Pharmaceutics Quiz Questions And Answers
Pharmaceutics is the study of medicines and their effect on the human body. Our fun yet informational Pharmaceutics Quiz Questions And Answers is made to test your knowledge of the basic concepts of medicine. Let's see how well you can score! Make sure to pick the correct option to get a full score. Interestingly this quiz an aid in your examination preparation, so make sure to attempt with caution. Good Luck & keep studying!
Questions and Answers
- 1.
Unequal distribution of color on a tablet, refers to
- A.
Picking
- B.
Mottling
- C.
Capping
- D.
Sticking
Correct Answer
B. MottlingExplanation
Mottling refers to the unequal distribution of color on a tablet. This means that the color on the tablet is not evenly spread or distributed, resulting in patches or uneven areas of color. It could be caused by various factors such as improper mixing of colorants during the tablet manufacturing process or uneven compression of the tablet ingredients. Mottling can affect the appearance and quality of the tablet, and may indicate a manufacturing defect.Rate this question:
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- 2.
Match the following and find out the correct combination 1. Capping (P) Separation of a tablet into 2 or more layers 2. Lamination (Q) Unequal distribution of color on a tablet 3. Mottling (R) Separation of top/bottom crowns of a tablet from the main body 4. Sticking (S) Adherence of tablet material to the die wall
- A.
2-P, 3-Q, 1-R, 4-S
- B.
1-P, 2-Q, 3-R, 4-S
- C.
3-P, 1-Q, 2-R, 4-S
- D.
4-P, 1-Q, 3-R, 2-S
Correct Answer
A. 2-P, 3-Q, 1-R, 4-SExplanation
Capping refers to the separation of a tablet into 2 or more layers, which matches with option 2. Lamination refers to the unequal distribution of color on a tablet, which matches with option 3. Mottling refers to the separation of top/bottom crowns of a tablet from the main body, which matches with option 1. Sticking refers to the adherence of tablet material to the die wall, which matches with option 4. Therefore, the correct combination is 2-P, 3-Q, 1-R, 4-S.Rate this question:
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- 3.
Which of these is responsible for sticking?
- A.
Excessive moisture
- B.
Low moisture
- C.
Both
- D.
None
Correct Answer
A. Excessive moistureExplanation
Excessive moisture is responsible for sticking. When there is too much moisture present, it can cause surfaces or objects to stick together. This is because the excess moisture creates a barrier between the two surfaces, causing them to adhere to each other. This can be seen in various situations, such as when wet paper sticks together or when humid weather causes doors or windows to become difficult to open or close.Rate this question:
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- 4.
Which of the following mixer is a first high shear powder blender/mixer
- A.
Diosna Mixer
- B.
Littleford lodige mixer
- C.
Flow mixer
- D.
Gral mixer
Correct Answer
B. Littleford lodige mixerExplanation
The Littleford Lodige mixer is considered to be the first high shear powder blender/mixer. This mixer is known for its ability to effectively blend and mix powders, granules, and other solid materials with high shear forces. It is designed to provide efficient and homogeneous mixing, resulting in a uniform product. The Littleford Lodige mixer is widely used in industries such as pharmaceuticals, chemicals, and food processing, where high shear mixing is required for optimal product quality.Rate this question:
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- 5.
If the dose of a drug is inadequate, then it generally requires the following one, to make up its bulk
- A.
Binders
- B.
Disintegrants
- C.
Lubricants
- D.
Diluents
Correct Answer
D. DiluentsExplanation
Diluents are substances that are added to a drug to increase its bulk and make it easier to handle and administer. If the initial dose of a drug is not enough, it may require a larger quantity to achieve the desired effect. Therefore, diluents would be needed in order to increase the overall amount of the drug and ensure that it is properly distributed and absorbed in the body.Rate this question:
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- 6.
The first and most widely used diluent in tablet formulation is
- A.
Dextrose
- B.
Lactose
- C.
MCC
- D.
Starch
Correct Answer
B. LactoseExplanation
Lactose is the correct answer because it is the most commonly used diluent in tablet formulation. Diluents are added to tablets to increase their bulk and aid in the manufacturing process. Lactose is a sugar derived from milk and has excellent compressibility, flowability, and compatibility with other tablet ingredients. It also provides good binding properties and helps to create tablets that are hard and have a smooth surface. Lactose is widely available, cost-effective, and has low hygroscopicity, making it an ideal choice for tablet formulation.Rate this question:
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- 7.
Anhydrous lactose has the advantage overhydrous lactose
- A.
Improved flow
- B.
Absence of milard reaction
- C.
Improved Compressibility
- D.
High microbial load
Correct Answer
B. Absence of milard reactionExplanation
Anhydrous lactose has the advantage over hydrous lactose because it does not undergo the Maillard reaction. The Maillard reaction is a chemical reaction between amino acids and reducing sugars that can occur during the heating or processing of food. This reaction can lead to the formation of brown pigments, off-flavors, and reduced nutritional value. By using anhydrous lactose, which does not contain any water molecules, the Maillard reaction can be avoided, resulting in a product with improved quality and stability.Rate this question:
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- 8.
Which of the following is not a commercially available starch product?
- A.
Sta-Rx 1500
- B.
Celutab
- C.
Emdex
- D.
Sugar tab
Correct Answer
D. Sugar tabExplanation
Sugar tab is not a commercially available starch product because it is made of sugar, not starch. Starch is a complex carbohydrate that is commonly used in various food and industrial applications, such as thickening agents, stabilizers, and binders. However, sugar tab is made of sugar, which is a simple carbohydrate and has different properties and uses compared to starch.Rate this question:
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- 9.
Which of the following is a synthetic adhesive?
- A.
PVP
- B.
MC
- C.
HPMC
- D.
HPC
Correct Answer
A. PVPExplanation
PVP is a synthetic adhesive because it stands for polyvinylpyrrolidone, which is a polymer that is commonly used as an adhesive in various industries. It has excellent adhesive properties and is known for its ability to bond different materials together. PVP is widely used in applications such as paper and packaging, woodworking, and medical adhesives. It is a popular choice due to its strong bonding strength, versatility, and resistance to moisture and chemicals.Rate this question:
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- 10.
Which of the following is a water soluble lubricant?
- A.
Stearic acid
- B.
Mineral oil
- C.
PEG
- D.
Magnesium stearate
Correct Answer
C. PEGExplanation
PEG (Polyethylene glycol) is a water soluble lubricant. It is a polymer compound that has the ability to dissolve in water, making it suitable for use as a lubricant in various applications. PEG is commonly used in pharmaceuticals, cosmetics, and personal care products due to its water solubility and lubricating properties. Stearic acid, mineral oil, and magnesium stearate, on the other hand, are not water soluble lubricants. Stearic acid is a fatty acid that is insoluble in water, while mineral oil and magnesium stearate are hydrophobic substances that do not dissolve in water.Rate this question:
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- 11.
Find out the correct statements regarding a sweetener, saccharin (P) It is 500 times sweeter than sucrose, but it is carcinogenic (Q) It is 500 times sweeter than sucrose, but it has bitter taste (R) It is sweeter than sucrose, but it is safe (S) It is sweeter than sucrose, but it is unstable
- A.
P, S
- B.
P, R
- C.
P, Q
- D.
R, S
Correct Answer
C. P, QExplanation
Saccharin is 500 times sweeter than sucrose, but it has a bitter taste. This means that statement P is correct. Additionally, statement Q is also correct as it states that saccharin is sweeter than sucrose but has a bitter taste. Therefore, the correct answer is P, Q.Rate this question:
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- 12.
Aerosil is used as
- A.
Glidant
- B.
Lubricant
- C.
Antiadherant
- D.
None
Correct Answer
A. GlidantExplanation
Aerosil is commonly used as a glidant in various industries. A glidant is a substance that is added to powders to improve their flow properties and reduce their tendency to stick to surfaces. Aerosil, which is a brand name for fumed silica, has excellent gliding properties and is often used in pharmaceuticals, cosmetics, and food processing to enhance the flowability of powders during manufacturing and packaging processes. It helps prevent clumping and ensures uniform distribution, making it easier to handle and process powders effectively.Rate this question:
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- 13.
What is the pH of duodenum?
- A.
2-3
- B.
7-8
- C.
4-6
- D.
10
Correct Answer
C. 4-6Explanation
The pH of the duodenum is typically between 4-6. This slightly acidic to neutral pH range is necessary for the proper digestion and absorption of nutrients in the small intestine. The duodenum receives acidic chyme from the stomach, and the slightly acidic environment helps to activate digestive enzymes and facilitate the breakdown of proteins, fats, and carbohydrates. Additionally, the acidic pH helps to create an optimal environment for the action of pancreatic enzymes and bile salts, which further aid in digestion and absorption of nutrients.Rate this question:
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- 14.
Tablets, which are placed between cheek and teeth, are known as
- A.
Buccal
- B.
Sublingual
- C.
Lozenges
- D.
Troches
Correct Answer
A. BuccalExplanation
Tablets that are placed between the cheek and teeth are known as buccal tablets. Buccal administration involves placing medication in the buccal cavity, where it dissolves and is absorbed through the buccal mucosa. This route of administration allows for direct absorption into the bloodstream, bypassing the digestive system and liver metabolism. Buccal tablets are designed to slowly release the medication, providing a controlled and sustained release of the drug.Rate this question:
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- 15.
Which statement is not correct?
- A.
Buccal routes avoids first pass metabolism
- B.
Parenteral route avoids first pass metabolism
- C.
Sublingual route avoids first pass metabolism
- D.
Oral route avoids first pass metabolism
Correct Answer
D. Oral route avoids first pass metabolismExplanation
The statement "Oral route avoids first pass metabolism" is not correct. The oral route does not avoid first pass metabolism. When a drug is taken orally, it is absorbed through the gastrointestinal tract and enters the liver before reaching the systemic circulation. In the liver, the drug may undergo metabolism by enzymes, which can significantly reduce the bioavailability of the drug. This is known as first pass metabolism. Therefore, the correct answer is the statement "Oral route avoids first pass metabolism."Rate this question:
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- 16.
Match the following ingredients according to their purpose in the formulation of tablets and find out the correct set 1. Glidant (P) Pre- gelatinized starch 2. Diluent (Q) Pyramine 3. Adherent (R) Colloidal silica 4. Disintegrant (S) Calcium sulphate (T) Sodium alginate
- A.
1-R, 2-S, 3-P, 4-T
- B.
1-S, 2-R, 3-Q, 4-P
- C.
1-R, 2-S, 3-T, 4-Q
- D.
1-Q, 2-T, 3-R, 4-P
Correct Answer
A. 1-R, 2-S, 3-P, 4-TExplanation
In tablet formulation, a glidant is used to improve the flowability of the powder mixture. Pre-gelatinized starch is commonly used as a glidant. A diluent is used to increase the bulk of the tablet and provide a suitable size for swallowing. Calcium sulphate is commonly used as a diluent. An adherent is used to help the tablet maintain its shape and prevent it from crumbling. Colloidal silica is commonly used as an adherent. A disintegrant is used to promote the breakup of the tablet into smaller particles when it comes into contact with water. Sodium alginate is commonly used as a disintegrant. Therefore, the correct set of ingredients and their purposes in the formulation of tablets is 1-R, 2-S, 3-P, 4-T.Rate this question:
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- 17.
Enteric coating is achieved by using
- A.
HPMC
- B.
CMC
- C.
CAP
- D.
Povidine
Correct Answer
C. CAPExplanation
Enteric coating is achieved by using CAP, which stands for cellulose acetate phthalate. CAP is a commonly used polymer in pharmaceuticals for enteric coating. Enteric coating is a process that involves applying a protective layer to tablets or capsules to prevent them from dissolving in the stomach. This coating ensures that the medication is released and absorbed in the intestines instead, where it can be more effective. CAP is known for its ability to withstand the acidic environment of the stomach and dissolve in the alkaline environment of the intestines, making it an ideal choice for enteric coating.Rate this question:
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- 18.
The disintegration time for sugar coated tablets is
- A.
30 min.
- B.
45 min.
- C.
60 min.
- D.
75 min.
Correct Answer
C. 60 min.Explanation
The disintegration time for sugar coated tablets is 60 minutes. This means that it takes approximately 60 minutes for the sugar coating on the tablets to dissolve and for the tablet to break apart into smaller pieces. This is an important factor to consider for patients who may have difficulty swallowing whole tablets, as a longer disintegration time may make it easier for them to consume the medication.Rate this question:
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- 19.
Flow rate of granules from the hopper can be improved by adding
- A.
Disintegrant
- B.
Glidant
- C.
Binder
- D.
Lubricant
Correct Answer
B. GlidantExplanation
Adding a glidant to the granules in the hopper can improve the flow rate. A glidant is a substance that reduces friction between particles, allowing them to flow more easily. By reducing the interparticle friction, the granules can move more freely through the hopper, resulting in an improved flow rate. This can be particularly beneficial in processes where a consistent and efficient flow of granules is required, such as in pharmaceutical manufacturing or bulk material handling.Rate this question:
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- 20.
Given below are equipment used in the manufacture of following products P-T. Match them and find out correct answer 1. Zenasi (P) Tablet granules 2. Hepa filter (Q) Tablet coating 3. Chilsonator (R) Emulsion 4. Accela cota (S) Injectables (T) Capsule
- A.
(a) 1-T, 2-S, 3-P, 4-Q
- B.
1-P, 2-Q, 3-S, 4-R
- C.
(c) 1-T, 2-R, 3-Q, 4-P
- D.
1-S, 2-R, 3-P, 4-Q
Correct Answer
A. (a) 1-T, 2-S, 3-P, 4-QExplanation
Zenasi is used for tablet granules, Hepa filter is used for injectables, Chilsonator is used for tablet coating, and Accela cota is used for emulsion. Therefore, the correct match is 1-T, 2-S, 3-P, 4-Q.Rate this question:
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- 21.
Match the ingredients according to their purpose in the formulation & find out correct set 1. Film coating 2. Syrups 3. Emulsification 4. Enteric coating (P) Sodium benzoate (Q) Ethyl cellulose (R) Eudragit (S) Sucrose (T) Sodium oleate
- A.
1-P, 2-Q, 3-R, 4-S
- B.
1-R, 2-S, 3-T, 4-Q
- C.
1-T, 2-P, 3-S, 4-Q
- D.
1-R, 2-S, 3-Q, 4-T
Correct Answer
B. 1-R, 2-S, 3-T, 4-QExplanation
1. Film coating is the purpose of Eudragit (R).
2. Syrups are made with Sucrose (S).
3. Emulsification is achieved with Sodium oleate (T).
4. Enteric coating is the purpose of Ethyl cellulose (Q).Rate this question:
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- 22.
Match the following regions in GIT with the pH levels indicated from P-T and find out correct answer 1. Mouth 2. Stomach 3. Deodenum 4. Large intestine (P) 5-6 (Q) 6.8-7.5 (R) 6.8-7 (S) 3-5 (T) 1.5-3
- A.
1-Q, 2-T, 3-S, 4-R
- B.
1-P, 2-R, 3-S, 4-T
- C.
1-S, 2-T, 3-Q, 4-R
- D.
1-R, 2-S, 3-T, 4-P
Correct Answer
A. 1-Q, 2-T, 3-S, 4-RExplanation
The correct answer is 1-Q, 2-T, 3-S, 4-R. The pH level in the mouth is slightly acidic, ranging from 6.8 to 7.5. The stomach has a highly acidic environment, with a pH level between 1.5 and 3. The small intestine, specifically the duodenum, has a slightly acidic to neutral pH level of 6.8 to 7. Lastly, the large intestine has a slightly acidic pH level of 5 to 6. Therefore, the given answer matches the correct pH levels for each region in the GIT.Rate this question:
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- 23.
In sugar coating of tablets, subcoating done?
- A.
To prevent moisture absorption
- B.
To round the edge & build tablet size
- C.
To smoothen the surface
- D.
To prevent the tablet from breaking due to vibration
Correct Answer
B. To round the edge & build tablet sizeExplanation
Subcoating is done in sugar coating of tablets to round the edges and build the tablet size. This process involves applying multiple layers of coating material to the tablet, which helps in giving it a smooth and rounded appearance. It also helps in increasing the size of the tablet, making it easier to swallow. By rounding the edges, the tablet becomes less likely to cause irritation or injury to the throat or digestive system.Rate this question:
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- 24.
Some possible causes are mentioned in P-T, for the following defects during the film coating of tablets. Match them 1. Chipping 2. Cracking 3. Orange peel 4. Blistering (P) Poor spreading during spraying (Q) Over heating during spraying (R) Higher internal stresses in film (S) Excessive coating process (T) Precipitation of polymer due to high temperature/poor solvent
- A.
1-S, 2-R, 3-P, 4-Q
- B.
1-T, 2-S, 3-R, 4-P
- C.
1-P, 2-Q, 3-R, 4-S
- D.
1-R, 2-P, 3-Q, 4-T
Correct Answer
A. 1-S, 2-R, 3-P, 4-QExplanation
The correct answer is 1-S, 2-R, 3-P, 4-Q. Chipping is caused by excessive coating process (S), cracking is caused by higher internal stresses in the film (R), orange peel is caused by poor spreading during spraying (P), and blistering is caused by over heating during spraying (Q).Rate this question:
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- 25.
Sub coating is given to the tablets
- A.
To increase the bulkiness
- B.
To avoid deterioration due to microbial attack
- C.
To prevent the solubility in acidic medium
- D.
To avoid stickness
Correct Answer
D. To avoid sticknessExplanation
The sub coating is given to the tablets to avoid stickiness. This is because stickiness can make it difficult to handle and package the tablets. By applying a sub coating, a layer is created on the surface of the tablet that prevents it from sticking to other tablets or surfaces. This improves the overall quality and appearance of the tablets and ensures that they can be easily handled and stored without any issues.Rate this question:
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- 26.
The following ingredients are commonly used as coating agents for film coating except
- A.
CAP
- B.
Carnauba wax
- C.
HEC
- D.
Sodium CMC
Correct Answer
B. Carnauba waxExplanation
Carnauba wax is not commonly used as a coating agent for film coating. CAP, HEC, and Sodium CMC are commonly used coating agents in film coating processes. Carnauba wax, on the other hand, is typically used in various other applications such as car wax, furniture polish, and food glaze.Rate this question:
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- 27.
The ingredients mentioned in P-S are used in various stages of sugar coating of tablets. Match them and find out correct ans 1. Seal coating 2. Sub coating 3. Syrup coating 4. Polishing (P) Gelatin (Q) Carnauba wax (R) PEG 4000 (S) Cane sugar
- A.
1-S, 2-P, 3-R, 4-Q
- B.
1-Q, 2-S, 3-R, 4-P
- C.
1-P, 2-Q, 3-R, 4-S
- D.
1-R, 2-P, 3-Q, 4-S
Correct Answer
A. 1-S, 2-P, 3-R, 4-QExplanation
The correct answer is 1-S, 2-P, 3-R, 4-Q. In sugar coating tablets, gelatin is used for seal coating, carnauba wax is used for sub coating, PEG 4000 is used for syrup coating, and cane sugar is used for polishing.Rate this question:
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- 28.
The Wurster process can be used to
- A.
Coat tablets
- B.
Determine the disintegration time
- C.
Gas sterilize parenteral solution
- D.
Automatic filling of capsules
Correct Answer
A. Coat tabletsExplanation
The Wurster process is a method used to coat tablets. It involves suspending the tablets in a fluidized bed and applying a coating material to them. This process is commonly used in the pharmaceutical industry to improve the appearance, taste, and stability of tablets. The coating can also help control the release of the active ingredient in the tablet. Therefore, the correct answer is "Coat tablets."Rate this question:
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- 29.
Which of this is the first process that must occur before a drug can become available for absorption from a tablet dosage form?
- A.
Dissolution of the drug in GI fluids
- B.
Dissolution of the drug in epithelium
- C.
Ionization of the drug
- D.
Disintegration of the drug
Correct Answer
D. Disintegration of the drugExplanation
Before a drug can become available for absorption from a tablet dosage form, the first process that must occur is the disintegration of the drug. Disintegration refers to the breakdown of the tablet into smaller particles, which allows for the drug to dissolve and be released. Once the drug is disintegrated, it can then proceed to the next step of dissolution in gastrointestinal (GI) fluids, where it will further dissolve and become available for absorption into the bloodstream.Rate this question:
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- 30.
Tablets are placed into coating chamber & hot air is introduced through the bottom of the chamber. Coating solution is applied through an atomizing nozzle from the upper end of the chamber. This technique is called
- A.
Sealing before sugar coating
- B.
Coating by air suspension
- C.
Spay-pan coating
- D.
Chamber coating
Correct Answer
B. Coating by air suspensionExplanation
The correct answer is "Coating by air suspension." In this technique, tablets are placed in a coating chamber and hot air is introduced from the bottom. The coating solution is then applied through an atomizing nozzle from the upper end of the chamber. This creates a suspension of the coating solution in the air, which allows for even and uniform coating of the tablets.Rate this question:
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- 31.
A synthetic sweetening agent which is approximately 200 times sweeter than sucrose & has no taste is
- A.
Saccharin
- B.
Aspartane
- C.
Cyclamate
- D.
Sorbitol
Correct Answer
B. AspartaneExplanation
Aspartame is a synthetic sweetening agent that is approximately 200 times sweeter than sucrose (table sugar) and has no taste. It is commonly used as a sugar substitute in various food and beverage products. Aspartame is often preferred by individuals looking to reduce their sugar intake or manage their weight, as it provides sweetness without the added calories.Rate this question:
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- 32.
Shellac is used the purpose of coating tablets as
- A.
Polishing agent
- B.
Film coating agent
- C.
Enteric coating agent
- D.
Sub-coating agent for sugar coating
Correct Answer
C. Enteric coating agentExplanation
Shellac is used as an enteric coating agent for tablets. Enteric coating is a type of coating that is designed to protect the tablet from being dissolved or disintegrated in the acidic environment of the stomach. It allows the tablet to pass through the stomach intact and then dissolve and release the medication in the alkaline environment of the intestines. Shellac is a natural resin derived from the lac beetle and it forms a protective barrier around the tablet, preventing it from being broken down in the stomach.Rate this question:
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- 33.
Dose dumping is a problem in the formulation of
- A.
Compressed tab
- B.
Suppository
- C.
Soft gelatin capsules
- D.
Controlled release dug products
Correct Answer
D. Controlled release dug productsExplanation
Controlled release drug products are prone to dose dumping. Dose dumping refers to the rapid release of a large amount of drug from a formulation, which can lead to adverse effects or reduced therapeutic efficacy. This is particularly a concern with controlled release formulations because they are designed to release the drug gradually over a specific period of time. If dose dumping occurs, it can result in a sudden and potentially dangerous increase in drug concentration in the body. Therefore, it is important to carefully design and monitor controlled release drug products to prevent dose dumping.Rate this question:
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- 34.
Select the equation that gives the rate of drug dissolution from a tablet
- A.
Fick’s law
- B.
Henderson-Hasselbatch equation
- C.
Noyes-Whitney equation
- D.
Michelis Menton equation
Correct Answer
C. Noyes-Whitney equationExplanation
The Noyes-Whitney equation is used to calculate the rate of drug dissolution from a tablet. It states that the rate of dissolution is directly proportional to the surface area of the tablet and the concentration difference between the drug in the tablet and its surrounding medium, and inversely proportional to the thickness of the diffusion layer. This equation is commonly used in pharmaceutical sciences to understand and predict the release of drugs from solid dosage forms.Rate this question:
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- 35.
Which of the following substance is used as mucoadhesive
- A.
Acacia
- B.
Sodium CMC
- C.
Burnt sugar
- D.
Saccharin
Correct Answer
B. Sodium CMCExplanation
Sodium CMC (Sodium Carboxymethylcellulose) is used as a mucoadhesive substance. Mucoadhesive substances are those that can stick to the mucous membranes, such as those in the mouth or nasal cavity, for an extended period of time. Sodium CMC is commonly used in pharmaceutical and oral care products due to its ability to adhere to the mucous membranes, providing sustained release of medication or prolonged contact time for oral products. Acacia, burnt sugar, and saccharin do not possess mucoadhesive properties.Rate this question:
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- 36.
In the preparation of multi-layer tablets, one of the following is used for hydrophilic matrix coating.
- A.
Shellac
- B.
CMC
- C.
Stearyl alcohol
- D.
Bees Wax
Correct Answer
A. ShellacExplanation
Shellac is used for hydrophilic matrix coating in the preparation of multi-layer tablets. Shellac is a natural polymer derived from the lac beetle and is known for its excellent film-forming properties. It forms a hydrophilic matrix when applied as a coating on tablets, allowing for controlled release of the drug. Shellac also provides protection to the tablet from moisture and other environmental factors. Therefore, it is commonly used as a coating material in the pharmaceutical industry.Rate this question:
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- 37.
The diameter of the mesh aperture in the I.P. disintegration apparatus is given below. Choose the correct size
- A.
2 mm
- B.
4 mm
- C.
1 mm
- D.
1.50 mm
Correct Answer
A. 2 mmExplanation
The correct size for the diameter of the mesh aperture in the I.P. disintegration apparatus is 2 mm. This means that the openings in the mesh of the apparatus are 2 mm in diameter. The size of the mesh aperture is important in the disintegration process as it determines the size of particles that can pass through the mesh. In this case, a 2 mm diameter aperture suggests that particles up to 2 mm in size can pass through the mesh during the disintegration process.Rate this question:
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- 38.
Diclofenac tablet with CAP has been administered to a patient. Where do you expect the drug to be released?
- A.
Stomach
- B.
Oral cavity
- C.
Small intestine
- D.
Liver
Correct Answer
C. Small intestineExplanation
When a diclofenac tablet with CAP (controlled-release) is administered, the drug is expected to be released in the small intestine. This is because controlled-release formulations are designed to deliver the drug slowly and steadily over a prolonged period of time. The small intestine is an ideal site for drug release as it has a large surface area for absorption and a longer transit time compared to the stomach or oral cavity. Additionally, the small intestine contains enzymes and bile salts that aid in the absorption of drugs, making it an optimal location for drug release.Rate this question:
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- 39.
Which of the following flavor is used in a formulation containing sour taste?
- A.
Wild cherry
- B.
Vanilla
- C.
Citrus
- D.
Chocolate
Correct Answer
C. CitrusExplanation
Citrus flavor is used in a formulation containing sour taste because citrus fruits like lemons, oranges, and limes have a naturally sour taste. Adding citrus flavor to a formulation can help to enhance the sourness and provide a tangy flavor profile. Wild cherry, vanilla, and chocolate flavors do not have a sour taste, making them unsuitable for a formulation requiring a sour flavor.Rate this question:
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- 40.
Durability of a tablet to combined effects of shock & abrasion is evaluated by using
- A.
Hardness tester
- B.
Disintegration test apparatus
- C.
Friabilator
- D.
Screw guage
Correct Answer
C. FriabilatorExplanation
The correct answer is Friabilator because a friabilator is specifically designed to measure the durability of tablets by subjecting them to rotational forces and abrasion. It simulates the conditions tablets may encounter during transportation and handling. The tablets are placed in a drum that rotates, causing them to collide with each other and the walls of the drum. The amount of tablet weight loss is then measured, indicating the level of fragility and resistance to abrasion. This test helps determine if the tablet can withstand shocks and abrasion without breaking or crumbling.Rate this question:
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- 41.
A retardant material that forms a hydrophilic matrix in the formulation of matrix tablets is
- A.
HPMC
- B.
CAP
- C.
Polyethylene
- D.
Carnaubaa wax
Correct Answer
A. HPMCExplanation
HPMC (Hydroxypropyl methylcellulose) is a retardant material that forms a hydrophilic matrix in the formulation of matrix tablets. It is a cellulose derivative that swells and forms a gel-like matrix when it comes into contact with water. This matrix controls the release of the active pharmaceutical ingredient (API) from the tablet, allowing for a sustained and controlled release over time. HPMC is commonly used in pharmaceutical formulations due to its biocompatibility, stability, and ability to provide controlled drug release.Rate this question:
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- 42.
A water soluble substance used as coating material in micro encapsulation process is
- A.
Polyethylene
- B.
Silicone
- C.
HEC
- D.
Paraffin
Correct Answer
C. HECExplanation
HEC, or Hydroxyethyl cellulose, is a water soluble substance that is commonly used as a coating material in the microencapsulation process. It is a derivative of cellulose and is known for its thickening, stabilizing, and film-forming properties. HEC is often used in industries such as pharmaceuticals, cosmetics, and food, where it is used to encapsulate active ingredients and provide controlled release. Its water solubility makes it an ideal choice for coating materials in microencapsulation, as it can easily dissolve and form a protective film around the core material.Rate this question:
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- 43.
One of the following is used as a pH dependant controlled release excipient
- A.
Carnuaba wax
- B.
HPMCP
- C.
MC
- D.
Glyceryl mono stearate
Correct Answer
D. Glyceryl mono stearateExplanation
Glyceryl mono stearate is used as a pH dependent controlled release excipient. It is a type of emulsifier that can be used to control the release rate of drugs in pharmaceutical formulations. The release of the drug can be adjusted based on the pH of the surrounding environment, allowing for targeted delivery to specific areas of the body. This makes glyceryl mono stearate a suitable excipient for formulations that require pH-dependent release profiles.Rate this question:
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- 44.
In the tablet coating process, inadequate spreading of coating solution before drying causes
- A.
Orange peel effect
- B.
Sticking effect
- C.
Blistering effect
- D.
Picking effect
Correct Answer
A. Orange peel effectExplanation
The inadequate spreading of the coating solution before drying in the tablet coating process can lead to the orange peel effect. This effect refers to the appearance of a rough, bumpy texture on the tablet surface, resembling the texture of an orange peel. It occurs when the coating solution does not spread evenly across the tablet surface, resulting in an uneven drying process. This can be caused by factors such as improper spray technique, high viscosity of the coating solution, or inadequate air flow in the coating equipment.Rate this question:
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- 45.
Crown thickness of a tablet is measured by
- A.
Micrometer
- B.
Pychnometer
- C.
Hydrometer
- D.
All of the above
Correct Answer
A. MicrometerExplanation
The crown thickness of a tablet is measured using a micrometer. A micrometer is a precise measuring instrument that is commonly used to measure small distances or thicknesses with high accuracy. It consists of a calibrated screw mechanism that allows for precise measurement by turning the screw until it comes into contact with the object being measured. Therefore, a micrometer is the appropriate tool for measuring the crown thickness of a tablet.Rate this question:
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- 46.
Friabilator is operated at
- A.
100 RPM
- B.
75 RPM
- C.
50 RPM
- D.
25 RPM
Correct Answer
D. 25 RPMExplanation
The correct answer is 25 RPM. The friabilator is operated at this speed to measure the friability of tablets. Friability refers to the tendency of tablets to crumble or break when subjected to mechanical stress. A lower RPM is preferred to ensure that the tablets are not excessively stressed, which could lead to inaccurate results. Therefore, operating the friabilator at 25 RPM helps to maintain the integrity of the tablets while still providing a reliable measurement of their friability.Rate this question:
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- 47.
Enteric coated tablet disintegrate in.....……hours in simulated intestinal fluid
- A.
1
- B.
2
- C.
3
- D.
4
Correct Answer
A. 1Explanation
Enteric coated tablets are designed to resist disintegration and dissolution in the acidic environment of the stomach and instead disintegrate in the alkaline environment of the intestines. This delayed release allows the active ingredient of the tablet to be released in the intestines where it can be absorbed more effectively. Therefore, the correct answer is 1, indicating that enteric coated tablets disintegrate in 1 hour in simulated intestinal fluid.Rate this question:
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- 48.
In dissolution test, flask is maintained at
- A.
37oC ± 0.5oC
- B.
37oC ± 1oC
- C.
37oC ± 0.6oC
- D.
37oC ± 1.5Oc
Correct Answer
A. 37oC ± 0.5oCExplanation
The correct answer is 37°C ± 0.5°C. In dissolution testing, it is important to maintain a specific temperature to ensure consistent and accurate results. The range of ± 0.5°C allows for slight temperature fluctuations while still maintaining the desired temperature of 37°C. This range ensures that the dissolution process is carried out under controlled conditions, minimizing any potential impact on the results.Rate this question:
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- 49.
Capping is prevented by using one of the following punches
- A.
Flat
- B.
Circular
- C.
Square
- D.
Rectangular
Correct Answer
A. FlatExplanation
Capping, which refers to the formation of a raised area around the tablet edge, can be prevented by using a flat punch. This type of punch ensures that the compression force is evenly distributed across the tablet, resulting in a uniform and smooth surface. The flat punch helps to maintain the integrity of the tablet and prevents any excess material from being pushed to the edges, thus avoiding the occurrence of capping.Rate this question:
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- 50.
Plating of punch faces are done by
- A.
Chromium
- B.
Zinc
- C.
Iron
- D.
All
Correct Answer
A. ChromiumExplanation
The correct answer is Chromium because plating of punch faces is commonly done using chromium. Chromium plating provides excellent corrosion resistance, hardness, and wear resistance to the punch faces, making them more durable and long-lasting. It also gives a smooth and attractive finish to the punches. Zinc and iron plating are not typically used for punch faces, and the option "All" is not accurate as not all metals are suitable for plating punch faces.Rate this question:
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Copy of On line quiz on HAP by Prof. V.P.Rawal, by MET Institute of D.pharmcy Nashik
Copy of On line quiz on HAP by Prof. V.P.Rawal, by MET Institute of D.pharmcy Nashik
Pharmaquize: PH I Sawkar Pharmacy College, Jaitapur , Satara.
Pharmaquize: PH I Sawkar Pharmacy College, Jaitapur , Satara.
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