Neurodegenerative Diseases

49 Questions | By Icanhasfarm | Updated: Mar 22, 2022 | Attempts: 1727

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Based on Dr. Pak's Lecture on Alzheimer's and Parkinson's Diseases. These questions are all multiple-multiple choice. That is, you may choose more than one correct answer.

Questions and Answers

1.

Alzheimer's Disease
- A.
  
  Was cured in 2004
- B.
  
  Has no cure
- C.
  
  Can be reversed with drugs
- D.
  
  Can be reversed with therapy
2.

Late symptoms include all of the following EXCEPT:
- A.
  
  Behavior problems
- B.
  
  Loss of Speech
- C.
  
  Difficulty with self-care
- D.
  
  Hallucinations
3.

The greatest risk factor for Alzheimer's is:
- A.
  
  Exposure to nicotine
- B.
  
  Gender
- C.
  
  Age
- D.
  
  Genetics
- E.
  
  Head injury
4.

Hallmarks of Alzheimer's Include:
- A.
  
  Degeneration of hippocampal and cortical neurons
- B.
  
  Reduced cholinergic transmission
- C.
  
  Neuritic plaques
- D.
  
  Neurofibrillary Tangles
- E.
  
  Micro Tubules
5.

Which form of ABeta is most prone to aggregation?
- A.
  
  AB40
- B.
  
  AB41
- C.
  
  AB42
- D.
  
  AB43
6.

Mutations in genes such as APP, PS1, and PS2:
- A.
  
  Increase risk for Alzheimer's
- B.
  
  Are autosomal dominant
- C.
  
  Are autosomal recessive
- D.
  
  Are solely responsible for Alzheimer's
7.

APP mutations are associated with:
- A.
  
  Early Onset
- B.
  
  Middle Onset
- C.
  
  Late Onset
- D.
  
  More AB aggregation
- E.
  
  More tau aggregation
8.

The Swedish mutation is at the ___ while the Arctic mutation is at the ____
- A.
  
  C-terminus of B-secretase site, N-terminus of B-secretase site
- B.
  
  AB peptide coding sequence, N-terminus of B-secretase site
- C.
  
  N-terminus of B-secretase site, AB peptide coding sequence
- D.
  
  C-terminus of gamma-secretase site, AB peptide coding sequence
9.

This mutation leads to the earliest development of AD:
- A.
  
  APP
- B.
  
  PS1
- C.
  
  PS2
- D.
  
  PS3
- E.
  
  S3G4
10.

Tau is present in __ where it stabilizes ___ but loses its abilities when ____
- A.
  
  Dendrites, microtubules, dephosphorylated
- B.
  
  Axons, microtubules, hyperphosphorylated
- C.
  
  Soma, proteins, dephosphorylated
- D.
  
  Soma, proteins, hyperphosphorylated
11.

This APOE reduces AD risk:
- A.
  
  E2
- B.
  
  E3
- C.
  
  E4
- D.
  
  E5
12.

ApoE4 works by:
- A.
  
  Necrosis
- B.
  
  Apoptosis
- C.
  
  Increasing neurofibrillary tangles
- D.
  
  Reducing solubility of AB
13.

Donepezil or Aricept works by:
- A.
  
  Preventing breakdown of Ach
- B.
  
  Inhibition of cholinesterase
- C.
  
  Doing the same as Rivastigmine and Galantamine
14.

Memantine or Namenda is:
- A.
  
  An AMPA blocker
- B.
  
  An NMDA blocker
- C.
  
  FDA approved
- D.
  
  Banned by the FDA
15.

Crossword puzzles can reduce risk for AD
- A.
  
  True
- B.
  
  False
16.

NSAIDs can reduce risk for AD:
- A.
  
  True
- B.
  
  False
17.

Opioids can reduce risk for AD:
- A.
  
  True
- B.
  
  False
18.

Parkinson's is:
- A.
  
  A movement disorder
- B.
  
  A neurodegenerative disorder
- C.
  
  An airborne pathogen
- D.
  
  Curable
19.

Symptoms of Parkinson's include all of the following except:
- A.
  
  Tachykinesia
- B.
  
  Rigidity
- C.
  
  Resting tremor
- D.
  
  Postural instability
- E.
  
  Bradykinesia
20.

Parkinson's may lead to depression
- A.
  
  True
- B.
  
  False
21.

Parkinson's may change a person's handwriting and speech:
- A.
  
  True
- B.
  
  False
22.

The basal ganglia includes:
- A.
  
  Amygdala
- B.
  
  The striatum
- C.
  
  The globus pallidus
- D.
  
  Subthalamic nuclei
- E.
  
  Substantia Nigra
23.

The basal ganglia help:
- A.
  
  Impulse control
- B.
  
  Initiate movement
- C.
  
  End a movement
- D.
  
  Suppress unwanted movement
- E.
  
  Suppress cravings
24.

The substantia nigra provides ___ for the striatum
- A.
  
  GABA
- B.
  
  5HT
- C.
  
  Dopamine
- D.
  
  Glutamate
25.

The striatum delicately balances ____ and ____
- A.
  
  GABA, Glutamate
- B.
  
  DA, Ach
- C.
  
  5HT, DA
- D.
  
  Ach, nicotine

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