Roll-up cigarettes, also known as hand-rolled cigarettes, are made by rolling loose tobacco in a rolling paper. These cigarettes do not undergo the same manufacturing processes as commercially produced cigarettes, which means they may contain higher levels of harmful substances such as tar, nicotine, and carcinogens. Smoking any form of tobacco, including roll-up cigarettes, has been linked to an increased risk of developing various types of cancer, including lung, mouth, throat, and esophageal cancer. Therefore, it can be concluded that roll-up cigarettes do cause cancer.