Industrial Pharmacy I- Tablet

The slugging or recompression method of tablet manufacture involves compressing the drug powder into a tablet form. This method can be used to make tablets containing drugs that are unstable in the presence of moisture because it allows for the incorporation of moisture-sensitive drugs into a tablet matrix, protecting them from exposure to moisture. This helps to maintain the stability and effectiveness of the drug.

Capping refers to the phenomenon where the top or bottom crowns of a tablet become partially or completely separated. This can occur due to various reasons such as improper formulation, inadequate compression force, or excessive moisture content. Capping can lead to issues with the tablet's appearance, integrity, and performance. Therefore, it is crucial to ensure proper manufacturing processes and quality control measures to prevent capping in tablet production.

Spray dried lactose is a directly compressible diluent because it has been processed into a fine powder form that can easily be compressed into tablets. This type of lactose is specifically designed for use in tablet manufacturing, as it provides good flowability, compressibility, and uniformity. Starch, dextrose, and sorbitol are not directly compressible diluents as they require additional processing or formulation techniques to be suitable for tablet compression.