Respiratory Quiz - Module 11

1. Patients treated with LTRAs are more likely to suffer an exacerbation requiring systemic corticosteroids, especially in patients with moderate-severe compared to those with mild asthma.

True

False

(true) Inhaled corticosteroids are the preferred first line therapy for moderate to severe asthmatics.

Explanation

(true) Inhaled corticosteroids are the preferred first line therapy for moderate to severe asthmatics.

2. LTRAs are a good add on therapy for patients with asthma who are still symptomatic on low or medium dose inhaled corticosteroids

True

False

LTRAs (Leukotriene Receptor Antagonists) are medications that can be added to the treatment plan for patients with asthma who are still experiencing symptoms despite being on low or medium doses of inhaled corticosteroids. LTRAs work by blocking the action of leukotrienes, which are substances in the body that cause inflammation and constriction of the airways. By adding LTRAs to the treatment regimen, it can help to further control symptoms and improve asthma control for these patients. Therefore, the statement is true.

Explanation

LTRAs (Leukotriene Receptor Antagonists) are medications that can be added to the treatment plan for patients with asthma who are still experiencing symptoms despite being on low or medium doses of inhaled corticosteroids. LTRAs work by blocking the action of leukotrienes, which are substances in the body that cause inflammation and constriction of the airways. By adding LTRAs to the treatment regimen, it can help to further control symptoms and improve asthma control for these patients. Therefore, the statement is true.

3. Montelukast is effective and safe for prevention of exercise induced bronchospasm in patients with exercise induced asthma

True

False

Montelukast is a medication that is commonly used to treat asthma. It works by blocking the action of certain chemicals in the body that cause inflammation and constriction of the airways. Exercise-induced bronchospasm is a common symptom in patients with exercise-induced asthma, where physical activity triggers bronchial constriction and difficulty breathing. Studies have shown that Montelukast is effective and safe in preventing exercise-induced bronchospasm in these patients, making the statement true.

Explanation

Montelukast is a medication that is commonly used to treat asthma. It works by blocking the action of certain chemicals in the body that cause inflammation and constriction of the airways. Exercise-induced bronchospasm is a common symptom in patients with exercise-induced asthma, where physical activity triggers bronchial constriction and difficulty breathing. Studies have shown that Montelukast is effective and safe in preventing exercise-induced bronchospasm in these patients, making the statement true.

4. Montelukast is particularly effective in aspirin induced asthma because of the common physiological pathway that is shared between aspirin metabolism and leukotrienes

True

False

Montelukast is effective in aspirin-induced asthma because it targets the common physiological pathway shared between aspirin metabolism and leukotrienes. Aspirin-induced asthma is characterized by an overproduction of leukotrienes, which are inflammatory mediators involved in the pathogenesis of asthma. Montelukast is a leukotriene receptor antagonist that inhibits the binding of leukotrienes to their receptors, reducing inflammation and bronchoconstriction in the airways. Therefore, it is particularly effective in treating aspirin-induced asthma, as it specifically targets the underlying mechanism of this condition.

Explanation

Montelukast is effective in aspirin-induced asthma because it targets the common physiological pathway shared between aspirin metabolism and leukotrienes. Aspirin-induced asthma is characterized by an overproduction of leukotrienes, which are inflammatory mediators involved in the pathogenesis of asthma. Montelukast is a leukotriene receptor antagonist that inhibits the binding of leukotrienes to their receptors, reducing inflammation and bronchoconstriction in the airways. Therefore, it is particularly effective in treating aspirin-induced asthma, as it specifically targets the underlying mechanism of this condition.

5. LTRAs are a good choice for a patient who requires mild controller therapy but can be managed without ICS as it more convenient and has much less side effects

True

False

LTRAs (Leukotriene Receptor Antagonists) are a good choice for patients who require mild controller therapy but can be managed without Inhaled Corticosteroids (ICS). This is because LTRAs are more convenient to use and have fewer side effects compared to ICS. LTRAs work by blocking the action of leukotrienes, which are substances in the body that cause inflammation and narrowing of the airways. By blocking leukotrienes, LTRAs help to reduce inflammation and improve breathing in patients with mild asthma. Therefore, it is true that LTRAs are a good choice for patients who require mild controller therapy but can be managed without ICS.

Explanation

LTRAs (Leukotriene Receptor Antagonists) are a good choice for patients who require mild controller therapy but can be managed without Inhaled Corticosteroids (ICS). This is because LTRAs are more convenient to use and have fewer side effects compared to ICS. LTRAs work by blocking the action of leukotrienes, which are substances in the body that cause inflammation and narrowing of the airways. By blocking leukotrienes, LTRAs help to reduce inflammation and improve breathing in patients with mild asthma. Therefore, it is true that LTRAs are a good choice for patients who require mild controller therapy but can be managed without ICS.

6. Most patients with viral bronchiolitis have allergic inflammation

True

False

(false) Patients have infection and non-allergic inflammation

Explanation

(false) Patients have infection and non-allergic inflammation

7. Most patients with viral bronchiolitis have bronchospasm

True

False

(false) the airway obstruction comes from swelling and mucous in the airways caused directly by the viral infection.

Explanation

(false) the airway obstruction comes from swelling and mucous in the airways caused directly by the viral infection.

8. Leukotriene receptor antagonists (LTRAs) are equally effective as inhaled corticosteroids for treating the inflammation associated with asthma.

True

False

(false) Although LTRAs are effective, they are not as strong anti-inflammatories as inhaled corticosteroids (ICS).

Explanation

(false) Although LTRAs are effective, they are not as strong anti-inflammatories as inhaled corticosteroids (ICS).

9. Montelukast prevents exercise induced bronchospasm for up to 6 hours after administration

True

False

(false) Duration of action is up to 24 hours after dosing

Explanation

(false) Duration of action is up to 24 hours after dosing

10. LTRAs are the most effective add on therapy for patients with asthma who are still symptomatic on low or medium dose inhaled corticosteroids

True

False

(false) Long acting beta 2 agonists are equally effective and perhaps more effective add on therapy (especially when given in a single inhaler), but have potential for more side effects and are contraindicated in children below the age of 5f

Explanation

(false) Long acting beta 2 agonists are equally effective and perhaps more effective add on therapy (especially when given in a single inhaler), but have potential for more side effects and are contraindicated in children below the age of 5f

11. Aspirin induced asthma is a very uncommon manifestation of asthma

True

False

(false) Aspirin induced asthma affects approximately 10% of adult patients with asthma

Explanation

(false) Aspirin induced asthma affects approximately 10% of adult patients with asthma