Random 20 Questions - Clinical Biochemistry
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Nitisinone is used in
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Tyrosinemia type I
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Alkaptonuria
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Either of the above
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None of the above
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This quiz titled 'Random 20 questions - clinical biochemistry' assesses knowledge in clinical biochemistry, focusing on disorders like Type 1 tyrosinemia and the use of drugs like Nitisinone. It tests understanding of biochemical markers and genetic syndromes, essential for students and professionals in medical and biochemical fields.
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- 2.
Type 1 tyrosinemia is due to deficiency of
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Fumarylacetoacetate hydrolase
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Tyrosine aminotransferase
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4-hydroxyphenylpyruvate dioxygenase
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None of the above
Correct Answer
A. Fumarylacetoacetate hydrolaseExplanation
Type I, II, III defects are given in order.Rate this question:
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- 3.
FALSE about Cathepsin K is
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Main enzyme involved in bone resorption
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Degraded by cathepsin S
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cysteine protease present in ER
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None of the above
Correct Answer
A. cysteine protease present in ERExplanation
it is a lysosomal cysteine protease. Glucose 6 phosphatase is present in ER.Rate this question:
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- 4.
Select the mismatched pair
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CA 125 - ovarian cancer
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CA 19-9 - adeno carcinoma pancreas
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CA 50 - bladder cancer
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CA 15-3 - CA breast
Correct Answer
A. CA 50 - bladder cancerExplanation
CA 50 - colorectal carcinomaRate this question:
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- 5.
Alcohol can precipitate
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Symptoms of carcinoid
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Pain in osteoid osteoma
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Gout
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All of the above
Correct Answer
A. All of the aboveExplanation
Alcohol can precipitate symptoms of carcinoid, pain in osteoid osteoma, and gout. Carcinoid is a type of tumor that releases hormones, and alcohol can stimulate the release of these hormones, leading to symptoms. Osteoid osteoma is a benign bone tumor that causes localized pain, and alcohol consumption can exacerbate this pain. Gout is a form of arthritis caused by high levels of uric acid in the blood, and alcohol can increase uric acid production and trigger gout attacks. Therefore, all of the above conditions can be worsened by alcohol consumption.Rate this question:
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- 6.
Which is not a pheochroma associated syndrome ?
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NF-1
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NF-2
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MEN 2A
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MEN 2B
Correct Answer
A. NF-2Explanation
Bilateral vestibular schwannomas / acoustic neuroma is found in NF2.Rate this question:
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- 7.
Predominant estrogen produced by the fetoplacental unit is
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Estradiol
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Estriol
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Estrione
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All of the above
Correct Answer
A. EstriolExplanation
Estriol is less potent than E2.
Measured in triple test for down syndrome.
Placenta does not express P450C17. Fetal adrenal glands play a central role in placental steroidogenesis and maintainance of pregnancy, onset of labor.
DHEAS produced by fetal adrenal is converted into Estriol by placenta.Rate this question:
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- 8.
Intracellular shift of pottasium is done by all except
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Insulin
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Beta 2 agonists
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Acidosis
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Alkalosis
Correct Answer
A. AcidosisExplanation
The intracellular shift of potassium is a process that involves moving potassium ions from the extracellular fluid into the intracellular space. Insulin and beta 2 agonists are known to promote this shift by stimulating the activity of the sodium-potassium pump. Alkalosis, which is a condition characterized by increased blood pH, can also cause an intracellular shift of potassium. However, acidosis, which is a condition characterized by decreased blood pH, does not promote the intracellular shift of potassium. Therefore, acidosis is the correct answer as it is not involved in the intracellular shift of potassium.Rate this question:
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- 9.
Which is not true about myotonic dystrophy type I ?
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Autosomal dominant inheritance
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CTG trinucleotide repeat disorders
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Frontal balding of men, blue dot cataract, cardiac conduction defects
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Phenomenon of anticipation is not seen.
Correct Answer
A. Phenomenon of anticipation is not seen.Explanation
Anticipation is early onset and increased severity of disease in next generation. peculiar to trinucleotide repeat disorders.Rate this question:
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- 10.
Select the mismatched pair
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Fragile X - CTG
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Frederich's ataxia - GAA
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Huntigton - CAG
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None of the above
Correct Answer
A. Fragile X - CTGExplanation
The correct answer is "Fragile X - CTG" because Fragile X syndrome is caused by an expansion of the CGG trinucleotide repeat in the FMR1 gene, not CTG. CTG repeat expansions are associated with other genetic disorders, such as myotonic dystrophy. Therefore, Fragile X and CTG do not match.Rate this question:
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- 11.
Which is not a feature of mitochondrial inheritance
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Maternal transmission
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Heteroplasmy
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Replicative seggregation
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Premutation
Correct Answer
A. PremutationExplanation
premutation is seen in trinucleotide repeat expansion.Rate this question:
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- 12.
Which is not a component of garrod's tetrad
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Alkaptonuria
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Albinism
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Tyrosinemia
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Essential pentosuria
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Cystinuria
Correct Answer
A. TyrosinemiaExplanation
Tyrosinemia is not a component of Garrod's tetrad. Garrod's tetrad refers to the four inborn errors of metabolism that Garrod identified, which include alkaptonuria, albinism, cystinuria, and pentosuria. Tyrosinemia is a separate metabolic disorder characterized by the body's inability to break down the amino acid tyrosine. It is not included in Garrod's tetrad.Rate this question:
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- 13.
Subtype of aquaporin mutation seen in neuromyelitis optica is
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AQP1
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AQP2
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AQP3
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AQP4
Correct Answer
A. AQP4Explanation
AQP2 is mutated in DI.Rate this question:
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- 14.
Which is a feature of central pontine myelinosis
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Spastic quadriplegia
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Pseudobulbar palsy
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Delerium
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All of the above
Correct Answer
A. All of the aboveExplanation
Central pontine myelinolysis (CPM) is a neurological disorder characterized by the destruction of the myelin sheath in the central pons region of the brain. This condition can result in various symptoms, including spastic quadriplegia, which refers to muscle stiffness and weakness in all four limbs. Pseudobulbar palsy is another feature of CPM, which involves difficulty in controlling facial movements, speech, and swallowing. Delirium, a state of confusion and disorientation, can also occur in individuals with CPM. Therefore, the correct answer is "All of the above" as all these features can be present in central pontine myelinolysis.Rate this question:
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- 15.
FALSE about McCune–Albright syndrome is
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Gain of function mutation of Gs
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Precocious puberty
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Bilateral Café-au-lait spots
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Polyostotic fibrous dysplasia due to postzygotic mutation of GNAS1
Correct Answer
A. Bilateral Café-au-lait spotsExplanation
gain of function mutation of Gs results in uncontrolled production of hormones, hence precocious puberty.Rate this question:
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- 16.
Peak testosterone level is seen at
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4 AM
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8 AM
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4 PM
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8 PM
Correct Answer
A. 8 AMExplanation
very easy to answer... :-)Rate this question:
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- 17.
Delta bilirubin is
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Conjugatd bilirubin noncovalently bound to albumin
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Conjugatd bilirubin covalently bound to albumin
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Unconjugatd bilirubin covalently bound to albumin
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Unconjugatd bilirubin noncovalently bound to albumin
Correct Answer
A. Conjugatd bilirubin covalently bound to albuminExplanation
Delta bilirubin refers to conjugated bilirubin that is covalently bound to albumin. Conjugated bilirubin is a water-soluble form of bilirubin that has been processed by the liver and is ready for excretion. It is bound to albumin, a protein in the blood, through a covalent bond. This form of bilirubin is typically found in conditions where there is impaired liver function or bile flow, such as in obstructive jaundice or liver disease.Rate this question:
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- 18.
Tartrate-resistant acid phosphatase (TRAP) is a marker of
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Hairy cell leukemia
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Osteoclast
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Marcophages
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All of the above
Correct Answer
A. All of the aboveExplanation
Don't jump into conclusion in the first option itself !!!Rate this question:
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- 19.
Germline mutation of p53 mutation results in
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Lynch syndrome
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Li fraumeni syndrome
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Gardner syndrome
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All of the above
Correct Answer
A. Li fraumeni syndromeExplanation
Germline mutation of p53 gene is associated with Li Fraumeni syndrome. This syndrome is a rare inherited disorder that predisposes individuals to a wide range of cancers, including breast cancer, brain tumors, sarcomas, and leukemia. The p53 gene is a tumor suppressor gene that plays a crucial role in regulating cell growth and preventing the formation of tumors. When there is a mutation in this gene, it can lead to the development of Li Fraumeni syndrome, which is characterized by an increased risk of multiple types of cancer at an early age.Rate this question:
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- 20.
Components of Lynch syndrome are
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Breast cancer, endometrial cancer and ovarian cancer.
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Breast cancer, colon cancer and endometrial cancer
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Breast cancer, colon cancer and ovarian cancer.
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Colon cancer, endometrial cancer and ovarian cancer
Correct Answer
A. Colon cancer, endometrial cancer and ovarian cancerExplanation
Lynch syndrome is the other name of HNPCC. Molecular basis is microsatellite instability caused by defective DNA mismatch repair genes.Rate this question:
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Current Version
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Mar 19, 2023Quiz Edited by
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May 26, 2014Quiz Created by
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