Pnh - High Yield Topic Series

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| By Kar
Kar, Assistant Professor (Biochemistry)
Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi
Quizzes Created: 33 | Total Attempts: 50,084
| Attempts: 153
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  • 1/10 Questions

    Pancytopenia with cellular marrow is seen in

    • G6PD deficiency
    • PNH
    • Acquired aplastic anemia
    • Thalassemia
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About This Quiz

This 'PNH - High Yield Topic Series' quiz assesses key knowledge areas related to Paroxysmal Nocturnal Hemoglobinuria (PNH), focusing on its diagnosis, associated risks, genetic aspects, and cellular characteristics. Essential for medical students and professionals.

Pnh - High Yield Topic Series - Quiz

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  • 2. 

    Gene defective in PNH is

    • GIGA

    • PIGA

    • GPIA

    • PGIA

    Correct Answer
    A. PIGA
    Explanation
    phosphatidylinositol glycan A (PIGA) is needed to make glycosylphosphatidylinositol (GPI) anchor.

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  • 3. 

    PNH causes Extra vascular Hemolysis

    • True

    • False

    Correct Answer
    A. False
    Explanation
    PNH causes INTRA vascular Hemolysis

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  • 4. 

    Lab findings of PNH are all of the following, EXCEPT

    • Increased reticulocyte count

    • Increased LDH

    • Increased serum haptoglobin

    • Decreased serum haptoglobin

    Correct Answer
    A. Increased serum haptoglobin
    Explanation
    These are the features of all Hemolytic anemias

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  • 5. 

    Decay-accelerating factor (DAF) is 

    • CD55

    • CD59

    • CD5b

    • CD35

    Correct Answer
    A. CD55
    Explanation
    CD55 is the correct answer because Decay-accelerating factor (DAF) is also known as CD55. CD55 is a protein that is found on the surface of cells and helps to protect them from being attacked by the body's immune system. It does this by preventing the complement system, which is part of the immune system, from damaging the cells. CD59, CD5b, and CD35 are not alternative names for Decay-accelerating factor (DAF).

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  • 6. 

    The Diagnostic test for PNH

    • Sugar Water Test

    • Hams test

    • FISH

    • Flowcytometry

    Correct Answer
    A. Flowcytometry
    Explanation
    Flow cytometry is a diagnostic test for PNH (Paroxysmal Nocturnal Hemoglobinuria). It is a laboratory technique that uses laser technology to analyze and measure the physical and chemical characteristics of cells in a fluid sample. In the case of PNH, flow cytometry is used to detect and quantify the presence of abnormal red blood cells that lack certain proteins on their surface, which is a characteristic feature of PNH. This test is highly sensitive and specific, making it a reliable method for diagnosing PNH. Other tests mentioned, such as the Sugar Water Test, Hams test, and FISH, may have different applications but are not specifically used for diagnosing PNH.

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  • 7. 

    PNH patients are at increased risk of developing

    • AML

    • ALL

    • CML

    • CLL

    Correct Answer
    A. AML
    Explanation
    Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) have an increased risk of developing Acute Myeloid Leukemia (AML). PNH is a rare blood disorder characterized by the destruction of red blood cells, leading to symptoms such as anemia, fatigue, and blood clots. PNH is caused by a mutation in the PIG-A gene, which results in the deficiency of certain proteins on the surface of blood cells. This deficiency increases the risk of abnormal cell growth and the development of AML, a type of cancer that affects the bone marrow and blood. Therefore, AML is the correct answer.

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  • 8. 

    FALSE regarding PNH

    • Thrombotic episodes

    • Impotence

    • Coomb's test positive

    • Eculizumab is used for treatment

    • Refractory anemia/Aplastic anemia

    Correct Answer
    A. Coomb's test positive
    Explanation
    The correct answer is "coomb's test positive". This means that in the case of PNH, the Coombs test, which is used to detect antibodies against red blood cells, is positive. This indicates that there is an immune-mediated destruction of red blood cells in PNH. The other statements mentioned, such as thrombotic episodes, impotence, eculizumab treatment, and refractory/aplastic anemia, are not associated with PNH.

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  • 9. 

    Eculizumab is a monoclonal antibody directed against 

    • C5

    • C6

    • C7

    • C3b

    Correct Answer
    A. C5
    Explanation
    Eculizumab is a monoclonal antibody that specifically targets the C5 protein. By binding to C5, eculizumab prevents its cleavage into C5a and C5b, which are important components of the complement system. This inhibition of C5 prevents the formation of the membrane attack complex (MAC) and the release of pro-inflammatory mediators, ultimately reducing the destruction of red blood cells in conditions such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

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  • 10. 

    Mode of Inheritance of PNH is

    • Autosomal Dominant

    • Autosomal recessive

    • X- linked recessive

    • X- linked dominant

    • None

    Correct Answer
    A. None
    Explanation
    PNH is an ACQUIRED STEM CELL DISORDER !!

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  • Current Version
  • Jul 22, 2024
    Quiz Edited by
    ProProfs Editorial Team
  • May 10, 2012
    Quiz Created by
    Kar
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