Random 20 Questions - Clinical Biochemistry
Difficulty level - Easy to Moderate
- 1.Nitisinone is used in
- A.
Tyrosinemia type I
- B.
Alkaptonuria
- C.
Either of the above
- D.
None of the above
- 2.Type 1 tyrosinemia is due to deficiency of
- A.
Fumarylacetoacetate hydrolase
- B.
Tyrosine aminotransferase
- C.
4-hydroxyphenylpyruvate dioxygenase
- D.
None of the above
- 3.FALSE about Cathepsin K is
- A.
Main enzyme involved in bone resorption
- B.
Degraded by cathepsin S
- C.
cysteine protease present in ER
- D.
None of the above
- 4.Select the mismatched pair
- A.
CA 125 - ovarian cancer
- B.
CA 19-9 - adeno carcinoma pancreas
- C.
CA 50 - bladder cancer
- D.
CA 15-3 - CA breast
- 5.Alcohol can precipitate
- A.
Symptoms of carcinoid
- B.
Pain in osteoid osteoma
- C.
Gout
- D.
All of the above
- 6.Which is not a pheochroma associated syndrome ?
- A.
NF-1
- B.
NF-2
- C.
MEN 2A
- D.
MEN 2B
- 7.Predominant estrogen produced by the fetoplacental unit is
- A.
Estradiol
- B.
Estriol
- C.
Estrione
- D.
All of the above
- 8.Intracellular shift of pottasium is done by all except
- A.
Insulin
- B.
Beta 2 agonists
- C.
Acidosis
- D.
Alkalosis
- 9.Which is not true about myotonic dystrophy type I ?
- A.
Autosomal dominant inheritance
- B.
CTG trinucleotide repeat disorders
- C.
Frontal balding of men, blue dot cataract, cardiac conduction defects
- D.
Phenomenon of anticipation is not seen.
- 10.Select the mismatched pair
- A.
Fragile X - CTG
- B.
Frederich's ataxia - GAA
- C.
Huntigton - CAG
- D.
None of the above
- 11.Which is not a feature of mitochondrial inheritance
- A.
Maternal transmission
- B.
Heteroplasmy
- C.
Replicative seggregation
- D.
Premutation
- 12.Which is not a component of garrod's tetrad
- A.
Alkaptonuria
- B.
Albinism
- C.
Tyrosinemia
- D.
Essential pentosuria
- E.
Cystinuria
- 13.Subtype of aquaporin mutation seen in neuromyelitis optica is
- A.
AQP1
- B.
AQP2
- C.
AQP3
- D.
AQP4
- 14.Which is a feature of central pontine myelinosis
- A.
Spastic quadriplegia
- B.
Pseudobulbar palsy
- C.
Delerium
- D.
All of the above
- 15.FALSE about McCune–Albright syndrome is
- A.
Gain of function mutation of Gs
- B.
Precocious puberty
- C.
Bilateral Café-au-lait spots
- D.
Polyostotic fibrous dysplasia due to postzygotic mutation of GNAS1
- 16.Peak testosterone level is seen at
- A.
4 AM
- B.
8 AM
- C.
4 PM
- D.
8 PM
- 17.Delta bilirubin is
- A.
Conjugatd bilirubin noncovalently bound to albumin
- B.
Conjugatd bilirubin covalently bound to albumin
- C.
Unconjugatd bilirubin covalently bound to albumin
- D.
Unconjugatd bilirubin noncovalently bound to albumin
- 18.Tartrate-resistant acid phosphatase (TRAP) is a marker of
- A.
Hairy cell leukemia
- B.
Osteoclast
- C.
Marcophages
- D.
All of the above
- 19.Germline mutation of p53 mutation results in
- A.
Lynch syndrome
- B.
Li fraumeni syndrome
- C.
Gardner syndrome
- D.
All of the above
- 20.Components of Lynch syndrome are
- A.
Breast cancer, endometrial cancer and ovarian cancer.
- B.
Breast cancer, colon cancer and endometrial cancer
- C.
Breast cancer, colon cancer and ovarian cancer.
- D.
Colon cancer, endometrial cancer and ovarian cancer
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