Multiple Choice Quiz Questions On Wound Healing

Collagen is a protein that provides strength and support to various tissues in the body. It forms a structural framework for cells, organs, and tissues, giving them stability and integrity. Collagen helps in maintaining the shape and structure of tissues, such as skin, tendons, ligaments, and bones. It also contributes to the elasticity and flexibility of these tissues. Therefore, the role of collagen is primarily to provide strength and support to the body.

The maximum strength of a scar is 80% compared to unwounded skin. This means that scars are generally weaker and less durable than normal skin, as they only possess 80% of the strength of unwounded skin.

Vitamin C is needed for collagen synthesis. Collagen is a protein that helps in maintaining the structure and elasticity of various tissues in the body. Vitamin C plays a crucial role in the synthesis of collagen by acting as a cofactor for the enzymes involved in collagen production. Without sufficient vitamin C, the body is unable to produce collagen effectively, leading to various health issues such as weakened connective tissues, impaired wound healing, and increased susceptibility to infections. Therefore, vitamin C is essential for collagen synthesis.

The correct answer is Coagulation, inflammatory, fibroplasia, and remodeling. This sequence of phases represents the process of tissue repair, according to Bailey's. The coagulation phase involves the formation of a blood clot to control bleeding. The inflammatory phase involves the recruitment of immune cells and the release of inflammatory mediators to remove debris and prevent infection. The fibroplasia phase involves the production of new collagen and the formation of granulation tissue. The remodeling phase involves the reorganization and maturation of the new tissue to restore its strength and function.

The optimal time to operate on irradiated tissue is between 3 weeks and 3 months. This is because during this time frame, the tissue has had enough time to heal and recover from the effects of radiation, but it is not too long that the tissue becomes too fibrotic and difficult to operate on. Operating within this window allows for the best chances of successful surgery and optimal outcomes for the patient.

The correct answer is 80%/20%. The dermis is composed mainly of collagen, with type I collagen being the most abundant and type III collagen being present in smaller amounts. In intact dermis, approximately 80% of the collagen is type I collagen, while only around 20% is type III collagen.

During the fibroplasia phase, fibroblasts migrate into the wound after 48-72 hours. This phase is characterized by the migration and proliferation of fibroblasts, which are responsible for producing collagen and other extracellular matrix components. Fibroblasts play a crucial role in wound healing by forming a connective tissue matrix that helps to close the wound and promote tissue repair. The migration of fibroblasts typically occurs within the first few days after injury, which is why the correct answer is 48-72 hours.

Serotonin is a vasoactive substance involved in the coagulation phase of tissue repair that causes both vasoconstriction and vasodilation. It is released from platelets and acts on blood vessels to constrict them, reducing blood flow and preventing excessive bleeding. However, serotonin can also cause vasodilation in certain tissues, allowing increased blood flow to promote healing and repair. This dual action of serotonin makes it an important player in the regulation of blood vessel diameter during tissue repair.

The correct answer is STSG-FTSG-Flap. This order represents the level of contraction from most to least. STSG (Split-thickness skin graft) involves removing the top layers of skin and placing it on a wound, resulting in the highest level of contraction. FTSG (Full-thickness skin graft) involves removing all layers of skin and placing it on a wound, resulting in less contraction compared to STSG. Flap involves transferring tissue from one area of the body to another, resulting in the least amount of contraction.

Vitamin A may mitigate the detrimental effects of chronic prednisone therapy on wound healing. Vitamin A is known to play a crucial role in the process of wound healing by promoting cell growth, collagen synthesis, and immune function. Chronic prednisone therapy can impair wound healing due to its immunosuppressive effects. Therefore, supplementing with vitamin A can help counteract these effects and improve wound healing in patients on prednisone therapy for rheumatoid arthritis.