Bio1334 Genetics - Molecular Genetics - Origins Of Variation In Genomes (Lectures 8 And 9)

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Bio1334 Genetics - Molecular Genetics - Origins Of Variation In Genomes (Lectures 8 And 9)

Lecture 8​1. Demonstrate a sound understanding of the molecular basis of genetic variation2. Appreciate that some types of genetic variation may have phenotypic effects3. Demonstrate understanding of the nature of gene mutation Lecture 9Differentiate between mitosis and meiosis Describe the essential features of homologous recombination Appreciate in outline the mechanisms of homologous recombination Diagram eukaryotic gene targeting by homologous recombination Diagram recombination in bacteria


Questions and Answers
  • 1. 
    True or False?"Monozygotic twins have no genomic differences."
    • A. 

      True

    • B. 

      False

  • 2. 
    True or False?"Monozygotic twins have no epigenetic differences."
    • A. 

      True

    • B. 

      False

  • 3. 
    Two or more alleles of a gene, common in a population are termed ____________.
  • 4. 
    Complete the sentence below:The sequencing method Sanger (chain-termination) produces a typical sequence of length ________ bases.
  • 5. 
    Complete the sentence below:Next-generation sequencing (NGS) is a sequencing method that produces gene sequences of typical length _______ bases.
  • 6. 
    Approximately what percentage of the human genome contains SNPs?
  • 7. 
    Complete the sentence below:Insertion or deletion of a base in a genetic sequence (INDELs) results in a ___________ mutation, meaning all codons thereafter the single point mutation are affected.
  • 8. 
    True or False?"A mutated version of an allele is referred to as the wild type."
    • A. 

      True

    • B. 

      False

  • 9. 
    What are Mendelian disorders?
    • A. 

      Disorders caused by the inheritance of a single causative (mutant) gene.

    • B. 

      Disorders caused by the inheritance of several causative (mutant) genes.

    • C. 

      Disorders that have a late onset.

    • D. 

      Disorders that are unrelated to any mutations within the genes.

  • 10. 
    Complete the sentence below:Intercalating agents are ________ molecules that intercalate between base pairs, causing a frame-shift mutation.
  • 11. 
    Which of the following is correct?
    • A. 

      Mitosis occurs in somatic cells, resulting in two genetically identical daughter cells.

    • B. 

      Mitosis occurs in somatic cells, resulting in two genetically different daughter cells.

    • C. 

      Mitosis occurs in somatic cells, resulting in four genetically identical daughter cells.

    • D. 

      Mitosis occurs in somatic cells, resulting in four genetically different daughter cells.

    • E. 

      Mitosis occurs in sex cells, resulting in four genetically different daughter cells.

    • F. 

      Mitosis occurs in sex cells, resulting in two genetically identical daughter cells.

  • 12. 
    Complete the following sentence:Homologous combination occurs during the process of _________ within eukaryotes. It is the breakage and joining of DNA.
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