Neurodegenerative Diseases

49 Questions | Total Attempts: 901

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Neurodegenerative Diseases

Based on Dr. Pak's Lecture on Alzheimer's and Parkinson's Diseases. These questions are all multiple-multiple choice. That is, you may choose more than one correct answer.


Questions and Answers
  • 1. 
    Alzheimer's Disease
    • A. 

      Was cured in 2004

    • B. 

      Has no cure

    • C. 

      Can be reversed with drugs

    • D. 

      Can be reversed with therapy

  • 2. 
    Late symptoms include all of the following EXCEPT:
    • A. 

      Behavior problems

    • B. 

      Loss of Speech

    • C. 

      Difficulty with self-care

    • D. 

      Hallucinations

  • 3. 
    The greatest risk factor for Alzheimer's is:
    • A. 

      Exposure to nicotine

    • B. 

      Gender

    • C. 

      Age

    • D. 

      Genetics

    • E. 

      Head injury

  • 4. 
    Hallmarks of Alzheimer's Include:
    • A. 

      Degeneration of hippocampal and cortical neurons

    • B. 

      Reduced cholinergic transmission

    • C. 

      Neuritic plaques

    • D. 

      Neurofibrillary Tangles

    • E. 

      Micro Tubules

  • 5. 
    Which form of ABeta is most prone to aggregation?
    • A. 

      AB40

    • B. 

      AB41

    • C. 

      AB42

    • D. 

      AB43

  • 6. 
    Mutations in genes such as APP, PS1, and PS2:
    • A. 

      Increase risk for Alzheimer's

    • B. 

      Are autosomal dominant

    • C. 

      Are autosomal recessive

    • D. 

      Are solely responsible for Alzheimer's

  • 7. 
    APP mutations are associated with:
    • A. 

      Early Onset

    • B. 

      Middle Onset

    • C. 

      Late Onset

    • D. 

      More AB aggregation

    • E. 

      More tau aggregation

  • 8. 
    The Swedish mutation is at the ___ while the Arctic mutation is at the ____
    • A. 

      C-terminus of B-secretase site, N-terminus of B-secretase site

    • B. 

      AB peptide coding sequence, N-terminus of B-secretase site

    • C. 

      N-terminus of B-secretase site, AB peptide coding sequence

    • D. 

      C-terminus of gamma-secretase site, AB peptide coding sequence

  • 9. 
    This mutation leads to the earliest development of AD:
    • A. 

      APP

    • B. 

      PS1

    • C. 

      PS2

    • D. 

      PS3

    • E. 

      S3G4

  • 10. 
    Tau is present in __ where it stabilizes ___ but loses its abilities when ____
    • A. 

      Dendrites, microtubules, dephosphorylated

    • B. 

      Axons, microtubules, hyperphosphorylated

    • C. 

      Soma, proteins, dephosphorylated

    • D. 

      Soma, proteins, hyperphosphorylated

  • 11. 
    This APOE reduces AD risk:
    • A. 

      E2

    • B. 

      E3

    • C. 

      E4

    • D. 

      E5

  • 12. 
    ApoE4 works by:
    • A. 

      Necrosis

    • B. 

      Apoptosis

    • C. 

      Increasing neurofibrillary tangles

    • D. 

      Reducing solubility of AB

  • 13. 
    Donepezil or Aricept works by:
    • A. 

      Preventing breakdown of Ach

    • B. 

      Inhibition of cholinesterase

    • C. 

      Doing the same as Rivastigmine and Galantamine

  • 14. 
    Memantine or Namenda is:
    • A. 

      An AMPA blocker

    • B. 

      An NMDA blocker

    • C. 

      FDA approved

    • D. 

      Banned by the FDA

  • 15. 
    Crossword puzzles can reduce risk for AD
    • A. 

      True

    • B. 

      False

  • 16. 
    NSAIDs can reduce risk for AD:
    • A. 

      True

    • B. 

      False

  • 17. 
    Opioids can reduce risk for AD:
    • A. 

      True

    • B. 

      False

  • 18. 
    Parkinson's is:
    • A. 

      A movement disorder

    • B. 

      A neurodegenerative disorder

    • C. 

      An airborne pathogen

    • D. 

      Curable

  • 19. 
    Symptoms of Parkinson's include all of the following except:
    • A. 

      Tachykinesia

    • B. 

      Rigidity

    • C. 

      Resting tremor

    • D. 

      Postural instability

    • E. 

      Bradykinesia

  • 20. 
    Parkinson's may lead to depression
    • A. 

      True

    • B. 

      False

  • 21. 
    Parkinson's may change a person's handwriting and speech:
    • A. 

      True

    • B. 

      False

  • 22. 
    The basal ganglia includes:
    • A. 

      Amygdala

    • B. 

      The striatum

    • C. 

      The globus pallidus

    • D. 

      Subthalamic nuclei

    • E. 

      Substantia Nigra

  • 23. 
    The basal ganglia help:
    • A. 

      Impulse control

    • B. 

      Initiate movement

    • C. 

      End a movement

    • D. 

      Suppress unwanted movement

    • E. 

      Suppress cravings

  • 24. 
    The substantia nigra provides ___ for the striatum
    • A. 

      GABA

    • B. 

      5HT

    • C. 

      Dopamine

    • D. 

      Glutamate

  • 25. 
    The striatum delicately balances ____ and ____
    • A. 

      GABA, Glutamate

    • B. 

      DA, Ach

    • C. 

      5HT, DA

    • D. 

      Ach, nicotine

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