Block 7 Temp Reg & Cancer

22 Questions | Total Attempts: 287

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Cancer Quizzes & Trivia

Turning points from Johanessen and Sands


Questions and Answers
  • 1. 
    Acclimatization to a hot environment includes the following change in sweat?
    • A. 

      More dilute

    • B. 

      More oily

    • C. 

      Delayed onset

    • D. 

      More volatile

    • E. 

      More salty

  • 2. 
    Core temperature is elevated during fever and exercise.   What distinguishes the rise in core temperature during fever from that during exercise?
    • A. 

      Increased basal metabolic rate

    • B. 

      Reduced sweat formation

    • C. 

      Non-shivering thermogenesis

    • D. 

      Reduced skin blood flow

    • E. 

      Increased thermal setpoint

  • 3. 
    A surgical sympathectomy has completely interrupted the sympathetic nerves to a patient’s arm. How would you expect the thermoregulatory skin blood flow and sweating responses in that arm to be affected? Vasoconstriction                              Vasodilation                       Sweat  in the cold                                       in the heat                          formation
    • A. 

      Abolished……………....……Intact…………………...........Intact

    • B. 

      Abolished…………....………Intact………………...........…Abolished

    • C. 

      Abolished………....…………Abolished…………...............Intact

    • D. 

      Abolished……………......…..Abolished…………...........…Abolished

  • 4. 
    The gain or loss of heat as infrared energy between two objects that are not in physical contact with each other is called what?
    • A. 

      Conduction

    • B. 

      Convection

    • C. 

      Radiation

    • D. 

      Evaporation

  • 5. 
    Which of the following is TRUE regarding the regulation of body temperature?
    • A. 

      In a temperate climate under normal conditions, the greatest loss of body heat occurs through radiation

    • B. 

      During water immersion, heat is mainly lost via radiation

    • C. 

      The thalamus is the centre for integrating thermal information

    • D. 

      As the skin possesses thermoreceptors, its temperature is regulated more closely than the core temperature

  • 6. 
    Which of the following is TRUE regarding sweating and heat loss?
    • A. 

      Heat loss through sweating is controlled by the parasympathetic nervous system

    • B. 

      The efficacy of sweating as a mechanism of heat loss is increased in tropical rain forest

    • C. 

      Profuse sweating can lead to heat exhaustion

    • D. 

      Common sweat is secreted by the apocrine glands

  • 7. 
    Pathogens that produce fever cause which of the following?
    • A. 

      Decreased production of interleukin-1 (IL-1)

    • B. 

      Decreased set-point temperature in the hypothalamus

    • C. 

      Shivering

    • D. 

      Vasodilation of blood vessels in the skin

  • 8. 
    What happens to glycolysis when p53 is mutated?
    • A. 

      Oxidative pentose pathway flux increases.

    • B. 

      Non-oxidative pentose pathway flux decreases.

    • C. 

      Glycolysis decreases

    • D. 

      The amount of NADPH produced by the PPP decreases.

    • E. 

      More pyruvate enters the mitochondria.

  • 9. 
    Which enzyme is responsible for the increase flux through the nonoxidative PPP in tumors?
    • A. 

      Hexose Kinase 1

    • B. 

      Phosphofructokinase-1

    • C. 

      TP53-induced glycolysis and apoptosis regulator

    • D. 

      Glucose 6-Phosphate Dehydrogenase

    • E. 

      Pyruvate Kinase M2

  • 10. 
    What molecule “fills up” the TCA cycle with carbon compounds so that it can keep working?
    • A. 

      Glucose

    • B. 

      Lactate

    • C. 

      Glutamine

    • D. 

      Alanine

    • E. 

      Aspartate

  • 11. 
    Which of the following enzymes do tumor cells use to generate enough NADPH to keep fatty acid and nucleotide synthesis going?  
    • A. 

      Glucose 6-Phosphate Dehydrogenase

    • B. 

      Malic enyzme

    • C. 

      Transketolase

    • D. 

      Glucose-6-Kinase

    • E. 

      NADH Dehydrogenase

  • 12. 
    What is one benefit, to cancer cells, to have the HK2-VDAC interaction on the outer mitochondrial membrane?
    • A. 

      Pyruvate acid gets into the mitochondria more readily

    • B. 

      Glucose gets into the mitochondria more easily

    • C. 

      HK2 has a readily available source of ATP for phosphorylating glucose

    • D. 

      The mitochondria can make ATP quicker so the cancer cells has a lot of ATP

    • E. 

      Having the HK2-VDAC interaction slows down the glycolysis that is occurring in the cancer cell

  • 13. 
    The heat transfer mechanism that occurs between the sun and the outer layer of the skin is called what?
    • A. 

      Conduction

    • B. 

      Convection

    • C. 

      Radiation

    • D. 

      Evaporation

  • 14. 
    The heat transfer mechanism that occurs between arteries and veins in a countercurrent exchange is called what?
    • A. 

      Conduction

    • B. 

      Convection

    • C. 

      Radiation

    • D. 

      Evaporation

  • 15. 
    What is the major heat source to retain body temperature for a nude 65-kg adult person in a 29oC/84.2oF environment?
    • A. 

      Brain

    • B. 

      Brown adipose tissue

    • C. 

      Liver

    • D. 

      Skeletal muscle

    • E. 

      White adipose tissue

  • 16. 
    Which of the following is a human thermoregulatory response controlled by cholinergic sympathetics?
    • A. 

      Brown adipose tissue thermogenesis

    • B. 

      Hand vasomotion

    • C. 

      Shivering thermogenesis

    • D. 

      Sweat secretion

    • E. 

      Thermoregulatory behavior

  • 17. 
    Which of the following will most faithfully reflect changes in human core temperature that could be caused by immersion in a warm body bath?
    • A. 

      Oral temperature

    • B. 

      Rectal temperature

    • C. 

      Axillary temperature

    • D. 

      Tympanic temperature

    • E. 

      Esophageal temperature at the cardia

  • 18. 
    In a man passively warmed such that his mean skin temperature reaches 40.5oC/104.9oF, which of the following circulatory responses will occur?
    • A. 

      Increased cardiac output, decreased splanchnic blood flow

    • B. 

      Increased cardiac output, increased muscle blood flow

    • C. 

      Unchanged cardiac output, decreased right atrial pressure

    • D. 

      Unchanged cardiac output, decreased renal blood flow

  • 19. 
    Which of the following is true at the beginning of the rising phase of fever?
    • A. 

      Sweat secretion is stimulated

    • B. 

      Mean skin temperature is below normal

    • C. 

      Muscle blood flow is decreased

    • D. 

      Behavioral thermoregulatory responses are inhibited

    • E. 

      Warm-sensitive neurons in the integration center are excited

  • 20. 
    The principal physical mechanism that accounts for the transfer of heat within the body is what?
    • A. 

      Conduction

    • B. 

      Convection

    • C. 

      Radiation

    • D. 

      Evaporation

  • 21. 
    When the environmental temperature increases moderately, what happens to blood flow to the skin?
    • A. 

      It decreases to stop the transport of heat from the skin surface to deeper tissues

    • B. 

      It decreases because the local thermoreceptors in the skin sense an increase in body temperature

    • C. 

      It increases because the sweat glands release vasodilators

    • D. 

      It increases as part of the body temperature regulatory mechanisms

    • E. 

      It increases as the metabolic needs of the skin tissue increase

  • 22. 
    If someone is experiencing heat exhaustion.  Which of the following would definitively indicate that they are now at risk for heat stroke?
    • A. 

      Increased sympathetic dilation of their blood vessels

    • B. 

      Increased hypotension

    • C. 

      Their skin becomes very dry

    • D. 

      They suddenly faint

    • E. 

      They have an increased volume of sweat production

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