Chronic Constipation: According To Uptodate

Prunes are indeed an effective laxative. They are high in fiber and contain a natural laxative compound called sorbitol. Sorbitol helps to soften the stool and promote bowel movements, relieving constipation. Prunes also contain dihydrophenylisatin, a compound that stimulates the bowel muscles and aids in digestion. Therefore, consuming prunes can help regulate bowel movements and alleviate constipation, making them an effective natural laxative.

Bisocodyl is a stimulant laxative that works by irritating the lining of the intestines, causing them to contract and move stool along. It is commonly used for the short-term relief of constipation and to prepare the bowels for medical procedures or surgery. Milk of Magnesia (MOM) is an osmotic laxative, PEG is a stool softener, and Psyllium is a bulk-forming laxative.

Lupiprostone is a medication that activates chloride channels in the intestines, leading to an increase in stool liquidity. This helps to alleviate constipation and improve bowel movements. The answer accurately describes the mechanism of action of Lupiprostone.

Synthetic sugars like lactulose and sorbitol are actually used as laxatives and are known to relieve constipation. Therefore, they do not generally cause constipation.

Docusate (Colace) is the drug least likely to help constipation because it is a stool softener that works by increasing the amount of water in the stool, making it easier to pass. However, it does not stimulate bowel movements or provide any additional relief for constipation. Psyllium (Metamucil), Polyethylene glycol (Miralax), Magnesium hydroxide suspension (Milk of Magnesia), and Lactulose (Enulose) are all laxatives that can help relieve constipation by either softening the stool, increasing bowel movements, or both.