Antidepressants Quiz: How Much You Know?

15 Questions | Total Attempts: 113

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Antidepressants Quiz: How Much You Know?

How much do you know about antidepressants? Antidepressants work on certain neurotransmitters in the brain. These neurotransmitters mainly include serotonin and norepinephrine, both of which play a role in boosting your mood. Antidepressants can help alleviate the signs of depression, low mood, irritability, and anxiety. If you want to learn more about antidepressants, this quiz can be of service. Take this amazing quiz and prepare to get happy.


Questions and Answers
  • 1. 
    The two types of unipolar depression are.
    • A. 

      Reactive - biochemical disorder in brain; endogenous - genetic cause

    • B. 

      Reactive - response to death; exogenous - adverse effect of some medication

    • C. 

      Reactive - response to circumstance; endogenous - biochemical disorder

  • 2. 
    Which of the following statements provides evidence for the monoamine theory of depression?
    • A. 

      Reserpine (inhibits brain storage of noradrenaline and serotonin) causes depression

    • B. 

      Reserpine (inhibits brain storage of adrenaline, histamine and acetylcholine) is a treatment for depression

    • C. 

      Amphetamine (causes release of noradrenaline) has no effect in depressed patients

  • 3. 
    Which of the following statements provides evidence against the monoamine theory of depression?
    • A. 

      Cocaine (inhibits reuptake of noradrenaline) treats depression

    • B. 

      Urinary excretion of the serotonin metabolite 5-HIAA is unchanged in depressed patients

    • C. 

      Urinary and cerebral spinal fluid concentrations of the noradrenaline metabolite MOPEG are reduced by 25% in depressed patients

  • 4. 
    The two sub-types of tricyclic antidepressants are...
    • A. 

      Dibenzazepines; dibenzocycloheptenes

    • B. 

      Hydrazines; propargylamines

    • C. 

      Piperazines; piperidines

  • 5. 
    What is the mechanism of action of TCAs?
    • A. 

      Competitive antagonist for inhibitors of neurotransmitters in synaptic cleft, meaning more re-uptake, so neurotransmitters exert effects for shorter lengths of time

    • B. 

      Non-competitive agonist for re-uptake of neurotransmitters in synaptic cleft, meaning no re-uptake, so neurotransmitters exert effects for longer

    • C. 

      Competitive antagonist for re-uptake of neurotransmitters in synaptic cleft, meaning no re-uptake, so neurotransmitters exert effects for longer

  • 6. 
    Which neurotransmitter receptors are potentially affected by TCAs?
    • A. 

      Muscarinic; histaminic; B-adrenoceptors

    • B. 

      Nicotinic; adrenergic (a and b)

    • C. 

      Histaminic; nicotinic; a-adrenoceptors

  • 7. 
    What is the mechanism of action of MAOIs?
    • A. 

      Catalyse breakdown of noradrenaline and serotonin

    • B. 

      Inhibit breakdown of noradrenaline and serotonin

    • C. 

      Inhibit breakdown of adrenaline and serotonin

  • 8. 
    What is the cheese reaction?
    • A. 

      Decreased absorption of vasoactive amines from diet; too many so pathway becomes saturated, build up; can lead to cerebral hemorrhage and death

    • B. 

      Absorption of vasoactive amines from diet, cannot be broken down, build up; can lead to cerebral hemorrhage and death

    • C. 

      Absorption of vasoactive amines from diet, cannot be broken down, build up; can lead to high intercranial pressure and fitting

  • 9. 
    What are the sub-types of MAOIs?
    • A. 

      Typical, atypical

    • B. 

      Dibenzapines, dibenzocycloheptenes

    • C. 

      Hydrazines, propargylamines, cyclopropylamines, reversible inhibitors

  • 10. 
    What is the mechanism of action of SSRIs?
    • A. 

      Selectively block serotonin reuptake into the pre-synaptic cell

    • B. 

      Non-selectively block serotonin and noradrenaline reuptake into the pre-synaptic cell

    • C. 

      Selectively increase affinity of the post-synaptic receptors for serotonin

  • 11. 
    Serotonin syndrome is...
    • A. 

      Very common; supraventricular tachycardia; high intercranial pressure and abdominal cramps

    • B. 

      An adverse effect; bradycardia and sweating; fitting and liver failure

    • C. 

      Technically a form of poisoning; tachycardia and shivering; seizures and renal failure

  • 12. 
    The theory for the 2-3 week delay in effectiveness of SSRIs is...
    • A. 

      They are administered as pro-drugs with exteremely long half-lives

    • B. 

      Autoreceptors quickly become desensitised to newly increased levels of serotonin; 2-3 weeks is the time taken for more to be synthesised

    • C. 

      They are metabolised very slowly by P450 enzymes

  • 13. 
    Noradrenaline reuptake inhibitors produce...
    • A. 

      Atropine-like side effects

    • B. 

      Alpha-block-like side effects

    • C. 

      Suicidal thoughts

  • 14. 
    L-Tryptophan is found in... and contains...
    • A. 

      Evening Primrose Oil; L-Dopa, the precursor to serotonin

    • B. 

      St John's Wort; L-Trytophan, the precursor to serotonin

    • C. 

      St John's Wort; L-Dopa, the precursor to dopamine

  • 15. 
    Lithium is administered as... and is particulraly used in...
    • A. 

      Lithium esters; preventing fluctuations in bipolar depression

    • B. 

      Lithium anhydride; stabilising the depressive phase in bipolar depression

    • C. 

      Lithium carbonate; stabilising the manic phase in bipolar depression

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