Block 2 Biochem Clotting System

37 Questions

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Biochemistry Quizzes & Trivia

Questions and Answers
  • 1. 
    Which of the following contains exposed collagen to which platelets bind during vascular injury?
    • A. 

      Endothelial cells

    • B. 

      Subendothelial cells

    • C. 

      Platelets

    • D. 

      Clotting factors

    • E. 

      Von Willebrand Factor

  • 2. 
    Which of the following is an INHIBITOR of platelet adhesion and aggregation?
    • A. 

      Prostacyclin

    • B. 

      Fibrin

    • C. 

      Fibrinogen

    • D. 

      Von Willebrand Factor

    • E. 

      Thrombin

  • 3. 
    Platelet adhesion, the process of platelets binding to exposed subendothelial tissue after vascular injury, is primarily mediated by?
    • A. 

      Endothelial cells

    • B. 

      Subendothelial cells

    • C. 

      Platelets

    • D. 

      Clotting factors

    • E. 

      Von Willebrand Factor

  • 4. 
    ____________ is insoluble, while its precursor ____________ is soluble.
    • A. 

      Fibrinogen, Fibrin

    • B. 

      Fibrin, Fibrinogen

    • C. 

      Thrombin, prothrombin

    • D. 

      Prothrombin, thrombin

    • E. 

      None of the above

  • 5. 
    Which of the following is a protease responsible for converting fibrinogen to fibrin?
    • A. 

      Fibrin

    • B. 

      Thromboxane

    • C. 

      Thrombin

    • D. 

      Prothrombin

    • E. 

      Prostacyclin

  • 6. 
    Which of the following is the point where extrinsic and intrinsic pathways converge?
    • A. 

      X

    • B. 

      Xa

    • C. 

      IX

    • D. 

      IXa

    • E. 

      VIIa

  • 7. 
    Which of the following is NOT correlated with Factor Xa?
    • A. 

      Point of convergence between extrinsic pathway and intrinsic pathway

    • B. 

      Is the activated form of Factors X

    • C. 

      Inhibition of Factor VII to VIIa

    • D. 

      Hydrolyzes and activates prothrombin to thrombin

  • 8. 
    Which of the following is NOT part of the tenase complex?
    • A. 

      Ca2+

    • B. 

      Factor VIIIa

    • C. 

      Factor IXa

    • D. 

      Factor X

    • E. 

      Factor VIIa

  • 9. 
    Which of the following initiates the extrinsic pathway of the clotting cascade?
    • A. 

      Factor III (Tissue Factor)

    • B. 

      Factor VII

    • C. 

      Factor VIII

    • D. 

      Factor IX

    • E. 

      Factor X

  • 10. 
    Factor II is known as _____________, while Factor IIa is known as __________.
    • A. 

      Fibrinogen, Fibrin

    • B. 

      Fibrin, Fibrinogen

    • C. 

      Thrombin, prothrombin

    • D. 

      Prothrombin, thrombin

    • E. 

      None of the above

  • 11. 
    Which of the following is NOT inhibited by heparin?
    • A. 

      Factor XIIa

    • B. 

      Factor XIa

    • C. 

      Factor IXa

    • D. 

      Factor Xa

    • E. 

      Thrombin

    • F. 

      Fibrin

  • 12. 
    Which of the following is NOT an inhibitor of thrombin?
    • A. 

      Heparin

    • B. 

      Alpha2-macroglobulin

    • C. 

      Alpha1-antitrypsin

    • D. 

      Heparin cofactor II

    • E. 

      All are inhibitors of thrombin

  • 13. 
    Which of the following is primarily responsible for degradation of fibrin clots?
    • A. 

      Plasmin

    • B. 

      Plasminogen

    • C. 

      Thrombin

    • D. 

      Prothrombin

    • E. 

      Factor III

  • 14. 
    Hemophilia A is classic hemophilia. It is a disease referring to the inability to clot blood. Which of the following is deficient in this X-linked recessive disorder?
    • A. 

      Factor VII

    • B. 

      Factor VIII

    • C. 

      Factor IX

    • D. 

      Factor X

    • E. 

      Factor Xa

  • 15. 
    Hemophilia B results from a deficiency of which clotting factor?
    • A. 

      Factor VII

    • B. 

      Factor VIII

    • C. 

      Factor IX

    • D. 

      Factor X

    • E. 

      Factor XIII

  • 16. 
    Von Willebrand Disease (vWD) is due to an inherited deficiency in von Willebrand Factor (vWF). Which of the following factors are also affected as a result of deficiency of vWF?
    • A. 

      Factor VII

    • B. 

      Factor VIII

    • C. 

      Factor IX

    • D. 

      Factor X

    • E. 

      Factor Xa

  • 17. 
    Which of the following is heparin treatment MOST correlated to?
    • A. 

      Hemophilia A

    • B. 

      Hemophila B

    • C. 

      Disorders of fibrinogen and Factor XIII

    • D. 

      Von Willebrand Disease

    • E. 

      Factor XI and Contact Activation

    • F. 

      Antithrombin deficiency

  • 18. 
    Calcium is the trivial name for which of the following factors?
    • A. 

      Factor I

    • B. 

      Factor II

    • C. 

      Factor III

    • D. 

      Factor IV

    • E. 

      Factor V

  • 19. 
    Which of the following inactivates the extrinsic pathway?
    • A. 

      Lipoprotein associated coagulation inhibitor

    • B. 

      Thrombin

    • C. 

      Prothrombin

    • D. 

      fibrin

    • E. 

      Fibrinogen

  • 20. 
    Which of the following works with thrombin in aiding the degradation of clotting factors?
    • A. 

      Thrombomodulin

    • B. 

      Protein C

    • C. 

      Protein S

    • D. 

      All of the above

    • E. 

      None of the above

  • 21. 
    Which of the following is PRIMARILY responsible for formation of fibrin polymers?
    • A. 

      Factor VIIIa

    • B. 

      Factor IXa

    • C. 

      Factor Xa

    • D. 

      Factor XIIa

    • E. 

      Factor XIIIa

  • 22. 
    Which of the following is NOT calcium dependent?
    • A. 

      Factor II

    • B. 

      Factor III

    • C. 

      Factor VII

    • D. 

      Factor IX

    • E. 

      Factor X

  • 23. 
    Which of the following is NOT found in the prothrombinase complex?
    • A. 

      Calcium

    • B. 

      Factor Xa

    • C. 

      Disulfide bonds

    • D. 

      Factor Va

    • E. 

      Factor VIIIa

    • F. 

      Phospholipids

  • 24. 
    Prothrombin is cleaved to form a 2-chain active thrombin molecule, a serine protease, that will cleave fibrinogen to form fibrin. The short chain of the active thrombin molecule is the ____ chain.
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 25. 
    Thrombin combines with _________ present on endothelial cell surfaces forming a complex that converts protein C to protein Ca.
    • A. 

      Protein S

    • B. 

      Factor Va

    • C. 

      Thrombomodulin

    • D. 

      Factor VIIa

    • E. 

      Protein C

  • 26. 
    Which of the following is characterized by easy bruising and prolonged bleeding?
    • A. 

      Hemophilia A

    • B. 

      Hemophilia B

    • C. 

      Disorders of Fibrinogen and Factor XIII

    • D. 

      Von Willebrand Disease

    • E. 

      Factor XI and Contact Activation

    • F. 

      Antithrombin deficiency

  • 27. 
     Which of the following involves the transglutaminase reaction?
    • A. 

      Factor VIII

    • B. 

      Factor XIII

    • C. 

      Factor X

    • D. 

      Factor IX

    • E. 

      Factor II

  • 28. 
    Which of the following is characterized by prolonged coagulation time?
    • A. 

      Hemophilia A

    • B. 

      Hemophilia B

    • C. 

      Disorders of Fibrinogen and Factor XIII

    • D. 

      Von Willebrand Disease

    • E. 

      Factor XI and Contact Activation

    • F. 

      Antithrombin deficiency

  • 29. 
    Which of the following is also seen in women on oral contraceptives?
    • A. 

      Hemophilia A

    • B. 

      Hemophilia B

    • C. 

      Disorders of Fibrinogen and Factor XIII

    • D. 

      Von Willebrand Disease

    • E. 

      Factor XI and Contact Activation

    • F. 

      Antithrombin deficiency

  • 30. 
    Which of the following is the most commonly inherited bleeding disorder in humans?
    • A. 

      Hemophilia A

    • B. 

      Hemophilia B

    • C. 

      Disorders of Fibrinogen and Factor XIII

    • D. 

      Von Willebrand Disease

    • E. 

      Factor XI and Contact Activation

    • F. 

      Antithrombin deficiency

  • 31. 
    Which of the following is common in Ashkenazic Jews?
    • A. 

      Hemophilia A

    • B. 

      Hemophilia B

    • C. 

      Disorders of Fibrinogen and Factor XIII

    • D. 

      Von Willebrand Disease

    • E. 

      Factor XI and Contact Activation

    • F. 

      Antithrombin deficiency

  • 32. 
    Which of the following inhibits thrombin as well as Factors IXa, Xa, XIa, and XIIa?
    • A. 

      Antithrombin III

    • B. 

      Heparin

    • C. 

      Thrombomodulin

    • D. 

      Calcium

  • 33. 
    Vitamin ___ is responsible for the ___________ of coagulation factors.
    • A. 

      C, carboxylation

    • B. 

      C, decarboxylation

    • C. 

      K, carboxylation

    • D. 

      K, decarboxylation

  • 34. 
    Warfarin is a common anticoagulant. What is its mode of action?
    • A. 

      Competitive inhibition of Vitamin K

    • B. 

      Decarboxylation of clotting factors

    • C. 

      Inhibitor of thrombin

    • D. 

      Stabilizes fibrinogen and prevents its conversion to fibrin

    • E. 

      Conversion of Vitamin K epoxide to the quinone form

  • 35. 
    Rodenticides employ coumarin-type drugs such as warfarin to induce death by internal hemorrhaging. Which of the following enzymes are inhibited by these drugs?
    • A. 

      Vitamin K reductase

    • B. 

      Carboxylase-epoxidase

    • C. 

      Epoxide reductase

  • 36. 
    The prothrombin time test is used to measure clotting factors found in which pathway besides the common pathway?
    • A. 

      Intrinsic

    • B. 

      Extrinsic

  • 37. 
    The activated partial thromboplastin time test is used to measure clotting factors found in which pathway besides the common pathway?
    • A. 

      Intrinsic

    • B. 

      Extrinsic