Bio13312 Biochemistry - Lecture Nine - Enzymes And Coenzymes

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Bio13312 Biochemistry - Lecture Nine - Enzymes And Coenzymes

To introduce the six main classes of enzymeTo look at the effect of enzymes on reaction energetics. To introduce co-enzymes and co-factors. To consider general mechanisms of catalysis with a detailed case study on serine proteases.


Questions and Answers
  • 1. 
    Name 3 of the 6 main classes of enzyme.(Your answers will not be assessed, but you can check them in the feedback section below once you've submitted your answer.)
  • 2. 
    Complete the following sentence:For a favourable reaction, the products have _____ energy than the reactants.
    • A. 

      Lower

    • B. 

      Higher

    • C. 

      The same

  • 3. 
    What do catalysts do?
    • A. 

      Reduce activation energy

    • B. 

      Increase activation energy

    • C. 

      Make a thermodynamically unfavourable reaction favourable

  • 4. 
    Please fill answer below:The 'pocket' on the enzyme where the substrate fits is called the _____________.
  • 5. 
    Tight binding to either an enzyme or product is bad for catalysts.True or False?
    • A. 

      True

    • B. 

      False

  • 6. 
    Please complete the following sentence:Combination of a protein and co-factor/co-enzyme is called a ______________.
  • 7. 
    Please fill answer below:The protein alone without a co-factor/co-enzyme is called an ______________.
  • 8. 
    Please fill answer below: General acid-base catalyst enzymes stabilise unstable charged intermediates by transferring _______ to and from the intermediate – thereby decreasing the free energy of the transition state.
  • 9. 
    The ionic interactions between the enzyme bound metal and the substrate can:
    • A. 

      Orient a substrate for reaction

    • B. 

      Stabilise charged reaction states

    • C. 

      Mediate oxidation-reduction reactions

    • D. 

      All of the above

  • 10. 
    Serine proteases use a combination of _________ and ________ catalysis to hydrolyse proteins.
    • A. 

      Acid-base and covalent

    • B. 

      Acid-base and metal ion

    • C. 

      Metal ion and covalent