Pharmacology(2) Drugs Used In Asthma

23 Questions

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Pharmacology Quizzes & Trivia

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Questions and Answers
  • 1. 
    Asthma is defined as a syndrome in which there is(are)
    • A. 

      Recurrent reversible obstruction of the airways

    • B. 

      Intermittent attacks of dyspnoea, wheezing , and cough

    • C. 

      Disorders in breathing in

    • D. 

      Disorders in breathing out

    • E. 

      Recurrent irreversible obstruction of the airways in response to stimuli

  • 2. 
    The characteristic features of asthma is (are):
    • A. 

      Purely a Type I hypersensitivity reactions

    • B. 

      Bronchial hyper-responsiveness and inflammatory changes in the airways

    • C. 

      The immediate and the late phase

    • D. 

      Involving only the interaction of allergen with mast-cell-fixed IgE

    • E. 

      Occurrence only in adults

  • 3. 
    The term bronchial hyper-responsiveness refers to abnormal sensitivity  to:
    • A. 

      Allergens (in sensitized individuals)

    • B. 

      Exercise (the stimulus may be cold air)

    • C. 

      Respiratory infections

    • D. 

      Atmospheric pollutants such as sulphur dioxide, cigarette smoke

    • E. 

      Genetic dispositions

  • 4. 
    The immediate (early) phase:
    • A. 

      Occurs abruptly

    • B. 

      The cells involved in this phase are predominantly mast cells

    • C. 

      Can be reversed by bronchodilators (glucocorticoids, cromoglycate)

    • D. 

      Can be reversed by anti-inflammatory agents

    • E. 

      Can be reversed by sedatives and hypnotics

  • 5. 
    Bronchodilators are:
    • A. 

      Beta 2 antagonists

    • B. 

      Beta 1 agonists

    • C. 

      Beta 2 agonists

    • D. 

      Antimuscarinic drugs

    • E. 

      Methylxanthines

  • 6. 
    Short acting beta 2 mimetics (for an acute attack management) :
    • A. 

      Are administered via inhalation if possible

    • B. 

      Only orally

    • C. 

      i.v.

    • D. 

      S.c.

    • E. 

      Parenterally

  • 7. 
    Inhalation method(s) is (are):
    • A. 

      Intranasal administration for systemic absorption

    • B. 

      Metered dose inhaler-aerosol

    • C. 

      Aerosol administered via a nebulizer

    • D. 

      As a dry power (Turbohaler or Diskhaler)

    • E. 

      Intranasal administration for the local effects on nasal mucosa

  • 8. 
    Using metered dose inhaler -aerosol the dose of........ /puff is administered:
    • A. 

      1ug

    • B. 

      10 ug

    • C. 

      100ug

    • D. 

      1mg

    • E. 

      10 mg

  • 9. 
    The increase in FEV-1  after inhalation of 200 ug of salbutamol:
    • A. 

      Begins within 2 minutes

    • B. 

      Begins within 15 min

    • C. 

      Peaks at 1 hour

    • D. 

      Peaks at 3 hours

    • E. 

      Persists for 10-12 hours

  • 10. 
    Pharmacological effects of beta 2 agonists are:
    • A. 

      Relaxation of skeletal muscle

    • B. 

      Relaxation of bronchial smooth muscle

    • C. 

      Relaxation of uterine smooth muscle

    • D. 

      Decrease in heart rate, force of mycardial contraction, speed of impulse conduction

    • E. 

      Increase in ectopic foci in the myocardium and automaticity in pacemaker tissue

  • 11. 
    Adverse effects of beta 2 agonists are:
    • A. 

      Muscle tremor, headache and insomnia

    • B. 

      Tachycardia, flushing, palpitations and cardiac arrhythmias

    • C. 

      The risk of precipitating or exacerbating angina in patients with ischemic heart disease

    • D. 

      Acute urinary retention in patients with prostatic hypertrophy

    • E. 

      Hyperkalemia.

  • 12. 
    Muscarinic receptor antagonists (used for the treatment of asthma) involve:
    • A. 

      Fenoterol

    • B. 

      Ipratropium

    • C. 

      Berodual

    • D. 

      Atrovent

    • E. 

      Atropin

  • 13. 
    Ipratropium:
    • A. 

      Is administered orally

    • B. 

      Is more effective than salbutamol

    • C. 

      Could precipitate acute glaucoma

    • D. 

      Is used for patients with heart disease

    • E. 

      But cannot be used for patients with thyreotoxicosis

  • 14. 
    Methylxanthines used for the treatment of asthma are:
    • A. 

      Theophyllin

    • B. 

      Oxyphyllin

    • C. 

      Aminophyllin

    • D. 

      Pentoxiphyllin

    • E. 

      Caffeine

  • 15. 
    Theophylline  and/or aminophylline in the form of sustained release preparation:
    • A. 

      Is administered orally 4times/day

    • B. 

      Is administered orally once or twice a day

    • C. 

      Is administered i.v. once a day

    • D. 

      Is not dependent on food

    • E. 

      Has a reduced incidence of gastrointestinal adverse effects

  • 16. 
    Aminophylline is:
    • A. 

      Used i.v.( injections)

    • B. 

      Used orally

    • C. 

      Used orally in the form of sustained release preparations

    • D. 

      By inhalation

    • E. 

      Used i.v. (infusions)

  • 17. 
    Adverse effects of theophylline:
    • A. 

      Are generally related to its plasma concentration

    • B. 

      Include tachycardia, cardiac arrhythmias

    • C. 

      Do not comprise insomnia, headache, anxiety

    • D. 

      Include nauzea and vomiting

    • E. 

      Theophylline can induce anxiety and seizures

  • 18. 
    Theophylline produces bronchodilating effects by means of:
    • A. 

      Inhibition of mediator release from mast cells

    • B. 

      Antagonism of adenosine at A 2 receptors

    • C. 

      Anti-inflammatory activity on T lymphocytes

    • D. 

      Central stimulation of respiration

    • E. 

      Stimulation of beta 2 receptors

  • 19. 
    The therapeutic range of theophylline in plasma is:
    • A. 

      5-15 ug/ml in children

    • B. 

      8-15 ug/ml in adults

    • C. 

      20-40 ug/ml in adults

    • D. 

      0.5 - 5 ug/ml in children

    • E. 

      0.1 - 1 ug/ml in children

  • 20. 
    Pharmacokinetics of theophylline. Theophylline is:
    • A. 

      Not metabolised in the liver

    • B. 

      Excreted predominantly in non-changed form by the urine

    • C. 

      Used in patients with liver disease without caution

    • D. 

      Not used in patients with congestive heart failure

    • E. 

      Not used in patients with congestive heart failure

  • 21. 
    The half-life of theophylline is:
    • A. 

      Decreased by erythromycin

    • B. 

      Increased by cimetidine

    • C. 

      Increased by oral contraceptives

    • D. 

      Increased by phenytoin

    • E. 

      Decreased by carbamazepin

  • 22. 
    Glucocorticoids  are:
    • A. 

      Bronchodilators with a large effect on early-phase response

    • B. 

      Not bronchodilators, are not effective in the treatment of the early response to the eliciting agent

    • C. 

      Administered by inhalation they are extremely powerful anti-inflammatory drugs.

    • D. 

      Considered as first-line drugs in asthma prophylaxis, for all but the mildest cases

    • E. 

      For severe asthma an oral glucocorticoid is indicated

  • 23. 
    Glucocorticoids given by inhalation:
    • A. 

      Can cause oropharyngeal candidiasis

    • B. 

      In low doses cause adrenal suppression

    • C. 

      Are administered 2-4times daily

    • D. 

      Involve budesonide, beclomethasone

    • E. 

      Involve hydrocortisone, prednisolone , methylprednisolone