Cop 2015 Pharmaceutics I Practice With Aa Charges

9 Questions | Total Attempts: 77

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Cop 2015 Pharmaceutics I Practice With Aa Charges

PH, functional groups, etc


Questions and Answers
  • 1. 
    Aspartic acid is an amino acid with three different pKas. The approximate pKas are as follows: pKaC = 2.0 pKaN = 9.9 pKaR = 3.9 At a pH of 12, what is the charge of the most abundant species present?
    • A. 

      0

    • B. 

      2+

    • C. 

      2-

    • D. 

      1-

  • 2. 
    Aspartic acid is an amino acid with three different pKas. The approximate pKas are as follows: pKaC = 2.0 pKaN = 9.9 pKaR = 3.9 At a pH of 7, what is the charge of the most abundant species present?
    • A. 

      0

    • B. 

      2+

    • C. 

      2-

    • D. 

      1-

  • 3. 
    Aspartic acid is an amino acid with three different pKas. The approximate pKas are as follows: pKaC = 2.0 pKaN = 9.9 pKaR = 3.9 What is the pI, isoelectric point, of aspartic acid?
    • A. 

      2.0

    • B. 

      2.95

    • C. 

      7.4

    • D. 

      3.9

  • 4. 
    If the pKa of HA in this equation is 4.2, the major species present at pH 6 will be ionized.
    • A. 

      True

    • B. 

      False

  • 5. 
    If the pKa of HA in this equation is 6.9, the major species present at pH 3.9 will be ionized.
    • A. 

      True

    • B. 

      False

  • 6. 
    Asprin is an acidic drug. One way to counteract aspirin overdose is to:
    • A. 

      Increase pH of the urine

    • B. 

      Decrease pH of the urine

    • C. 

      Initiate forced acid diuresis

  • 7. 
    In the equation above, the anion comes from the base.
    • A. 

      True

    • B. 

      False

  • 8. 
    In order to make a drug more water soluble, you would increase the overall charge.
    • A. 

      True

    • B. 

      False

  • 9. 
    Melphalan, depicted above, is a drug used in chemotherapy. At physiological pH, the drug has two charged groups as shown in the above figure. This drug will diffuse passively across cellular membranes.
    • A. 

      True

    • B. 

      False

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