Pharm - Drugs For Depressive Disorders

21 Questions | Total Attempts: 483

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Pharm - Drugs For Depressive Disorders - Quiz

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Questions and Answers
  • 1. 
    Directions: questions 1-5 Match each antidepressant drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): This drug has pronounced anticholinergic properties
    • A. 

      Amitriptyline

    • B. 

      Bupropion

    • C. 

      Citalopram

    • D. 

      Fluoxetine

    • E. 

      Mirtazapine

    • F. 

      Phenelzine

    • G. 

      Selegiline

    • H. 

      Trazodone

    • I. 

      Venlafaxine

  • 2. 
    Directions: questions 1-5 Match each antidepressant drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): This drug is a selective inhibitor of MAO B
    • A. 

      Amitriptyline

    • B. 

      Bupropion

    • C. 

      Citalopram

    • D. 

      Fluoxetine

    • E. 

      Mirtazapine

    • F. 

      Phenelzine

    • G. 

      Selegiline

    • H. 

      Trazodone

    • I. 

      Venlafaxine

  • 3. 
    Directions: questions 1-5 Match each antidepressant drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): This drug has an active metabolite with a half life of about 10 days
    • A. 

      Amitriptyline

    • B. 

      Bupropion

    • C. 

      Citalopram

    • D. 

      Fluoxetine

    • E. 

      Mirtazapine

    • F. 

      Phenelzine

    • G. 

      Selegiline

    • H. 

      Trazodone

    • I. 

      Venlafaxine

  • 4. 
    Directions: questions 1-5 Match each antidepressant drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): This drug can prolong the Q-T interval on ECG
    • A. 

      Amitriptyline

    • B. 

      Bupropion

    • C. 

      Citalopram

    • D. 

      Fluoxetine

    • E. 

      Mirtazapine

    • F. 

      Phenelzine

    • G. 

      Selegiline

    • H. 

      Trazodone

    • I. 

      Venlafaxine

  • 5. 
    Directions: questions 1-5 Match each antidepressant drug with the appropriate description (each lettered option can be selected once, more than once, or not at all): This drug increases norepinephrine (but not 5-HT) availability in the synaptic cleft
    • A. 

      Amitriptyline

    • B. 

      Bupropion

    • C. 

      Citalopram

    • D. 

      Fluoxetine

    • E. 

      Mirtazapine

    • F. 

      Phenelzine

    • G. 

      Selegiline

    • H. 

      Trazodone

    • I. 

      Venlafaxine

  • 6. 
    Which of the following is a common mechanism of the long-term therapeutic effectiveness of most antidepressants drugs?
    • A. 

      Inhibition of monoamine metabolism

    • B. 

      Enhanced dopaminergic transmissions

    • C. 

      Down-regulation of postsynaptic CNS receptors

    • D. 

      Enhanced cholinergic transmission

    • E. 

      Impaired glutamatergic transmission

  • 7. 
    A 62-year-old woman with a long history of major depressive disorder was brought unconscious to the emergency room after her husband discovered she had taken several pills of amitriptyline in a suicide attempt. Which of the following symptoms did the patient most likely show?
    • A. 

      Bradycardia

    • B. 

      Pale skin

    • C. 

      Fecal incontinence

    • D. 

      Hyperpnea

    • E. 

      Hypertension

    • F. 

      Mydriasis

  • 8. 
    A 42-year-old man recently diagnosed with major depressive disorder had started a therapy with fluoxetine but two months later he had still a depressed mood most of the day. He was also restless and agitated nearly every day. The psychiatrist decided to change the therapy. Which of the following drug was most likely prescribed?
    • A. 

      Carbamazepine

    • B. 

      Mirtazapine

    • C. 

      Haloperidol

    • D. 

      Diazepam

    • E. 

      Bupropion

  • 9. 
    A 45-year-old man presented to his physician complaining of difficult erection during the intercourse. Past history of the patient was significant for an episode of ventricular tachycardia one year ago. He was recently diagnosed with a major depressive disorder and started a drug treatment two weeks ago. Which of the following drugs most likely caused the symptoms reported by the patient?
    • A. 

      Lithium

    • B. 

      Amitriptyline

    • C. 

      Fluoxetine

    • D. 

      Chlorpromazine

    • E. 

      Bupropion

    • F. 

      Mirtazapine

  • 10. 
    A 56-year-old man complained to his physician that he felt like he had a flu. He was dizzy, shivering, very irritable, anxious and nauseated. The man, diagnosed with a major depressive disorder, had taken paroxetine for 4 months, but three days ago he decided to stop the drug since his depression had been in full remission for the last two months. Medical history of the patient was significant for hypertension, presently treated with losartan and hydrochlorotiazide. Which of the following disorders best explains the syndrome reported by the patient?
    • A. 

      Acute depressive relapse

    • B. 

      SSRI discontinuation syndrome

    • C. 

      Poorly controlled hypertension

    • D. 

      Paroxetine-losartan interaction

    • E. 

      Serotonin syndrome

    • F. 

      Paroxetine-hydrochlorotiazide interaction

  • 11. 
    A 56-year-old man was admitted to the hospital because of generalized shaking, jerking movements of the limbs, twitching of the jaw and clenching of the teeth. The patient had been suffering from gastrointestinal reflux disease for two years. Four months ago the he was diagnosed with an obsessive-compulsive disorder and started a cognitive behavioral therapy and a pharmacological treatment. Three hours before admission he took a tablet of metoclopramide given by a friend. Which of the following drugs most likely triggered the adverse effect reported by the patient?
    • A. 

      Amitriptyline

    • B. 

      Lithium

    • C. 

      Zolpidem

    • D. 

      Paroxetine

    • E. 

      Bupropion

    • F. 

      Buspirone

  • 12. 
    A 23-year-old woman visited a psychiatrist because she felt very anxious when she had to eat or drink in public. She acknowledged that her ideas of being watched by others were irrational but could not remove it. She also realized that alcohol was effective to cope with her anxiety and started drinking 2-3 glasses of brandy every day. After further questioning a presumptive diagnosis was made and a cognitive behavioral therapy was ordered together with a pharmacological treatment. Which of the following drugs was most likely prescribed?
    • A. 

      Diazepam

    • B. 

      Zolpidem

    • C. 

      Bupropion

    • D. 

      Haloperidol

    • E. 

      Paroxetine

    • F. 

      Fluphenazine

  • 13. 
    A 47-year-old man complained to his physician that the drug he was taking was effective in relieving his anxiety but caused a disturbing adverse effect. The patient had been recently diagnosed with a social anxiety disorder and started a treatment with venlafaxine two weeks ago. Which of the following adverse effect did the patient most likely experience?
    • A. 

      Obstinate constipation

    • B. 

      Negligible orgasm during intercourse

    • C. 

      Urge urinary incontinence

    • D. 

      Dizziness and vertigo upon standing

    • E. 

      Dry mouth, most of the day

    • F. 

      Difficulty in near vision

  • 14. 
    A 47-year-old man recently diagnosed with a generalized anxiety disorder started an appropriate therapy with a drug that acts by increasing the availability of both norepinephrine and serotonin in the synaptic cleft of CNS neurons. Which of the following drugs was most likely prescribed?
    • A. 

      Amitriptyline

    • B. 

      Citalopram

    • C. 

      Venlafaxine

    • D. 

      Lorazepam

    • E. 

      Bupropion

    • F. 

      Trazodone

  • 15. 
    A 45-year-old woman complained of feeling dizziness to the point of fainting, upon standing up. She also felt drowsy most part of the day. The patient was admitted to the psychiatric unit two weeks ago because of her third episode of major depressive disorder. She had been receiving an antidepressant therapy for 10 days. Which of the following drugs most likely caused the patient’s symptoms?
    • A. 

      Bupropion

    • B. 

      Mirtazapine

    • C. 

      Amitriptyline

    • D. 

      Paroxetine

    • E. 

      Venlafaxine

    • F. 

      Lithium

  • 16. 
    A 43-year-old man recently diagnosed with major depressive disorder complained to his physician of a throbbing headache for most part of the day. The patient had started a treatment with paroxetine one month ago but his depressive symptoms were minimally improved. The physician decided to shift to another antidepressant that acts by increasing the availability of both norepinephrine and serotonin in the synaptic cleft of CNS neurons. Which of the following drugs was most likely prescribed?
    • A. 

      Amitriptyline

    • B. 

      Trazodone

    • C. 

      Sertraline

    • D. 

      Bupropion

    • E. 

      Citalopram

    • F. 

      Phenelzine

  • 17. 
    A 60-year-old man recently diagnosed with major depressive disorder was about to start an antidepressant therapy. Medical history of the patient was significant for open angle glaucoma for 5 years (presently treated with timolol and latanoprost) and for atrial fibrillation for 3 years (presently treated with atenolol). Which of the following antidepressant drugs would be contraindicated for this patient?
    • A. 

      Amitriptyline

    • B. 

      Fluoxetine

    • C. 

      Sertraline

    • D. 

      Venlafaxine

    • E. 

      Bupropion

    • F. 

      Citalopram

  • 18. 
    A 54-year-old woman complained to her physician that the drug she was taking caused diarrhea. The woman, recently diagnosed with social anxiety disorder, started a therapy with paroxetine two week ago. Which of the following molecular actions in the enteric nervous system most likely mediated the adverse effect the patient was suffering from?
    • A. 

      Blockade of M3 receptors

    • B. 

      Increased serotonergic activity

    • C. 

      Activation of beta-2 receptors

    • D. 

      Increased adrenergic activity

    • E. 

      Decreased histaminergic activity

    • F. 

      Activation of GABA-A receptors

  • 19. 
    A 56-year-old man reported to his physician that the drug he was taking was quite effective in relieving his anxiety, but caused insomnia and feeling of bad sleep. The man recently diagnosed with generalized anxiety disorder started an appropriate therapy 10 days ago. Which of the following drugs most likely caused the symptoms reported by the patient?
    • A. 

      Lorazepam

    • B. 

      Amitriptyline

    • C. 

      Trazodone

    • D. 

      Lithium

    • E. 

      Fluoxetine

    • F. 

      Clozapine

  • 20. 
    A 50-year-old depressed woman was admitted to hospital for agitation, insomnia and tremors. She had been taking fluoxetine, lorazepam and mirtazapine for several months. The dose of fluoxetine and mirtazapine had just been increased. Physical examination showed a confused patient with hyperhidrosis, hyperreflexia and myoclonus, but without focal neurological deficits. Vital sings were: blood pressure 105/60 mm Hg, heart rate, 130 bpm, respiratory rate 32 breaths/min,, body temperature 37/C. Blood tests on admission showed creatinine-kinase levels of 490 U/L (normal 26-140). Qualitative plasma tests for alcohol, opioids, benzodiazepines and tricyclic antidepressants were negative. An ECG indicated sinus tachycardia. A brain CT scan was normal. Which of the following disorders most likely caused the patient’s symptoms and signs?
    • A. 

      SSRI discontinuation syndrome

    • B. 

      Mirtazapine overdose

    • C. 

      Serotonin syndrome

    • D. 

      Brain glioblastoma

    • E. 

      Benzodiazepine abstinence syndrome

    • F. 

      Cerebral hemorrhage

  • 21. 
    A 25-yo woman with a history of depression is found unconscious and brought to the emergency department after ingesting an unknown quantity of amitryptyline. Her husband says that he does not know how long she had been lying unconscious at their home. Two hours after arrival, she dies, despite appropriate lifesaving measures. Which of the following is the most likely cause of death?
    • A. 

      Aspiration of gastric contents

    • B. 

      Hepatotoxicity

    • C. 

      Lethal Arrhythmia

    • D. 

      Renal Toxicity

    • E. 

      Respiratory depression

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