Blood Products
The collection/transfusion of blood products, including transplantation questions
- 1.
More oxygen will be released by RBCs if
- A.
Levels of 2,3 DPG are high
- B.
There is a low P50
- C.
Levels of 2,3 DPG are low
- D.
ATP is generated
- E.
All of the above
Correct Answer
A. Levels of 2,3 DPG are high -
- 2.
A new anticoagulant-preservative is being evaluated for storing of RBCs for 49 days. For approval it must demonstrate:
- A.
75% survival of RBCs in a recipient 12 hours after transfusion
- B.
80% survival of RBCs in a recipient 12 hours after transfusion
- C.
75% survival of RBCs in a recipient 24 hours after transfusion
- D.
80% survival of RBCs in a recipient 24hours after transfusion
Correct Answer
C. 75% survival of RBCs in a recipient 24 hours after transfusion -
- 3.
The levels of 2,3 DPG of stored blood return to normal in the recipient after what timeframe following transfusion?
- A.
4 hours
- B.
8 hours
- C.
12 hours
- D.
24 hours
- E.
72 hours
Correct Answer
D. 24 hours -
- 4.
Studies with platelet components have shown appox. 50% levels of Factor V and VIII after storage for
- A.
1 hour
- B.
16 hours
- C.
24 hours
- D.
72 hours
Correct Answer
D. 72 hours -
- 5.
Which of the following in stored blood correlates to red cell post-transfusion viability?
- A.
ATP
- B.
2,3 DPG
- C.
Dextrose
- D.
Sodium phosphate
- E.
Rate of transfusion
Correct Answer
A. ATP -
- 6.
Which of the following in stored blood correlates to red cell function post transfusion?
- A.
ATP
- B.
2,3 DPG
- C.
Dextrose
- D.
Sodium phosphate
Correct Answer
B. 2,3 DPG -
- 7.
What is the minimum amount of RBCs that can be collected in a 450mL collection bag?
- A.
300
- B.
405
- C.
425
- D.
450
Correct Answer
B. 405 -
- 8.
Rejuvenated cells must be washed prior to infusion to remove
- A.
Excessive hemolysis
- B.
High levels of potassium
- C.
Inosine which may be toxic
- D.
Stroma from old red cells
- E.
Cytokines
Correct Answer
C. Inosine which may be toxic -
- 9.
For proper irradiation the intended dose is
- A.
25 Gy in the middle of the component, 15 Gy at any other point
- B.
60Gy throughout the entire component container
- C.
25Gy throughout the entire component container
- D.
15 Gy initally, 25 midpoint, 60 at endpoint
Correct Answer
A. 25 Gy in the middle of the component, 15 Gy at any other point -
- 10.
The cryopreservation most often used for platelets is
- A.
DMSO
- B.
Glycerol
- C.
HES
- D.
Liquid nitrogen
- E.
Mannitol
Correct Answer
A. DMSO -
- 11.
Temperature recording sensors in a refrigerator should be placed
- A.
On the top shelf
- B.
On the middle shelf
- C.
On the bottom shelf
- D.
On the inside of the door
Correct Answer
A. On the top shelf -
- 12.
When shipping frozen blood on dry ice, the shipping container may be labeled as DRY ICE or_____.
- A.
Crystallized H30
- B.
Carbon Dioxide, Solid
- C.
Contains Cryogenic Material
- D.
Solid Nitrogen Pellets
- E.
Warning: Cold
Correct Answer
B. Carbon Dioxide, Solid -
- 13.
An autologous donor's hemoglobin shall be no lower than
- A.
9 g/dL
- B.
10 g/dL
- C.
11 g/dL
- D.
10.5 g/dL
- E.
12 g/dL
Correct Answer
C. 11 g/dL -
- 14.
Which of the following would defer an autologous donor?
- A.
HIV positive
- B.
Medication for hypertension
- C.
Receiving antibiotics
- D.
14 years of age
- E.
Hemoglobin 12 g/dL
Correct Answer
C. Receiving antibiotics -
- 15.
A person with which of the following surgeries would NOT be a candidate for perioperative blood salvage?
- A.
Abdominal
- B.
Cardiac
- C.
Liver transplant
- D.
Orthopedic
- E.
Eye surgery
Correct Answer
A. Abdominal -
- 16.
The purpose of registering donors is to:
- A.
Coordinate the donation process from start to finish
- B.
Identify donors and link them to previous records
- C.
Process the right number of donors to maintain optimal inventory levels
- D.
All of the above
Correct Answer
B. Identify donors and link them to previous records -
- 17.
Profound hypotension during plasma pheresis is associated with patients taking
- A.
ACE inhibitors
- B.
Aspirin containing medications
- C.
Fiber
- D.
Heparin
- E.
Acetaminophen
Correct Answer
A. ACE inhibitors -
- 18.
Extracorporeal volume during plasmapheresis must not exceed what percentage of the patient's blood volume?
- A.
5%
- B.
10%
- C.
15%
- D.
20%
- E.
25%
Correct Answer
C. 15% -
- 19.
For plasmapheresis what blood volume exchange is considered for maximum benefit to remove plasma constituents?
- A.
1
- B.
1 to 1.5
- C.
2
- D.
Up to 3
Correct Answer
B. 1 to 1.5 -
- 20.
For patients undergoing daily plasmapheresis the PT, PTT and fibrinogen levels are checked:
- A.
Immediately before and after the procedure
- B.
Each morning
- C.
Hourly
- D.
Every 3 days
- E.
Weekly
Correct Answer
D. Every 3 days -
- 21.
Which of the following markers are used to ID progenitor cells?
- A.
CD4
- B.
CD8
- C.
CD22
- D.
CD34
- E.
CD44
Correct Answer
D. CD34 -
- 22.
The most effective way(s) to promote progenitor cells in circulation and is used clinically is:
- A.
Administration of dextran to the donor
- B.
Apheresis performed in the late afternoon
- C.
Combination of chemotherapy and growth factors
- D.
Repetitive apheresis in committed donors
Correct Answer
C. Combination of chemotherapy and growth factors -
- 23.
Which of the following is NOT a condition with established indications for effective use of therapeutic apheresis?
- A.
Guillain-Barre syndrome
- B.
Multiple sclerosis
- C.
Myasthenia gravis
- D.
TTP
Correct Answer
B. Multiple sclerosis -
- 24.
Which of the following is an indeterminate Western Blot result?
- A.
Anti-HIV positive by EIA, no bands seen on Western Blot
- B.
Anti-HIV positive by EIA, p24 and g41 seen on Western Blot
- C.
Anti-HIV positive by EIA, p17 seen on Western Blot
- D.
Anti-HIV positive by EIA, pg120/160 seen on Western Blot
Correct Answer
C. Anti-HIV positive by EIA, p17 seen on Western Blot -
- 25.
What donor medication is a permanent deferral?
- A.
Proscar
- B.
Accutane
- C.
Soriatane
- D.
Tegison
Correct Answer
D. Tegison -
- 26.
A patient who is pregnant may donate after what time frame post delivery?
- A.
3 days
- B.
2 weeks
- C.
6 weeks
- D.
8 weeks
Correct Answer
C. 6 weeks -
- 27.
What cellular line is the last to become engrafted?
- A.
Platelets
- B.
Red cells
- C.
White cells
- D.
Unknown
Correct Answer
A. Platelets -
- 28.
Which of the following neutrophil counts is used for evidence of engraftment?
- A.
500 per microliter
- B.
1500 per microliter
- C.
10,000 per microliter
- D.
500, 000 per microliter
Correct Answer
A. 500 per microliter -
- 29.
Rescue Transplantation is the term used when
- A.
Allogeneic HLA-mismatched donors are used
- B.
An organ failed and must be replaced immediately
- C.
Autologous HPCs are used
- D.
Grafts from pigs are used for heart valves
Correct Answer
C. Autologous HPCs are used -
- 30.
The benefits of GVT (Graft verses Tumor/Leukemia) is limited to which of the following types of transplants?
- A.
HLA-matched
- B.
HLA-mismatched
- C.
Syngeneic (identical twin)
- D.
Bone marrow is used rather than peripheral HPC's
Correct Answer
A. HLA-matched -
- 31.
Which of the following is NOT expected in hemolytic anemia?
- A.
Decreased haptoglobin
- B.
Decreased hemoglobin
- C.
Decreased serum LDH
- D.
Increased reticulocytes
Correct Answer
C. Decreased serum LDH -
- 32.
The first course of therapy for a person with hemolysis due to a warm autoantibody is
- A.
Corticosteroids
- B.
IVIG
- C.
Plasma exchange
- D.
Splenectomy
- E.
Aspirin meds
Correct Answer
A. Corticosteroids -
- 33.
How many mgs of iron are in one unit of blood?
- A.
10
- B.
40
- C.
200
- D.
400
Correct Answer
C. 200 -
- 34.
Which of the following is a transmembrane protein of the red cell?
- A.
Actin
- B.
Ankyrin
- C.
Band 3
- D.
Spectrin
Correct Answer
C. Band 3 -
- 35.
Which blood group is the urea transporter on the red cell membrane?
- A.
Duffy
- B.
Kell
- C.
Rh
- D.
Kidd
- E.
Colton
Correct Answer
D. Kidd -
- 36.
What percentage of oxygen is normally released be red cells in the tissue?
- A.
25%
- B.
50%
- C.
75%
- D.
100%
Correct Answer
A. 25% -
- 37.
Chronic graft vs host disease
- A.
Is associated with increased survival rate
- B.
Is associated with ABO incompatible transplants
- C.
Occurs within 2 weeks of transplant and lasts 2 months
- D.
Occurs in less than 5% of transplant cases
Correct Answer
A. Is associated with increased survival rate -
- 38.
Which is the most common indicator to base a decision on whether to perform an exchange transfusion in an infant with HDFN?
- A.
Albumin levels
- B.
Anemia
- C.
Antibody specificity
- D.
Bilirubin levels
Correct Answer
D. Bilirubin levels -
- 39.
WHen Doppler methodology is used, cordocentesis is performed when the peak systolic velocity value is:
- A.
.5 of the median
- B.
At the median
- C.
1.5 of the median
- D.
2.0 of the median
Correct Answer
C. 1.5 of the median -
- 40.
The types of von Willebrand's disease that should not use desmonpressin (DDAVP) is
- A.
Type I
- B.
Type IIa
- C.
Type IIb
- D.
Type III
Correct Answer
C. Type IIb -
- 41.
The change in production of IgM to IgG is an example of
- A.
Epitope switching
- B.
Isotype switching
- C.
Immune surveillance
- D.
Antibody specificity
Correct Answer
B. Isotype switching -
- 42.
Most newborns type as which of the following Lewis phenotypes?
- A.
Le(a-b-)
- B.
Le(a+b-)
- C.
Le(a-b+)
- D.
Le(a+b+)
Correct Answer
A. Le(a-b-) -
- 43.
The mode of inheritance of the Kell antigens K (KEL1) and k (KEL2) is:
- A.
X-linked dominant
- B.
X-linked recessive
- C.
Autosomal recessive
- D.
Autosomal codominant
Correct Answer
D. Autosomal codominant -
- 44.
Which of the following HLA antigens corresponds to Bgb?
- A.
HLA-B7
- B.
HLA-B17
- C.
HLA-B27
- D.
HLA-A28
Correct Answer
B. HLA-B17 -
- 45.
A strong linkage disequilibrium exists between
- A.
HLA-A1 and HLA-B8
- B.
HLA-A1 and HLA-B27
- C.
HLA-A30 and HLA-B27
- D.
HLA-A1 and HLA-B45
Correct Answer
A. HLA-A1 and HLA-B8 -
- 46.
Blood donors in the US make up appox. what percentage of the population?
- A.
1%
- B.
4%
- C.
15%
- D.
25%
Correct Answer
B. 4% -
- 47.
Which of the following is associated with an HLA class I allele?
- A.
Anklosing spondylitis
- B.
Type 1 insulin-dependent diabetes mellitus
- C.
Narcolepsy
- D.
Rheumatoid Arthritis
Correct Answer
A. Anklosing spondylitis -
- 48.
A donor weighing 80 lbs can donate what volume of whole blood?
- A.
450mL
- B.
405 mL
- C.
385 mL
- D.
325 mL
Correct Answer
D. 325 mL -
- 49.
Which of the following donor records must be maintained indefinitely?
- A.
Temporary deferral
- B.
Donor typing (ABO/Rh)
- C.
QC for typing antisera
- D.
Signed consent forms
Correct Answer
A. Temporary deferral -
- 50.
Which of the following blood components may carry a risk of CMV infection?
- A.
FFP
- B.
Cryo
- C.
Platelets
- D.
All of the above
- E.
None of the above
Correct Answer
C. Platelets -
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Jan 23, 2013Quiz Edited by
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Mar 02, 2011Quiz Created by
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