Antidepressants Quiz: How Much You Know?

15 Questions | Total Attempts: 70

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Antidepressants Quiz: How Much You Know?

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Questions and Answers
  • 1. 
    The two types of unipolar depression are.
    • A. 

      Reactive - biochemical disorder in brain; endogenous - genetic cause

    • B. 

      Reactive - response to death; exogenous - adverse effect of some medication

    • C. 

      Reactive - response to circumstance; endogenous - biochemical disorder

  • 2. 
    Which of the following statements provides evidence for the monoamine theory of depression?
    • A. 

      Reserpine (inhibits brain storage of noradrenaline and serotonin) causes depression

    • B. 

      Reserpine (inhibits brain storage of adrenaline, histamine and acetylcholine) is a treatment for depression

    • C. 

      Amphetamine (causes release of noradrenaline) has no effect in depressed patients

  • 3. 
    Which of the following statements provides evidence against the monoamine theory of depression?
    • A. 

      Cocaine (inhibits reuptake of noradrenaline) treats depression

    • B. 

      Urinary excretion of the serotonin metabolite 5-HIAA is unchanged in depressed patients

    • C. 

      Urinary and cerebral spinal fluid concentrations of the noradrenaline metabolite MOPEG are reduced by 25% in depressed patients

  • 4. 
    The two sub-types of tricyclic antidepressants are...
    • A. 

      Dibenzazepines; dibenzocycloheptenes

    • B. 

      Hydrazines; propargylamines

    • C. 

      Piperazines; piperidines

  • 5. 
    What is the mechanism of action of TCAs?
    • A. 

      Competitive antagonist for inhibitors of neurotransmitters in synaptic cleft, meaning more re-uptake, so neurotransmitters exert effects for shorter lengths of time

    • B. 

      Non-competitive agonist for re-uptake of neurotransmitters in synaptic cleft, meaning no re-uptake, so neurotransmitters exert effects for longer

    • C. 

      Competitive antagonist for re-uptake of neurotransmitters in synaptic cleft, meaning no re-uptake, so neurotransmitters exert effects for longer

  • 6. 
    Which neurotransmitter receptors are potentially affected by TCAs?
    • A. 

      Muscarinic; histaminic; B-adrenoceptors

    • B. 

      Nicotinic; adrenergic (a and b)

    • C. 

      Histaminic; nicotinic; a-adrenoceptors

  • 7. 
    What is the mechanism of action of MAOIs?
    • A. 

      Catalyse breakdown of noradrenaline and serotonin

    • B. 

      Inhibit breakdown of noradrenaline and serotonin

    • C. 

      Inhibit breakdown of adrenaline and serotonin

  • 8. 
    What is the cheese reaction?
    • A. 

      Decreased absorption of vasoactive amines from diet; too many so pathway becomes saturated, build up; can lead to cerebral hemorrhage and death

    • B. 

      Absorption of vasoactive amines from diet, cannot be broken down, build up; can lead to cerebral hemorrhage and death

    • C. 

      Absorption of vasoactive amines from diet, cannot be broken down, build up; can lead to high intercranial pressure and fitting

  • 9. 
    What are the sub-types of MAOIs?
    • A. 

      Typical, atypical

    • B. 

      Dibenzapines, dibenzocycloheptenes

    • C. 

      Hydrazines, propargylamines, cyclopropylamines, reversible inhibitors

  • 10. 
    What is the mechanism of action of SSRIs?
    • A. 

      Selectively block serotonin reuptake into the pre-synaptic cell

    • B. 

      Non-selectively block serotonin and noradrenaline reuptake into the pre-synaptic cell

    • C. 

      Selectively increase affinity of the post-synaptic receptors for serotonin

  • 11. 
    Serotonin syndrome is...
    • A. 

      Very common; supraventricular tachycardia; high intercranial pressure and abdominal cramps

    • B. 

      An adverse effect; bradycardia and sweating; fitting and liver failure

    • C. 

      Technically a form of poisoning; tachycardia and shivering; seizures and renal failure

  • 12. 
    The theory for the 2-3 week delay in effectiveness of SSRIs is...
    • A. 

      They are administered as pro-drugs with exteremely long half-lives

    • B. 

      Autoreceptors quickly become desensitised to newly increased levels of serotonin; 2-3 weeks is the time taken for more to be synthesised

    • C. 

      They are metabolised very slowly by P450 enzymes

  • 13. 
    Noradrenaline reuptake inhibitors produce...
    • A. 

      Atropine-like side effects

    • B. 

      Alpha-block-like side effects

    • C. 

      Suicidal thoughts

  • 14. 
    L-Tryptophan is found in... and contains...
    • A. 

      Evening Primrose Oil; L-Dopa, the precursor to serotonin

    • B. 

      St John's Wort; L-Trytophan, the precursor to serotonin

    • C. 

      St John's Wort; L-Dopa, the precursor to dopamine

  • 15. 
    Lithium is administered as... and is particulraly used in...
    • A. 

      Lithium esters; preventing fluctuations in bipolar depression

    • B. 

      Lithium anhydride; stabilising the depressive phase in bipolar depression

    • C. 

      Lithium carbonate; stabilising the manic phase in bipolar depression