Ultimate Knowledge Trivia On Neuro! Quiz

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  • 1/12 Questions

    An 83-year-old man is brought to the emergency department by his daughter, who explains that her father started having "fits." The examination reveals an alert, otherwise healthy, man, who frequently has uncontrollable flailing movements of his left arm. Which of the following structures is most likely involved in this lesion?

    • CerebelIar cortex plus nuclei
    • Lenticular nucleus
    • Subthalamic nucleus
    • Ventral lateral nucleus
    • Ventral posterolateral nucleus
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About This Quiz

The human brain comprises of 60% of fat and is one of the fattest organs in the human body weighing 3 pounds. It is responsible for most of our body`s functions. How much do you know about the parts and functions of the brain? Test your knowledge of Neuro by taking up the quiz below.

Ultimate Knowledge Trivia On Neuro! Quiz - Quiz

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  • 2. 

    A 58-year-old left-handed man is referred to a neurologist for "involuntary left-hand twitches". Between six months and a year ago he noticed that when his left hand was resting it would shake. He can stop the shaking by looking at his hand and concentrating. There is no tremor in his right hand and his lower extremities are not affected. He has had no trouble walking. There is no behavioral or language change. He has bilateral cogwheel rigidity. (ii) What is the most appropriate pharmacotherapy for his condition?

    • Alteplase

    • Carbamazepine

    • Levodopa/carbidopa

    • Glatiramer

    • Interferon beta-l aIpha

    • Sertraline

    Correct Answer
    A. Levodopa/carbidopa
    Explanation
    The most appropriate pharmacotherapy for the patient's condition is levodopa/carbidopa. This is because the patient is presenting with involuntary left-hand twitches, which could be indicative of Parkinson's disease. Levodopa is a precursor to dopamine and helps to replenish dopamine levels in the brain, while carbidopa helps to prevent the breakdown of levodopa before it reaches the brain. This combination is commonly used to manage the symptoms of Parkinson's disease, including tremors and rigidity.

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  • 3. 

    A patient presented with, a severe tremor, bradykinesia and rigidity, and progressive cognitive decline. He was diagnosed with a neurodegenerative disorder and his dyskinetic symptoms were treated with L-dopa/carbidopa. A CT scan showed pigmented cell loss in the substantia nigra. Which neurotransmitter is primarily involved in this disorder?

    • 5-hydroxytryptamine

    • Acetylcholine

    • GABA (y-aminobutyric actd)

    • Norepinephrine

    • Dopamine

    Correct Answer
    A. Dopamine
    Explanation
    The patient's symptoms of severe tremor, bradykinesia, rigidity, and cognitive decline are consistent with Parkinson's disease, a neurodegenerative disorder. Parkinson's disease is characterized by the loss of dopamine-producing cells in the substantia nigra of the brain. Dopamine is the primary neurotransmitter involved in this disorder, as its deficiency leads to the motor and cognitive symptoms observed in the patient. The treatment with L-dopa/carbidopa aims to replenish dopamine levels in the brain and alleviate the dyskinetic symptoms.

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  • 4. 

    Which of the following is the prominent population of melanin-containing cells located immediately internal to the crus cerebri?

    • Locus ceruleus

    • Pontine nuclei

    • Red nucleus

    • Reticular formation

    • Substantia nigra

    Correct Answer
    A. Substantia nigra
    Explanation
    The substantia nigra is the prominent population of melanin-containing cells located immediately internal to the crus cerebri. It is a region of the midbrain that is involved in the production of dopamine, a neurotransmitter that plays a crucial role in movement control. The melanin-containing cells in the substantia nigra give it a dark color, hence the name "substantia nigra," which means "black substance" in Latin.

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  • 5. 

    A 64-year-old man is brought to a rural health clinic by a neighbor. The history reveals that the man is a recluse, lives by himself, and does not regularly visit a physician. The examination reveals that the man has difficulty walking, chorea, and dystonia, and is suffering from dementia. The neighbor believes that the man's father died from a similar disease. A tentative diagnosis of Huntington's disease is made. Absence of which of the following structures in an MRI of this man would be consistent with this diagnosis?

    • Anterior lobe of cerebellum

    • Head of the caudate

    • Lateral thalamic nuclei

    • Substantia nigra

    • Subthalamic nucleus

    Correct Answer
    A. Head of the caudate
    Explanation
    The absence of the head of the caudate in an MRI of this man would be consistent with a diagnosis of Huntington's disease. Huntington's disease is a neurodegenerative disorder characterized by movement abnormalities, cognitive decline, and psychiatric symptoms. The head of the caudate is one of the areas of the brain that is most affected by the disease, leading to the motor and cognitive symptoms observed in this patient.

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  • 6. 

    A 58-year-old left-handed man is referred to a neurologist for "involuntary left-hand twitches". Between six months and a year ago he noticed that when his left hand was resting it would shake. He can stop the shaking by looking at his hand and concentrating. There is no tremor in his right hand and his lower extremities are not affected. He has had no trouble walking. There is no behavioral or language change. He has bilateral cogwheel rigidity. (i) What is the most likely diagnosis for this patient?

    • Progressive Supranuclear palsy

    • Guillain-Barre syndrome

    • Multiple Sclerosis

    • Parkinson's disease

    • Stroke

    Correct Answer
    A. Parkinson's disease
    Explanation
    The most likely diagnosis for this patient is Parkinson's disease. This is indicated by the presence of involuntary left-hand twitches, which are a common symptom of Parkinson's. The fact that the shaking can be stopped by looking at the hand and concentrating is also characteristic of Parkinson's disease. Additionally, the absence of tremor in the right hand and unaffected lower extremities further supports this diagnosis. The presence of bilateral cogwheel rigidity is another common feature of Parkinson's disease.

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  • 7. 

    A 59-year-old man, who is a family physician, confides in a neurology colleague that he believes he has early-stage Parkinson's disease. The neurological examination reveals a slight resting tremor of the left hand, slow gait, and lack of the normal range of facial expression. Which of the following is the most likely location of the degenerative changes at this stage of the physician's disease?

    • Bilateral substantia nigra

    • Left globus pallidus

    • Left substantia nigra

    • Right globus pallidus

    • Right substantia nigra

    Correct Answer
    A. Right substantia nigra
    Explanation
    The correct answer is Right substantia nigra. Parkinson's disease is characterized by degenerative changes in the substantia nigra, a region of the brain that produces dopamine. The symptoms described in the question, such as resting tremor and slow gait, are consistent with Parkinson's disease. The fact that the symptoms are predominantly on the left side of the body suggests that the degenerative changes are more advanced on the right side of the brain, affecting the right substantia nigra.

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  • 8. 

    A 68~year-old woman is brought to the emergency department by her godson. He explains that she unexpectedly began to have sudden movements of her left arm. The examination reveals a slender woman with hypertension and periodic, uncontrollable flailing movements of her left upper extremity suggestive of hemiballismus. Assuming this resulted from vascular occlusion, MRI would most likely show an infarction in which of the following structures?

    • Left substantia nigra

    • Left subthalamic nucleus

    • Right motor cortex

    • Right substantia nigra

    • Right subthalamic nucleus

    Correct Answer
    A. Right subthalamic nucleus
    Explanation
    The correct answer is Right subthalamic nucleus. Hemiballismus is a movement disorder characterized by sudden, involuntary, and violent flinging movements of one side of the body. It is commonly caused by a lesion in the contralateral subthalamic nucleus. In this case, the patient's left upper extremity is affected, indicating that the lesion is likely on the right side. Therefore, an MRI would most likely show an infarction in the Right subthalamic nucleus.

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  • 9. 

    A 58-year-old left handed man is referred to a neurologist for "involuntary left-hand twitches". Between six months and a year ago he noticed that when his left hand was resting it would shake. He can stop the shaking by looking at his hand and concentrating. There is no tremor in his right hand and his lower extremities are not affected. He has had no trouble walking. There is no behavioral or language change. He has bilateral cogwheel rigidity. (iii) The patient is also given tolcapone to supplement L-dopa/carbidopa therapy. What is the mechanism of action of tolcapone?

    • It is a muscarinic antagonist, it controls the tremor better than L-dopa

    • It is a dopamine receptor (D2) agonist, it allows reduction of t-dopa/carbidopa dosing

    • It blocks dopamine co-transporters thus increasing dopamine levels in the caudate/putamen

    • It is a Monoamine oxidase inhibitor, it increases dopamine levels in the caudate putamen

    • It is a COMT inhibitor, it maximizes the uptake of L-dopa into the brain

    Correct Answer
    A. It is a COMT inhibitor, it maximizes the uptake of L-dopa into the brain
    Explanation
    Tolcapone is a COMT inhibitor, which means it inhibits the enzyme catechol-O-methyltransferase (COMT). This enzyme is responsible for breaking down dopamine in the brain. By inhibiting COMT, tolcapone increases the levels of dopamine in the brain, specifically in the caudate/putamen region. This helps to maximize the uptake of L-dopa (a precursor to dopamine) into the brain, leading to better control of symptoms such as tremors. Therefore, tolcapone is used as a supplement to L-dopa/carbidopa therapy in order to enhance its effectiveness in treating Parkinson's disease symptoms.

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  • 10. 

    A 58-year-old left handed man is referred to a neurologist for "involuntary left-hand twitches". Between six months and a year ago he noticed that when his left hand was resting it would shake. He can stop the shaking by looking at his hand and concentrating. There is no tremor in his right hand and his lower extremities are not affected. He has had no trouble walking. There is no behavioral or language change. He has bilateral cogwheel rigidity. (iv) Which agent has produced a syndrome similar to the one seen in this patient?  

    • Cocaine

    • CO (Carbon monoxide)

    • MOMA (3, 4-MethyleneDioxyMethAmphetamine)

    • MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine)

    • Sulphonamides

    Correct Answer
    A. MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine)
    Explanation
    MPTP is the correct answer because it is known to produce a syndrome similar to the one seen in this patient. MPTP is a compound that can cause parkinsonism in humans and animals. It is selectively toxic to the substantia nigra, which is the area of the brain that is affected in Parkinson's disease. Symptoms of MPTP-induced parkinsonism include resting tremor, rigidity, and a lack of involvement of the lower extremities. This matches the symptoms described in the patient, making MPTP the most likely agent responsible for his condition.

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  • 11. 

    A 58-year-old left-handed man is referred to a neurologist for "involuntary left-hand twitches". Between six months and a year ago he noticed that when his left hand was resting it would shake. He can stop the shaking by looking at his hand and concentrating. There is no tremor in his right hand and his lower extremities are not affected. He has had no trouble walking. There is no behavioral or language change. He has bilateral cogwheel rigidity. (v) Which enzyme is normally present in the neurons whose degeneration leads to the patient's disorder?

    • COMT (Catechol-O-methyltransfe rase)

    • Dopamine -beta-hydroxylase

    • Phenyl ethanolami ne-N-methyl transferase

    • Tryptophan hydroxylase

    • Tyrosine hydroxylase

    Correct Answer
    A. COMT (Catechol-O-methyltransfe rase)
    Explanation
    The correct answer is COMT (Catechol-O-methyltransferase). This is because the patient's symptoms, such as involuntary left-hand twitches and cogwheel rigidity, are consistent with Parkinson's disease. In Parkinson's disease, there is degeneration of dopaminergic neurons in the substantia nigra, which leads to a decrease in dopamine levels. COMT is an enzyme that metabolizes dopamine, and its activity is increased in Parkinson's disease. Therefore, the degeneration of dopaminergic neurons in this patient's disorder is likely due to the activity of COMT.

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  • 12. 

    Group A monkeys were given MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine) and developed akinesia, rigidity, and tremor which were irreversible. Group B monkeys were treated with a drug prior to being given the neurotoxin and the second group failed to develop Parkinsonian symptoms. Which one of the following drugs were given to group B monkeys?

    • A COMT (Catechol-O-methyltransferase) inhibitor

    • A dopamine-beta hydroxylase inhibitor

    • A monoamine oxidase B inhibitor

    • A dopamine co-transporter inhibitor

    Correct Answer
    A. A monoamine oxidase B inhibitor
    Explanation
    Group B monkeys were treated with a monoamine oxidase B (MAO-B) inhibitor prior to being given the neurotoxin. This drug prevented the development of Parkinsonian symptoms in this group. MAO-B inhibitors work by blocking the enzyme monoamine oxidase B, which is responsible for breaking down dopamine in the brain. By inhibiting this enzyme, the MAO-B inhibitor increases dopamine levels in the brain, which helps to protect against the neurotoxic effects of MPTP and prevents the development of Parkinsonian symptoms.

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  • Current Version
  • Mar 22, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Jan 24, 2012
    Quiz Created by
    Chachelly
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