NCLEX Pharmacology Quiz 29 Anti-inflammatory And Antineoplastic Drugs

1. Enrique who is under chemotherapy has the following CBC results: WBC 5000/mm³, RBC platelet 10,000/mm³. Which of the following is he at risk for?

Infection

Bleeding

Angina

None of the above

A platelet count of 10,000/mm3 means that the client does not have enough platelets to clot the blood; therefore, the possibility of bleeding is high. Choice A is a normal value of WBC. Angina would only be a risk if the client had a lower RBC count.

Explanation

A platelet count of 10,000/mm3 means that the client does not have enough platelets to clot the blood; therefore, the possibility of bleeding is high. Choice A is a normal value of WBC. Angina would only be a risk if the client had a lower RBC count.

2. Lorraine who is on chemotherapy has a history of cardiac disease. The client is at risk for cardiac complications because:

White blood cells are reduced.

Oxygen-carrying capacity may be reduced.

Sodium levels may rise meaning fluid overload.

Hematocrit is lowered.

If hemoglobin and red cell counts drop from myelosuppression, the oxygen-carrying capacity will fall, leaving the person at risk for angina.

Explanation

If hemoglobin and red cell counts drop from myelosuppression, the oxygen-carrying capacity will fall, leaving the person at risk for angina.

3. Nurse Corrine may expect to administer azathioprine (Imuran) to a transplant client in which of the following conditions?

Prevention of chronic rejection

Prevention of acute rejection

Management of chronic rejection

Treatment of acute rejection

Azathioprine inhibits humoral and cellular immunity during the early stages of lymphoid differentiation and is useful in preventing the onset of acute rejection.

Explanation

Azathioprine inhibits humoral and cellular immunity during the early stages of lymphoid differentiation and is useful in preventing the onset of acute rejection.

4. Which of the following client comments demonstrates that teaching has been successful regarding cyclosporine therapy?

“I need to mix the medicine in Styrofoam.”

“I should take the medication on an empty stomach.”

“I need to be consistent about when i take it and also monitor how much fat is in my food.”

“If I vomit I should take another dose.”

Cyclosporines need to be taken consistently in relation to meals. and fat content should not vary to maintain serum levels.

Explanation

Cyclosporines need to be taken consistently in relation to meals. and fat content should not vary to maintain serum levels.

5. Gold compounds are contraindicated in clients with:

Liver dysfunction

Cardiac disease

Preexisting dermatitis

Rheumatoid arthritis

An adverse reaction to gold compounds is liver toxicity; therefore. use care in clients with preexisting liver dysfunction.

Explanation

An adverse reaction to gold compounds is liver toxicity; therefore. use care in clients with preexisting liver dysfunction.

6. Frequent eye examinations are recommended in clients receiving:

Chloroquine

Colchicine

Penicillamine

Gold compounds

Corneal deposits are an adverse reaction associated with chloroquine administration. necessitating frequent eye examination.

Explanation

Corneal deposits are an adverse reaction associated with chloroquine administration. necessitating frequent eye examination.

7. Which of the following is the priority nursing diagnosis for a client undergoing chemotherapy?

Decreased cardiac output

Fear

Altered nutrition

Anxiety

Decreased cardiac output is more important than the other choices because it can jeopardize the client’s life.

Explanation

Decreased cardiac output is more important than the other choices because it can jeopardize the client’s life.

8. In a transplant client. the action of cyclosporine is to:

Defend the body against foreign antigens.

Inhibit T cells in response to antigens.

Inhibit B cell immunoglobulin.

Intensify the production of T lymphocytes

The primary action of cyclosporine is to inhibit T-cell generation in response to transplant antigens.

Explanation

The primary action of cyclosporine is to inhibit T-cell generation in response to transplant antigens.

9. Nurse Pia is instructing a client receiving probenecid (Benemid). she should cover all of the following information except the need to:

Change dietary habits.

Increase fluid intake.

Have frequent laboratory work done.

Recognize side effects.

Side effects of probenecid treatment are relatively benign. and there is no indication that there is a need for frequent laboratory evaluation.

Explanation

Side effects of probenecid treatment are relatively benign. and there is no indication that there is a need for frequent laboratory evaluation.

10. Which of the following laboratory tests should be monitored when a client is receiving azathioprine?

CBC

BUN

Electrolytes

Sedimentation rate

CBC will identify leukopenia. a common side effect.

Explanation

CBC will identify leukopenia. a common side effect.

11. Combination chemotherapy is used in the treatment of cancer because:

Single-agent therapy produces cell lines that are resistant.

Two drugs are more likely to work.

Single-agent therapy requires larger doses for long remissions.

Two cancers may be present.

Single-agent therapy tends to produce resistant tumor cells, making remission or cure impossible.

Explanation

Single-agent therapy tends to produce resistant tumor cells, making remission or cure impossible.

12. Antirheumatics are used to:

Directly affect the inflammatory response

Encourage excretion of autoantibodies

Retard progression of joint deterioration

Mediate the action of NSAIDs

These drugs cannot stop the disease itself but are believed to retard or prevent the process of joint deterioration. For choice A. the inflammatory process is affected indirectly. Autoantibodies are not excreted. Disease modifying antirheumatic drugs are used in combination with NSAIDs but do not mediate their effect.

Explanation

These drugs cannot stop the disease itself but are believed to retard or prevent the process of joint deterioration. For choice A. the inflammatory process is affected indirectly. Autoantibodies are not excreted. Disease modifying antirheumatic drugs are used in combination with NSAIDs but do not mediate their effect.

13. Client teaching for mycophenolate mofetil must include instructions to:

Take with food.

Avoid use of corticosteroid.

Monitor for adverse effects.

Practice effective contraception.

Effective contraception is essential because of the potential for teratogenic effects. It is recommended that the drug be taken on empty stomach. The drug is often given with corticosteroid. All medication should be monitored for side effects.

Explanation

Effective contraception is essential because of the potential for teratogenic effects. It is recommended that the drug be taken on empty stomach. The drug is often given with corticosteroid. All medication should be monitored for side effects.

14. Which of the following contributes most to the debilitation of an individual during a course of chemotherapy?

Diarrhea

Alopecia

Constipation

Pain

Diarrhea will cause debilitation as fluid and nutrients are lost at a time when the body most needs to be nourished.

Explanation

Diarrhea will cause debilitation as fluid and nutrients are lost at a time when the body most needs to be nourished.

15. Which of the following agents can be used in treatment of rheumatoid arthritis. Sj?gren's syndrome. and SLE?

Auranofin (Ridaura)

Allopurinol (Zyloprim)

Sulfasalazine (Azulfidine)

Chloroquine (Aralen)

Chloroquine has had documented success in the treatment of rheumatoid arthritis. Sj?gren’s syndrome. and SLE. Auranofin and sulfasalazine are used in the treatment of rheumatoid arthritis. but none are used in the treatment of all three syndromes.

Explanation

Chloroquine has had documented success in the treatment of rheumatoid arthritis. Sj?gren’s syndrome. and SLE. Auranofin and sulfasalazine are used in the treatment of rheumatoid arthritis. but none are used in the treatment of all three syndromes.

NCLEX Pharmacology Quiz 29 Anti-iNFLammatory And Antineoplastic Drugs