Block 1 Part 2

22 Questions | Total Attempts: 234

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Development Quizzes & Trivia

1st semester mini practice exam


Questions and Answers
  • 1. 
    Dr. Thompson A 14-year-old female presents to you with a case of severe scoliosis present since birth.  Radiology shows that the curvature of her spine has caused a marked elevation of her right 1st rib.  What type of (i) motor and (ii) sensory deficits do you expect to see in her presentation? Answer:     Motor Loss in:, Sensory Loss In
    • A. 

      Abduction of the wrist ; Medial forearm

    • B. 

      Flexion of the forearm ; Lateral forearm

    • C. 

      Abduction of the arm ; Lateral arm

    • D. 

      Extension of the forearm ; Dorsum of hand

    • E. 

      Adduction of the wrist ; Medial arm

  • 2. 
    Rafael Nadal is vying for a sixth French Open title this week.  Coming into the championship match against Novak Djokavic, Rafa is feeling some pain during his “back hand” movement (extension of the forearm).  What muscles are least likely to be irritated in his forearm?
    • A. 

      Extensor carpi radialis brevis

    • B. 

      Extensor carpi radialis longus

    • C. 

      Extensor digitorum

    • D. 

      Extensor digiti minimi

    • E. 

      Extensor carpi ulnaris

  • 3. 
    Dr. Kirera  A five-year-old girl is brought to the doctor’s office after her left upper limb was violently pulled by another kid while playing at the park. The girl is screaming and appears to be in excruciating pain. She holds her injured limb in a flexed position close to her belly. Radiographic examination reveals radial head dislocation from the anular ligament of radius. The radius is also retracted proximally on the lateral side. Which of the following explains why the girl is in great pain?
    • A. 

      Trapped radial nerve

    • B. 

      Pinched anular ligament of radius

    • C. 

      Strained anconeus muscle tendons

    • D. 

      Trapped radial recurrent collateral artery

    • E. 

      Lacerated synovial membrane

  • 4. 
    Dr. Kalliecharan Which of the following cell types has an abundance of rough endoplasmic reticulum and displays a basophilic cytoplasm?
    • A. 

      Mast cell

    • B. 

      Adipocyte

    • C. 

      Plasma cell

    • D. 

      Macrophage

    • E. 

      Mesenchymal cell

  • 5. 
    During the 3rd week of development
    • A. 

      Epiblast cells migrating into the cranial end of the primitive streak forms paraxial mesoderm

    • B. 

      The embryonic disk is composed of two layers

    • C. 

      The endodermal layer migrates into the primitive streak to form the somites

    • D. 

      The endodermal layer gives rise to the skin

    • E. 

      The cardiogenic area lies at the base of the primitive streak

  • 6. 
    Which of the following basic components of connective tissue will stain acidophilic ?
    • A. 

      Type I collagen fibers

    • B. 

      Mast cells

    • C. 

      Elastic fibers

    • D. 

      Ground substance

    • E. 

      Proteoglycans and glycosaminoglycans

  • 7. 
    During the 1st and 2nd week of development
    • A. 

      The cytotrophoblasts lack plasma membranes

    • B. 

      The blastocyst is composed only of epiblast and syncytiotrophoblast

    • C. 

      The morula implants into the endometrium

    • D. 

      The syncytiotrophoblast degrades the endometrium of the uterus

    • E. 

      The prechordal plate is composed of epiblast cells

  • 8. 
    Which structure has desmosine that is involved in the cross-linking of molecules?
    • A. 

      Collagen type I

    • B. 

      Collagen type II

    • C. 

      Elastic fibers

    • D. 

      Reticular fibers

    • E. 

      Microfibrils

  • 9. 
    Which of the following is derived from ectoderm?
    • A. 

      Bones of the arm

    • B. 

      Cartilage of the trachea

    • C. 

      Simple columnar cells of the stomach

    • D. 

      Medullary region of the Adrenal gland

    • E. 

      Epidermis of skin

  • 10. 
    The basal lamina is composed of
    • A. 

      Laminins and reticular fibers

    • B. 

      Fibronectin and lamina lucida.

    • C. 

      Lamina lucida and densa

    • D. 

      Lamina lucida and lamina reticularis.

    • E. 

      Cadherins and intermediate filaments.

  • 11. 
    Dr. Larsen In the pediatric hospital, you are seeing at a one-year-old girl. In her file, there is a karyotype showing five small acrocentric chromosomes. What would be the most likely karyotype of this girl?
    • A. 

      47XYY

    • B. 

      46XX, r(16)

    • C. 

      47XX, +21

    • D. 

      45XY, rob(14;21)

    • E. 

      47XX, +22

  • 12. 
    In the pedigree below is shown a family where two people are affected by benign neonatal epilepsy, a disease that shows a carrier risk in the population of 1/100. Person II-3 marries a healthy woman and has a healthy daughter. The daughter marries a healthy, unrelated man; based on your best estimate of the inheritance pattern of this disease, what is the best estimate of the risk that they will have an affected child?                            
    • A. 

      1 in 800

    • B. 

      1 in 50

    • C. 

      1 in 100

    • D. 

      1 in 200

    • E. 

      1 in 400

  • 13. 
    The q-arm of an acrocentric chromosome has exchanged places with the p-arm of a submetacentric chromosome; both breakpoints are in band 12 of the respective chromosome arm. There are 46 chromosomes in the karyotype. The individual has a normal phenotype. This rearrangement represents which of the following?
    • A. 

      Balanced Robertsonian translocation

    • B. 

      Paracentric inversion

    • C. 

      Balanced reciprocal translocation

    • D. 

      Unbalanced reciprocal translocation

    • E. 

      Unbalanced Robertsonian translocation

  • 14. 
     A study reported three families with several members showing loss or eyesight, type I microtia, and microdontia with widely spaced teeth. Most patients in addition have heart problems. This description best fits with which genetic concept?
    • A. 

      Locus heterogeneity

    • B. 

      Contigous gene disorder

    • C. 

      Allelic heterogeneity

    • D. 

      Pleiotropy

    • E. 

      Fitness

  • 15. 
    Dr. Meisenberg Coffee is a stimulant that can enhance effects of the autonomic nervous system. It is especially likely to enhance effects that are mediated by
    • A. 

      β-adrenergic receptors

    • B. 

      Nicotinic acetylcholine receptors

    • C. 

      Muscarinic acetylcholine receptors

    • D. 

      α1-adrenergic receptors

    • E. 

      α2-adrenergic receptors

  • 16. 
    A pharmaceutical company is developing a new anti-obesity drug. In-vitro screening tests show that one of the side effects of this drug is the inhibition of the constitutive nitric oxide synthase. One likely side effect of this drug is
    • A. 

      Hypoglycemia

    • B. 

      Insulin resistance

    • C. 

      Diarrhea

    • D. 

      Hypertension

    • E. 

      Long-lasting erections

  • 17. 
     Dr. Sands Fred is married to Helen, who was previously married to George, now deceased.  George and Helen conceived one child together and adopted one child.  Fred and Helen have also conceived one child.  All members of Helen’s current family have had DNA fingerprinting done at a single VNTR locus.   Unfortunately, the sheet that identified each child has been misplaced.  Identify which fingerprint in each lane (in lanes 5, 6, and 7) correspond to each child. (see question 37 for image) Which child was adopted by George and Helen?
    • A. 

      Child 2

    • B. 

      Child 3

    • C. 

      Child 1

    • D. 

      Not enough information to tell

  • 18. 
    • A. 

      A mutation in a cell-surface mitogen receptor that made it active even in the absence of its mitogen ligand

    • B. 

      A mutation that destroyed the kinase activity of the S-cyclin-Cdk complex

    • C. 

      A mutation that allowed the kinase subunit of the G1-Cdk complex to be active independent of its phosphorylation status

    • D. 

      A mutation that prevented binding of Rb to gene regulatory proteins

  • 19. 
    Dr. Smolanoff A deficiency of each of the following enzymes of the Embden-Myerhof glycolytic pathway leads to a nonspherocytic hemolytic anemia. A deficiency of which of the following enzymes leads to an increase in 2,3-bisphosphoglycerate levels in erythrocytes?
    • A. 

      Aldolase

    • B. 

      Pyruvate kinase

    • C. 

      Phosphoglucose isomerase

    • D. 

      Hexokinase

    • E. 

      Triose phosphate isomerase

  • 20. 
    Streptococcus mutans, found in dental plaque, produces lactic acid from the metabolism of carbohydrates. Topical fluoride treatment in the dental office can slow the production of lactic acid, resulting in the accumulation of which metabolite?
    • A. 

      Glucose-6-phosphate

    • B. 

      Fructose-1,6-bisphosphate

    • C. 

      Glyceraldehyde-3-phosphate

    • D. 

      2-phosphoglycerate

    • E. 

      Phosphoenolpyruvate

  • 21. 
    What is meant by the steady-state assumption that underlies the Michaelis-Menton relationship between substrate concentration and reaction velocity?
    • A. 

      ) The reaction velocity is linearly related to substrate concentration

    • B. 

      The rate of breakdown of the enzyme-substrate complex equals the rate of formation of the complex

    • C. 

      The reaction velocity is independent of substrate concentration

    • D. 

      The rate of formation of product equals the rate of disappearance of substrate

    • E. 

      The amount of enzyme remains constant

  • 22. 
    The statin drugs, e.g, Mevacor(Lovastatin), bind noncovalently to the enzyme HMG-CoA reductase because they mimic the transition state of the enzyme. This means they:
    • A. 

      Are irreversible in their action.

    • B. 

      Are considered suicide inhibitors.

    • C. 

      Bind to the allosteric site of the enzyme.

    • D. 

      Make the binding of the substrate appear tighter, i.e., appear to make Km of the enzyme smaller.

    • E. 

      Compete with the substrate HMG-CoA for binding to the active site