Learn More About Pharmaceutics - Pharmaceutics Review Quiz
128 Questions
| Total Attempts: 1021
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Pharmaceutics is the discipline of pharmacy that deals with the process of turning a new chemical entity or old drugs into a medication to be used safely and effectively by patients. It is also called the science of dosage form design. Learn More About Pharmaceutics in this Pharmaceutics Review Quiz
Questions and Answers
- 1.A direct compression process to make tablets can only be used for drugs that are heat sensitive, light sensitive or moisture sensitive.
- A.
True
- B.
False
- 2.Patients should not take an antacid product along with an enteric coated tablet.
- A.
True
- B.
False
- 3.A non-steroidal anti-inflammatory drug, such as aspirin, is enterically coated to stabilize the aspirin against degradation in the acidic environment of the stomach.
- A.
True
- B.
False
- 4.A drug must first dissolve in the GI fluid before absorption from a tablet dosage form can occur. Soft gelatin capsules may contain oily solutions of drugs
- A.
True
- B.
False
- 5.The Pellicle effect seen with hard gelatin capsules is not a problem with HPMC. Drugs are typically more stable in aqueous solution than they are in the dry state.
- A.
True
- B.
False
- 6.Allegra D is a bilayer tablet product whereas Effexor XR is an extended release capsule product containing coated pellets.
- A.
True
- B.
False
- 7.The results of the Phase 1 clinical trial need to be approved by the FDA before an IND is submitted for review to the FDA.
- A.
True
- B.
False
- 8.Lactose and dicalcium phosphate are the two most common diluents presently in commercial tablet and capsule formulations.
- A.
True
- B.
False
- 9.Enteric polymers are insoluble in acid and dissolve at pH 5.5 and above release the contents of the coated pellet, tablet or capsule in the duodenum and the upper small intestine.
- A.
True
- B.
False
- 10.Deliquescent drugs should not be formulated into hard gelatin capsules.
- A.
True
- B.
False
- 11.Magnesium stearate and stearic acid are the two most common lubricants utilized by innovator and generic pharmaceutical companies in commercial tablet formulations.
- A.
True
- B.
False
- 12.Efflorescent granules are typically comprised of citric acid and tartaric acid in combination with sodium bicarbonate.
- A.
True
- B.
False
- 13.Drugs with a high therapeutic index will have a low MTC and a high MEC
- A.
True
- B.
False
- 14.A major difference between ANDA and a NDA is that the NDA contains some stability data on the finished product.
- A.
True
- B.
False
- 15.Eutectic formation results when water is absorbed into an excipient resulting in an increase in the number of water molecules in the crystal and increasing the hardness of tablets following compression.
- A.
True
- B.
False
- 16.The slugging or recompression method of tablet manufacture can be used to make tablets containing drugs that are unstable in the presence of moisture.
- A.
True
- B.
False
- 17.Sporanox capsules contain coated beads that are not formulated to sustain the release of the active ingredient (Itraconazole).
- A.
True
- B.
False
- 18.The surface area of a powder increases when the particle size is decreased.
- A.
True
- B.
False
- 19.A thermolabile drug is one that is unstable to heat. Lamination or capping of a tablet can results from poor bonding between granules in a tablet compact.
- A.
True
- B.
False
- 20.The Angle of Repose is a physical property of a powder that is used as a measure of flow. As the Angle of Repose decreases, the flow properties increase.
- A.
True
- B.
False
- 21.Soft gelatin capsules are very useful dosage forms to deliver drugs that are poorly soluble in water. Which one of the following vehicles CANNOT be used in soft gelatin capsules
- A.
Miglyol 812
- B.
Peanut oil
- C.
Purified water
- D.
Castor oil
- E.
Polyethylene glycol
- 22.Select the one correct answer
- A.
A ball mill may be used to increase the surface area of a solid drug substance
- B.
The transit time in the stomach is always longer than the transit time for a dosage form in the small intestine
- C.
Talc is often used in capsule formulations to promote wetting of the powder and dissolution of the drug substance, following the disintegration of the hard gelatin capsule
- D.
Powders are ideal dosage forms for unpleasant tasting drugs
- 23.CONI-Snap capsules offer significant advantages over traditional hard gelatin capsules in overcoming problems related to deliquescence.
- A.
True
- B.
False
- 24.Ac-Di-Sol is a superdisintegrant for tablets and releases carbon dioxide during the dissolution process.
- A.
True
- B.
False
- 25.Granules are irregular agglomerates fo small particles which behave as a single large particle.
- A.
True
- B.
False
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