Saudi Nuclear Medicine Club " Quiz #1 " @saudi_nmc

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| By Zeem

Zeem

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Quizzes Created: 5 | Total Attempts: 784

Questions: 10 | Attempts: 253 | Updated: Mar 20, 2023

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Saudi Nuclear Medicine Club " Quiz #1 " @saudi_nmc - Quiz

" Quiz #1 " @saudi_nmc
Time: 5mins
10 Questions
Number of Attempts Allowed: 5
Good Luck :)

Questions and Answers

1.
1. NPO means:
- A.
  
  No preparation for exam.
- B.
  
  Nothing by mouth.
- C.
  
  Patient may drink water but should not eat.
- D.
  
  None of the above.
Correct Answer
B. Nothing by mouth.

Explanation
NPO stands for nil per os, which means nothing by mouth.

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2.

2. The presence of 12 μg Al +3 in 1 ml of 99m Tc eluate is:
- A.
  
  An example of radionuclidic impurity
- B.
  
  An example of chemical impurity
- C.
  
  An example of radiochemical impurity
- D.
  
  Acceptable since it is less than 15 μg/ml
Correct Answer
B. An example of chemical impurity

Explanation
Al3+ in 99mTc eluate is an example of chemical impurity. Al3+ ions from the alumina column of the molybdenum generator must be less than 10 μg Al3+/ml of eluate, the limit set by the United States Pharmacopeia. This chemical impurity may result in reduced image quality due to poor labeling.

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3.

3. Radiochemical impurities often result from:
- A.
  
  Introduction of water into the kit
- B.
  
  Introduction of oxygen into the kit
- C.
  
  Introduction of nitrogen into the kit
Correct Answer(s)
A. Introduction of water into the kit
B. Introduction of oxygen into the kit

Explanation
Radiochemical impurity is the activity that is present in forms other than the desired form and will affect the biodistribution
of the radiopharmaceutical. Introduction of air or water into the preparation vial can result in radiochemical impurity. During kit preparation, following addition of the isotope, an equivalent amount of gas may be withdrawn into the syringe to normalize the pressure in the vial.

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4.

4. Which one of the following statements is true about hybrid PET/CT or SPECT/CT imaging systems?
- A.
  
  The same detector is used for both modalities.
- B.
  
  Images do not have to be checked for patient motion.
- C.
  
  Daily QC takes less time than for standalone systems.
- D.
  
  The two modalities are acquired simultaneously.
- E.
  
  The CT provides anatomic correlation for the SPECT/PET.
Correct Answer
E. The CT provides anatomic correlation for the SPECT/PET.

Explanation
In addition to providing a map of tissue attenuation values, the CT serves to localize features seen on the SPECT/CT

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5.

5. A HAMA response occurs because:
- A.
  
  A kit contains pyrogens.
- B.
  
  Monoclonal antibodies are produced from mouse cells which the human body recognizes as a foreign protein.
- C.
  
  A patient is allergic to 111 In.
- D.
  
  Monoclonal antibodies are produced from human cells that trigger an immune response in the patient.
Correct Answer
B. Monoclonal antibodies are produced from mouse cells which the human body recognizes as a foreign protein.

Explanation
HAMA stands for human antimurine (aka antimouse) antibody. It is a response that the human immune system may mount against a foreign antigen.

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6.

6. Which body decides on the acceptable levels of radionuclidic impurity?
- A.
  
  USP
- B.
  
  NRC
- C.
  
  FDA
Correct Answer(s)
A. USP
B. NRC

Explanation
The Nuclear Regulatory Commission has set a limit of 99Mo in 99mTc eluate at 0.15 μCi/mCi of 99mTc at the time the dose is administered. The United States Pharmacopeia regulates this radionuclidic impurity as well.

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7.

7. What is the optimal scanning time for neoplasm when using 67 Ga citrate?
- A.
  
  4 h
- B.
  
  6 h
- C.
  
  24 h
- D.
  
  48 h
Correct Answer
D. 48 h

Explanation
67 Ga has a half-life of 72 h, and so imaging can take place over several days. Imaging for infection is often performed on the same day as the injection and continues at 24 h and onward at 24 h intervals. Tumor imaging is usually begun at 48 h and continued at 24 h intervals.

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8.

8. If no gallbladder is seen at 1 h following injection of 99m Tc DISIDA, what should be done?
- A.
  
  Cimetidine should be given.
- B.
  
  Images should be taken at 24 h.
- C.
  
  Images should be taken at 4 h.
- D.
  
  The exam should be ended.
Correct Answer
C. Images should be taken at 4 h.

Explanation
Patients should fast 2–4 h before hepatobiliary imaging. The gallbladder may not be visualized in patients who have recently eaten and in patients who have fasted for extended periods. The use of morphine can hasten visualization of the gallbladder by increasing bile flow to the gallbladder relative to the intestine. For patients in an extended fast, sincalide may be used . If there is no gallbladder seen 1 hour following injection of radiopharmaceutical, delayed images should be obtained.

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9.

9. What is the method of localization for a perfusion lung study?
- A.
  
  Sequestration
- B.
  
  Compartmental containment
- C.
  
  Active transport
- D.
  
  Capillary blockade
Correct Answer
D. Capillary blockade

Explanation
The method is mechanical, based on the size of the particles in the radiopharmaceutical being too large to pass through the capillaries.

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10.

10. What pharmaceuticals may be used for bone marrow imaging:
- A.
  
  99m Tc albumin colloid
- B.
  
  99m Tc sulfur colloid
- C.
  
  99m Tc PYP
- D.
  
  99m Tc MDP
Correct Answer(s)
A. 99m Tc albumin colloid
B. 99m Tc sulfur colloid

Explanation
Pharmaceuticals that can be used for bone marrow imaging include 99m Tc albumin colloid and 99m Tc sulfur colloid. These radiopharmaceuticals are commonly used in nuclear medicine for imaging the bone marrow. They are injected into the patient's bloodstream and are taken up by the bone marrow, allowing for visualization and assessment of the bone marrow. Other options listed, such as 99m Tc PYP and 99m Tc MDP, are not typically used for bone marrow imaging but may have other applications in nuclear medicine.

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Current Version
Mar 20, 2023

Quiz Edited by
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May 02, 2020

Quiz Created by
Zeem

Saudi Nuclear Medicine Club " Quiz #1 " @saudi_nmc

NPO means:

2. The presence of 12 μg Al +3 in 1 ml of 99m Tc eluate is:

3. Radiochemical impurities often result from:

4. Which one of the following statements is true about hybrid PET/CT or SPECT/CT imaging systems?

5. A HAMA response occurs because:

6. Which body decides on the acceptable levels of radionuclidic impurity?

7. What is the optimal scanning time for neoplasm when using 67 Ga citrate?

8. If no gallbladder is seen at 1 h following injection of 99m Tc DISIDA, what should be done?

9. What is the method of localization for a perfusion lung study?

10. What pharmaceuticals may be used for bone marrow imaging: