Random 20 Questions - Clinical Biochemistry

20 Questions | Total Attempts: 223

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Clinical Biochemistry Quizzes & Trivia

Difficulty level - Easy to Moderate


Questions and Answers
  • 1. 
    Nitisinone is used in
    • A. 

      Tyrosinemia type I

    • B. 

      Alkaptonuria

    • C. 

      Either of the above

    • D. 

      None of the above

  • 2. 
    Type 1 tyrosinemia is due to deficiency of 
    • A. 

      Fumarylacetoacetate hydrolase

    • B. 

      Tyrosine aminotransferase

    • C. 

      4-hydroxyphenylpyruvate dioxygenase

    • D. 

      None of the above

  • 3. 
    FALSE about Cathepsin K is
    • A. 

      Main enzyme involved in bone resorption

    • B. 

      Degraded by cathepsin S

    • C. 

      cysteine protease present in ER

    • D. 

      None of the above

  • 4. 
    Select the mismatched pair
    • A. 

      CA 125 - ovarian cancer

    • B. 

      CA 19-9 - adeno carcinoma pancreas

    • C. 

      CA 50 - bladder cancer

    • D. 

      CA 15-3 - CA breast

  • 5. 
    Alcohol can precipitate 
    • A. 

      Symptoms of carcinoid

    • B. 

      Pain in osteoid osteoma

    • C. 

      Gout

    • D. 

      All of the above

  • 6. 
    Which is not a pheochroma associated syndrome ?
    • A. 

      NF-1

    • B. 

      NF-2

    • C. 

      MEN 2A

    • D. 

      MEN 2B

  • 7. 
    Predominant estrogen produced by the fetoplacental unit is
    • A. 

      Estradiol

    • B. 

      Estriol

    • C. 

      Estrione

    • D. 

      All of the above

  • 8. 
    Intracellular shift of pottasium is done by all except
    • A. 

      Insulin

    • B. 

      Beta 2 agonists

    • C. 

      Acidosis

    • D. 

      Alkalosis

  • 9. 
    Which is not true about myotonic dystrophy type I ?
    • A. 

      Autosomal dominant inheritance

    • B. 

      CTG trinucleotide repeat disorders

    • C. 

      Frontal balding of men, blue dot cataract, cardiac conduction defects

    • D. 

      Phenomenon of anticipation is not seen.

  • 10. 
    Select the mismatched pair
    • A. 

      Fragile X - CTG

    • B. 

      Frederich's ataxia - GAA

    • C. 

      Huntigton - CAG

    • D. 

      None of the above

  • 11. 
    Which is not a feature of mitochondrial inheritance
    • A. 

      Maternal transmission

    • B. 

      Heteroplasmy

    • C. 

      Replicative seggregation

    • D. 

      Premutation

  • 12. 
    Which is not a component of garrod's tetrad
    • A. 

      Alkaptonuria

    • B. 

      Albinism

    • C. 

      Tyrosinemia

    • D. 

      Essential pentosuria

    • E. 

      Cystinuria

  • 13. 
    Subtype of aquaporin mutation seen in neuromyelitis optica is
    • A. 

      AQP1

    • B. 

      AQP2

    • C. 

      AQP3

    • D. 

      AQP4

  • 14. 
    Which is a feature of central pontine myelinosis
    • A. 

      Spastic quadriplegia

    • B. 

      Pseudobulbar palsy

    • C. 

      Delerium

    • D. 

      All of the above

  • 15. 
    FALSE about McCune–Albright syndrome is 
    • A. 

      Gain of function mutation of Gs

    • B. 

      Precocious puberty

    • C. 

      Bilateral Café-au-lait spots

    • D. 

      Polyostotic fibrous dysplasia due to postzygotic mutation of GNAS1

  • 16. 
    Peak testosterone level is seen at 
    • A. 

      4 AM

    • B. 

      8 AM

    • C. 

      4 PM

    • D. 

      8 PM

  • 17. 
    Delta bilirubin is
    • A. 

      Conjugatd bilirubin noncovalently bound to albumin

    • B. 

      Conjugatd bilirubin covalently bound to albumin

    • C. 

      Unconjugatd bilirubin covalently bound to albumin

    • D. 

      Unconjugatd bilirubin noncovalently bound to albumin

  • 18. 
    Tartrate-resistant acid phosphatase (TRAP) is a marker of 
    • A. 

      Hairy cell leukemia

    • B. 

      Osteoclast

    • C. 

      Marcophages

    • D. 

      All of the above

  • 19. 
    Germline mutation of p53 mutation results in 
    • A. 

      Lynch syndrome

    • B. 

      Li fraumeni syndrome

    • C. 

      Gardner syndrome

    • D. 

      All of the above

  • 20. 
    Components of Lynch syndrome are
    • A. 

      Breast cancer, endometrial cancer and ovarian cancer.

    • B. 

      Breast cancer, colon cancer and endometrial cancer

    • C. 

      Breast cancer, colon cancer and ovarian cancer.

    • D. 

      Colon cancer, endometrial cancer and ovarian cancer

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