Block 3 Cardiac And Smooth Muscle Function

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  • 1/12 Questions

    Which form of the followng contractions is typicaI for skeletaI but not for cardiac muscle?

    • Isotonic contraction
    • Isometric contraction
    • Single twitches
    • Tetanic twitches
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Muscle Physiology Quizzes & Trivia
About This Quiz

Explore the mechanisms of muscle function in 'Block 3 Cardiac and Smooth Muscle Function'. This quiz covers the dynamics of cardiac and smooth muscle contraction and relaxation, including molecular interactions and physiological responses crucial for medical and biomedical students.

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  • 2. 

    In an experiment you want to prevent the cardiac muscle contraction. There are different possibilities to achieve this goal , One is:

    • To increase the extracellular Ca2+ concentration

    • To increase Ca2+ entry through DHP receptors

    • To increase Ca2+ release through ryanodin receptors

    • To decrease the extracellular Ca2+ concentration to zero

    • To block the activity of Ca2+/3Na+ exchanger

    Correct Answer
    A. To decrease the extracellular Ca2+ concentration to zero
  • 3. 

    The arteries of some organs show a property that is called autoregulation of blood pressure. Increase in pressure stretches the wall of the vessel, causing Ca2+ entry into smooth muscle cells through stretch sensitiveCa2+channels. Contraction is then initiated by Ca2+ binding to:

    • Troponin C

    • Calsequestrin

    • Tropomycin

    • Calmodulin

    Correct Answer
    A. Calmodulin
    Explanation
    In the given scenario, the increase in pressure causes Ca2+ entry into smooth muscle cells through stretch-sensitive Ca2+ channels. Once Ca2+ enters the cells, it binds to calmodulin. Calmodulin is a protein that plays a crucial role in regulating smooth muscle contraction. When Ca2+ binds to calmodulin, it activates the calmodulin-dependent protein kinase, which then initiates the contraction of smooth muscle cells. Therefore, in this case, the contraction is initiated by Ca2+ binding to calmodulin.

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  • 4. 

    Which characteristic or component is shared by skeletaI muscle and smooth muscle?

    • Thick and thin filaments arranged in sarcomeres

    • Troponin

    • Elevation of intracellular[Ca++] for excitation-contraction coupling

    • Spontaneous depolarization of the membrane potential

    • High degree of electrical coupling between cells

    Correct Answer
    A. Elevation of intracellular[Ca++] for excitation-contraction coupling
    Explanation
    Both skeletal muscle and smooth muscle share the characteristic of elevation of intracellular [Ca++] for excitation-contraction coupling. This means that an increase in the concentration of calcium ions inside the muscle cells is necessary for the contraction of both types of muscles. Calcium ions play a crucial role in triggering the interaction between the thick and thin filaments, leading to muscle contraction.

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  • 5. 

    In the contraction and relaxation of cardiac muscle, through what process does calcium reenter the sareoplasmic reticulum?

    • Simple diffusion

    • Facilitated diffusion

    • Secondary active transport

    • Endocytosis

    • Primary active transport

    Correct Answer
    A. Primary active transport
    Explanation
    During the contraction and relaxation of cardiac muscle, calcium is released from the sarcoplasmic reticulum to initiate muscle contraction. After contraction, calcium needs to be removed from the cytoplasm to allow for muscle relaxation. This removal of calcium is achieved through the process of primary active transport, where energy from ATP is used to pump calcium ions back into the sarcoplasmic reticulum against their concentration gradient. This process ensures that the calcium levels in the cytoplasm are kept low, allowing for proper muscle relaxation.

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  • 6. 

    Skeletal muscle, but not cardiac muscle, can undergo tetanic contractions. Cardiac muscle cannot, why is this?

    • Action potential and contraction are of similar duration

    • Autonomic nerve stimulation is not frequent enough

    • Lnsufficlent Cl is released from the sarcoplasmic reticulum

    • Return of Ca 2' to the sarcoplasmic reticulum by Ca-ATPase is too fast

    Correct Answer
    A. Action potential and contraction are of similar duration
    Explanation
    In skeletal muscle, the action potential and contraction have similar durations, allowing for the sustained contraction known as tetanic contraction. However, in cardiac muscle, the action potential and contraction have different durations. The action potential in cardiac muscle is longer than the contraction, which prevents tetanic contractions from occurring. This is important for the proper functioning of the heart, as it allows for relaxation and refilling of the chambers between contractions.

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  • 7. 

    Which of the following drugs would DIRECTLY inhibit the initiation or an action potential in the AV node of the heart thereby decreasing conduction velocity and contractility?

    • Lidocaine, a Class I antiarrhythmetic, voltage-gated Na+ channel blocker

    • Sympathetic stimulation

    • Ibutilide, a Class III antiarrhythmetic, that activates the (If) slow Na' channels

    • Diltiazem, a class IV antiarrhythmetic, voltage-gated Ca+ channel blocker

    • A large cup of caffeinated coffee

    Correct Answer
    A. Diltiazem, a class IV antiarrhythmetic, voltage-gated Ca+ channel blocker
    Explanation
    Diltiazem is a class IV antiarrhythmic drug that blocks voltage-gated Ca+ channels. The AV node of the heart relies on these Ca+ channels for the initiation and conduction of action potentials. By blocking these channels, diltiazem directly inhibits the initiation or action potential in the AV node, leading to a decrease in conduction velocity and contractility. This ultimately results in a decrease in heart rate and can be used to treat certain arrhythmias.

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  • 8. 

    In the contraction and relaxation of smooth muscle, what event ends crossbridge cycling?

    • Dephosphorylation of myosin molecules

    • Phosphorylation of troponin molecules

    • Movement of tropomyosin over myosin binding sites

    • Storage of all of the calcium ions within the sarcoplasmic reticulum

    • Restoration of normal resting membrane potential

    Correct Answer
    A. Dephosphorylation of myosin molecules
    Explanation
    During the contraction and relaxation of smooth muscle, the crossbridge cycling is ended by the dephosphorylation of myosin molecules. This dephosphorylation process allows the myosin heads to detach from actin filaments, leading to muscle relaxation. Phosphorylation of myosin molecules is actually necessary for the initiation of crossbridge cycling, not its termination. The movement of tropomyosin over myosin binding sites and restoration of normal resting membrane potential are not directly involved in ending crossbridge cycling. Storage of all calcium ions within the sarcoplasmic reticulum is important for muscle relaxation, but it does not directly end crossbridge cycling.

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  • 9. 

    The flow of calcium into the cell is an essential component of the upstroke phase of action potentials in:  

    • Cardiac ventricular muscle

    • Cardiac AV nodal tissue

    • Skeletal muscle fibers

    • Nerve cell bodies

    • Presynaptic nerve terminals

    Correct Answer
    A. Cardiac AV nodal tissue
    Explanation
    The upstroke phase of action potentials refers to the rapid depolarization of the cell membrane. In cardiac AV nodal tissue, the flow of calcium into the cell is necessary for the upstroke phase of action potentials. This influx of calcium ions triggers the opening of voltage-gated sodium channels, leading to the depolarization of the cell membrane and the initiation of the action potential. In contrast, in cardiac ventricular muscle, skeletal muscle fibers, nerve cell bodies, and presynaptic nerve terminals, the upstroke phase of action potentials is primarily mediated by the flow of sodium ions into the cell.

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  • 10. 

    The acetylcholine receptors on smooth muscle are

    • G-protein linked

    • Ligand gated mixed cationic channels

    • Ligand gated cl channels

    • Voltage gated mixed cationic channels

    • ATPdependent Ca 2-pumps

    Correct Answer
    A. G-protein linked
    Explanation
    The acetylcholine receptors on smooth muscle are G-protein linked. G-protein linked receptors are a type of cell surface receptor that activate intracellular signaling pathways through the activation of G-proteins. These receptors are involved in a variety of physiological processes, including muscle contraction. In the case of acetylcholine receptors on smooth muscle, the binding of acetylcholine to the receptor activates a G-protein, which then initiates a signaling cascade leading to muscle contraction.

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  • 11. 

    Comparing the process of excitation-contraction coupling in smooth muscle with that of skeletal and cardiac muscles it is correct to say that smooth muscle is unique in which of the following ways?

    • Actin is phosphorylated

    • Calcium binds to tropomyosin.

    • Extracellular calcium is required

    • Regulation is on the thick filament

    Correct Answer
    A. Regulation is on the thick filament
    Explanation
    Smooth muscle is unique in that the regulation of excitation-contraction coupling occurs on the thick filament. In skeletal and cardiac muscles, regulation primarily occurs on the thin filament. This means that in smooth muscle, the interaction between actin and myosin is regulated by factors associated with the thick filament, such as myosin light chain phosphorylation. In contrast, in skeletal and cardiac muscles, regulation is primarily mediated by the binding of calcium to tropomyosin on the thin filament. Additionally, smooth muscle does not require extracellular calcium for contraction, unlike skeletal and cardiac muscles.

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  • 12. 

    Which of the following best describes the relationship between preload, afterload, and muscle fiber shortening velocity of the heart?

    • An increase in afterload causes an increase in shortening velocity

    • For a given afterload, an increase in preload leads to an increase in shortening velocity

    • A decrease in afterload causes a decrease in shortening velocity

    • For a given shortening velocity, an increase in preload causes a decrease in afterload

    • For a given preload, an increase in afterload causes an increase in shortening velocity

    Correct Answer
    A. For a given afterload, an increase in preload leads to an increase in shortening velocity
    Explanation
    An increase in preload leads to an increase in the amount of blood filling the heart before contraction. This increased filling stretches the muscle fibers, allowing for a stronger contraction and therefore an increase in shortening velocity. Afterload, on the other hand, refers to the resistance the heart must overcome to eject blood. An increase in afterload would make it more difficult for the heart to contract and shorten, resulting in a decrease in shortening velocity. Therefore, the relationship between preload, afterload, and muscle fiber shortening velocity is that an increase in preload leads to an increase in shortening velocity, while an increase in afterload causes a decrease in shortening velocity.

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  • Current Version
  • Mar 18, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Nov 16, 2011
    Quiz Created by
    Chachelly

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