Pharmacology- Musculoskeletal Issues & Non-opioid Analgesia (Nsaid's)

25 Questions | By A.dozier731 | Last updated: Mar 20, 2022 | Total Attempts: 119

Questions

Settings

Create your own Quiz

Pharmacology- Musculoskeletal Issues & Non-opioid Analgesia (Nsaid

Questions and Answers

1.

__________________ is the original NSAID
2.

True or false: NSAIDs ↓ sensitivity of vessels to bradykinin and histamine, affect T lymphocytes, & reverse vasodilation of inflammation
- A.
  
  True
- B.
  
  False
3.

___________ inhibitors were developed to inhibit prostaglandin synthesis at sites of inflammation, and higher incidence of CV thrombotic events.
- A.
  
  COX-2
- B.
  
  COX -1
4.

Antiplatelet effect of NSAIDs comes from blocking the ___________ enzyme and producing thromboxane
- A.
  
  COX-1
- B.
  
  Cox-2
5.

Select all: General ADE in NSAIDs
- A.
  
  Headaches, tinnitus
- B.
  
  Contispation, anorexia
- C.
  
  Confusion, irritability
- D.
  
  Fluid retention, hypertension
- E.
  
  Nausea, vomiting
6.

What is the First-line Treatment of MSK Pain?
- A.
  
  acetaminophen
- B.
  
  Aspirin
- C.
  
  Ibuprofen
- D.
  
  Aleve
7.

In the nonpharmacologic treatment of MK pain, what does the acronym R.I.C.E stand for?
- A.
  
  Relax, Intervene, Compression, elevation
- B.
  
  Rest, Ice, Compression, Elevation
- C.
  
  Relax, Ice, Compression, Elevation
- D.
  
  Relieve, Intervene, Compression, elevation
8.

Treatment of MSK Pain: If a patient has moderate pain, consider starting ____________ at the same time as nonpharmacologic treatment
- A.
  
  Salicylates
- B.
  
  NSAIDs
- C.
  
  Acetaminophen
9.

Avoid aspirin in children/adolescents because it can cause ___________ syndrome
- A.
  
  Turner
- B.
  
  Reye's
- C.
  
  Guillain-Barré
- D.
  
  Sjogren's
10.

Select all: Agents used in pharmacologic Treatment of OA
- A.
  
  Acetaminophen
- B.
  
  NSAIDs
- C.
  
  COX-2 inhibitors
- D.
  
  Cox-1 inhibitors
- E.
  
  Intraarticular injection of steroids
11.

True or false: Gout Aims of treatment includes: decreasing symptoms of an acute attack, decreasing the risk of recurrent attacks and increasing serum urate levels
- A.
  
  True
- B.
  
  False
12.

What is the first-line treatment for Gout in a patient with acute symptoms?
- A.
  
  Colchicine
- B.
  
  NSAIDs
- C.
  
  Corticosteroids
- D.
  
  Uricosuric drugs
13.

What is the first-line treatment for Gout in Preventative therapy?
- A.
  
  Colchicine
- B.
  
  keterolac
- C.
  
  Allopurinol
- D.
  
  Methylprednisolone
14.

What medication is used for ACUTE Gout attacks and causes significant Gi distress (diarrhea, N/V, abd. pain)?
- A.
  
  Febuxostat
- B.
  
  Allopurinol
- C.
  
  Colchicine
- D.
  
  Probenecid
15.

Which Gout medications reduce production of uric acid by inhibition of xanthine oxidase (an enzyme that converts hypoxanthine to xanthine and xanthine to uric acid)
- A.
  
  Allopurinol
- B.
  
  Febuxostat
- C.
  
  Probenecid
- D.
  
  Colchicine
16.

Gout is caused by the buildup of what substance in the body?
- A.
  
  Calcium
- B.
  
  Uric acid
- C.
  
  Pyruvic acid
- D.
  
  Oxalate
17.

Acute attacks of gouty arthritis may occur early in treatment with allopurinol (Zyloprim, Purinol) because:
- A.
  
  Allopurinol (Zyloprim, Purinol) increases urate synthesis
- B.
  
  Urate crystals move from tissue to plasma
- C.
  
  Allopurinol (Zyloprim, Purinol) increases release of chemotactic factors
- D.
  
  A & B
- E.
  
  A, B & C
18.

Rational indication(s) for allopurinol (Zyloprim, Purinol) administration:
- A.
  
  Chronic tophaceous gout;when tophi reabsorption more rapid with uricosuric agents
- B.
  
  When probenecid or sulfinpyrazone cannot be used
- C.
  
  presence of renal functional impairment
- D.
  
  in a patient with recurrent renal stones
- E.
  
  All of the above
19.

Previously most popular drug for treating inflammation of acute gouty arthritis -- NSAIDs now more commonly used because of diarrhea associated with earlier medication:
- A.
  
  Allopurinol (Zyloprim, Purinol)
- B.
  
  colchicine
- C.
  
  Acetaminophen (Tylenol, Panadol)
- D.
  
  probenecid (Benemid)
20.

___________________reduces uric acid synthesis: for management of gout
- A.
  
  Colchicine
- B.
  
  Probenecid (Benemid)
- C.
  
  Allopurinol (Zyloprim, Purinol)
- D.
  
  Oxaprozin (Daypro)
21.

This drug inhibits the secretion of many weak acids (penicillin, methotrexate) in addition to inhibiting reabsorption of uric acid and is used orally to treat chronic gout:
- A.
  
  Allopurinol
- B.
  
  Probenecid
- C.
  
  Febuxostat
- D.
  
  Colchicine
22.

Which medication for Gout should a patient NOT use if they are allergic to Sulfonamides?
- A.
  
  Probenecid
- B.
  
  Colchicine
- C.
  
  Allopurinol
- D.
  
  Febuxostat
23.

What class of Gout medications should a patient not use concurrently with Uricosuric Agents because it can antagonize its effect?
- A.
  
  NSAIDs
- B.
  
  Salicylates
- C.
  
  Xanthine Oxidase Inhibitors
24.

Gout medication that enhances the effects of CNS depressants and sympathomimetic agents, may interfere w/ vitamin B12 absorption and have Increased toxicity w/ concurrent use of clarithromycin, erythromycin, and grapefruit juice
- A.
  
  Allopurinol
- B.
  
  Febuxostat
- C.
  
  Colchicine
- D.
  
  Probenecid
25.

Both of these Gout medications decrease concentrations of less soluble uric acid- ↓ precipitation of uric acid crystals in joints and tissues
- A.
  
  Colchicine
- B.
  
  Allopurinol
- C.
  
  Febuxostat
- D.
  
  Probenecid