Includes antifungals, glaucoma drugs, allergy, and a few general questions from the first lecture
Quinolones (moxifloxacin, gatifloxacin, besifloxacin)
Bacitracin or erythromycin ophthalmic ointment
Naphazoline (AK-con)
IV antibiotics (nafcillin)
Bacterial conjunctivitis
Orbital cellulitis
Hordeolum
Blepharitis
Polyenes
Azoles
Echinocandins
Allylamines
Penicillium derivatives
A large volume of distribution means the blood concentration is high
The volume of distribution is measured along with serum creatinine
The volume of distribution is only related to the two-compartment model
The volume of distribution is a theoretical pharmacokinetic parameter that is calculated by dividing drug injected by plasma concentration before elimination starts
Absorption is dependent on drug solubility.
Increased lipid solubility enhances drug distribution
The goal of metabolism is to convert substances into water soluble forms
Most drugs are eliminated according to zero-order kinetics
Seborrheic blepharitis
Hordeolum
Viral conjunctivitis
Orbital cellulitis
Citirizine (Zyrtec)
Fluconazole
Acetylcysteine (Mucomyst)
Amphitericin
Alkylamines
Phenothiazines
Piperidines
Piperazines
Betaxolol (Betoptic)
Mannitol
Latanoprost (Xalatan)
Dorzolamide (Trusopt)
Apraclonidine (Iodipine)
They are parasympathomimetic agents
They should be avoided in patients with hypertension
The most effective one is phenylephrine (Sudafed PE)
Prolonged use can result in rhinitis medicamentosa
Expectorants
Mast cell stabilizers
Mucolytics
Anticholinergic agents
Ciclopirox (Penlac Lacquer)
Tolnaftate (Tinactin)
Terbinafine (Lamisil)
Ketoconazole (Nizoral)
Liquefy pulmonary secretions
Increase pulmonary secretions and decrease viscosity
Reduce bronchoconstriction caused by leukotrienes
Prevent mast cell degranuation
Warfarin (Coumadin)
Amphotericin
Acetazolamide
Erythromycin
Combigan
Cosopt
Alphagan P
Pilocarpine
They are nonselective antihistamines.
The group includes brompheniramine (Dimetapp)
They cause more sedation than ethanolamines
The group contains chlorpheniramine (ChlorTrimeton)
Carbachol
Echothiophate
Dorzolamide
Latanoprost
Pre-operative situations in which neuromuscular blocking agents may be used
Severe COPD or asthma
Concurrent use of MAOIs
Coronary artery disease
S. pneumoniae
H. influenzae
Pseudomonas
Proteus sp.
Phenyephrine (Neo-Synephrine)
Azelastine (Astelin)
Oxymetazoline (Afrin)
Flunisolide (Nasarel)
Inhibits ergosterol synthesis by enzyme disruption, increasing permeability of the membrane
Binds to ergosterol in the cell membrane, allowing cell leakage
Inhibits the synthesis of beta D glucan, a component of fungal cell wall construction
Binds to beta D glucan in the cellular membrane, increasing permeability
Oropharyngeal candidiasis
Tinea pedis
Tinea unguium
Vulvovaginal candidiasis
Ketoconazole
Itraconazole
Voriconazole
Fluconasole
Cyproheptadine (Periactin)
Cetirizine (Zyrtec)
Desloratadine (Clarinex
Hydroxyzine (Atarax)
Desloratadine (Clarinex)
Phenindamine (Nolahist)
Diphenhydramine (Benadryl)
Fexofenadine (Allegra)
Voriconazole
Amphotericin
Fluconazole
Itraconazole
Timolol
Acetazolamide
Brimonidine
Pilocarpine
Increased gastric pH
Concurrent electrolyte depletion, e.g. taking thiazides
Interference with CYP450 metabolism of other drugs the patient is taking
Therapeutic failure due in the presence of another drug that induces CYP450 enzymes
Hydroxyzine (Atarax)
Cyproheptadine (Periactin)
Clemastine (Tavist)
Triplennamine (PBZ)
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