Block 9 Pharm Adrenergic W Exp Prt 1
- 1.This drug is a alpha-2 selective receptor agonist
- A.
Albuterol
- B.
Apraclonidine
- C.
Cocaine
- D.
Amphetamine
- E.
Dobutamine
- F.
Dopamine
- G.
Epinephrine
- H.
Ephedrine
- I.
Methyldopa
- J.
Norepinephrine
- K.
Phenylephrine
- L.
Salmeterol
- M.
Tyramine
- 2.This drug is a long-acting beta-2 selective receptor agonist
- A.
Albuterol
- B.
Apraclonidine
- C.
Cocaine
- D.
Amphetamine
- E.
Dobutamine
- F.
Dopamine
- G.
Epinephrine
- H.
Ephedrine
- I.
Methyldopa
- J.
Norepinephrine
- K.
Phenylephrine
- L.
Salmeterol
- M.
Tyramine
- 3.This drug is an indirect acting adrenergic agent sometimes used as antihypertensive
- A.
Albuterol
- B.
Apraclonidine
- C.
Cocaine
- D.
Amphetamine
- E.
Dobutamine
- F.
Dopamine
- G.
Epinephrine
- H.
Ephedrine
- I.
Methyldopa
- J.
Norepinephrine
- K.
Phenylephrine
- L.
Salmeterol
- M.
Tyramine
- 4.This drug may cause a severe hypertensive crisis if taken together with a MAO inhibitor
- A.
Albuterol
- B.
Apraclonidine
- C.
Cocaine
- D.
Amphetamine
- E.
Dobutamine
- F.
Dopamine
- G.
Epinephrine
- H.
Ephedrine
- I.
Methyldopa
- J.
Norepinephrine
- K.
Phenylephrine
- L.
Salmeterol
- M.
Tyramine
- 5.A 33-year-old man admitted to the hospital because of a car accident, started a blood transfusion. Few minutes later he complained of nausea and pruritus and developed dyspnea with audibly wheezing. His skin was mottled and cold, heart rate was 120 bpm and blood pressure fell to 80/ 40 mm Hg. An IV injection of epinephrine was given. Which of the following actions of the drug most likely contributed to its therapeutic efficacy in this patient?
- A.
Increased glycogenolysis
- B.
Beta-2 receptor mediated vasodilation
- C.
Stimulation of platelet aggregation
- D.
Inhibition of insulin secretion
- E.
Inhibition of mast cell degranulation
- F.
Stimulation of eicosanoid biosynthesis
- 6.The effects of epinephrine on the heart are most likely mediated by which of the following postreceptor mechanisms?
- A.
Opening of ligand gated K+ channels
- B.
Opening of ligand-gated Na+ channels
- C.
Simulation of phospholipase C
- D.
Stimulation of phospholipase A2
- E.
Stimulation of adenylyl cyclase
- 7.Which of the following molecular actions best explains the decrease in heart rate observed with norepinephrine infusion in a healthy subject?
- A.
Activation of myocardial alpha-2 receptors
- B.
Stimulation of aortic baroreceptors
- C.
Activation of Nm receptors
- D.
Blockade of myocardial muscarinic receptors
- E.
Stimulation of chemoreceptors of aortic bodies
- 8.A 34-year-old woman was in the dentist office to have an endodontic therapy. Before starting the procedure the dentist injected near the tooth a solution of lidocaine plus epinephrine in order to provide local anesthesia. The epinephrine-induced increased duration of lidocaine effect was most likely mediated by the activation of which of the following receptors?
- A.
Beta -1
- B.
Beta -2
- C.
Beta -3
- D.
Alpha-1
- E.
Alpha-2
- 9.Which of the following is the most common adverse effect of phenylephrine given locally into the eye for diagnostic purposes?
- A.
Lacrimation
- B.
Tachycardia
- C.
Difficulty in far vision
- D.
Photophobia
- E.
Running nose
- 10.Which of the following is a pharmacological effect of isoproterenol?
- A.
Stimulation of renin secretion
- B.
Inhibition of insulin release
- C.
Reflex bradycardia
- D.
Release of inflammatory mediators from mast cells
- E.
Stimulation of platelet aggregation
- 11.Which of the following is a pharmacological effect of albuterol on the respiratory system?
- A.
Increased microvascular permeability
- B.
Decreased bronchial secretions
- C.
Release of histamine from mast cells
- D.
Increased residual respiratory volume
- E.
Increased mucociliary clearance
- 12.Which of the following is a common adverse effect of selective beta-2 receptor agonists in children?
- A.
A-V block
- B.
Restlessness
- C.
Sleepiness
- D.
Postural hypotension
- E.
Ventricular tachycardia
- 13.A 57-year-old homeless alcoholic man was brought to the hospital by the police who found him lying on a sidewalk. Physical examination showed evident signs of alcohol withdrawal and a therapy was started which included clonidine. Which of the following phrases best explains the most likely mechanism of action of the drug in this patient?
- A.
Decreased central sympathetic outflow
- B.
Activation of peripheral alpha-1 receptors
- C.
Decreased central parasympathetic outflow
- D.
Activation of peripheral alpha-2 receptors
- E.
Blockade of alpha receptors on tractus solitarius
- F.
Blockade of alpha receptors on locus ceruleus
- 14.Which of the following autonomic drugs given IV to healthy subjects can cause an increase in cardiac contractility, a slight increase in heart rate and no major changes or a decrease in systemic vascular resistance?
- A.
Phenylephrine
- B.
Norepinephrine
- C.
Isoproterenol
- D.
Epinephrine
- E.
Dobutamine
- 15.Which of the following statements best explains the main mechanism of adrenergic actions of cocaine?
- A.
Inhibition of monoamine oxidase A
- B.
Blockade of alpha-2 receptors in sympathetic terminals
- C.
Inhibition of norepinephrine reuptake into sympathetic nerve terminals
- D.
Stimulation of epinephrine release from adrenal medulla
- E.
Stimulation of norepinephrine release from sympathetic nerve terminals
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