.
Increase affinity of GABA receptor for GABA, increasing channel opening, increasing Cl- influx into cell, causing hyperpolarisation, decreasing the excitability of neurons
Increase affinity of GABA receptor for bdzs, increasing channel opening, increasing Cl- influx into cell, causing depolarisation, decreasing excitability of neurons
Increase affinity of GABA receptor for GABA, increasing channel opening, increasing Cl- influx into cell, causing rapid repolarisation, increasing the excitability of neurons
Reduction of anxiety/aggression; increased drowsiness; reduction of muscle tone; anticonvulsant
Reduction of anxiety but not aggression; sedation and induction of sleep; increased muscle tone; anticonvulsant
Reduction of anxiety/aggression; sedation and induction of sleep; reduction of muscle tone; anticonvulsant
Short - nordiazepam; long - oxazepam
Short - temazepam; long - nordiazepam
Short - oxazepam; long - nordiazepam
Flumazenizenil; reverses effects of bdzs in case of poisoning
Zolpidem; reverses effects of bdzs in cause of adverse effects
Amitriptyline; prolongs effects of bdzs
Buspirone; tandospirone
Citalopram; zolpidem
Quinidine; lidocaine
Sleep disturbance; aggression
Sweating; tremor; tachycardia
Apprehension; dread
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