Chem II Quiz 2

68 Questions | Total Attempts: 76

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Chem II Quiz 2

Review of material for test 2. Local anesthetics, pKa, diffusion, mixtures.


Questions and Answers
  • 1. 
    A non-uniform mixture that has regions of different composition is known as what?
    • A. 

      Heterogeneous mixture

    • B. 

      Homogeneous mixture

    • C. 

      Colloid

    • D. 

      Solvent

  • 2. 
    Albumin is an example of a…
    • A. 

      Heterogeneous mixture

    • B. 

      Colloid

    • C. 

      Solution

    • D. 

      Solvent

  • 3. 
    Theoretically, what would happen if you added another drug to change the pH of Hespan?
    • A. 

      Nothing, Hespan is a solution

    • B. 

      Since Hespan is a solution, changing the pH may cause precipitation

    • C. 

      Since Hespan is a colloid changing the pH may cause precipitation

    • D. 

      Nothing, Hespan is a colloid

  • 4. 
    How would you classify blood?
    • A. 

      Homogeneous mixture

    • B. 

      Solution

    • C. 

      Colloid

    • D. 

      Heterogeneous mixture

  • 5. 
    How much will one mole of H2SO4 weigh?        
    • A. 

      98 grams

    • B. 

      49 grams

    • C. 

      60 grams

    • D. 

      25 grams

  • 6. 
    How much will one mole of Propofol (C12H18O) weigh?       
    • A. 

      15 grams

    • B. 

      178 grams

    • C. 

      98 grams

    • D. 

      29 grams

  • 7. 
    Which the following is not true regarding acids?
    • A. 

      Acids are proton donors

    • B. 

      Acids will have a low pKa

    • C. 

      After donating a proton, they will form conjugate acid

    • D. 

      Acids will have a low pH

  • 8. 
    Which of the following pH’s is classified as more neutral?
    • A. 

      5.3

    • B. 

      7.4

    • C. 

      11.9

    • D. 

      2.6

  • 9. 
    Which of the following pH’s would be classified as a strong base?
    • A. 

      5.3

    • B. 

      7.4

    • C. 

      11.9

    • D. 

      2.6

  • 10. 
    What is Henry’s law?
    • A. 

      States that the solubility of a gas (amount of gas that dissolves in a liquid) is directly proportional to the partial pressure of that gas in the gas phase and inverse to temperature.

    • B. 

      States that in a mixture of gases, the pressure exerted by each gas is the same as that which it would exert if it alone occupied the container

    • C. 

      States that if you had two different containers containing two different gases at the same temperature and pressure, then they contain the same number of molecules.

    • D. 

      States that volume is proportional to temperature, or V/T=constant.

  • 11. 
    If you increase the partial pressure of anesthetic agents in the lungs, according to Henry’s law what will happen to the gases solubility in the blood?
    • A. 

      Solubility does not change, it is constant

    • B. 

      Anesthetic solubility will increase

    • C. 

      Anesthetic solubility will decrease

  • 12. 
    How many milligrams of local anesthetic are in 12 cc of 0.25% Bupivicaine?
    • A. 

      2.5 mg

    • B. 

      250 mg

    • C. 

      48 mg

    • D. 

      30 mg

  • 13. 
    How many ml’s of local anesthetic 1% lidocaine could be given max to a patient who weighs 60 kg?
    • A. 

      24 ml

    • B. 

      42 ml

    • C. 

      15 ml

    • D. 

      19 ml

  • 14. 
    You are the SRNA for a patient undergoing  an arthroplasty on their left foot. The surgeon wants to know how many ml’s 0.5% bupivacaine with epi he can inject into the patient. This patient weighs 50 kg.
    • A. 

      32 ml

    • B. 

      25 ml

    • C. 

      40 ml

    • D. 

      70 ml

  • 15. 
    1:400,000 epinephrine  contains how much epi per cc?
    • A. 

      50 mcg

    • B. 

      2.5 mcg

    • C. 

      5 mcg

    • D. 

      10 mcg

  • 16. 
    If an acidic drug with a pKa of 3.5 is placed into the stomach (pH 2) what will happen to the drug?
    • A. 

      There will be more ionized then unionized drug and will not be well absorbed.

    • B. 

      There will be 50% ionized and 50% unionized drug

    • C. 

      There will be more unionized then ionized drug and it can be absorbed

    • D. 

      None of above

  • 17. 
    What would happen if an acidic drug with a pKa of 4 is placed into the intestines (pH 8)?
    • A. 

      There will be more ionized then unionized drug and the drug will not be well absorbed

    • B. 

      There will be 50% ionized and 50% unionized drug

    • C. 

      There will be more unionized then ionized drug and it can be absorbed

    • D. 

      None of above

  • 18. 
    How will metabolic acidosis affect the absorption of acidic drugs?
    • A. 

      There will be no effect

    • B. 

      Less drug will be absorbed since more of the drug will be unionized

    • C. 

      The drug will be eliminated from the body completely

    • D. 

      More drug will be absorbed since more of the drug will unionized

  • 19. 
    What will happen if a basic drug with a pkA of 11 is placed into a basic solution with a pH of 9?
    • A. 

      The ionized form will predominate

    • B. 

      There will be a 50/50 split of ionized vs unionized

    • C. 

      The unionized form will predominate

    • D. 

      None of above

  • 20. 
    Local anesthetics are considered to be weak bases.
    • A. 

      True

    • B. 

      False

  • 21. 
    What is the mechanism of action of local anesthetics?
    • A. 

      Mimics acetylcholinesterase to Cause sustained depolarization rendering the NMJ unable to conduct further impulses=Muscle relaxation

    • B. 

      Produces skeletal muscle relaxation by a direct action on excitation-contraction coupling, presumably by decreasing the amount of calcium released from the sarcoplasmic reticulum

    • C. 

      Dependent upon type of anesthetic as ester and amides have different MOA’s

    • D. 

      Prevents passage of sodium ions through ion selective channels in nerve membranes to block nerve conduction.

  • 22. 
    In regard to local anesthetics their _______ nature allows them pass through cell membranes, but once inside the cell membrane their ______ portion binds inside the cell.
    • A. 

      Lipophilic, hydrophilic

    • B. 

      Hydrophilic, lipophilic

    • C. 

      Ionized, unionized

    • D. 

      None of above

  • 23. 
    The _____   the pKa of a local anesthetic, the ______ the degree of ionization at physiologic pH
    • A. 

      Higher, Lower

    • B. 

      Higher, greater

    • C. 

      PKa has no effect on degree of ionization

  • 24. 
    Which form of the local anesthetic is most active at the intracellular receptor site?
    • A. 

      Anionic Form

    • B. 

      Lipophilic form

    • C. 

      Cationic form

    • D. 

      Polar form

  • 25. 
    The potency of local anesthetic is directly related to…
    • A. 

      Protein Binding

    • B. 

      Degree of Ionization

    • C. 

      Chirality of molecule

    • D. 

      Lipid Solubility

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