Bio1334 Genetics - Molecular Genetics - Origins Of Variation In Genomes (Lectures 8 And 9)
Lecture 8
1. Demonstrate a sound understanding of the molecular basis of genetic variation2. Appreciate that some types of genetic variation may have phenotypic effects
3. Demonstrate understanding of the nature of gene mutation
Lecture 9Differentiate between mitosis and meiosis Describe the essential features of homologous recombination Appreciate in outline the mechanisms of homologous recombination Diagram eukaryotic gene targeting by homologous recombination Diagram recombination in bacteria
- 1.
True or False?"Monozygotic twins have no genomic differences."
- A.
True
- B.
False
Correct Answer
A. True -
- 2.
True or False?"Monozygotic twins have no epigenetic differences."
- A.
True
- B.
False
Correct Answer
B. False -
- 3.
Two or more alleles of a gene, common in a population are termed ____________.
Correct Answer
polymorphisms - 4.
Complete the sentence below:The sequencing method Sanger (chain-termination) produces a typical sequence of length ________ bases.
Correct Answer
800
8 hundred
eight hundred
eight-hundred - 5.
Complete the sentence below:Next-generation sequencing (NGS) is a sequencing method that produces gene sequences of typical length _______ bases.
Correct Answer
100 - 6.
Approximately what percentage of the human genome contains SNPs?
Correct Answer
0.1
0.1% - 7.
Complete the sentence below:Insertion or deletion of a base in a genetic sequence (INDELs) results in a ___________ mutation, meaning all codons thereafter the single point mutation are affected.
Correct Answer
Frameshift
Frame shift
Frame-shift - 8.
True or False?"A mutated version of an allele is referred to as the wild type."
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
The normal allele/organism is termed 'wild type'.Rate this question:
-
- 9.
What are Mendelian disorders?
- A.
Disorders caused by the inheritance of a single causative (mutant) gene.
- B.
Disorders caused by the inheritance of several causative (mutant) genes.
- C.
Disorders that have a late onset.
- D.
Disorders that are unrelated to any mutations within the genes.
Correct Answer
A. Disorders caused by the inheritance of a single causative (mutant) gene. -
- 10.
Complete the sentence below:Intercalating agents are ________ molecules that intercalate between base pairs, causing a frame-shift mutation.
Correct Answer
Planar - 11.
Which of the following is correct?
- A.
Mitosis occurs in somatic cells, resulting in two genetically identical daughter cells.
- B.
Mitosis occurs in somatic cells, resulting in two genetically different daughter cells.
- C.
Mitosis occurs in somatic cells, resulting in four genetically identical daughter cells.
- D.
Mitosis occurs in somatic cells, resulting in four genetically different daughter cells.
- E.
Mitosis occurs in sex cells, resulting in four genetically different daughter cells.
- F.
Mitosis occurs in sex cells, resulting in two genetically identical daughter cells.
Correct Answer
A. Mitosis occurs in somatic cells, resulting in two genetically identical daughter cells. -
- 12.
Complete the following sentence:Homologous combination occurs during the process of _________ within eukaryotes. It is the breakage and joining of DNA.
Correct Answer
Meiosis
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Nov 11, 2015Quiz Edited by
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Nov 11, 2015Quiz Created by
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