Overview Of Renal Cell Carcinoma Assessment

20 Questions | Total Attempts: 50

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Cell Quizzes & Trivia

Questions and Answers
  • 1. 
    What is the kidney’s outer layer of fibrous tissue called?
    • A. 

      Gerota’s fascia

    • B. 

      Renal capsule

    • C. 

      Renal cortex

    • D. 

      Medulla

    • E. 

      None of the responses are correct

  • 2. 
    Which of the following is not a function of the kidneys?
    • A. 

      Excretion of waste and foreign substances

    • B. 

      Regulation of blood glucose

    • C. 

      Regulation of blood volume

    • D. 

      Regulation of blood pH

    • E. 

      Regulation of protein synthesis

  • 3. 
    What is the median age of diagnosis for RCC in the US?
    • A. 

      59 years

    • B. 

      61 years

    • C. 

      65 years

    • D. 

      71 years

    • E. 

      None of the responses are correct

  • 4. 
    Which of the following is not a risk factor for RCC?
    • A. 

      Hypertension

    • B. 

      Race

    • C. 

      Advanced renal cell disease

    • D. 

      Age

    • E. 

      All of the responses are correct

  • 5. 
    What percentage of kidney cancers is classified as RCC?
    • A. 

      5-10%

    • B. 

      75%

    • C. 

      80%

    • D. 

      90%

    • E. 

      None of the responses are correct

  • 6. 
    What is the most predominant RCC histological type?
    • A. 

      Papillary carcinoma

    • B. 

      Chromophobe RCC

    • C. 

      Collecting duct carcinoma

    • D. 

      Clear cell

    • E. 

      None of the responses are correct

  • 7. 
    What percentage of patients with RCC present with metastatic disease?
    • A. 

      15%

    • B. 

      30%

    • C. 

      45%

    • D. 

      75%

    • E. 

      None of the responses are correct

  • 8. 
    Name the two most common sites of metastases associated with RCC
    • A. 

      Skin, liver

    • B. 

      Lung, soft tissue

    • C. 

      Lung, CNS

    • D. 

      Soft tissue, bone

    • E. 

      Skin, CNS

  • 9. 
    Select the statement that best describes the relationship between the Von Hippel-Lindau (VHL) gene, the HIF pathway and its role in angiogenesis in patients with RCC.
    • A. 

      The VHL mutation results in the downregulation of HIF and induces genes that promote angiogenesis.

    • B. 

      The VHL mutation results in the upregulation of HIF and interferes with genes that promote angiogenesis.

    • C. 

      The VHL mutation results in the upregulation of HIF and induces genes that promote angiogenesis.

    • D. 

      The VHL mutation results in the downregulation of HIF and hinders genes that promote angiogenesis.

    • E. 

      None of the responses are correct

  • 10. 
    The PI3K/AKT/mTOR pathway is a key regulator of which cellular function (s)?
    • A. 

      Angiogenesis

    • B. 

      Cell growth

    • C. 

      Survival

    • D. 

      Angiogenesis and cell growth

    • E. 

      Angiogenesis, cell growth and survival

  • 11. 
    Which imaging study is the preferred means for viewing a renal mass?
    • A. 

      X-Ray

    • B. 

      CT with or without contrast

    • C. 

      Abdominal MRI

    • D. 

      Renal angiography

    • E. 

      Abdominal ultrasound

  • 12. 
    What is the stage of a RCC tumor classified as T2, N1, MO?
    • A. 

      Stage I

    • B. 

      Stage II

    • C. 

      Stage III

    • D. 

      Stage IV

  • 13. 
    The rate of RCC has _________ by __ each year for the last 65 years.
    • A. 

      Increased, 2%

    • B. 

      Increased, 7%

    • C. 

      Increased, 12%

    • D. 

      Decreased, 2%

    • E. 

      Decreased, 7%

  • 14. 
    Which is the most common type of hereditary RCC diagnosed?
    • A. 

      Hereditary Papillary RCC

    • B. 

      Hereditary leiomyoma-RCC

    • C. 

      Birt-Hogg-Dube syndrome

    • D. 

      VHL disease

    • E. 

      Hereditary renal oncocytoma

  • 15. 
    Which of the following is not a predictor of short survival?
    • A. 

      Hgb < LLN

    • B. 

      < 1 year from diagnosis to start of systemic treatment

    • C. 

      Karnofsky PFS ≤ 70

    • D. 

      LDH > 1.5X ULN

    • E. 

      ≥ 1 site organ metastasis

  • 16. 
    What is the average 5-year survival rate for a Stage IV RCC patient?
    • A. 

      23%

    • B. 

      64%

    • C. 

      82%

    • D. 

      96%

    • E. 

      None of the responses are correct

  • 17. 
    In what part of the kidney does clear cell RCC originate?
    • A. 

      Collecting duct

    • B. 

      Distal convoluted tubule

    • C. 

      Proximal convoluted tubule

    • D. 

      Glomerulus

    • E. 

      None of the responses are correct

  • 18. 
    Which statistic best characterizes RCC?
    • A. 

      It has a higher incidence in men

    • B. 

      It has a higher incidence in women

    • C. 

      Its incidence is equally distributed among men and women

    • D. 

      The overall 5-year relative survival for all stages is 48.3%

    • E. 

      It is the 11th most common cancer diagnosed in the US

  • 19. 
    Within what period of time do tumor recurrences primarily recur?
    • A. 

      1-3 years

    • B. 

      3-5 years

    • C. 

      5-7 years

    • D. 

      7-10 years

    • E. 

      10-15 years

  • 20. 
    Recurrence of RCC in the local tumor bed and the contralateral kidney is ___________
    • A. 

      Rare

    • B. 

      Unheard of

    • C. 

      Common

    • D. 

      Likely

    • E. 

      Normal