Fluoroquinolones

1. Fluoroquinolones are synthetic analogs of nalidixic acid

True

False

2. Clinical application of fluoroquinolones

UTIs

Bacterial diarrhea

RTI

All of the above

3. Ciprofloxacin is the drug of choice for prophylaxis and treatment of anthrax

True

False

4. Improved gram +ve coverage fluoroquinolones :

Moxifloxacin

Gemifloxacin

Enoxacin

C+B

A+B

5. Ciprofloxacin is the most active against gram +ve bacteria

True

False

6. Norfloxacin :

The least active against gram +ve & -ve bacteria

Excellent grame -ve coverage & moderate gram +ve

Improved gram +ve coverage

None of the mentioned

7. One of the adverse reaction of fluoroquinolones is QTc prolongation so we should avoid use it with :

Antiarrythmic drugs

Sulfadoxine

Rifampin

A+B

8. One of the resistance mechanism of gram -ve bacteria to fluoroquinolones is reduction in porins protein

True

False

9. Respiratory fluoroquinolones:

Levofloxacin

Ciprofloxacin

Gemifloxacin

A+B

A+C

10. DNA gyrase is the primary drug target in gram +ve bacteria

True

False