Block 7 Skin Genomic Imprinting MCQ's

21 Questions | Total Attempts: 216

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Block 7 Skin Genomic Imprinting MCQ

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Questions and Answers
  • 1. 
    What structure connects the cell to the underlying extracellular matrix?
    • A. 

      Hernidesmosorne

    • B. 

      Desmosome

    • C. 

      Gap junction

    • D. 

      Paciniar corpuscle

    • E. 

      Merckel Corpuscles

    • F. 

      Meissner corpuscles

  • 2. 
    A 34-year-old woman is prescribed a topical medication to treat a dermatological condition. Which of the followings statements concerning this medication and its clinical use is most likely correct?
    • A. 

      The drug vehicle exerts minimal influence on the absorption of this medication

    • B. 

      Application of the drug creates a concentration gradient in the patient's skin

    • C. 

      The topical agent is applied four times daily to the affected area

    • D. 

      The possibility of this drug undergoing extensive metabolism in the skin is very low

    • E. 

      The drug possesses a molecular mass of 1600 Da

  • 3. 
    A 19 year old man has facial and upper back lesions that have waxed and waned for the past 6 years. On examination the lesions have a grayish white plug in the central region. Both his parents had the same lesion at this age. The lesions worsen when he visits his aunt in Arizona. Which of the following organisms is most likely to be a part of the pathogenesis?
    • A. 

      Staphylococcus aureus

    • B. 

      Herpes simplex virus type 1

    • C. 

      Group A Streptocci

    • D. 

      Mycob3cter-furn teprae

    • E. 

      Propionibacteilum acnes

  • 4. 
    In the drawing below, pick the cell (A, B, C, D, or E) that would be actively engaged in secreting lamellar bodies to waterproof the skin
    • A. 

      A

    • B. 

      B

    • C. 

      C

    • D. 

      D

    • E. 

      E

  • 5. 
    Which of the cell types below is directly responsible for the formation of a keloid?
    • A. 

      Cell type A

    • B. 

      Cell type B

    • C. 

      Cell type C

    • D. 

      Cell type D

    • E. 

      None of the above

  • 6. 
    A 28-year-old man reports to his family practitioner complaining of intense itching and the emergence of a pimple-like rash up and down the length cf his arms and legs. The patient reveals that he returned to the United States one week ago after participating in medical mission work in a poor area of a Latin American country. Laboratory investigations of a skin scraping from the patient reveal the presence of Sarcoptes scabiei. The physician prescribes a topical medication that works by disrupting the sodium channel current of the target organism's neurons leading to its paralysis, which of the following agents was prescribed for the patient?
    • A. 

      Iverrnectin

    • B. 

      Lindane

    • C. 

      Doxepin

    • D. 

      Permethrin

    • E. 

      Bexarotene

  • 7. 
    SKIN Which of the following structures in the skin is the LEAST likely to be damaged by a second-degree burn?
    • A. 

      Dermal papellae

    • B. 

      Meissner's corpuscles

    • C. 

      Langerhan's cells

    • D. 

      Pacnian corpuscles

    • E. 

      Merkel cells

  • 8. 
    Which one of the following describes the secretory mechanism by which sebum ls produced?
    • A. 

      Apocrine

    • B. 

      Merocrine

    • C. 

      Eccrine

    • D. 

      Holocrine

    • E. 

      Paracrine

  • 9. 
    You accidentally press your arm against a hot iron, and receive a second-degree burn on a patch of skin. Which of the following cell types is most likely to be killed by this burn?   
    • A. 

      Cells within the Meissner's corpuscle

    • B. 

      Cells within the hair root matrix

    • C. 

      Fat cells in the hypodermis

    • D. 

      Keratinacytes of the stratum corneum

    • E. 

      Smooth muscle cells of the arrector pilli muscle

  • 10. 
    Cytogenetic analysis revealed that a female with Prader Willi syndrome had no visible deletion on chromosome 15q. An alternative explanation of the syndrome in this female IS
    • A. 

      Heterozygosity for the paternal chromosome 15

    • B. 

      Trisomy for chromosome 15

    • C. 

      Isodisomy of the paternal chromosome 15

    • D. 

      Uniparental disomy of the maternal chromosome 15

  • 11. 
    Neurofibrornatosis type 1 (NF1) is inherited as an autosomal dominant condition. The cardinal features are cafe au lait spots, small soft fleshy growth known as neurofibromata and Lisch nodules in the iris. NF1 is caused by mutations of a gene termed neurofibromin located on chromosome 17. Loss of heterozygosity for markers for chromosome 17 markers has been observed in small benign neurofibromata. This feature is an indication that:
    • A. 

      The gene responsible is likely to be a fibroblast growth factor receptor

    • B. 

      The gene responsible is likely to be an oncogene

    • C. 

      The gene responsible is showing recessive inheritance at cellular level

    • D. 

      A balanced translocation involving an oncogene on chromosome 17 has occurred

    • E. 

      Gene amplification of an oncogene is responsible for the presence of fibromata

  • 12. 
    Martha is 31 she comes to a genetic clinic from a referral from her family physician. The history below reveals several individuals with colon cancer on the side of her mother. Martha's mother died in an accident at the age of 38 and was known to be healthy. Martha explains that she is fine and she has been diagnosed with any health problem and she considers herself unlikely to be at risk of any problem. What is the most appropriate statement that the physician will provide to Martha?
    • A. 

      The high frequency of colon cancer suggests that her maternal grandfather (II-1) is a carrier of a recessive trait

    • B. 

      Because her mother and uncles were not affected it is unlikely that she develop colon cancer

    • C. 

      Martha should only have a colonoscopy only when she reaches the age of 50

    • D. 

      Her 60-year old maternal uncle (III-4) should have a colonoscopy

    • E. 

      Her mother likely was a carrier of this trait, but her father III-1 likely was not a carrier and thus her siblings are unaffected

  • 13. 
    Prader-Willi syndrome results from different molecular mechanisms. You have a patient that you suspect has this disorder and you send blood samples on the patient and both parents to the lab for genotyping using a DNA polymorphic marker located close to the centrorneric region on chromosome 15. The following genotypes are found. What is the most likely interpretation of this result? (F=-- father; P= patient; M= Mother)
    • A. 

      A new mutation in the gametes contributed by the father

    • B. 

      Paternal deletion

    • C. 

      Laboratory error

    • D. 

      Non paternity

    • E. 

      Maternal uniparentaidisomy

  • 14. 
    The best statement for genomic imprinting is:
    • A. 

      An irreversible process transmitted through successive generations

    • B. 

      Marking of alleles within specific chromosomal regions during male and female gametagenesis

    • C. 

      Occurs mainly on chromosome 15 for humans.

    • D. 

      Occurs mainly during male gametogenesis

    • E. 

      Is known to involve DNA glycosylation

  • 15. 
    How could the following pedigrees be explained by genetic imprinting?
    • A. 

      Maternal uniparental disomy (UPD)

    • B. 

      Paternal uniparental disomy (UPD)

    • C. 

      Paternal expressed gene

    • D. 

      Maternal expressed gene

    • E. 

      New mutation

  • 16. 
    What rash is often described as a target lesion with a red center, pale zone and a outer dark ring. The lesions are generally symmetrical and may have itching?
    • A. 

      Erythema multiforme

    • B. 

      Erythema nodosum

    • C. 

      Erythema rubra

    • D. 

      Erythema

  • 17. 
    What is the term for dilated superficial blood vessels?
    • A. 

      Hemangioma

    • B. 

      Angiomia

    • C. 

      Angiosarcorna

    • D. 

      Telangiectasia

    • E. 

      Alopecia

  • 18. 
    A 67 year old Caucasian woman presents with reddish papules and pustules on her cheek, nose and chin. She says that her face becomes worse if she uses hot water and during summers. What is the diagnosis?
    • A. 

      Simple Acne

    • B. 

      Acne vulgaris

    • C. 

      Acne rosacea

    • D. 

      Verruca vulgaris

    • E. 

      Pemphigus vulgaris

  • 19. 
    The appearance of rashes or other skin lesions is indicative of cellular response to various types of challenges. Which one of the following skin reactions is most likely to be primarily due to an infectious disease process?
    • A. 

      Impetigo

    • B. 

      Miliaria rubra

    • C. 

      Rosacea

    • D. 

      Psoriasis

    • E. 

      Miliaria crystalline

  • 20. 
    A 17-year-old male developed a headaches (ever, chills, nausea, and muscle pain) 11/2 weeks after returning from a fishing trip with his father in Minnesota. During the interview, the patient remembers removing ticks from his skin. Laboratory investigations reveal elevated liver enzymes, thrombocytopenia, and leucopenia. The patient is treated with a 7-day course of doxycycline (100 mg every 12 hours) and recovers fully. Serological tests later confirm an infection with the intracellular, Gram-negative bacterium, Anapiasma phaaocytophilum, What is the vector of this disease
    • A. 

      Ixodes oeciticus

    • B. 

      Ixodes scapularis

    • C. 

      Dermacentor variabilis

    • D. 

      Ambiyornma americanum

    • E. 

      Dermacentor andersoni

  • 21. 
    A 27-year-old female presents with wheals on her neck (Image 1) caused by the organism shown in Image 2.  What organism is this?
    • A. 

      Ixodes sp. Tick

    • B. 

      Body louse

    • C. 

      Crab louse

    • D. 

      Bed bug

    • E. 

      Blister beetle

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