Chemotherapy Drugs I
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Pay close attention to how the question asks for the answer!For most questions there is an option to view answer to give you some details about the previous answer and some FYI info pertaining to it. I recommend you review these for all of the questions. ENTERING YOUR NAME IS OPTIONAL! NO ONE CAN SEE YOUR SCORE! Chemotherapy drugs:Class, Subclass, Mechanism, Resistance, Toxicity, Dose Limiting Toxicity, ADM, Other.
- 1.Name the 3 subclasses of alkylating agents.
- A.
Nitrogen Mustards
- B.
Folate Antagonists
- C.
Nitrosureas
- D.
Platinum Compounds
- E.
Nucleotide Analogs
- 2.This Nitrogen Mustard will not cross the Blood Brain Barrier (BBB).
- 3.This alkylating agent has delayed-type bone marrow suppression. Answer as follows: Subclass, Drug.
- 4.This drug is a bifunctional agent that is used to treat chronic lymphocytic leukemia and non-Hodgkins lymphoma. (Answer as Subclass, Drug)
- 5.This drug traps Acrolein and protects from bladder toxicities but has NO anticancer activity.(Answer: Class, Drug)
- 6.Which of the following are Antimetabolites? (Select all that apply)
- A.
Methotrexate
- B.
Capecitabine
- C.
Dacarbazine
- D.
Hydroxyurea
- E.
5-Fluorouracil
- 7.Name the 3 Nitrosureas in alphabetical order. (Answer: Drug, Drug, Drug)
- 8.Following treatment with Methotrexate, this drug is used to "rescue" cells. (Class, Drug)
- 9.This Platinum Compound lacks cross-resistance with the other two platinum compounds.
- 10.Which of the following is commonly used to treat pancreatic islet cell carcinoma and pancreatic adenocarcinoma due to its enhanced uptake by pancreatic beta cells? (Note it is also used to treat colorectal cancer)
- A.
Carmustine
- B.
Bendamustine
- C.
Capecitabine
- D.
Streptozocin
- E.
Lomustine
- 11.The mechanism of action of this drug is as follows:Loses Cl-; forms carbonium ion that attacks nucleophiles.It has a half life of less than 10 minutes following IV injection.Answer: Class, Subclass, Drug
- 12.Which of the following drugs are used to treat glioblastomas?
- A.
Cyclophosphamide
- B.
Lomustine
- C.
Carmustine
- D.
Temozolomide
- E.
Dacarbazine
- 13.What chemo agent's DLT includes ALL of the following:NephrotoxicityNeurotoxicityOtotoxicityMinimal marrow toxicityAnswer: Class, Subclass, Drug
- 14.This drug is activated by HGPRTase, thus resistance is acquired via decreased activity of HGPRTase.
- A.
Hydroxyurea
- B.
6-Mercaptopurine
- C.
Cyclophosphamide
- D.
Temozolomide
- E.
Dacarbazine
- 15.The following Alkylating Agent has a high oil-to-water partition coefficient, thus bone marrow suppression from it may persist due to storage in adipose tissue and liver. Answer: Subclass, Drug
- 16.Which drug has the following characteristics:Mechanism: Inhibits DNA polymerase alpha causing termination of DNA synthesisResistance: Cytidine deaminase detoxificationToxicity: Potent myelosuppressive, neurotoxicity with renal impairmentADME: Sensitive to dosing scheduleOther: Combo therapy for leukemias
- A.
Bendamustine
- B.
5-Fluorouracil
- C.
Cytosine Arabinoside
- D.
6-Mercaptopurine
- E.
Leucovorin
- 17.This drug is an Alkylating Agent that is less toxic than cisplatin, but also less active.Answer: Subclass, Drug
- 18.Of the following Antimetabolites, which is/are Folate Antagonists?
- A.
5-FU
- B.
Capecitabine
- C.
Cytosine Arabinoside
- D.
6-Mercaptopurine
- E.
Methotrexate
- 19.This alkylator is localized to the liver and has an increased half-life. It's DLT includes bone marrow suppression.ADME: Dose IVUsed to treat Melanoma, Hodgkin's DiseaseAnswer: Drug
- 20.5-Fluorouracil is a pyrimidine analog that irreversibly inhibits Thymidylate Synthase. What drug is an analog of 5-FU?Answer: Drug
- 21.What drug fits the following criteria:Lacks cross-resistance with other alkylating agents.Toxicity: Secondary leukemia or lung cancerDLT: PneumonitisADME: Oral, non-cell cycle phase specificAnswer: Drug
- 22.Resistance to which of the following drugs is due to cellular acquisition of Aldehyde Oxidase?
- A.
Mechlorethamine
- B.
Cyclophosphamide
- C.
Bendamustine
- D.
Carmustine
- E.
Lomustine
- 23.A patient is recieving ongoing treatment for gliobastoma. Select all of the following that could be used to treat this tumor.
- A.
Cyclophosphamide
- B.
Carmustine
- C.
Lomustine
- D.
Dacarbazine
- E.
Temozolomide
- 24.Patients with a deficiency in Dihydrothymidine Dehydrogenase can have a fatal interaction with which of the following drugs:
- A.
Methotrexate
- B.
5-Fluorouracil
- C.
Hydroxyurea
- D.
Cytosine Arabinoside
- E.
Oxaliplatin
- 25.There is a risk of secondary neoplasia, bone marrow suppression, as well as birth defects associated with which chemotherapy drug that is commonly used to treat chronic and acute myelogenous leukemia (CML and AML):
- A.
Hydroxyurea
- B.
Cytosine Arabinoside
- C.
6-Mercaptopurine
- D.
Bendomustine
- E.
Carmustine
- 26.A patient is being treated for Hodgekins disease. More than one of the following drugs are commonly used to treat patients with this condition. Which ones are they?
- A.
Bendamustine
- B.
Procarbazine
- C.
Dacarbazine
- D.
Methotrexate
- E.
5-FU
- 27.Which of the following is administered orally due to the fact that it is readily absorbed by the GI tract?
- A.
5-FU
- B.
Mechlorethamine
- C.
Carmustine
- D.
Lomustine
- E.
Dacarbazine
- 28.Name, in alphabetical order, the 4 drugs that fit the following criteria:Class: AntimetabolitesSublcass: Nucleotide AnalogsAlphabetize drugs with numbers by the first letter after the number and a hyphen, i.e. 8-Drug.
- 29.This chemo drug is commonly used to treat small-cell and non small-cell lung cancers as well as ovarian cancer.
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