Cop 2015 Pharmaceutics Lecture 08/18/2011
16 Questions
| Total Attempts: 38
Questions and Answers
- 1.Which is the stronger acidic functional group?
- A.
Phenol, pKa 9-11
- B.
Sulfonic acid, pKa 0-1
- C.
Sulfonimide, pKa 5-6
- 2.Acid strength increases as pKa increases.
- A.
True
- B.
False
- 3.Which is the stronger basic functional group?
- A.
Imine, pKa 3-4
- B.
Aromatic amine, pKa 5-6
- C.
Guanidine, pKa 10-11
- D.
Arylamine, pKa 4-5
- 4.As pKb increases, the strength of the base also increases.
- A.
True
- B.
False
- 5.As pKa increases, the strength of the base also increases.
- A.
True
- B.
False
- 6.Amphiprotic molecules are:
- A.
Mostly basic
- B.
Mostly acidic
- C.
Neither basic nor acidic
- D.
Both basic and acidic
- 7.When calculating the pH of an amphiprotic solution, which of these will factor into the equation? (Two correct answers)
- A.
PKa at which the amphiprotic molecule loses a proton, pKa1
- B.
PKa at which the amphiprotic molecule gains a proton, pKa2
- C.
PKw
- D.
Concentration
- 8.Adding a strong acid, such as HCl, to a weakly basic drug will produce the salt form of the drug. The product is:
- A.
A weak base
- B.
A weak acid
- C.
A strong base
- D.
A strong acid
- E.
Neutral
- 9.Adding a strong base, such as NaOH, to a weakly acidic drug will produce the salt form of the drug. The product is:
- A.
A weak base
- B.
A weak acid
- C.
A strong base
- D.
A strong acid
- E.
Neutral
- 10.
If you were trying to calculate the pH of the reaction below, the pKa of which molecule would be used in the calculation?- A.
Maleic acid
- B.
Chlorpheniramine
- C.
Chlorpheniramine maleate
- D.
Water
- 11.
If you were trying to calculate the pH of the reaction below, the pKb of which molecule would be used in the calculation?
- A.
Maleic acid
- B.
Chlorpheniramine
- C.
Chlorpheniramine maleate
- D.
Water
- 12.
In the above reaction assume the base is very strong. The reaction will favor:
- A.
The charged state
- B.
The uncharged state
- 13.The pKa of a weak base is 8.3. What is the pKb for this base?
- A.
5.7
- B.
8.3
- C.
-1.3
- D.
4.7
- 14.The pKb for a strong base is 1.6. What is the pKa for this base?
- A.
2.6
- B.
1.6
- C.
12.4
- D.
7
- 15.
Without knowing the pKa of each molecule, which is the strongest base?
- A.
1.
- B.
2.
- 16.
Resonance stabilizes electron pairs and, in some molecules, such as number 1 above, resonance stabilization contributes to the molecule being a weaker base.
- A.
True
- B.
False
.png "Resonance stabilizes electron pairs and, in some molecules, such as number 1 above, resonance stabilization contributes to the molecule being a weaker base.")
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