1.
A halogenated anesthetic that causes fast induction and recovery
A. 
B. 
C. 
D. 
E. 
F. 
G. 
H. 
I. 
2.
This drug can trigger an attack of acute porphyria in risk patients.
A. 
B. 
C. 
D. 
E. 
F. 
G. 
H. 
I. 
3.
This drug has the highest incidence of postanesthetic nausea and vomiting.
A. 
B. 
C. 
D. 
E. 
F. 
G. 
H. 
I. 
4.
This inhaled anesthetic substantially reduced the needed concentration of other inhaled anesthetics given concomitantly
A. 
B. 
C. 
D. 
E. 
F. 
G. 
H. 
I. 
5.
This drug causes a cataleptic state called dissociative anesthesia
A. 
B. 
C. 
D. 
E. 
F. 
G. 
H. 
I. 
6.
New potential general anesthetics were tested in laboratory animals. The minimum
alveolar concentration (MAC) of each drug is reported in the table below:
Which of the following drug has the highest potency?
A. 
B. 
C. 
D. 
E. 
7.
A 43-year-old man underwent surgery to remove a prostatic cancer. Sevoflurane was used
for general anesthesia. The drug has a minimum alveolar concentration (MAC) of 2.0. Which
of the following phrases best describes the MAC of an inhalational anesthetic?
A. 
The blood/gas partition coefficient of the anesthetic
B. 
The concentration of anesthetic needed for short surgery
C. 
The ED50 on a conventional quantal dose-response curve
D. 
The maximal efficacy of the anesthetic
E. 
The concentration of anesthetic in the inspired air
8.
A 48-year-old woman underwent surgery to remove an uterine myoma. General anesthesia
was induced with propofol and maintained by sevoflurane and nitrous oxide. The blockade
of which of the following receptors most likely mediated the effectiveness of nitrous oxide in
this patient?
A. 
B. 
C. 
D. 
E. 
9.
A 44-year-old man underwent surgery because of a prolapsed intervertebral disk. General
anesthesia was induced with propofol and maintained with sevoflurane. When
administration of sevoflurane was discontinued the patient regained consciousness in few
minutes. Which of the following statements best explains why sevoflurane caused a rapid
anesthetic recovery?
A. 
It redistributed rapidly to the lipid tissue
B. 
It is rapidly metabolized
C. 
D. 
It has a low blood/gas partition coefficient
E. 
It concentrates mainly into the cerebral cortex
10.
A 63-year-old woman underwent surgery to remove a vulvar cancer. The patient was a
heavy smoker and had been suffering from chronic obstructive pulmonary disease for 20
years. General Anesthesia was induced with propofol and maintained with sevoflurane.
Which of the following sevoflurane effects most likely occurred during surgery?
A. 
B. 
Increased ventilatory response to carbon dioxide
C. 
D. 
Increased skeletal muscle tone
E. 
11.
A 52-year-old woman underwent hysterectomy to remove an endometrial carcinoma.
Anesthesia was induced with thiopental and maintained with nitrous oxide and halothane.
Which of the following statements best explains why another anesthetic like halothane was
added to nitrous oxide ?
A. 
To achieve a more complete analgesia
B. 
To maintain unconsciousness and muscle relaxation
C. 
To prevent sensitization of the myocardium to catecholamines
D. 
To prevent anesthesia induced respiratory depression
E. 
To prevent post anesthetic nausea and vomiting
12.
A 12-year-old was admitted to the hospital with the admitting diagnosis of acute
appendicitis. Family history of the patient indicated that his father underwent surgery few
years ago ad suffered a serious disorder just after the beginning of general anesthesia.
Further analysis indicated that the disorder was an inherited autosomal dominant disease.
Because of this the anesthesiologist avoided the use of halogenated anaesthetics in this
boy. Which of the following was most likely the disorder suffered by the patient’s father?
A. 
Acute intermittent porphyria
B. 
C. 
D. 
E. 
13.
A 43-year-old woman underwent dilation and curettage because of an abnormal vaginal
bleeding. General anesthesia was performed with thiopental. The patient lost consciousness
in about 10 seconds and regained it 15 minutes later. Which of the following phrases best
explains why general anesthesia induced by a standard dose of thiopental lasts 5-15
minutes?
A. 
Slow distribution of the drug into the CNS
B. 
Fast elimination of the drug from the body
C. 
Redistribution of the drug into peripheral tissues
D. 
Rapid biotransformation of the drug by the brain
E. 
Poor diffusion of the drug into the central neurons
14.
A 61-year-old man underwent surgery to remove a prostate cancer. An IV injection of
thiopental was performed and the patient lost consciousness in 10 seconds. Which of the
following mechanism of action most likely mediated the anesthetic effect of the drug?
A. 
Increased affinity of GABA for its GABA-A receptor
B. 
Enhancement of beta-carboline affinity for GABA-A receptor
C. 
Blockade of NMDA glutamate receptors in the CNS
D. 
Enhancement of Cl- channel opening in the absence of GABA
E. 
Activation of GABA-B receptors on presynaptic terminals
15.
A 61-year-old woman underwent colonoscopy because of rectal bleeding. The woman
was very afraid of the procedure and asked for a general anesthesia. Since she had been
suffering from coronary artery disease for seven years, etomidate was chosen for
anesthesia. Which of the following effects most likely occurred in this patient during the
postanesthetic period?
A. 
B. 
C. 
D. 
E. 
16.
A 4-year-old girl, who had been suffering from asthma for six months, was scheduled for
a short suture procedure that was anticipated to take approximately 10 minutes. She was
brought to the operation room by her parents and was in distress over parting from them
and afraid of the doctors. Which of the following drugs would be appropriate for providing
sedation and analgesia to this girl?
A. 
B. 
C. 
D. 
E. 
17.
A 49-year-old woman underwent abdominal surgery to remove a colon cancer. The
anesthesia was performed with thiopental, fentanyl and nitrous oxide. Which of the following
adverse effects was most likely to occur shortly after the recovery from anesthesia?
A. 
B. 
C. 
D. 
E. 
18.
A 52-year-old man underwent liver biopsy for a suspected liver cancer. Conscious
sedation was induced with a drug combination that has the advantage of being reversible by
the administration of specific receptor antagonists. Which of the following pairs of drugs
was most likely administered ?
A. 
B. 
C. 
D. 
E. 
19.
A 57-year-old man was undergoing surgery to remove a kidney carcinoma. The
anesthesia was induced withy propofol, maintained with halothane, and supplemented by
succinylcholine. A few minutes into the operation the patient exhibited fever of 104° F,
skeletal muscle contracture, and profuse diaphoresis. His blood pressure dropped to 80/50
mm Hg and the heart rate was 125 bpm. Which of the following molecular actions best
explains the signs and symptoms of the patient?
A. 
Excessive release of acetylcholine from motor neuron terminals
B. 
Opening of K+ channels in skeletal muscle membrane
C. 
Excessive release of Ca++ from sarcoplasmic reticulum
D. 
Blockade of Ca++ channel in skeletal muscle membrane
E. 
Opening of Cl- channels in motor end plate
20.
A 63-year-old man underwent surgery to remove a laringeal carcinoma. The man was an
heavy smoker and had been suffering from COPD for 15 years. General anesthesia was
induced by propofol and maintained by sevoflurane and nitrous oxide. A low dose of
ketamine was added to provide additional analgesia. The blockade of which of the following
receptors most likely mediated the therapeutic efficacy of ketamine in this patient?
A. 
B. 
C. 
D. 
E.