Blood Products

1. For plasmapheresis what blood volume exchange is considered for maximum benefit to remove plasma constituents?

1

1 to 1.5

2

Up to 3

2. The most effective way(s) to promote progenitor cells in circulation and is used clinically is:

Administration of dextran to the donor

Apheresis performed in the late afternoon

Combination of chemotherapy and growth factors

Repetitive apheresis in committed donors

3. WHen Doppler methodology is used, cordocentesis is performed when the peak systolic velocity value is:

.5 of the median

At the median

1.5 of the median

2.0 of the median

4. Which of the following in stored blood correlates to red cell function post transfusion?

ATP

2,3 DPG

Dextrose

Sodium phosphate

5. The most common antibody associated with HDN is

ABO

D

K

C

6. Which of the following is NOT expected in hemolytic anemia?

Decreased haptoglobin

Decreased hemoglobin

Decreased serum LDH

Increased reticulocytes

7. A new anticoagulant-preservative is being evaluated for storing of RBCs for 49 days. For approval it must demonstrate:

75% survival of RBCs in a recipient 12 hours after transfusion

80% survival of RBCs in a recipient 12 hours after transfusion

75% survival of RBCs in a recipient 24 hours after transfusion

80% survival of RBCs in a recipient 24hours after transfusion

8. Which is the most common indicator to base a decision on whether to perform an exchange transfusion in an infant with HDFN?

Albumin levels

Anemia

Antibody specificity

Bilirubin levels

9. Which of the following is NOT an advantage of blood component therapy?

It allows for optimum storage of each component

It provides products that can better meet patient's needs

It decreases the risk of disease transmission

It maximizes the use on donated whole blood

10. More oxygen will be released by RBCs if

Levels of 2,3 DPG are high

There is a low P50

Levels of 2,3 DPG are low

ATP is generated

All of the above

11. Profound hypotension during plasma pheresis is associated with patients taking

ACE inhibitors

Aspirin containing medications

Fiber

Heparin

Acetaminophen

12. Which of the following markers are used to ID progenitor cells?

CD4

CD8

CD22

CD34

CD44

13. For proper irradiation the intended dose is

25 Gy in the middle of the component, 15 Gy at any other point

60Gy throughout the entire component container

25Gy throughout the entire component container

15 Gy initally, 25 midpoint, 60 at endpoint

14. Massively transfused liver disease patients are at risk for hypocalcemia due to the inability to:

Conjugate steroids

Excrete potassium

Synthesize albumin

Metabolize citrate

15. Extracorporeal volume during plasmapheresis must not exceed what percentage of the patient's blood volume?

5%

10%

15%

20%

25%

16. Which of the following is NOT a condition with established indications for effective use of therapeutic apheresis?

Guillain-Barre syndrome

Multiple sclerosis

Myasthenia gravis

TTP

17. The mode of inheritance of the Kell antigens K (KEL1) and k (KEL2) is:

X-linked dominant

X-linked recessive

Autosomal recessive

Autosomal codominant

18. Temperature recording sensors in a refrigerator should be placed

On the top shelf

On the middle shelf

On the bottom shelf

On the inside of the door

19. What cellular line is the last to become engrafted?

Platelets

Red cells

White cells

Unknown

20. Which of the following in stored blood correlates to red cell post-transfusion viability?

ATP

2,3 DPG

Dextrose

Sodium phosphate

Rate of transfusion

21. How many mgs of iron are in one unit of blood?

10

40

200

400

22. An autologous donor's hemoglobin shall be no lower than

9 g/dL

10 g/dL

11 g/dL

10.5 g/dL

12 g/dL

23. A patient who is pregnant may donate after what time frame post delivery?

3 days

2 weeks

6 weeks

8 weeks

24. When shipping frozen blood on dry ice, the shipping container may be labeled as DRY ICE or_____.

Crystallized H30

Carbon Dioxide, Solid

Contains Cryogenic Material

Solid Nitrogen Pellets

Warning: Cold

25. What is the minimum amount of RBCs that can be collected in a 450mL collection bag?

300

405

425

450

26. The levels of 2,3 DPG of stored blood return to normal in the recipient after what timeframe following transfusion?

4 hours

8 hours

12 hours

24 hours

72 hours

27. The cryopreservation most often used for platelets is

DMSO

Glycerol

HES

Liquid nitrogen

Mannitol

28. Which of the following is associated with an HLA class I allele?

Anklosing spondylitis

Type 1 insulin-dependent diabetes mellitus

Narcolepsy

Rheumatoid Arthritis

29. Studies with platelet components have shown appox. 50% levels of Factor V and VIII after storage for

1 hour

16 hours

24 hours

72 hours

30. Most newborns type as which of the following Lewis phenotypes?

Le(a-b-)

Le(a+b-)

Le(a-b+)

Le(a+b+)

31. Blood donors in the US make up appox. what percentage of the population?

1%

4%

15%

25%

32. A donor weighing 80 lbs can donate what volume of whole blood?

450mL

405 mL

385 mL

325 mL

33. Which of the following HLA antigens corresponds to Bgb?

HLA-B7

HLA-B17

HLA-B27

HLA-A28

34. For patients undergoing daily plasmapheresis the PT, PTT and fibrinogen levels are checked:

Immediately before and after the procedure

Each morning

Hourly

Every 3 days

Weekly

35. Which blood group is the urea transporter on the red cell membrane?

Duffy

Kell

Rh

Kidd

Colton

36. What donor medication is a permanent deferral?

Proscar

Accutane

Soriatane

Tegison

37. Which of the following neutrophil counts is used for evidence of engraftment?

500 per microliter

1500 per microliter

10,000 per microliter

500, 000 per microliter

38. The change in production of IgM to IgG is an example of

Epitope switching

Isotype switching

Immune surveillance

Antibody specificity

39. The first course of therapy for a person with hemolysis due to a warm autoantibody is

Corticosteroids

IVIG

Plasma exchange

Splenectomy

Aspirin meds

40. Which of the following is a transmembrane protein of the red cell?

Actin

Ankyrin

Band 3

Spectrin

41. Which of the following is an indeterminate Western Blot result?

Anti-HIV positive by EIA, no bands seen on Western Blot

Anti-HIV positive by EIA, p24 and g41 seen on Western Blot

Anti-HIV positive by EIA, p17 seen on Western Blot

Anti-HIV positive by EIA, pg120/160 seen on Western Blot

42. Rescue Transplantation is the term used when

Allogeneic HLA-mismatched donors are used

An organ failed and must be replaced immediately

Autologous HPCs are used

Grafts from pigs are used for heart valves

43. The types of von Willebrand's disease that should not use desmonpressin (DDAVP) is

Type I

Type IIa

Type IIb

Type III

44. What percentage of oxygen is normally released be red cells in the tissue?

25%

50%

75%

100%

45. The purpose of registering donors is to:

Coordinate the donation process from start to finish

Identify donors and link them to previous records

Process the right number of donors to maintain optimal inventory levels

All of the above

46. Which of the following donor records must be maintained indefinitely?

Temporary deferral

Donor typing (ABO/Rh)

QC for typing antisera

Signed consent forms

47. Which of the following blood components may carry a risk of CMV infection?

FFP

Cryo

Platelets

All of the above

None of the above

48. The benefits of GVT (Graft verses Tumor/Leukemia) is limited to which of the following types of transplants?

HLA-matched

HLA-mismatched

Syngeneic (identical twin)

Bone marrow is used rather than peripheral HPC's

49. Rejuvenated cells must be washed prior to infusion to remove

Excessive hemolysis

High levels of potassium

Inosine which may be toxic

Stroma from old red cells

Cytokines

50. Which of the following would defer an autologous donor?

HIV positive

Medication for hypertension

Receiving antibiotics

14 years of age

Hemoglobin 12 g/dL

51. A person with which of the following surgeries would NOT be a candidate for perioperative blood salvage?

Abdominal

Cardiac

Liver transplant

Orthopedic

Eye surgery

52. A strong linkage disequilibrium exists between

HLA-A1 and HLA-B8

HLA-A1 and HLA-B27

HLA-A30 and HLA-B27

HLA-A1 and HLA-B45

53. Chronic graft vs host disease

Is associated with increased survival rate

Is associated with ABO incompatible transplants

Occurs within 2 weeks of transplant and lasts 2 months

Occurs in less than 5% of transplant cases

Blood Products

1. For plasmapheresis what blood volume exchange is considered for maximum benefit to remove plasma constituents?

2.

What first name or nickname would you like us to use?

2. The most effective way(s) to promote progenitor cells in circulation and is used clinically is:

3. WHen Doppler methodology is used, cordocentesis is performed when the peak systolic velocity value is:

4. Which of the following in stored blood correlates to red cell function post transfusion?

5. The most common antibody associated with HDN is

6. Which of the following is NOT expected in hemolytic anemia?

7. A new anticoagulant-preservative is being evaluated for storing of RBCs for 49 days. For approval it must demonstrate:

8. Which is the most common indicator to base a decision on whether to perform an exchange transfusion in an infant with HDFN?

9. Which of the following is NOT an advantage of blood component therapy?

10. More oxygen will be released by RBCs if

11. Profound hypotension during plasma pheresis is associated with patients taking

12. Which of the following markers are used to ID progenitor cells?

13. For proper irradiation the intended dose is

14. Massively transfused liver disease patients are at risk for hypocalcemia due to the inability to:

15. Extracorporeal volume during plasmapheresis must not exceed what percentage of the patient's blood volume?

16. Which of the following is NOT a condition with established indications for effective use of therapeutic apheresis?

17. The mode of inheritance of the Kell antigens K (KEL1) and k (KEL2) is:

18. Temperature recording sensors in a refrigerator should be placed

19. What cellular line is the last to become engrafted?

20. Which of the following in stored blood correlates to red cell post-transfusion viability?

21. How many mgs of iron are in one unit of blood?

22. An autologous donor's hemoglobin shall be no lower than

23. A patient who is pregnant may donate after what time frame post delivery?

24. When shipping frozen blood on dry ice, the shipping container may be labeled as DRY ICE or_____.

25. What is the minimum amount of RBCs that can be collected in a 450mL collection bag?

26. The levels of 2,3 DPG of stored blood return to normal in the recipient after what timeframe following transfusion?

27. The cryopreservation most often used for platelets is

28. Which of the following is associated with an HLA class I allele?

29. Studies with platelet components have shown appox. 50% levels of Factor V and VIII after storage for

30. Most newborns type as which of the following Lewis phenotypes?

31. Blood donors in the US make up appox. what percentage of the population?

32. A donor weighing 80 lbs can donate what volume of whole blood?

33. Which of the following HLA antigens corresponds to Bgb?

34. For patients undergoing daily plasmapheresis the PT, PTT and fibrinogen levels are checked:

35. Which blood group is the urea transporter on the red cell membrane?

36. What donor medication is a permanent deferral?

37. Which of the following neutrophil counts is used for evidence of engraftment?

38. The change in production of IgM to IgG is an example of

39. The first course of therapy for a person with hemolysis due to a warm autoantibody is

40. Which of the following is a transmembrane protein of the red cell?

41. Which of the following is an indeterminate Western Blot result?

42. Rescue Transplantation is the term used when

43. The types of von Willebrand's disease that should not use desmonpressin (DDAVP) is

44. What percentage of oxygen is normally released be red cells in the tissue?

45. The purpose of registering donors is to:

46. Which of the following donor records must be maintained indefinitely?

47. Which of the following blood components may carry a risk of CMV infection?

48. The benefits of GVT (Graft verses Tumor/Leukemia) is limited to which of the following types of transplants?

49. Rejuvenated cells must be washed prior to infusion to remove

50. Which of the following would defer an autologous donor?

51. A person with which of the following surgeries would NOT be a candidate for perioperative blood salvage?

52. A strong linkage disequilibrium exists between

53. Chronic graft vs host disease