Pharmacology Exam 3 Study Guide Quiz

Congenital hypothyroidism is a condition where a baby is born with an underactive thyroid gland. This can lead to mental retardation if not treated promptly. Iodine deficiency is a known cause of congenital hypothyroidism, and it is preventable by ensuring an adequate intake of iodine. Therefore, it is true that congenital hypothyroidism due to iodine deficiency is a major preventable cause of mental retardation globally.

The correct answer is "All of the above." In Grave's disease, all three types of auto-antibodies mentioned are commonly found. Thyroid Stimulating Immunoglobulins (TSIs) mimic the action of TSH and stimulate the thyroid gland to produce excessive amounts of thyroid hormones. Thyroid Growth Stimulating Immunoglobulins (TGSIs) promote the growth of thyroid cells, leading to goiter. TSH-Binding Inhibitor Immunoglobulins (TBII) interfere with the binding of TSH to its receptor, further stimulating the production of thyroid hormones. Therefore, all three auto-antibodies play a role in the development and progression of Grave's disease.

When Ca2+ is mobilized from bone, it leads to bone resorption, which means that the bone tissue is broken down and reabsorbed by the body. This process weakens the bone structure and can result in skeletal instability. Therefore, the statement that mobilization of Ca2+ from bone causes skeleton instability is true.

PTH, or parathyroid hormone, increases bone resorption, which is the process of breaking down bone tissue. This leads to the release of calcium into the extracellular fluid. PTH also stimulates the kidneys to reabsorb calcium, reduces calcium excretion, and enhances the production of calcitriol, the active form of vitamin D. Overall, PTH plays a crucial role in maintaining calcium homeostasis in the body by increasing calcium levels in the blood.

directly

Thyroid hormones are the only known iodine-containing compounds with biological activity. This means that iodine is a crucial component of thyroid hormones, and without iodine, these hormones would not be able to carry out their biological functions. Therefore, it is true that thyroid hormones are the only iodine-containing compounds with biological activity.

Prolia is the first biologic medication used for the treatment of bone loss. It is a prescription drug that helps to increase bone density and reduce the risk of fractures. Therefore, the statement "The first biologic bone loss Rx is Prolia" is true.

Estrogen receptors alpha and beta have the ability to form homodimers and heterodimers before binding to estrogen receptor response elements. Additionally, when bound to DNA, they can recruit co-activators as well as co-repressors. Therefore, all of the given options are correct explanations for the functions of estrogen receptors alpha and beta.

When selecting an antimicrobial, several factors need to be considered. These include the identification of the infecting organism, as different organisms may respond differently to specific drugs. The site of infection is also important, as certain drugs may be more effective in treating infections in specific areas of the body. Safety of the medication is crucial to ensure that it does not cause harm to the patient. Determining the organism's susceptibility to a particular drug helps in selecting the most effective treatment. Patient-specific factors, such as allergies or other medical conditions, should also be taken into account. Lastly, the cost of the medication is a practical consideration that may influence the choice of antimicrobial.

The second phase in biphasic insulin secretion is translocation. This refers to the movement of insulin-containing vesicles from the cytoplasm of beta cells to the cell membrane, allowing the release of insulin into the bloodstream. Translocation is an essential step in the regulation of blood sugar levels, as it enables the timely and controlled release of insulin in response to glucose levels in the body.

In Type 2 diabetes, hepatic glucose production is indeed altered. The liver plays a crucial role in regulating blood glucose levels by producing glucose through a process called gluconeogenesis. In individuals with Type 2 diabetes, there is an increased production of glucose by the liver, leading to elevated blood sugar levels. This occurs due to insulin resistance, where the body's cells do not respond effectively to insulin, causing the liver to overproduce glucose. Therefore, the statement that hepatic glucose production is altered in Type 2 diabetes is true.

During the follicular phase of the menstrual cycle, the hypothalamus releases gonadotropin-releasing hormone (GnRH), which binds to its receptors in the pituitary gland. This binding stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones play a crucial role in the development and maturation of ovarian follicles and the release of an egg during ovulation. Therefore, the statement is true as it accurately describes the hormonal changes that occur during the follicular phase.

After the insulin receptor binds insulin and undergoes autophosphorylation, it phosphorylates IRS-1 on its Tyr residues. The SH2 domain of Grb2 then binds to the phosphorylated Tyr of IRS-1. Sos binds to Grb2, which in turn binds to Ras, causing GDP release and GTP binding to Ras. Activated Ras then binds and activates Raf-1. Raf-1 phosphorylates MEK on two Ser residues, activating it. MEK, in turn, phosphorylates ERK on a Thr and a Tyr residue, leading to its activation. Once activated, ERK moves into the nucleus and phosphorylates nuclear transcription factors such as Elk1, activating them. This activation of Elk1 and SRF stimulates the transcription and translation of genes needed for cell division.

Vitamin D deficiency can lead to an over-secretion of parathyroid hormone (PTH), which in turn can result in bone loss. PTH helps regulate the levels of calcium and phosphorus in the body, and when there is a deficiency of vitamin D, the body is unable to properly absorb and utilize calcium. As a result, the parathyroid glands produce more PTH to compensate, which can cause the bones to release calcium, leading to bone loss. Therefore, the statement that vitamin D deficiency causes over-secretion of PTH and bone loss is true.

Pancreatic β cells take up glucose via GLUT2. GLUT2 is a glucose transporter protein that is expressed in the plasma membrane of pancreatic β cells. It allows the entry of glucose into the cells, which is necessary for the production and release of insulin. GLUT2 has a high Km value, which means it has a low affinity for glucose and is responsible for facilitating the transport of glucose in and out of the cells depending on the concentration gradient. This allows pancreatic β cells to sense and respond to changes in blood glucose levels.

Rosiglitazone (Avandia) and Pioglitazones (Actos) are Thiazolidinediones. Thiazolidinediones are a class of oral medication used to treat type 2 diabetes. They work by increasing the body's sensitivity to insulin, helping to lower blood sugar levels. Nateglinide and Miglitol, on the other hand, are not Thiazolidinediones. Nateglinide is a meglitinide that stimulates the release of insulin from the pancreas, while Miglitol is an alpha-glucosidase inhibitor that slows down the digestion of carbohydrates.

Ethinyl estradiol 3-methyl ether is not a progestin because it is a synthetic estrogen derivative, not a progestin hormone. Progestins are synthetic versions of the hormone progesterone, which are used in various forms of hormonal contraception and hormone replacement therapy. Progesterone, 17a-acetoxyprogesterone (pregnane), 19-nortestosterone (estrane), and norgestrel (gonane) are all examples of progestins.

The liver is the major site of conversion of T4 to T3 outside the thyroid. This conversion is important for the regulation of thyroid hormone levels in the body. The liver contains enzymes that facilitate the conversion process, allowing T4 to be converted into the more active form of thyroid hormone, T3. This conversion is crucial for the proper functioning of various physiological processes in the body, including metabolism, growth, and development.

anterior pituitary consists of non-neuronal
posterior pituitary consists of neuronal

negative feedback

The given answer is correct because it accurately identifies the step in the pathway where the insulin receptor phosphorylates IRS-1 on its Tyr residues. This step is crucial for the activation of downstream signaling molecules, such as Grb2 and Ras, which ultimately lead to the activation of ERK and the stimulation of gene transcription and cell division.

Spironolactone is the correct answer because it competitively antagonizes mineralocorticoid receptors. This means that it blocks the action of mineralocorticoids, such as aldosterone, at their receptors. By doing so, spironolactone reduces the reabsorption of sodium and water in the kidneys and promotes the excretion of potassium, leading to diuresis and natriuresis. Spironolactone is commonly used as a potassium-sparing diuretic and is also effective in treating conditions such as hypertension and heart failure.

“Rule of thumb”: Different pituitary cells make different hormones

recombinant DNA technology

The phases of the menstrual cycle include follicular development and endometrial development, mid-cycle/ovulation, and the luteal phase. During the follicular phase, follicles in the ovaries mature and prepare to release an egg. The endometrial phase involves the thickening of the uterine lining in preparation for potential implantation of a fertilized egg. Mid-cycle/ovulation is when the mature egg is released from the ovary. The luteal phase occurs after ovulation and is characterized by the production of progesterone to support a potential pregnancy.

Follicular cells are responsible for synthesizing T4 and T3. These cells are found in the thyroid gland, which is responsible for producing and releasing thyroid hormones. T4 and T3 are important hormones that regulate metabolism, growth, and development in the body. Therefore, it is the follicular cells in the thyroid gland that play a crucial role in the production of these hormones.

Hypothyroidism is the most common cause of thyroid dysfunction. This condition occurs when the thyroid gland does not produce enough thyroid hormones, resulting in a slower metabolism. It can be caused by various factors such as autoimmune diseases, iodine deficiency, certain medications, or damage to the thyroid gland. Hypothyroidism can lead to symptoms like fatigue, weight gain, cold intolerance, and depression. It is important to diagnose and treat hypothyroidism promptly to prevent complications and improve the patient's quality of life.

Posterior surface

Bisphosphonates are a class of drugs commonly used for the prevention and treatment of postmenopausal osteoporosis. They work by inhibiting bone resorption, which helps to maintain bone density and reduce the risk of fractures. Bisphosphonates have been extensively studied and have shown to be effective in reducing the rate of bone loss and decreasing the incidence of fractures in postmenopausal women. Therefore, they are considered the first-line treatment option for this condition.

MODY (Maturity-Onset Diabetes of the Young) is a specific-defined gene mutation of diabetes Mellitus. It is a rare form of diabetes that is caused by a mutation in a single gene. Unlike Type 1 and Type 2 diabetes, which have multiple causes and risk factors, MODY is caused by a specific genetic mutation that affects the body's ability to produce insulin. People with MODY often develop diabetes at a younger age and have a strong family history of the disease.

Glucose is phosphorylated by glucokinase. This means that a phosphate group is added to the glucose molecule, resulting in the formation of glucose-6-phosphate. Phosphorylation is an important process in glucose metabolism as it helps to trap glucose inside the cell and initiate further metabolic reactions.

The correct answer is Fusion. In biphasic insulin secretion, the first phase involves the fusion of insulin-containing vesicles with the cell membrane of pancreatic beta cells. This fusion allows the release of a rapid and initial burst of insulin into the bloodstream in response to increased blood glucose levels. This first phase is followed by a second phase, which involves a slower and sustained release of insulin.

The thyroid gland produces three fundamentally different hormones: thyroxine (T4), triiodothyronine (T3), and calcitonin. Thyroxine and triiodothyronine are responsible for regulating metabolism and energy production in the body. Calcitonin helps to regulate calcium levels in the blood by promoting its uptake into the bones. Glucocorticoids, on the other hand, are hormones produced by the adrenal glands, not the thyroid gland, and are involved in regulating metabolism, immune function, and stress response.

The statement suggests that T4 has the ability to bind both transthyretin and albumin, while T3 does not possess this capability. This implies that T4 has a broader binding range compared to T3, which supports the statement being true.

Calcium is an essential mineral that is not produced by the body, so it must be obtained from dietary sources. The statement correctly states that calcium enters the body from dietary sources. Furthermore, the statement also correctly states that calcium is absorbed exclusively from the intestine. This means that the body can only absorb calcium from the food we eat through the intestinal wall. Therefore, the answer "True" is the correct choice.

Nateglinide and Replaglinide are both classified as Meglitinides. These drugs are commonly used to treat type 2 diabetes by stimulating the release of insulin from the pancreas. They work by targeting the beta cells in the pancreas to increase insulin secretion, helping to lower blood sugar levels. Rosiglitazone/Avandia and Metformin, on the other hand, belong to different drug classes and have different mechanisms of action for managing diabetes.

Phosphorylated Elk1 joins SRF to stimulate the transcription and translation of a set of genes needed for cell division. This statement explains the role of phosphorylated Elk1 in activating SRF (serum response factor) and promoting the expression of genes required for cell division. Elk1 is phosphorylated by ERK, which is activated through a signaling cascade involving Raf-1, MEK, and Ras. The activation of Elk1 and subsequent stimulation of gene expression is an important step in the cellular response to growth factors and is essential for cell division.

Vitamin D increases the movement of Ca2+ in the intestine through three steps. First, it decreases the diffusion of Ca2+ through the cell. This means that less Ca2+ is able to passively move through the cell. Second, it increases the movement of Ca2+ across the mucosal membrane. This means that more Ca2+ is actively transported across the membrane. Third, it increases the diffusion of Ca2+ through the cell. This means that more Ca2+ is able to passively move through the cell. Lastly, it increases the energy-dependent extrusion of Ca2+ across the serosal membrane. This means that more Ca2+ is actively transported out of the cell and into the bloodstream.

Occurs at same rate

increases oxygen consumption

Perchlorate and Thiocyanate are both ionic inhibitors used in the treatment of hyperthyroidism. These substances work by blocking the uptake of iodine by the thyroid gland, which is necessary for the production of thyroid hormones. By inhibiting this process, the production of excessive thyroid hormones is reduced, helping to control the symptoms of hyperthyroidism. Carbimazole is not an ionic inhibitor, but rather an antithyroid medication that works by inhibiting the production of thyroid hormones. Propranolol is a beta-blocker that is sometimes used to manage the symptoms of hyperthyroidism, but it does not directly inhibit the production or uptake of thyroid hormones.

greater stimulus

measure hemoglobin

Insulin absorption and duration of action can be influenced by various factors. The injection site plays a crucial role as insulin is absorbed differently in different areas of the body. Blood flow is also important as it affects the rate at which insulin is distributed throughout the body. Temperature can impact insulin absorption, with higher temperatures potentially increasing absorption. Physical activity can also affect insulin absorption and action by increasing blood flow and altering the body's metabolism. Overall, all of these factors, including injection site, blood flow, temperature, and physical activity, can have an impact on how insulin is absorbed and how long it remains active in the body.

Metformin is a biguanide. Biguanides are a class of oral diabetes medications that work by reducing the production of glucose in the liver and improving the body's response to insulin. They are commonly used to treat type 2 diabetes. Glipizide, Actos, and Avandia are not biguanides. Glipizide is a sulfonylurea medication, while Actos and Avandia belong to a class of medications called thiazolidinediones.

thyroid gland is not essential for life

less effective

Metformin is a first-line therapy for type 2 diabetes mellitus (T2DM) because it has been shown to effectively lower blood glucose levels. It works by enhancing glucose absorption from the gastrointestinal (GI) tract and increasing glucose uptake into tissues. Additionally, metformin reduces hepatic glucose output by decreasing the rates of gluconeogenesis, which is the production of glucose by the liver. Metformin also activates AMPK, a cellular enzyme that helps regulate energy balance and glucose metabolism. Therefore, the correct answer is A, C, and D, as all of these statements accurately describe the actions and effects of metformin.

Hyperglycemia

The graafian follicle is responsible for producing estrogen (E2) and inhibin. The graafian follicle is a mature ovarian follicle that contains the developing egg. As it grows, it secretes estrogen, which plays a crucial role in the regulation of the menstrual cycle and the development of secondary sexual characteristics. Additionally, the graafian follicle also produces inhibin, a hormone that helps regulate the production of follicle-stimulating hormone (FSH) from the pituitary gland.

In this step, the SH2 domain of Grb2 binds to the phosphorylated tyrosine (P-Tyr) residues of IRS-1. Sos, which is bound to Grb2, then binds to Ras. This binding of Sos to Ras causes the release of GDP (guanosine diphosphate) and the binding of GTP (guanosine triphosphate) to Ras. This activation of Ras is an important step in the insulin signaling pathway, as it leads to the activation of downstream signaling cascades, ultimately resulting in the stimulation of cell division.

SERMs (Selective Estrogen Receptor Modulators) are the first-line alternative for patients who are intolerant to bisphosphonates. SERMs, such as raloxifene, work by selectively binding to estrogen receptors and have both estrogenic and antiestrogenic effects. They help to maintain bone density and reduce the risk of fractures in postmenopausal women. Calcitonin is another medication used for osteoporosis, but it is not typically considered the first-line alternative. Calcimimetics, on the other hand, are used for the treatment of hyperparathyroidism and are not indicated for osteoporosis.

low affinity

Type II

Dopamine is not a stimulatory factor in the regulation of insulin secretion. Insulin secretion is primarily regulated by factors such as dietary amino acids, acetylcholine (via the vagus nerve), glucose-dependent insulinotropic peptide (GIP), and fatty acids. Dopamine, on the other hand, is known to inhibit insulin secretion rather than stimulate it. Therefore, it is not considered a stimulatory factor in the regulation of insulin secretion.

Stimulated by TRH and inhibited by T3 and T4

Calcimimetics are metabolized by CYP2D6 and also inhibit CYP2D6. This means that calcimimetics are both substrates and inhibitors of the CYP2D6 enzyme. CYP2D6 is an important enzyme in drug metabolism, responsible for the breakdown of many medications in the body. When calcimimetics are metabolized by CYP2D6, they can also inhibit the enzyme, potentially leading to drug-drug interactions with other medications that are also metabolized by CYP2D6.

Early diagnosis, careful glucose monitoring, and control can greatly improve outcomes for diabetic patients. Early diagnosis allows for prompt intervention and management of the disease, preventing further complications. Careful glucose monitoring helps in maintaining blood sugar levels within the target range, reducing the risk of hyperglycemia or hypoglycemia. Control of diabetes through medication, lifestyle modifications, and adherence to treatment plans can prevent the progression of the disease and minimize the impact on the patient's health. Overall, these measures contribute to better management of diabetes and improved patient outcomes.

golgi apparatus

The adrenal cortex has two major functional compartments:
-The zona glomurosa secretes aldosterone
-The zonae fasciculata/reticularis secretes glucocorticoids (cortisol) and weak androgens

Insulin regulates hepatic glucose production through multiple mechanisms. It signals via PI3K in the hypothalamus, which helps regulate appetite and energy balance. Insulin also activates phosphodiesterases in the liver, leading to the breakdown of cAMP, a molecule that promotes glucose production. Additionally, insulin activates hepatic PP-1, an enzyme that de-phosphorylates glycogen phosphorylase a, thereby inhibiting glycogen breakdown and reducing glucose release from the liver. Therefore, all of the given options are correct explanations for how insulin regulates hepatic glucose production.

small burst of neuronal activity

Dopamine D2 agonists

Insulin desensitizers are not oral medications for Type 2 diabetes mellitus. Insulin secretagogues, α-Glucosidase inhibitors, and Dipeptidyl Peptidase 4 (DPPIV) inhibitors are all oral medications commonly used to treat Type 2 diabetes mellitus. Therefore, the correct answer is "Insulin desensitizers."

Vancomycin is an antibiotic that works by inhibiting the synthesis of the bacterial cell wall. It does this by binding to the D-Ala-D-Ala of the pentapeptide, which prevents the trans-glycosylation step in peptidoglycan polymerization. This ultimately leads to the disruption of the bacterial cell wall, making it bactericidal for dividing microorganisms. Vancomycin is particularly effective against gram-positive organisms and is important in treating multiple drug-resistant organisms such as MRSA and enterococci.

Miglitol and Acarbose are α-Glucosidase inhibitors. These drugs work by slowing down the digestion and absorption of carbohydrates in the small intestine. By inhibiting the α-Glucosidase enzyme, they prevent the breakdown of complex carbohydrates into simple sugars, thereby reducing the post-meal rise in blood glucose levels. Actos and Avandia, on the other hand, are thiazolidinediones used to treat type 2 diabetes by improving insulin sensitivity.

decreased PTH secretion

Secondary hypothyroidism: failure of pituitary
Tertiary hypothyroidism: failure of hypothalamus

The correct answer is A and B. GnRH secretion is inhibited by estrogen and stimulated by estrogen. This means that the secretion of GnRH is regulated by the presence or absence of estrogen in the body. Additionally, the secretion amplitude (not frequency) of GnRH is regulated at the level of the pituitary.

During the follicular phase, estrogen (E2) and inhibin feedback to the pituitary and hypothalamus to inhibit LH and FSH release. Estrogen acts as a negative feedback signal to prevent excessive production of LH and FSH, while inhibin specifically inhibits FSH release. This feedback mechanism helps regulate the levels of these hormones and ensure proper follicular development and ovulation. Progesterone and estradiol are not involved in inhibiting LH and FSH release during the follicular phase.

axial

Estradiol, estrone, and estriol are all natural estrogens. Estrogens are hormones that are primarily produced in the ovaries and play a crucial role in the development and regulation of the female reproductive system. These hormones are responsible for the development of secondary sexual characteristics, regulation of the menstrual cycle, and maintenance of pregnancy. Estradiol is the most potent and abundant estrogen, while estrone and estriol are less potent but still important in various physiological processes. Esthinylestradiol, on the other hand, is a synthetic estrogen commonly used in hormonal contraceptives.

osteoblasts

Parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (calcitriol) are the most important regulatory hormones for calcium and phosphate regulation. PTH acts on the bones, kidneys, and intestines to increase calcium levels in the blood by promoting bone resorption, reducing calcium excretion in the urine, and enhancing calcium absorption in the intestines. Calcitriol, the active form of vitamin D, works in conjunction with PTH to increase calcium absorption in the intestines and promote bone mineralization. Together, PTH and calcitriol play a crucial role in maintaining calcium and phosphate homeostasis in the body.

Tetracyclines are a group of antibiotics that inhibit protein synthesis. They do this by binding to the 30S subunit of the ribosome, which prevents the binding of tRNA to the A site. This blocks the incorporation of amino acids into the growing peptide chain. Therefore, the correct answer is A and B, as tetracyclines both bind to the 30S subunit and block tRNA binding to the A site.

In this step, it is stated that Activated Ras binds and activates Raf-1. This means that once Ras is activated by Sos, it binds to Raf-1 and triggers its activation. Raf-1 is a protein kinase that plays a crucial role in the MAP kinase signaling pathway. Once activated, Raf-1 phosphorylates MEK, which in turn phosphorylates ERK. The activation of Raf-1 is an important step in the cascade of events that ultimately leads to the phosphorylation of nuclear transcription factors and the stimulation of gene expression required for cell division.

OPG (osteoprotegerin) is a protein that plays a crucial role in regulating bone remodeling. It acts as a decoy receptor for RANKL (receptor activator of nuclear factor kappa-B ligand), preventing it from binding to RANK (receptor activator of nuclear factor kappa-B) on osteoclasts. Osteoclasts are responsible for bone resorption, so when OPG is present, it inhibits the interaction between RANKL and RANK, ultimately suppressing bone resorption. Therefore, in conditions where bone resorption needs to be decreased, OPG would be favored.

Growth hormone is primarily secreted during sleep, with the highest quantities being released at night. Ghrelin, a hormone produced in the stomach, stimulates the release of growth hormone-releasing hormone (GHRH), which in turn triggers the secretion of growth hormone. Somatostatin (SST) inhibits the release of growth hormone, acting as a negative regulator. Growth hormone indirectly stimulates the release of insulin-like growth factors (IGFs), which are responsible for the growth-promoting effects of growth hormone.

inhibitory

increase 1α-hydroxylase

Tetracyclines, chloramphenicol, macrolides, clindamycin, and linezolid are all protein synthesis inhibitors that target bacteria. These drugs work by interfering with the bacterial ribosomes, which are responsible for protein synthesis. By inhibiting protein synthesis, these antibiotics prevent the bacteria from producing essential proteins needed for their survival and growth. This ultimately leads to the death or inhibition of bacterial growth, making these drugs effective against bacterial infections.

24-hydroxylase activity is stimulated by calcitrol and inhibited by factors that stimulate 1α-hydroxylase.

Stress can stimulate the release of prolactin. Prolactin is a hormone that is secreted by the pituitary gland and is involved in various physiological processes, such as milk production in lactating females. During times of stress, the body activates the hypothalamic-pituitary-adrenal (HPA) axis, which leads to the release of stress hormones such as cortisol. This activation of the HPA axis can also stimulate the release of prolactin. Therefore, stress can act as a stimulator for the release of prolactin.

Chloramphenicol is an antibiotic that is known to penetrate bacterial cells via facilitated diffusion. This means that it can easily enter the bacterial cell through a specific transport mechanism. Additionally, chloramphenicol binds reversibly to the 50S ribosomal subunit at the P site. This binding inhibits the transpeptidation reaction, which is essential for bacterial protein synthesis. Therefore, chloramphenicol's ability to penetrate bacterial cells and inhibit protein synthesis makes it an effective antibiotic against certain bacterial infections.

activated cAMP

agonist

The correct answer includes all the classes of anti-thyroid Rx. Anti-thyroid drugs are medications specifically used to treat hyperthyroidism by inhibiting the production of thyroid hormones. Ionic inhibitors are substances that block the uptake of iodine by the thyroid gland, thereby reducing the production of thyroid hormones. High concentrations of iodide also inhibit the production of thyroid hormones. Radioactive iodine is used in the treatment of hyperthyroidism to destroy or reduce the function of the thyroid gland. Adjuvant Rx refers to additional treatments or medications used in conjunction with the primary therapy.

heterodimeric

The Thryotropin Releasing Hormone is made in several areas of the hypothalamus and secreted at the median eminence. It is also synthesized and secreted throughout the brain as a neurotransmitter. Additionally, it is secreted in a pulsatile manner from the anterior hypothalamus.

The steps in thyroid hormone biosynthesis include the uptake of iodide, oxidation and iodination, formation of T4 and T3 from iodotyrosines, resorption, proteolysis of colloid, secretion of thyroid hormones, and conversion of T4 to T3 in peripheral tissues. These steps are essential for the production and release of thyroid hormones in the body.

The growth hormone receptor is responsible for causing autophosphorylation of JAK2 and recruitment of IRS-1. This means that when the growth hormone binds to its receptor, it activates JAK2, leading to its own phosphorylation. Additionally, the receptor recruits IRS-1, which is a signaling molecule that plays a role in transmitting signals from the receptor to downstream pathways. Therefore, the correct answer is A and B.

Oxytocin is a nonpeptide hormone and neurotransmitter. It is released in response to suckling, cervix changes, and stress. It also stimulates prostaglandin synthesis.

Glibenclamide and Glipizide are both sulfonylureas. Sulfonylureas are a class of oral medications commonly used to treat type 2 diabetes. They work by stimulating the pancreas to produce more insulin, which helps lower blood sugar levels. Nateglinide, on the other hand, is a different type of medication called a meglitinide, and Metformin is a biguanide. Both Nateglinide and Metformin also help lower blood sugar levels, but they do so in different ways than sulfonylureas.

Parathyroid hormones (PTH) are known to reduce the formation of Type I collagen, alkaline phosphatase, and osteoclacin. Type I collagen is the most abundant collagen in the human body and is responsible for providing strength and structure to bones, tendons, and other connective tissues. Alkaline phosphatase is an enzyme involved in bone mineralization and is necessary for the proper formation of bones. Osteoclacin is a protein produced by osteoblasts, which plays a role in regulating bone mineralization. Therefore, the reduction in the formation of these substances by PTH can have detrimental effects on bone health and integrity.

Hypercalcemia, hypocalcemia, disturbed phosphate metabolism, vitamin D, and vitamin D deficiency are all disorders of mineral homeostasis. Hypercalcemia refers to high levels of calcium in the blood, while hypocalcemia refers to low levels of calcium in the blood. Disturbed phosphate metabolism refers to an imbalance in the levels of phosphate in the body. Vitamin D is essential for the regulation of calcium and phosphate levels in the body, and a deficiency in vitamin D can lead to mineral homeostasis disorders. Therefore, all of the given options are correct answers as they are all related to disorders of mineral homeostasis.

Calcitriol aids in the absorption and retention of Ca2+ and phosphate in the small intestine.

Tamoxifen, Raloxifene, and Toremifene are all selective estrogen receptor modulators (SERMs). SERMs are a class of drugs that selectively bind to estrogen receptors in different tissues, acting as estrogen agonists in some tissues and estrogen antagonists in others. These drugs are commonly used in the treatment of hormone receptor-positive breast cancer, as they inhibit the growth of cancer cells that rely on estrogen for growth. Additionally, Raloxifene is also used for the prevention and treatment of osteoporosis in postmenopausal women. Clomiphene, on the other hand, is not a SERM but rather a selective estrogen receptor modulator (SERM) that is used to induce ovulation in women with infertility issues.

Mitotane, Metyrapone, Aminoglutethimide, Ketoconazole, and Trilostane are all inhibitors of adrenocortical secretion. Adrenocortical secretion refers to the production and release of hormones by the adrenal cortex, which plays a crucial role in regulating various bodily functions. These inhibitors work by different mechanisms to inhibit the synthesis or release of adrenal hormones, such as cortisol. Mitotane is primarily used to treat adrenal cancer and can suppress adrenal function. Metyrapone inhibits the enzyme involved in cortisol synthesis. Aminoglutethimide blocks the conversion of cholesterol to cortisol. Ketoconazole inhibits several enzymes involved in steroid synthesis. Trilostane inhibits an enzyme that is necessary for cortisol synthesis.

The metabolic effects listed in the answer choices are glucose uptake, glycogen synthesis, and lipogenesis. Glucose uptake refers to the process of cells taking in glucose from the bloodstream to be used as a source of energy. Glycogen synthesis involves the formation of glycogen, which is a stored form of glucose in the liver and muscles. Lipogenesis is the process of synthesizing lipids or fats. These metabolic effects are all involved in the regulation and storage of energy in the body.

Propylthiouracil, Methimazole, and Carbimazole are all thioureylenes. These compounds are used in the treatment of hyperthyroidism, a condition in which the thyroid gland produces excessive amounts of thyroid hormones. Thioureylenes work by inhibiting the production of thyroid hormones, helping to reduce the symptoms of hyperthyroidism. Levothyroxine sodium, on the other hand, is not a thioureylene. It is a synthetic form of the thyroid hormone thyroxine and is used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough thyroid hormones.

Parathyroid hormone (PTH)

Clomiphene and Fulvestrant are both anti-estrogens. Clomiphene works by blocking estrogen receptors in the hypothalamus, which leads to an increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) production, stimulating ovulation. Fulvestrant, on the other hand, is a selective estrogen receptor degrader (SERD) that binds to estrogen receptors and causes their degradation, thereby inhibiting estrogen signaling. Tamoxifen and Formestane are not anti-estrogens; Tamoxifen is a selective estrogen receptor modulator (SERM) that has both estrogenic and anti-estrogenic effects depending on the tissue, while Formestane is an aromatase inhibitor that reduces estrogen production.

The correct answer includes a comprehensive list of different types of antimicrobials and their mechanisms of action. It covers agents that inhibit bacterial cell wall synthesis, bacteriostatic agents that disrupt ribosomal subunits to inhibit protein synthesis, bactericidal agents that alter protein synthesis by binding to ribosomal subunits, and agents that affect bacterial nucleic acid metabolism by inhibiting RNA polymerase or topoisomerases. This answer provides a thorough understanding of the different ways antimicrobials can target bacteria and inhibit their growth.