Block 13 Pharm Hypnotic Drugs

10 Questions | Total Attempts: 417

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Block 13 Pharm Hypnotic Drugs - Quiz

Questions and Answers
  • 1. 
    Benzodiazepines ...
    • A. 

      Have little effect on respiratory or cardiovascular functions when given at therapeutic doses in an otherwise healthy patient.

    • B. 

      May be safely prescribed for elderly patients at the same dose used for younger patients

    • C. 

      Have a good analgesic effect in case of neuropathic pain

    • D. 

      Can cause a strong psychological dependence but no physical dependence.

  • 2. 
    Benzodiazepines have many different effects on the CNS. However they are devoid of ________________ effects
    • A. 

      Sedative

    • B. 

      Hypnotic

    • C. 

      Muscle relaxant

    • D. 

      Antipsychotic

    • E. 

      Anticonvulsant

  • 3. 
    One of the following statements regarding the pharmacokinetics of benzodiazepines is correct
    • A. 

      Most of their metabolites are pharmacologically inactive

    • B. 

      The hepatic extraction ratio of most of them is > 80%

    • C. 

      Their intramuscular bioavailability is always higher than the oral bioavailability

    • D. 

      In general their half-lives correlate poorly with the duration of their major CNS Effects

    • E. 

      The duration of the central effects may be very prolonged in case of renal Failure

  • 4. 
    One of the following drugs is an active metabolite of many different benzodiazepines, including diazepam, desmethyldiazepam and temazepam
    • A. 

      Alprazolam

    • B. 

      Flumazenil

    • C. 

      Oxazepam

    • D. 

      Lorazepam

    • E. 

      Midazolam

  • 5. 
    The most common problems associates with the use of long-acting benzodiazepines are
    • A. 

      Mental confusion and anterograde amnesia

    • B. 

      Paradoxical excitement and irritability

    • C. 

      Disturbing dreams and early awakening

    • D. 

      Hangover effects

    • E. 

      Day time sedation and drowsiness

  • 6. 
    Recognized therapeutic indications for the use of benzodiazepines include
    • A. 

      Acute paranoia

    • B. 

      Pain due to occlusive arterial disease

    • C. 

      Chronic control of complex partial seizure

    • D. 

      Muscle spasms due to upper motor neuron disease

    • E. 

      Overflow incontinence in the elderly

  • 7. 
    Pharmacological action of barbiturates, often considered a side effect, includes
    • A. 

      Antimuscarinic action on the gastrointestinal tract

    • B. 

      A dose-related increase in intracranial pressure

    • C. 

      Minimal respiratory depression, even at high doses

    • D. 

      An increase in blood pressure, due to ganglionic stimulation

    • E. 

      A dose-related decrease in cardiac output

  • 8. 
    The onset and duration of action of a barbiturate like thiopental is influenced by all of the following factors EXCEPT
    • A. 

      Plasma half-like

    • B. 

      Lipid solubility of the drug

    • C. 

      Cerebral blood flow

    • D. 

      Amount of body fat

    • E. 

      Extent of tissue binding

  • 9. 
    One of the following statements correctly pairs the therapeutic use of barbiturates with the appropriate drug
    • A. 

      As a hypnotic for an elderly person -- pentobarbital

    • B. 

      To abate signs and symptoms of withdrawal from a sedative drug -- alprazolam

    • C. 

      For the treatment of chronic anxiety -- pentobarbital

    • D. 

      As an anticonvulsant for petit mal seizure -- phenobarbital

    • E. 

      As an anesthetic induction agent -- thiopental

  • 10. 
    One of the following drugs is LEAST LIKELY to alleviate withdrawal symptoms in an alcoholic patient
    • A. 

      Buspirone

    • B. 

      Lorazepam

    • C. 

      Diazepam

    • D. 

      Secobarbital

    • E. 

      Chloral hydrate

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