Trimethoprim

1. Resistance mechanism to trimethoprim

Reduce cell permeability

Over production of DFR

Production of an altered DFR with decreased affinity

All of the above

2. Trimethoprim-sulfamethoxazole

Given orally or IV

Wide distribution including CNS , CSF

Used to treat UTIs

All of the above

3. One of the side effects of Co-trimoxazole is renal damage

True

False

4. Clinical application of oral co-trimoxazole

Prostatitis

UTIs

Salmonella infections

All of the above

None of the mentioned

5. In trimethoprim-sulfamethoxazole combination , sulfamethoxazole has larger volume of distribution

True

False

6. One of the side effects of trimethoprim is hepatitis

True

False