine maleate

    • D. 

      Water

  • 12. 
    In the above reaction assume the base is very strong. The reaction will favor:
    • A. 

      The charged state

    • B. 

      The uncharged state

  • 13. 
    The pKa of a weak base is 8.3. What is the pKb for this base?
    • A. 

      5.7

    • B. 

      8.3

    • C. 

      -1.3

    • D. 

      4.7

  • 14. 
    The pKb for a strong base is 1.6. What is the pKa for this base?
    • A. 

      2.6

    • B. 

      1.6

    • C. 

      12.4

    • D. 

      7

  • 15. 
    Without knowing the pKa of each molecule, which is the strongest base?
    • A. 

      1.

    • B. 

      2.

  • 16. 
    Resonance stabilizes electron pairs and, in some molecules, such as number 1 above, resonance stabilization contributes to the molecule being a weaker base.
    • A. 

      True

    • B. 

      False

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