Understanding Substance Impact on Brain Functions

Psychoactive drugs primarily affect the central nervous system (CNS), which includes the brain and spinal cord. These drugs can alter brain function and can lead to changes in perception, mood, consciousness, cognition, and behavior.

The three major classifications of substances are stimulants, depressants, and psychedelics/hallucinogens. Other possible classifications may exist but this question focuses on the widely accepted three categories in the context of substance use disorders.

These substances are classified as stimulants because they increase alertness, attention, and energy.

Cocaine is a stimulant drug that can cause insomnia, increased heart rate, and elevated blood pressure when consumed. Alcohol is a depressant that typically does not have these effects. Marijuana is a psychoactive drug that may cause relaxation and altered perception. Caffeine is a stimulant but is less likely to result in insomnia, increased heart rate, and elevated blood pressure compared to cocaine.

Benzodiazepines are known for their sedative effects on the central nervous system, which commonly result in feelings of lethargy and drowsiness.

Hallucinations involve experiencing sensations that are not based on reality, whereas false memories, confusion, and phobias are distinct psychological phenomena.

The liver plays a crucial role in metabolic processes by breaking down substances in the bloodstream, such as drugs and alcohol. The pancreas is responsible for producing digestive enzymes, the kidneys filter waste from the blood, and the lungs are involved in oxygen and carbon dioxide exchange.

The nervous system is divided into the central nervous system, which includes the brain and spinal cord, and the peripheral nervous system, which comprises all other nerves in the body.

Loss of neurons in the hippocampus can negatively impact memory function as the hippocampus plays a crucial role in the formation and retrieval of memories.

Dopamine, GABA, and endorphins are all examples of neurotransmitters, which are chemical messengers that transmit signals across synapses between neurons in the nervous system.

Agonists are substances that activate a receptor by mimicking the action of a neurotransmitter. Antagonists bind to receptors but do not activate them, blocking the action of neurotransmitters. Inhibitors hinder the activity of specific enzymes or processes. Placebos have no pharmacological effect but may produce a psychological benefit.

An antagonist is a substance that binds to a receptor without activating it, blocking the receptor from responding to an agonist. In the context of opioids, an antagonist can prevent the opioid from stimulating the receptor and producing its effects.

Tolerance refers to the diminishing effect of a drug as a result of repeated use, leading to the need for higher doses to achieve the desired effect. Addiction is a psychological and physical dependence on a substance that leads to compulsive drug seeking and use. Withdrawal is the symptoms experienced when decreasing or stopping drug use. Dependence is the state of needing a drug to function normally, leading to withdrawal symptoms when the drug is stopped.

Reverse tolerance refers to the phenomenon where an individual requires less of a substance to feel its effects as their sensitivity increases over time. Tolerance buildup, substance dependence, and sensory adaptation do not specifically describe the situation where a user experiences a higher impact from a normal dose.

Cross tolerance refers to the development of tolerance to one drug due to exposure to another drug with similar effects. In this case, the individual has developed tolerance to both heroin and morphine due to their similar actions.

The symptoms of depression, nausea, and hyper reflexes are indicative of opioid withdrawal, not active opioid use or side effects of another medication or symptoms of a different medical condition.

Post-Acute Withdrawal Symptoms (PAWS) typically occur after a longer period of abstinence from substances, usually within 3-6 months of stopping substance use. It is important to distinguish between acute withdrawal symptoms that occur shortly after stopping use and PAWS which can last for months after the initial withdrawal period.

The DSM-5 categorizes substance use disorders into three levels of severity: Mild, moderate, and severe. These levels are based on the number of criteria met by an individual.

When cocaine is inhaled, it rapidly crosses the blood-brain barrier, resulting in a quick and intense rush of euphoria. Injection can also elicit a quick response, but inhalation is the fastest method of administration.

The correct answer is approximately 36 hours because it is the typical detection window for cocaine use in urine drug tests.

Cocaine inhibits the reabsorption of neurotransmitters such as norepinephrine, epinephrine, and dopamine, leading to increased levels in the brain.

Amphetamine has a longer duration of effects compared to cocaine due to its extended release formulation and slower metabolism in the body.

Amphetamines primarily impact the sympathetic nervous system, leading to increased heart rate, blood pressure, and dilation of bronchioles.

The effects of methamphetamines usually last for 4-6 hours before wearing off.

LSD can lead to drug-induced psychosis and hallucinogen persistent perception disorder as long-term effects. It does not cause irreversible brain damage, chronic migraines, or increased intelligence.

ALT liver enzymes are typically found in liver cells. When levels are elevated, it often indicates liver damage.

Dispositional tolerance is when the body becomes more efficient at excreting the drug, leading to a decrease in its effects over time.

A neuron is a specialized cell that transmits nerve impulses. It is an essential component of the nervous system, distinct from other cell types like muscle cells, plant cells, and chemical compounds.