Block 2 Biochem Clotting System
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- 1.Which of the following contains exposed collagen to which platelets bind during vascular injury?
- A.
Endothelial cells
- B.
Subendothelial cells
- C.
Platelets
- D.
Clotting factors
- E.
Von Willebrand Factor
- 2.Which of the following is an INHIBITOR of platelet adhesion and aggregation?
- A.
Prostacyclin
- B.
Fibrin
- C.
Fibrinogen
- D.
Von Willebrand Factor
- E.
Thrombin
- 3.Platelet adhesion, the process of platelets binding to exposed subendothelial tissue after vascular injury, is primarily mediated by?
- A.
Endothelial cells
- B.
Subendothelial cells
- C.
Platelets
- D.
Clotting factors
- E.
Von Willebrand Factor
- 4.____________ is insoluble, while its precursor ____________ is soluble.
- A.
Fibrinogen, Fibrin
- B.
Fibrin, Fibrinogen
- C.
Thrombin, prothrombin
- D.
Prothrombin, thrombin
- E.
None of the above
- 5.Which of the following is a protease responsible for converting fibrinogen to fibrin?
- A.
Fibrin
- B.
Thromboxane
- C.
Thrombin
- D.
Prothrombin
- E.
Prostacyclin
- 6.Which of the following is the point where extrinsic and intrinsic pathways converge?
- A.
X
- B.
Xa
- C.
IX
- D.
IXa
- E.
VIIa
- 7.Which of the following is NOT correlated with Factor Xa?
- A.
Point of convergence between extrinsic pathway and intrinsic pathway
- B.
Is the activated form of Factors X
- C.
Inhibition of Factor VII to VIIa
- D.
Hydrolyzes and activates prothrombin to thrombin
- 8.Which of the following is NOT part of the tenase complex?
- A.
Ca2+
- B.
Factor VIIIa
- C.
Factor IXa
- D.
Factor X
- E.
Factor VIIa
- 9.Which of the following initiates the extrinsic pathway of the clotting cascade?
- A.
Factor III (Tissue Factor)
- B.
Factor VII
- C.
Factor VIII
- D.
Factor IX
- E.
Factor X
- 10.Factor II is known as _____________, while Factor IIa is known as __________.
- A.
Fibrinogen, Fibrin
- B.
Fibrin, Fibrinogen
- C.
Thrombin, prothrombin
- D.
Prothrombin, thrombin
- E.
None of the above
- 11.Which of the following is NOT inhibited by heparin?
- A.
Factor XIIa
- B.
Factor XIa
- C.
Factor IXa
- D.
Factor Xa
- E.
Thrombin
- F.
Fibrin
- 12.Which of the following is NOT an inhibitor of thrombin?
- A.
Heparin
- B.
Alpha2-macroglobulin
- C.
Alpha1-antitrypsin
- D.
Heparin cofactor II
- E.
All are inhibitors of thrombin
- 13.Which of the following is primarily responsible for degradation of fibrin clots?
- A.
Plasmin
- B.
Plasminogen
- C.
Thrombin
- D.
Prothrombin
- E.
Factor III
- 14.Hemophilia A is classic hemophilia. It is a disease referring to the inability to clot blood. Which of the following is deficient in this X-linked recessive disorder?
- A.
Factor VII
- B.
Factor VIII
- C.
Factor IX
- D.
Factor X
- E.
Factor Xa
- 15.Hemophilia B results from a deficiency of which clotting factor?
- A.
Factor VII
- B.
Factor VIII
- C.
Factor IX
- D.
Factor X
- E.
Factor XIII
- 16.Von Willebrand Disease (vWD) is due to an inherited deficiency in von Willebrand Factor (vWF). Which of the following factors are also affected as a result of deficiency of vWF?
- A.
Factor VII
- B.
Factor VIII
- C.
Factor IX
- D.
Factor X
- E.
Factor Xa
- 17.Which of the following is heparin treatment MOST correlated to?
- A.
Hemophilia A
- B.
Hemophila B
- C.
Disorders of fibrinogen and Factor XIII
- D.
Von Willebrand Disease
- E.
Factor XI and Contact Activation
- F.
Antithrombin deficiency
- 18.Calcium is the trivial name for which of the following factors?
- A.
Factor I
- B.
Factor II
- C.
Factor III
- D.
Factor IV
- E.
Factor V
- 19.Which of the following inactivates the extrinsic pathway?
- A.
Lipoprotein associated coagulation inhibitor
- B.
Thrombin
- C.
Prothrombin
- D.
fibrin
- E.
Fibrinogen
- 20.Which of the following works with thrombin in aiding the degradation of clotting factors?
- A.
Thrombomodulin
- B.
Protein C
- C.
Protein S
- D.
All of the above
- E.
None of the above
- 21.Which of the following is PRIMARILY responsible for formation of fibrin polymers?
- A.
Factor VIIIa
- B.
Factor IXa
- C.
Factor Xa
- D.
Factor XIIa
- E.
Factor XIIIa
- 22.Which of the following is NOT calcium dependent?
- A.
Factor II
- B.
Factor III
- C.
Factor VII
- D.
Factor IX
- E.
Factor X
- 23.Which of the following is NOT found in the prothrombinase complex?
- A.
Calcium
- B.
Factor Xa
- C.
Disulfide bonds
- D.
Factor Va
- E.
Factor VIIIa
- F.
Phospholipids
- 24.Prothrombin is cleaved to form a 2-chain active thrombin molecule, a serine protease, that will cleave fibrinogen to form fibrin. The short chain of the active thrombin molecule is the ____ chain.
- A.
A
- B.
B
- C.
C
- D.
D
- E.
E
- 25.Thrombin combines with _________ present on endothelial cell surfaces forming a complex that converts protein C to protein Ca.
- A.
Protein S
- B.
Factor Va
- C.
Thrombomodulin
- D.
Factor VIIa
- E.
Protein C
- 26.Which of the following is characterized by easy bruising and prolonged bleeding?
- A.
Hemophilia A
- B.
Hemophilia B
- C.
Disorders of Fibrinogen and Factor XIII
- D.
Von Willebrand Disease
- E.
Factor XI and Contact Activation
- F.
Antithrombin deficiency
- 27.Which of the following involves the transglutaminase reaction?
- A.
Factor VIII
- B.
Factor XIII
- C.
Factor X
- D.
Factor IX
- E.
Factor II
- 28.Which of the following is characterized by prolonged coagulation time?
- A.
Hemophilia A
- B.
Hemophilia B
- C.
Disorders of Fibrinogen and Factor XIII
- D.
Von Willebrand Disease
- E.
Factor XI and Contact Activation
- F.
Antithrombin deficiency
- 29.Which of the following is also seen in women on oral contraceptives?
- A.
Hemophilia A
- B.
Hemophilia B
- C.
Disorders of Fibrinogen and Factor XIII
- D.
Von Willebrand Disease
- E.
Factor XI and Contact Activation
- F.
Antithrombin deficiency
- 30.Which of the following is the most commonly inherited bleeding disorder in humans?
- A.
Hemophilia A
- B.
Hemophilia B
- C.
Disorders of Fibrinogen and Factor XIII
- D.
Von Willebrand Disease
- E.
Factor XI and Contact Activation
- F.
Antithrombin deficiency
- 31.Which of the following is common in Ashkenazic Jews?
- A.
Hemophilia A
- B.
Hemophilia B
- C.
Disorders of Fibrinogen and Factor XIII
- D.
Von Willebrand Disease
- E.
Factor XI and Contact Activation
- F.
Antithrombin deficiency
- 32.Which of the following inhibits thrombin as well as Factors IXa, Xa, XIa, and XIIa?
- A.
Antithrombin III
- B.
Heparin
- C.
Thrombomodulin
- D.
Calcium
- 33.Vitamin ___ is responsible for the ___________ of coagulation factors.
- A.
C, carboxylation
- B.
C, decarboxylation
- C.
K, carboxylation
- D.
K, decarboxylation
- 34.Warfarin is a common anticoagulant. What is its mode of action?
- A.
Competitive inhibition of Vitamin K
- B.
Decarboxylation of clotting factors
- C.
Inhibitor of thrombin
- D.
Stabilizes fibrinogen and prevents its conversion to fibrin
- E.
Conversion of Vitamin K epoxide to the quinone form
- 35.Rodenticides employ coumarin-type drugs such as warfarin to induce death by internal hemorrhaging. Which of the following enzymes are inhibited by these drugs?
- A.
Vitamin K reductase
- B.
Carboxylase-epoxidase
- C.
Epoxide reductase
- 36.The prothrombin time test is used to measure clotting factors found in which pathway besides the common pathway?
- A.
Intrinsic
- B.
Extrinsic
- 37.The activated partial thromboplastin time test is used to measure clotting factors found in which pathway besides the common pathway?
- A.
Intrinsic
- B.
Extrinsic
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