Chemotherapy Drugs I

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    This alkylator is localized to the liver and has an increased half-life. It's DLT includes bone marrow suppression.ADME: Dose IVUsed to treat Melanoma, Hodgkin's DiseaseAnswer: Drug

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Chemotherapy drugs:
Class, Subclass, Mechanism, Resistance, Toxicity, Dose Limiting Toxicity, ADM, Other.

Chemotherapy Quizzes & Trivia

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  • 2. 

    This Nitrogen Mustard will not cross the Blood Brain Barrier (BBB).

    Explanation
    Consequently cyclophosphamide is NOT useful for treating metastasis to the brain.

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  • 3. 

    This Platinum Compound lacks cross-resistance with the other two platinum compounds.

    Explanation
    The other two Platinum Compounds (which are alkylating agents) are Cisplatin and Carboplatin.

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  • 4. 

    This chemo drug is commonly used to treat small-cell and non small-cell lung cancers as well as ovarian cancer.

  • 5. 

    This drug traps Acrolein and protects from bladder toxicities but has NO anticancer activity.(Answer: Class, Drug)

    Explanation
    This is often given with cyclophosphamide, a Nitrogen Mustard drug that produces the toxic chemical Acrolein following bioactivation by liver P450 and CYP2B6.

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  • 6. 

    5-Fluorouracil is a pyrimidine analog that irreversibly inhibits Thymidylate Synthase. What drug is an analog of 5-FU?Answer: Drug

    Explanation
    ADME: Oral dosing, generates 5-FU in tumor cells
    Used to treat: Metastatic breast cancer. Also injected into hepatic artery for treatment of colon carcinoma metastasis to the liver.

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  • 7. 

    Of the following Antimetabolites, which is/are Folate Antagonists?

    • 5-FU

    • Capecitabine

    • Cytosine Arabinoside

    • 6-Mercaptopurine

    • Methotrexate

    Correct Answer
    A. Methotrexate
    Explanation
    Recall Methotrexate competitively inhibits Dihidrofolate Reductase, thus inhibiting synthesis of Thymidine.

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  • 8. 

    What chemo agent's DLT includes ALL of the following:NephrotoxicityNeurotoxicityOtotoxicityMinimal marrow toxicityAnswer: Class, Subclass, Drug

    Correct Answer
    Alkylating agents, Platinum compounds, Cisplatin
    Alkylating agent, Platinum compound, Cisplatin
    Explanation
    Cl- diuresis reduces toxicity of Cisplatin. Other side-effects of this drug include Nausea and Vomiting.

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  • 9. 

    Name the 3 subclasses of alkylating agents.

    • Nitrogen Mustards

    • Folate Antagonists

    • Nitrosureas

    • Platinum Compounds

    • Nucleotide Analogs

    Correct Answer(s)
    A. Nitrogen Mustards
    A. Nitrosureas
    A. Platinum Compounds
    Explanation
    Folate antagonists and Nucleotide analogs are both subclasses of Antimetabolites.

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  • 10. 

    This drug is an Alkylating Agent that is less toxic than cisplatin, but also less active.Answer: Subclass, Drug

    Correct Answer(s)
    Platinum Compounds, Carboplatin
    Platinum Compound, Carboplatin
    Explanation
    Platinum compounds (Cisplatin, carboplatin, oxaliplatin) generate DNA cross-links.

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  • 11. 

    This drug is activated by HGPRTase, thus resistance is acquired via decreased activity of HGPRTase.

    • Hydroxyurea

    • 6-Mercaptopurine

    • Cyclophosphamide

    • Temozolomide

    • Dacarbazine

    Correct Answer
    A. 6-Mercaptopurine
    Explanation
    Note that some of the above drugs require some sort of bioactivation:
    Cyclophosphamide via liver P450 and CYP2B6.
    Temozolomide is metabolized to 5-amino-imidizole-4-carboxamide.

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  • 12. 

    Name the 3 Nitrosureas in alphabetical order. (Answer: Drug, Drug, Drug)

    Correct Answer
    Carmustine, Lomustine, Streptozocin
    Explanation
    Nitrosureas form interstrand crosslinks. O6 of guanine is the preferred site of attack.

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  • 13. 

    Patients with a deficiency in Dihydrothymidine Dehydrogenase can have a fatal interaction with which of the following drugs:

    • Methotrexate

    • 5-Fluorouracil

    • Hydroxyurea

    • Cytosine Arabinoside

    • Oxaliplatin

    Correct Answer
    A. 5-Fluorouracil
  • 14. 

    Which drug has the following characteristics:Mechanism: Inhibits DNA polymerase alpha causing termination of DNA synthesisResistance: Cytidine deaminase detoxificationToxicity: Potent myelosuppressive, neurotoxicity with renal impairmentADME: Sensitive to dosing scheduleOther: Combo therapy for leukemias

    • Bendamustine

    • 5-Fluorouracil

    • Cytosine Arabinoside

    • 6-Mercaptopurine

    • Leucovorin

    Correct Answer
    A. Cytosine Arabinoside
    Explanation
    Note that Bendamustine (A nitrosurea) is also used to treat certain types of Leukemias.

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  • 15. 

    Following treatment with Methotrexate, this drug is used to "rescue" cells. (Class, Drug)

    Correct Answer
    Ancillary agents, Leucovorin
    Ancillary agent, Leucovorin
    Explanation
    This drug is a reduced form of folic acid. Recall that Methotrexate competitively inhibits Dihydrofolate Reductase, an enzyme required for the continued synthesis of Thymidine (Nucleotide required for DNA synthesis/replication).

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  • 16. 

    Resistance to which of the following drugs is due to cellular acquisition of Aldehyde Oxidase?

    • Mechlorethamine

    • Cyclophosphamide

    • Bendamustine

    • Carmustine

    • Lomustine

    Correct Answer
    A. Cyclophosphamide
  • 17. 

    Which of the following is commonly used to treat pancreatic islet cell carcinoma and pancreatic adenocarcinoma due to its enhanced uptake by pancreatic beta cells? (Note it is also used to treat colorectal cancer)

    • Carmustine

    • Bendamustine

    • Capecitabine

    • Streptozocin

    • Lomustine

    Correct Answer
    A. Streptozocin
    Explanation
    Streptozocin is a Nitrosurea, along with Carmustine and Lomustine. Bendamustine is a Nitrogen Mustard. Capecitabine is an antimetabolite- nucleotide analog similar to 5-FU.

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  • 18. 

    The mechanism of action of this drug is as follows:Loses Cl-; forms carbonium ion that attacks nucleophiles.It has a half life of less than 10 minutes following IV injection.Answer: Class, Subclass, Drug

    Correct Answer
    Alkylating agents, Nitrogen mustards, Mechlorethamine
    Alkylating agent, Nitrogen mustard, Mechlorethamine
    Explanation
    Resistance to this drug is acquired by increasing the inactivation of the drug and decreasing uptake.

    Mechlorethamine is highly unstable and reactive. Its half-life is < 10 minutes. It is given via IV injection.

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  • 19. 

    The following Alkylating Agent has a high oil-to-water partition coefficient, thus bone marrow suppression from it may persist due to storage in adipose tissue and liver. Answer: Subclass, Drug

    Correct Answer
    Nitrosureas, Carmustine
    Nitrosurea, Carmustine
    Explanation
    Resistance to Carmustine is acquired by increased DNA repair. It is used to treat glioblastomas and brain tumors.

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  • 20. 

    What drug fits the following criteria:Lacks cross-resistance with other alkylating agents.Toxicity: Secondary leukemia or lung cancerDLT: PneumonitisADME: Oral, non-cell cycle phase specificAnswer: Drug

    Correct Answer
    Procarbazine
    Explanation
    Procarbazine is listed under the subclass "Other Alkylators".

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  • 21. 

    A patient is recieving ongoing treatment for gliobastoma. Select all of the following that could be used to treat this tumor.

    • Cyclophosphamide

    • Carmustine

    • Lomustine

    • Dacarbazine

    • Temozolomide

    Correct Answer(s)
    A. Carmustine
    A. Lomustine
    A. Temozolomide
  • 22. 

    This drug is a bifunctional agent that is used to treat chronic lymphocytic leukemia and non-Hodgkins lymphoma. (Answer as Subclass, Drug)

    Correct Answer(s)
    Nitrogen mustard, Bendamustine
    Nitrogen mustards, Bendamustine
    Explanation
    Functions as both an alkylator and purine-like antimetabolite.

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  • 23. 

    This alkylating agent has delayed-type bone marrow suppression. Answer as follows: Subclass, Drug.

    Correct Answer(s)
    Nitrogen mustards, Mechlorethamine
    Nitrogen mustard, Mechlorethamine
    Explanation
    This is the Dose Limiting Toxicity associated with Mechlorethamine usage.

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  • 24. 

    Which of the following drugs are used to treat glioblastomas?

    • Cyclophosphamide

    • Lomustine

    • Carmustine

    • Temozolomide

    • Dacarbazine

    Correct Answer(s)
    A. Lomustine
    A. Carmustine
    A. Temozolomide
    Explanation
    The more commonly used drug for glioblastomas is Temozolomide (listed as "other alkylators"). Note that Carmustine is a Nitrosurea.

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  • 25. 

    There is a risk of secondary neoplasia, bone marrow suppression, as well as birth defects associated with which chemotherapy drug that is commonly used to treat chronic and acute myelogenous leukemia (CML and AML):

    • Hydroxyurea

    • Cytosine Arabinoside

    • 6-Mercaptopurine

    • Bendomustine

    • Carmustine

    Correct Answer
    A. Hydroxyurea
  • 26. 

    Which of the following is administered orally due to the fact that it is readily absorbed by the GI tract?

    • 5-FU

    • Mechlorethamine

    • Carmustine

    • Lomustine

    • Dacarbazine

    Correct Answer
    A. Lomustine
  • 27. 

    Name, in alphabetical order, the 4 drugs that fit the following criteria:Class: AntimetabolitesSublcass: Nucleotide AnalogsAlphabetize drugs with numbers by the first letter after the number and a hyphen, i.e. 8-Drug.

    Correct Answer
    Capecitabine, Cytosine Arabinoside, 5-Fluorouracil, 6-Mercaptopurine
  • 28. 

    Which of the following are Antimetabolites? (Select all that apply)

    • Methotrexate

    • Capecitabine

    • Dacarbazine

    • Hydroxyurea

    • 5-Fluorouracil

    Correct Answer(s)
    A. Methotrexate
    A. Capecitabine
    A. Hydroxyurea
    A. 5-Fluorouracil
    Explanation
    Methotexate- Folate antagonist
    Capecitabine, 5-Fluorouracil - Nucleotide analogs
    Hydroxyurea- other (Blocks ribonucleotide reductase)

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  • 29. 

    A patient is being treated for Hodgekins disease. More than one of the following drugs are commonly used to treat patients with this condition. Which ones are they?

    • Bendamustine

    • Procarbazine

    • Dacarbazine

    • Methotrexate

    • 5-FU

    Correct Answer(s)
    A. Dacarbazine
    A. Methotrexate

Quiz Review Timeline (Updated): Jul 30, 2011 +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Jul 30, 2011
    Quiz Edited by
    ProProfs Editorial Team
  • Jan 18, 2010
    Quiz Created by
    Cody284
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