Pharm Practice Exam 1

1. Which of the following organisms is a culprit in acute or chronic inflammation of the lid margins?

H. influenza

S. peumoniae

S. aureus

E. coli

2. Which of the following would be used to treat the condition referred to in question 3?

Quinolones (moxifloxacin, gatifloxacin, besifloxacin)

Bacitracin or erythromycin ophthalmic ointment

Naphazoline (AK-con)

IV antibiotics (nafcillin)

3. Which of the following conditions can cause increased IOP?

Bacterial conjunctivitis

Orbital cellulitis

Hordeolum

Blepharitis

4. Which class includes caspofungin, micafungin and anidulafungin?

Polyenes

Azoles

Echinocandins

Allylamines

Penicillium derivatives

5. Which is true of the volume of distribution?

A large volume of distribution means the blood concentration is high

The volume of distribution is measured along with serum creatinine

The volume of distribution is only related to the two-compartment model

6. Which of the following is false?

Absorption is dependent on drug solubility.

Increased lipid solubility enhances drug distribution

The goal of metabolism is to convert substances into water soluble forms

Most drugs are eliminated according to zero-order kinetics

7. Which of the following can not be controlled with compresses and good hygiene?

Seborrheic blepharitis

Hordeolum

Viral conjunctivitis

Orbital cellulitis

8. What would be used to treat a patient with thick white deposits on the posterior pharyngeal wall and posterior tongue, along with redness and inflammation?

Citirizine (Zyrtec)

Fluconazole

Acetylcysteine (Mucomyst)

Amphitericin

9. Which family of nonselective antihistamines includes promethazine (Phenergan)?

Alkylamines

Phenothiazines

Piperidines

Piperazines

10. If a patient presents increased IOP following trauma, a red eye and sudden vision loss, which of the following drugs might be indicated?

Betaxolol (Betoptic)

Mannitol

Latanoprost (Xalatan)

Dorzolamide (Trusopt)

Apraclonidine (Iodipine)

11. Which is true of systemic decongestants?

They are parasympathomimetic agents

They should be avoided in patients with hypertension

The most effective one is phenylephrine (Sudafed PE)

Prolonged use can result in rhinitis medicamentosa

12. Which class of drugs is also used in acetaminophen overdose?

Expectorants

Mast cell stabilizers

Mucolytics

Anticholinergic agents

13. Which of the following would be used to treat a patient presenting with yellow, friable nails with debris underneath?

Ciclopirox (Penlac Lacquer)

Tolnaftate (Tinactin)

Terbinafine (Lamisil)

Ketoconazole (Nizoral)

14. What is the therapeutic goal of expectorants?

Liquefy pulmonary secretions

Increase pulmonary secretions and decrease viscosity

Reduce bronchoconstriction caused by leukotrienes

Prevent mast cell degranuation

15. Differences in alpha-1 glycoprotein occuring in response to surgery, chronic pain, acute MI or rheumatoid arthritis would be a consideration in which of the following?

Warfarin (Coumadin)

Amphotericin

Acetazolamide

Erythromycin

16. Which of the following is a combination of a alpha-2 agonist and a beta blocker for treatment of glaucoma?

Combigan

Cosopt

Alphagan P

Pilocarpine

17. Which is false of alkylamines?

They are nonselective antihistamines.

The group includes brompheniramine (Dimetapp)

They cause more sedation than ethanolamines

The group contains chlorpheniramine (ChlorTrimeton)

18. Which of the following is an indirect acting parasympathomimetic agent?

Carbachol

Echothiophate

Dorzolamide

Latanoprost

19. Which is a contraindication of indirect acting parasympathomimetic agents?

Pre-operative situations in which neuromuscular blocking agents may be used

Severe COPD or asthma

Concurrent use of MAOIs

Coronary artery disease

20. Which of the following drugs is not generally associated with bacterial conjunctivitis?

S. pneumoniae

H. influenzae

Pseudomonas

Proteus sp.

21. Which of the following is a nasal steroid?

Phenyephrine (Neo-Synephrine)

Azelastine (Astelin)

Oxymetazoline (Afrin)

Flunisolide (Nasarel)

22. What is the MOA of amphotericin?

Inhibits ergosterol synthesis by enzyme disruption, increasing permeability of the membrane

Binds to ergosterol in the cell membrane, allowing cell leakage

Inhibits the synthesis of beta D glucan, a component of fungal cell wall construction

Binds to beta D glucan in the cellular membrane, increasing permeability

23. Which of the following demands use of systemic antifungal treatment?

Oropharyngeal candidiasis

Tinea pedis

Tinea unguium

Vulvovaginal candidiasis

24. Which of the following is the least potent CYP450 inhibitor?

Ketoconazole

Itraconazole

Voriconazole

Fluconasole

25. The selective piperidines include:

Cyproheptadine (Periactin)

Cetirizine (Zyrtec)

Desloratadine (Clarinex

Hydroxyzine (Atarax)

26. Which of the following is not a piperidine?

Desloratadine (Clarinex)

Phenindamine (Nolahist)

Diphenhydramine (Benadryl)

Fexofenadine (Allegra)

27. Which is the superior treatment for invasive aspergillosis?

Voriconazole

Amphotericin

Fluconazole

Itraconazole

28. Which of the following does not treat glaucoma by decreasing production of aqueous humor?

Timolol

Acetazolamide

Brimonidine

Pilocarpine

29. Which of the following does not affect azoles?

Increased gastric pH

Concurrent electrolyte depletion, e.g. taking thiazides

Interference with CYP450 metabolism of other drugs the patient is taking

Therapeutic failure due in the presence of another drug that induces CYP450 enzymes

30. Which of the following is in the ethylenediamine class of nonselective antihistamines?

Hydroxyzine (Atarax)

Cyproheptadine (Periactin)

Clemastine (Tavist)

Triplennamine (PBZ)