Pcol 1 Final Exam Mw 1-3pm

50 Questions | Total Attempts: 19

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Pcol 1 Final Exam Mw 1-3pm

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Questions and Answers
  • 1. 
    As noted in Ms. Wiley’s patient profile, she was tested for H. pylori. Which of the following statements is/are true regarding H. pylori?
    • A. 

      It is present in the majority of patients with duodenal ulcer.

    • B. 

      H. pylori eradication can cure peptic ulcer disease and reduce ulcer recurrence.

    • C. 

      An active duodenal ulcer is best managed with a combination of antisecretory therapy plus appropriate antibiotic(s).

    • D. 

      Option 4

  • 2. 
    In the admission interview, the pharmacist records that the patient has recently completed a regimen of ibuprofen. This information is significant in the patient’s history because (you can tick more than once):
    • A. 

      Ibuprofen may cause ulcers even in H. pylori– negative individuals.

    • B. 

      Ibuprofen may injure the gastric mucosa directly.

    • C. 

      Ibuprofen inhibits synthesis of prostaglandins, thereby compromising the mucosal-protective effect of these substances.

  • 3. 
    If Ms. Wiley were allergic to penicillin, what antiinfective agent should be substituted for the amoxicillin?
    • A. 

      Azithromycin

    • B. 

      Cefaclor

    • C. 

      Clindamycin

    • D. 

      Metronidazole

    • E. 

      Vancomycin

  • 4. 
    As noted in the profile, Ms. Wiley received ranitidine. The elimination half-life for ranitidine is approximately 2 hours. What percentage of this drug would be eliminated from the body 4 hours after an intravenous (IV) bolus dose?
    • A. 

      12.5%

    • B. 

      25.0%

    • C. 

      50.0%

    • D. 

      75.0%

    • E. 

      87.5%

  • 5. 
    Ms. Wiley received ranitidine. Of the following H2 antagonists, which one is a particular concern because it interacts with a large number of other medications?
    • A. 

      Ranitidine

    • B. 

      Cimetidine

    • C. 

      Nizatidine

    • D. 

      Famotidine

  • 6. 
    All of the following reduce acid secretion by inhibiting the proton pump of the parietal cell except:
    • A. 

      Posaconazole

    • B. 

      Lansoprazole

    • C. 

      Pantoprazole

    • D. 

      Esomeprazole

    • E. 

      Omeprazole

  • 7. 
    After leaving the hospital, the patient is given prescriptions for Nexium, amoxicillin, and Biaxin to complete the H. pylori eradication regimen. You should counsel the patient regarding all of the following except which one?
    • A. 

      Refrigerate Biaxin suspension

    • B. 

      Continue Nexium 40 mg for a total of 10 days.

    • C. 

      Clarithromycin can be taken with food to minimize GI side effects.

    • D. 

      Taste disturbances are common with Biaxin.

    • E. 

      Complete a full 10 days of antibiotic/antisecretory therapy for optimal eradication results.

  • 8. 
    A drug that blocks some or all opioid receptor subtypes.
    • A. 

      Opioid antagonist

    • B. 

      Opiate

    • C. 

      Opioid

    • D. 

      Opioid peptides

  • 9. 
    A drug derived from alkaloids of the opium poppy.
    • A. 

      Opiate

    • B. 

      Opioid

    • C. 

      Opioid peptides

    • D. 

      Opioid agonist

  • 10. 
    A drug that can activate an opioid receptor to effect a submaximal response
    • A. 

      Partial agonist

    • B. 

      Opiate

    • C. 

      Opioid

    • D. 

      Opioid peptides

  • 11. 
    The class of drugs that includes opiates, opiopeptins, and all synthetic and semisynthetic drugs that mimic the actions of the opiates.
    • A. 

      Opioid

    • B. 

      Mixed agonist-antagonist

    • C. 

      Opioid antagonist

    • D. 

      Partial agonist

  • 12. 
    A drug that activates some opioid receptor subtypes and blocks other opioid receptor subtypes
    • A. 

      Mixed agonist-antagonist

    • B. 

      Opioid antagonist

    • C. 

      Partial agonist

    • D. 

      Opioid agonist

  • 13. 
    Endogenous peptides that act on opioid receptors.
    • A. 

      Opioid peptides

    • B. 

      Opioid agonist

    • C. 

      Partial agonist

    • D. 

      Opioid antagonist

  • 14. 
    A drug that activates some or all opioid receptor subtypes and does not block any
    • A. 

      Opioid agonist

    • B. 

      Partial agonist

    • C. 

      Opioid antagonist

    • D. 

      Mixed agonist-antagonist

  • 15. 
    This type of opioid receptor plays a major role in the respiratory depressant actions of opioids.
    • A. 

      Mu

    • B. 

      Delta

    • C. 

      Kappa

    • D. 

      Both Mu and Delta

  • 16. 
    This/these type of opioid receptor/s is/are involved in slowing GI transit
    • A. 

      Mu

    • B. 

      Delta

    • C. 

      Kappa

    • D. 

      Mu and Delta

    • E. 

      Mu and Kappa

  • 17. 
    This type of opioid receptor is involved in sedative actions.
    • A. 

      Beta

    • B. 

      Delta

    • C. 

      Kappa

    • D. 

      None of the above

  • 18. 
    This type of opioid receptor is involved in the development of tolerance.
    • A. 

      Kappa

    • B. 

      Mu

    • C. 

      Delta

    • D. 

      Kappa and Mu

  • 19. 
    Endorphins have highest affinity for _______________ receptors
    • A. 

      Mu

    • B. 

      Kappa

    • C. 

      Delta

    • D. 

      Enkephalins

  • 20. 
    Enkephalins have highest affinity for ______________ receptors
    • A. 

      Mu

    • B. 

      Kappa

    • C. 

      Delta

    • D. 

      Beta Endorphins

  • 21. 
    Kappa receptors has strong affinities on which Opioid peptide?
    • A. 

      5HT

    • B. 

      Dynorphins

    • C. 

      Beta Endorphins

    • D. 

      Adrenaline

  • 22. 
    Inhibitory postsynaptic potential
    • A. 

      Depolarization

    • B. 

      Hyperpolarization

    • C. 

      Repolarization

    • D. 

      Rest

  • 23. 
    At the presynaptic level, opioid receptor activation can close voltage-gated _____ ion channels to inhibit neurotransmitter release.
    • A. 

      Na+

    • B. 

      K+

    • C. 

      Cl-

    • D. 

      Ca++

  • 24. 
    The following are acute effects of Opioids except:
    • A. 

      Tolerance

    • B. 

      Analgesia

    • C. 

      Sedation

    • D. 

      Euphoria

    • E. 

      Respiratory Depression

  • 25. 
    The following are acute effects Opioids except:
    • A. 

      Constipation

    • B. 

      Nausea and Vomiting

    • C. 

      Spasm

    • D. 

      Antitussive

    • E. 

      Dependence

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