Pharmacology- Musculoskeletal Issues & Non-opioid Analgesia (Nsaid's)
.
- 1.__________________ is the original NSAID
- 2.True or false: NSAIDs ↓ sensitivity of vessels to bradykinin and histamine, affect T lymphocytes, & reverse vasodilation of inflammation
- A.
True
- B.
False
- 3.___________ inhibitors were developed to inhibit prostaglandin synthesis at sites of inflammation, and higher incidence of CV thrombotic events.
- A.
COX-2
- B.
COX -1
- 4.Antiplatelet effect of NSAIDs comes from blocking the ___________ enzyme and producing thromboxane
- A.
COX-1
- B.
Cox-2
- 5.Select all: General ADE in NSAIDs
- A.
Headaches, tinnitus
- B.
Contispation, anorexia
- C.
Confusion, irritability
- D.
Fluid retention, hypertension
- E.
Nausea, vomiting
- 6.What is the First-line Treatment of MSK Pain?
- A.
acetaminophen
- B.
Aspirin
- C.
Ibuprofen
- D.
Aleve
- 7.In the nonpharmacologic treatment of MK pain, what does the acronym R.I.C.E stand for?
- A.
Relax, Intervene, Compression, elevation
- B.
Rest, Ice, Compression, Elevation
- C.
Relax, Ice, Compression, Elevation
- D.
Relieve, Intervene, Compression, elevation
- 8.Treatment of MSK Pain: If a patient has moderate pain, consider starting ____________ at the same time as nonpharmacologic treatment
- A.
Salicylates
- B.
NSAIDs
- C.
Acetaminophen
- 9.Avoid aspirin in children/adolescents because it can cause ___________ syndrome
- A.
Turner
- B.
Reye's
- C.
Guillain-Barré
- D.
Sjogren's
- 10.Select all: Agents used in pharmacologic Treatment of OA
- A.
Acetaminophen
- B.
NSAIDs
- C.
COX-2 inhibitors
- D.
Cox-1 inhibitors
- E.
Intraarticular injection of steroids
- 11.True or false: Gout Aims of treatment includes: decreasing symptoms of an acute attack, decreasing the risk of recurrent attacks and increasing serum urate levels
- A.
True
- B.
False
- 12.What is the first-line treatment for Gout in a patient with acute symptoms?
- A.
Colchicine
- B.
NSAIDs
- C.
Corticosteroids
- D.
Uricosuric drugs
- 13.What is the first-line treatment for Gout in Preventative therapy?
- A.
Colchicine
- B.
keterolac
- C.
Allopurinol
- D.
Methylprednisolone
- 14.What medication is used for ACUTE Gout attacks and causes significant Gi distress (diarrhea, N/V, abd. pain)?
- A.
Febuxostat
- B.
Allopurinol
- C.
Colchicine
- D.
Probenecid
- 15.Which Gout medications reduce production of uric acid by inhibition of xanthine oxidase (an enzyme that converts hypoxanthine to xanthine and xanthine to uric acid)
- A.
Allopurinol
- B.
Febuxostat
- C.
Probenecid
- D.
Colchicine
- 16.Gout is caused by the buildup of what substance in the body?
- A.
Calcium
- B.
Uric acid
- C.
Pyruvic acid
- D.
Oxalate
- 17.Acute attacks of gouty arthritis may occur early in treatment with allopurinol (Zyloprim, Purinol) because:
- A.
Allopurinol (Zyloprim, Purinol) increases urate synthesis
- B.
Urate crystals move from tissue to plasma
- C.
Allopurinol (Zyloprim, Purinol) increases release of chemotactic factors
- D.
A & B
- E.
A, B & C
- 18.Rational indication(s) for allopurinol (Zyloprim, Purinol) administration:
- A.
Chronic tophaceous gout;when tophi reabsorption more rapid with uricosuric agents
- B.
When probenecid or sulfinpyrazone cannot be used
- C.
presence of renal functional impairment
- D.
in a patient with recurrent renal stones
- E.
All of the above
- 19.Previously most popular drug for treating inflammation of acute gouty arthritis -- NSAIDs now more commonly used because of diarrhea associated with earlier medication:
- A.
Allopurinol (Zyloprim, Purinol)
- B.
colchicine
- C.
Acetaminophen (Tylenol, Panadol)
- D.
probenecid (Benemid)
- 20.___________________reduces uric acid synthesis: for management of gout
- A.
Colchicine
- B.
Probenecid (Benemid)
- C.
Allopurinol (Zyloprim, Purinol)
- D.
Oxaprozin (Daypro)
- 21.This drug inhibits the secretion of many weak acids (penicillin, methotrexate) in addition to inhibiting reabsorption of uric acid and is used orally to treat chronic gout:
- A.
Allopurinol
- B.
Probenecid
- C.
Febuxostat
- D.
Colchicine
- 22.Which medication for Gout should a patient NOT use if they are allergic to Sulfonamides?
- A.
Probenecid
- B.
Colchicine
- C.
Allopurinol
- D.
Febuxostat
- 23.What class of Gout medications should a patient not use concurrently with Uricosuric Agents because it can antagonize its effect?
- A.
NSAIDs
- B.
Salicylates
- C.
Xanthine Oxidase Inhibitors
- 24.Gout medication that enhances the effects of CNS depressants and sympathomimetic agents, may interfere w/ vitamin B12 absorption and have Increased toxicity w/ concurrent use of clarithromycin, erythromycin, and grapefruit juice
- A.
Allopurinol
- B.
Febuxostat
- C.
Colchicine
- D.
Probenecid
- 25.Both of these Gout medications decrease concentrations of less soluble uric acid- ↓ precipitation of uric acid crystals in joints and tissues
- A.
Colchicine
- B.
Allopurinol
- C.
Febuxostat
- D.
Probenecid
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