Bio Behav Of Tumor Progres N Metastatsis

16 Questions | Total Attempts: 291

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Cancer Quizzes & Trivia

Questions and Answers
  • 1. 
    A 15 year old man followed by his physician has had painless lymphadenopathy in the right cervical region for the past 5 months. A lymph node biopsy shows many lymphocytes that are large, with clumped chromatin and occasional mitoses. The characterization of this population of lymphocytes as a neoplasm is best accomplished by:
    • A. 

      Immunohistochemical staining identifying leukocyte common antigen (LCA)

    • B. 

      Gene rearrangement studies that demonstrate monoclonality

    • C. 

      A differential white blood count showing a lymphocytosis

    • D. 

      Demonstrating fibrosis within the mass by light microscopy

  • 2. 
    Which of the following features is a definite microscopic feature of malignancy?
    • A. 

      Coarse nuclear chromatin

    • B. 

      High nuclear-cytoplasmic ratio

    • C. 

      Irregular nuclear membrane

    • D. 

      Atypical mitotic figures

    • E. 

      Prominent nucleoli

  • 3. 
    A 53-yr old woman feels a lump in her left breast. On examination, an irregular 3 cm mass seen fixed to the overlying skin, which is retracted. A mastectomy is performed; and the pathologist on sectioning the breast, finds a 3 x 3.5 cm ovoid mass that does not have discrete borders, but appears to infiltrate into surrounding stroma. The mass is firm, white and has a fibrous consistency. Which of the following features is most likely to be present on microscopic examination?
    • A. 

      Anaplasia

    • B. 

      Hyperplasia

    • C. 

      Desmoplasia

    • D. 

      Dysplasia

    • E. 

      Metaplasia

  • 4. 
    The metastatic potential of a malignant tumor would be enhanced by upregulation of the gene for which of the following proteins?
    • A. 

      Collagen type IV

    • B. 

      Desmin

    • C. 

      E-cadherin

    • D. 

      Matrix metalloproteinase

  • 5. 
    A 60-year-old woman develops a breast mass. A biopsy reveals a carcinoma. Immunoperoxidase stains for protease cathepsin D and matrix metalloproteinase-9 are markedly positive. Which of the following characteristics is most likely to be predicted by this finding
    • A. 

      Angiogenesis

    • B. 

      Invasion

    • C. 

      Monoclonality

    • D. 

      Aneuploidy

    • E. 

      Differentiation

  • 6. 
    A 66-year-old man has a routine physical examination and a stool sample proves positive for the presence of occult blood. He undergoes colonoscopy and a 5 cm sessile mass is present in the sigmoid. Biopsy of the mass yields a diagnosis of adenocarcinoma. Presence of which of the following is most likely to explain finding a mass of the cells from this neoplasm in the lung:
    • A. 

      Presence of vimentin in tumor cells

    • B. 

      Presence of keratin in tumor cells

    • C. 

      Increased laminin receptors on tumor cells

    • D. 

      Diminished apoptosis

    • E. 

      Tumor cell monoclonality

  • 7. 
    A 60-year-old man who is a chronic smoker has had a chronic cough for the past 10 yrs. He has begun to lose weight during the past year. A chest x-ray shows a right hilar mass. Lung biopsy shows a tumor comprising of malignant squamous cells. What is the most common initial pathway of spread of this lesion?
    • A. 

      Bloodstream

    • B. 

      Pleural cavity

    • C. 

      Contiguous spread to chest wall

    • D. 

      Lymphatics

    • E. 

      Seeding of body cavity

  • 8. 
    A 45-year-old woman presents to her physician with altered bowel habits. has an enlarged, non-tender lymph node that on biopsy reveals a metastatic neoplasm. Which of the following is the most likely primary neoplasm:
    • A. 

      Cerebral glioma

    • B. 

      Adenocarcinoma of colon

    • C. 

      Fibroadenoma of breast

    • D. 

      Liposarcoma of retroperitoneum

    • E. 

      Laryngeal papilloma

  • 9. 
    A 55-yr old man dies after a year-long illness. At autopsy, the liver contains multiple tumor masses 2-5 cm in size, firm and tan and that grossly resemble umbilication with central necrosis. Which of the following is most appropriate?
    • A. 

      There is multicentric origin of a benign neoplasm

    • B. 

      The neoplasm has a high grade

    • C. 

      A carcinogen was the underlying cause for the neoplasm.

    • D. 

      The neoplasm has an advanced stage

  • 10. 
    An autopsy is performed on a 56-year-old female with ascites, who was diagnosed with papillary serous cystadenocarcinoma of the ovary 3 years ago. The peritoneum is studded with small tumors and massive ascites is noted. Which of the following routes of tumor metastasis accounts for the autopsy findings?
    • A. 

      Direct tumor extension

    • B. 

      Hematogenous spread

    • C. 

      Lymphatic spread

    • D. 

      Seeding of body cavity

    • E. 

      Venous spread

  • 11. 
    Besides their local spread and a tendency to invade lymph nodes, carcinomas of the breast, thyroid and prostate share a tendency to metastasize to the same distant site. These metastasis cause an elevation of blood calcium. Name the organ involved by these distant metastases
    • A. 

      Liver

    • B. 

      Colon

    • C. 

      Bone

    • D. 

      Skin

    • E. 

      Lungs

  • 12. 
    Histologic grading of cancer is based on…
    • A. 

      Depth of invasion of normal tissue

    • B. 

      Presence of multiple activated oncogenes

    • C. 

      Degree of resemblance to normal tissue of origin

    • D. 

      No. of lymph nodes involved by metastasis

    • E. 

      No. of satellite nodules

  • 13. 
    An 80-year old man presents with a tumor on his left arm. A biopsy shows a tumor composed of spindle shaped cells suggestive of sarcoma that infiltrate the dermis. The pathologist is uncertain of the diagnosis, so he orders immunoperoxidase stains which show that the tumor is cytokeratin negative, S100 and GFAP negative, but is positive for vimentin. It can be stated that this tumor is a:
    • A. 

      Melanoma

    • B. 

      Squamous cell carcinoma

    • C. 

      Basal cell carcinoma

    • D. 

      Tumor of mesenchymal cells

    • E. 

      Tumor metastatic from glioblastoma

  • 14. 
    In order to establish the definitive diagnosis of a poorly differentiated bone tumor, the pathologist stained the section with antibodies to vimentin. Since the tumor cells were all positive, this proved that the tumor was
    • A. 

      Osteosarcoma

    • B. 

      Lymphoma

    • C. 

      Glioma

    • D. 

      Carcinoma

    • E. 

      Melanoma

  • 15. 
    A 49 year old man complains of pain in his left thigh for several months. The thigh is increased in size, compared to the right. A plain film x-ray reveals a 15 cm solid mass that does not appear to arise from bone, but has infiltrative margins. A biopsy reveals a mass composed of highly pleomorphic spindle cells suggestive of a sarcoma. Which of the following immuno-histochemical markers is most likely to be demonstrated in the cells of this mass:
    • A. 

      Cytokeratin

    • B. 

      NSE

    • C. 

      S-100

    • D. 

      Leukocyte common antigen

    • E. 

      Vimentin

  • 16. 
    A 50-yr old man presents with hematuria. An abdominal CT reveals a 2-cm right renal mass. Which of the following is the most important factor in staging of his disease?
    • A. 

      Histologic grade of tumor

    • B. 

      Metastasis to regional lymph nodes

    • C. 

      Growth rate of tumor cells

    • D. 

      Somatic mutations in p53

    • E. 

      Aneuploidy

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