Pharmacology- Musculoskeletal Issues & Non-opioid Analgesia (Nsaid's)

25 Questions | Total Attempts: 60

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Pharmacology- Musculoskeletal Issues & Non-opioid Analgesia (Nsaid

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Questions and Answers
  • 1. 
    __________________ is the original NSAID
  • 2. 
    True or false: NSAIDs ↓ sensitivity of vessels to bradykinin and histamine, affect T lymphocytes, & reverse vasodilation of inflammation
    • A. 

      True

    • B. 

      False

  • 3. 
    ___________  inhibitors were developed to inhibit prostaglandin synthesis at sites of inflammation, and higher incidence of CV thrombotic events. 
    • A. 

      COX-2

    • B. 

      COX -1

  • 4. 
    Antiplatelet effect of NSAIDs comes from blocking the ___________ enzyme and producing thromboxane
    • A. 

      COX-1

    • B. 

      Cox-2

  • 5. 
    Select all: General ADE in NSAIDs
    • A. 

      Headaches, tinnitus

    • B. 

      Contispation, anorexia

    • C. 

      Confusion, irritability

    • D. 

      Fluid retention, hypertension

    • E. 

      Nausea, vomiting

  • 6. 
    What is the First-line Treatment of MSK Pain? 
    • A. 

      acetaminophen

    • B. 

      Aspirin

    • C. 

      Ibuprofen

    • D. 

      Aleve

  • 7. 
    In the nonpharmacologic treatment of MK pain, what does the acronym R.I.C.E stand for?   
    • A. 

      Relax, Intervene, Compression, elevation

    • B. 

      Rest, Ice, Compression, Elevation

    • C. 

      Relax, Ice, Compression, Elevation

    • D. 

      Relieve, Intervene, Compression, elevation

  • 8. 
    Treatment of MSK Pain: If a patient has moderate pain, consider starting ____________ at the same time as nonpharmacologic treatment
    • A. 

      Salicylates

    • B. 

      NSAIDs

    • C. 

      Acetaminophen

  • 9. 
    Avoid aspirin in children/adolescents because it can cause ___________ syndrome
    • A. 

      Turner

    • B. 

      Reye's

    • C. 

      Guillain-Barré

    • D. 

      Sjogren's

  • 10. 
    Select all: Agents used in pharmacologic Treatment of OA
    • A. 

      Acetaminophen

    • B. 

      NSAIDs

    • C. 

      COX-2 inhibitors

    • D. 

      Cox-1 inhibitors

    • E. 

      Intraarticular injection of steroids

  • 11. 
    True or false: Gout Aims of treatment includes: decreasing symptoms of an acute attack, decreasing the risk of recurrent attacks and increasing serum urate levels
    • A. 

      True

    • B. 

      False

  • 12. 
    What is the first-line treatment for Gout in a patient with acute symptoms? 
    • A. 

      Colchicine

    • B. 

      NSAIDs

    • C. 

      Corticosteroids

    • D. 

      Uricosuric drugs

  • 13. 
    What is the first-line treatment for Gout in Preventative therapy?
    • A. 

      Colchicine

    • B. 

      keterolac

    • C. 

      Allopurinol

    • D. 

      Methylprednisolone

  • 14. 
    What medication is used for ACUTE Gout attacks and causes significant Gi distress (diarrhea, N/V, abd. pain)? 
    • A. 

      Febuxostat

    • B. 

      Allopurinol

    • C. 

      Colchicine

    • D. 

      Probenecid

  • 15. 
    Which Gout medications reduce production of uric acid by inhibition of xanthine oxidase (an enzyme that converts hypoxanthine to xanthine and xanthine to uric acid)
    • A. 

      Allopurinol

    • B. 

      Febuxostat

    • C. 

      Probenecid

    • D. 

      Colchicine

  • 16. 
    Gout is caused by the buildup of what substance in the body? 
    • A. 

      Calcium

    • B. 

      Uric acid

    • C. 

      Pyruvic acid

    • D. 

      Oxalate

  • 17. 
    Acute attacks of gouty arthritis may occur early in treatment with allopurinol (Zyloprim, Purinol) because: 
    • A. 

      Allopurinol (Zyloprim, Purinol) increases urate synthesis

    • B. 

      Urate crystals move from tissue to plasma

    • C. 

      Allopurinol (Zyloprim, Purinol) increases release of chemotactic factors

    • D. 

      A & B

    • E. 

      A, B & C

  • 18. 
    Rational indication(s) for allopurinol (Zyloprim, Purinol) administration:
    • A. 

      Chronic tophaceous gout;when tophi reabsorption more rapid with uricosuric agents

    • B. 

      When probenecid or sulfinpyrazone cannot be used

    • C. 

      presence of renal functional impairment

    • D. 

      in a patient with recurrent renal stones

    • E. 

      All of the above

  • 19. 
    Previously most popular drug for treating inflammation of acute gouty arthritis -- NSAIDs now more commonly used because of diarrhea associated with earlier medication:
    • A. 

      Allopurinol (Zyloprim, Purinol)

    • B. 

      colchicine

    • C. 

      Acetaminophen (Tylenol, Panadol)

    • D. 

      probenecid (Benemid)

  • 20. 
    ___________________reduces uric acid synthesis: for management of gout
    • A. 

      Colchicine

    • B. 

      Probenecid (Benemid)

    • C. 

      Allopurinol (Zyloprim, Purinol)

    • D. 

      Oxaprozin (Daypro)

  • 21. 
    This drug inhibits the secretion of many weak acids (penicillin, methotrexate) in addition to inhibiting reabsorption of uric acid  and is used orally to treat chronic gout: 
    • A. 

      Allopurinol

    • B. 

      Probenecid

    • C. 

      Febuxostat

    • D. 

      Colchicine

  • 22. 
    Which medication for Gout should a patient NOT use if they are allergic to Sulfonamides? 
    • A. 

      Probenecid

    • B. 

      Colchicine

    • C. 

      Allopurinol

    • D. 

      Febuxostat

  • 23. 
    What class of Gout medications should a patient not use concurrently with Uricosuric Agents because it can antagonize its effect? 
    • A. 

      NSAIDs

    • B. 

      Salicylates

    • C. 

      Xanthine Oxidase Inhibitors

  • 24. 
    Gout medication that enhances the effects of CNS depressants and sympathomimetic agents, may interfere w/ vitamin B12 absorption and have Increased toxicity w/ concurrent use of clarithromycin, erythromycin, and grapefruit juice
    • A. 

      Allopurinol

    • B. 

      Febuxostat

    • C. 

      Colchicine

    • D. 

      Probenecid

  • 25. 
    Both of these Gout medications decrease concentrations of less soluble uric acid- ↓ precipitation of uric acid crystals in joints and tissues
    • A. 

      Colchicine

    • B. 

      Allopurinol

    • C. 

      Febuxostat

    • D. 

      Probenecid

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