Opthalmic Drugs And Properties Quiz

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  • 1/55 Questions

    Dapiprazole and thymoxamine can be used to reverse mydriasis caused by phenylephrine (have a think about why that is).

    • True
    • False
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About This Quiz

Each part of the body comes with its fair share of potential ailments and shortcomings, and today we’ll be looking at one of the most important organs we possess – eyes! In this ophthalmic drugs and properties quiz we’ll see how much you really know about your eyes and the diseases and treatments that go along with them.

Opthalmic Drugs And Properties Quiz - Quiz

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  • 2. 

    It's used as a miotic in the united states and may come to the UK

    Explanation
    Dapiprazole is used as a miotic in the United States and may come to the UK. A miotic is a substance that causes constriction of the pupil of the eye. Dapiprazole is commonly used in ophthalmology to reverse the dilation of the pupil caused by mydriatic drugs, which are used to dilate the pupil for various eye examinations and procedures. It helps to restore normal pupil size and improve visual clarity. The statement suggests that dapiprazole is currently not available in the UK but there is a possibility that it may be introduced in the future.

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  • 3. 

    What are the 6 major therapeutic drug groups?

    Explanation
    The 6 major therapeutic drug groups are cardiovascular, CNS (central nervous system), respiratory, gastrointestinal, infection, and endocrine. These groups represent different areas of the body or specific conditions that drugs are used to treat. Cardiovascular drugs are used to treat conditions related to the heart and blood vessels. CNS drugs target the brain and nervous system. Respiratory drugs are used to treat conditions affecting the lungs and airways. Gastrointestinal drugs are used to treat digestive system disorders. Infection drugs are used to treat bacterial, viral, or fungal infections. Endocrine drugs are used to regulate hormone levels and treat endocrine disorders.

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  • 4. 

    Some evidence shows Ocuvite (PreserVision AREDS formula) may be beneficial for some patients who are at high risk of developing AMD (it may slow rate of progression). what are some contraindications for these supplements?

    Explanation
    The given answer states that contraindications for taking Ocuvite (PreserVision AREDS formula) supplements include diabetes, smoking, and vascular disease. This means that individuals with these conditions should avoid or be cautious when taking these supplements. This is because the evidence suggests that these supplements may not be beneficial or may even have negative effects on individuals with diabetes, smoking habits, or vascular disease. Therefore, it is recommended to avoid these supplements if one has any of these conditions.

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  • 5. 

    What is fluorescein used for?

    Explanation
    Fluorescein is used for assessing corneal integrity, tear break-up time (TBUT), applanation tonometry, contact lens fitting, and nasal duct patency. It is commonly used in ophthalmology to detect corneal abrasions or ulcers, evaluate tear film stability, measure intraocular pressure, fit contact lenses, and assess the patency of the nasal lacrimal duct.

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  • 6. 

    What drug is on the GSL, P, and POM lists? (think about what its used for)

    Explanation
    Sodium cromoglicate is listed on the GSL (General Sales List), P (Pharmacy) and POM (Prescription Only Medicines) lists. This suggests that it is available for purchase over the counter without a prescription, as well as being prescribed by a healthcare professional. Sodium cromoglicate is commonly used as a medication for treating allergic conditions such as hay fever and allergic conjunctivitis.

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  • 7. 

    Aciclovir and ganciclovir inhibit what?

    Explanation
    Aciclovir and ganciclovir are antiviral drugs that work by inhibiting viral DNA polymerase. DNA polymerase is an enzyme that plays a crucial role in the replication and synthesis of viral DNA. By inhibiting this enzyme, aciclovir and ganciclovir prevent the virus from replicating and spreading within the body. This ultimately helps to control and treat viral infections caused by DNA viruses such as herpes simplex virus and cytomegalovirus.

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  • 8. 

    What 6 information sources can be used to discover previously reported OARs specific to a particular drug or drug group?

    Explanation
    The correct answer includes six information sources that can be used to discover previously reported OARs (adverse reactions) specific to a particular drug or drug group. These sources are BNF (British National Formulary), eMC (electronic Medicines Compendium), emedINFO, MHRA (Medicines and Healthcare products Regulatory Agency), MIMS (Monthly Index of Medical Specialities), and texts. These sources are commonly used in healthcare settings to access comprehensive and up-to-date information about medications, including their potential adverse effects.

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  • 9. 

    Pharmacokinetics concerns what 5 processes (in order)?

    Explanation
    Pharmacokinetics is the study of how a drug is absorbed, distributed, metabolized, and eliminated by the body. The correct answer lists the five processes in the correct order: absorption, distribution, localization in tissues, biotransformation, and excretion. Absorption refers to the process by which a drug enters the bloodstream. Distribution involves the transport of the drug throughout the body. Localization in tissues refers to the drug's accumulation in specific tissues or organs. Biotransformation is the metabolism of the drug by enzymes in the body. Excretion is the elimination of the drug from the body, typically through urine or feces.

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  • 10. 

    What are most common causes of dry eye?

    Explanation
    Dry eye is a condition characterized by insufficient tear production or poor tear quality, leading to discomfort and irritation. The most common causes of dry eye are environmental factors such as dry climate, wind, and exposure to smoke or dust. Age is another significant factor, as tear production tends to decrease with age. Allergies can also contribute to dry eye symptoms, as the body's immune response can trigger inflammation in the eyes, leading to reduced tear production.

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  • 11. 

    Name the different pharmacological groups that miotics are drawn from (plural). 

    Explanation
    The different pharmacological groups that miotics are drawn from are adrenergic blockers, anticholinesterases, and parasympathomimetics. Miotics are a class of drugs that cause constriction of the pupil and increase the outflow of aqueous humor in the eye. Adrenergic blockers work by blocking the action of adrenaline, anticholinesterases inhibit the breakdown of acetylcholine, and parasympathomimetics mimic the action of the parasympathetic nervous system. All three of these pharmacological groups have different mechanisms of action but ultimately result in pupil constriction and increased outflow of aqueous humor.

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  • 12. 

    Drugs in the systemic circulation are transformed how?

    • Hydrolysis

    • Phagocytosis

    • Complex formation

    • Oxidation

    • Reduction

    Correct Answer(s)
    A. Hydrolysis
    A. Oxidation
    A. Reduction
    Explanation
    Drugs in the systemic circulation can undergo various transformations. Hydrolysis is a process in which the drug molecule is broken down into smaller components by the addition of water. Oxidation involves the drug molecule gaining oxygen or losing hydrogen, resulting in the formation of metabolites. Reduction, on the other hand, involves the drug molecule gaining hydrogen or losing oxygen. These transformations can occur in the liver or other tissues, and they play a crucial role in the metabolism and elimination of drugs from the body.

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  • 13. 

    What are some alternatives to cycloplegia?

    Correct Answer(s)
    autorefractors, fogging, mohindra technique
    Explanation
    Autorefractors, fogging, and the Mohindra technique are all alternative methods to cycloplegia. Autorefractors are instruments used to measure the refractive error of the eye without the need for cycloplegia. Fogging involves temporarily blurring the vision in order to relax the eye's focusing mechanism and obtain a more accurate refraction. The Mohindra technique is a method of subjective refraction that uses a trial frame and lenses to determine the best prescription for the patient. These alternatives can be used when cycloplegia is not desired or contraindicated.

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  • 14. 

    Atropine can be described as:

    • Acts on sclera to stop myopia progression

    • Alpha adrenergic antagonist

    • Causes pupil dilation

    • Causes cycloplegia

    • Causes change in AC/A ratio

    • Blocks only M3 receptors

    Correct Answer(s)
    A. Acts on sclera to stop myopia progression
    A. Causes pupil dilation
    A. Causes cycloplegia
    A. Causes change in AC/A ratio
  • 15. 

    Tick the drugs that need to be refridgerated

    • Thymoxamine

    • Tropicamide

    • Chloramphenicol minims

    • Fusidic acid

    • Polymyxin

    • Lidocaine

    • Proxymetacaine

    Correct Answer(s)
    A. Thymoxamine
    A. Chloramphenicol minims
    A. Proxymetacaine
    Explanation
    Thymoxamine, chloramphenicol minims, and proxymetacaine need to be refrigerated because they are all sensitive to temperature and require cold storage to maintain their stability and effectiveness. Refrigeration helps to prevent degradation and maintain the potency of these drugs.

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  • 16. 

    When are the adverse reactions to topical anaesthetics (10)?

    Correct Answer(s)
    corneal vulnerability, inhibited epithelial cell growth, increased corneal thickness, hypersensitivity, lightheadedness, reduced: IOP, tear flow, oxygen uptake, syncope, tinnitus,
  • 17. 

    What are 7 reasons why systemic and Ocular AR's peak around the age of 70-75?

    Correct Answer(s)
    decreased glomerular filtration rate, impaired liver or kidney function, multiple drug therapy, reduction in: brain mass, neurone density, and cerebral blood flow, slower metabolism
    Explanation
    As individuals age, there are several physiological changes that occur in the body. The decreased glomerular filtration rate refers to the decline in kidney function, which can affect the elimination of drugs from the body. Impaired liver or kidney function can also impact the metabolism and clearance of medications. Multiple drug therapy is common in older adults, which can increase the risk of drug interactions and adverse effects. Reduction in brain mass, neurone density, and cerebral blood flow can lead to cognitive decline and increased vulnerability to certain diseases. Slower metabolism is a natural part of aging and can affect the absorption and elimination of drugs. Together, these factors contribute to the peak of systemic and ocular adverse reactions in individuals around the age of 70-75.

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  • 18. 

    What are four components of the inflammatory response that need to be taken into account for pharmaceutical anti-inflammatory agents?

    Correct Answer(s)
    fibroblast, histamine, leukocytes, prostaglandins and leukotrienes
    Explanation
    The correct answer includes fibroblast, histamine, leukocytes, prostaglandins, and leukotrienes. These components are all involved in the inflammatory response. Fibroblasts are cells that produce connective tissue and play a role in wound healing. Histamine is released during an inflammatory response and causes blood vessels to dilate and become more permeable. Leukocytes, or white blood cells, are responsible for immune response and fighting off infections. Prostaglandins and leukotrienes are lipid compounds that are involved in the inflammatory process and can cause pain and swelling. Therefore, all of these components are important to consider when developing pharmaceutical anti-inflammatory agents.

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  • 19. 

    It's used to treat angina pectoris and cardiac arrhythmias

    Correct Answer(s)
    propranalol
    Explanation
    Propranolol is a medication that is commonly used to treat angina pectoris and cardiac arrhythmias. Angina pectoris is a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart, and propranolol helps by reducing the workload on the heart and improving blood flow. Cardiac arrhythmias refer to irregular heart rhythms, and propranolol can help regulate these rhythms by blocking certain receptors in the heart. Therefore, propranolol is an appropriate choice for treating both angina pectoris and cardiac arrhythmias.

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  • 20. 

    Powerful antihypertensive drug

    Correct Answer(s)
    guanethidine
    Explanation
    Guanethidine is a powerful antihypertensive drug. It works by blocking the release of certain chemicals in the body that can increase blood pressure. By inhibiting the release of these chemicals, guanethidine helps to lower blood pressure and reduce the risk of complications associated with hypertension. Therefore, guanethidine is considered a powerful antihypertensive drug.

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  • 21. 

    Used for raynaud's but produces a burning sensation when instilled in the eye (minims 0.5%-no longer produced)

    Correct Answer(s)
    thymoxamine
    Explanation
    Thymoxamine is a medication that was previously used for the treatment of Raynaud's phenomenon. However, when it is instilled in the eye, it can cause a burning sensation. This side effect is likely the reason why the medication is no longer produced in the form of minims with a concentration of 0.5%.

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  • 22. 

    List the irreversible anticholinesterases 

    Correct Answer(s)
    DFP, demacarium, ecothiophate
    Explanation
    DFP, demacarium, and ecothiophate are listed as irreversible anticholinesterases. Anticholinesterases are a class of drugs that inhibit the action of acetylcholinesterase, an enzyme responsible for breaking down acetylcholine in the body. By inhibiting this enzyme, these drugs increase the levels of acetylcholine, a neurotransmitter involved in various bodily functions. DFP, demacarium, and ecothiophate are considered irreversible anticholinesterases because they form a covalent bond with the enzyme, permanently inactivating it. This leads to prolonged elevation of acetylcholine levels, which can have therapeutic effects in conditions such as myasthenia gravis or glaucoma.

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  • 23. 

    Used for treatment of accomodative squints with convergence excess although procedure carries risk of iris cysts. 

    Correct Answer(s)
    ecothiophate iodide
    Explanation
    Ecothiophate iodide is a medication that is used for the treatment of accommodative squints with convergence excess. However, it is important to note that this procedure carries the risk of iris cysts.

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  • 24. 

    Used to treat myasthenia gravis 

    Correct Answer(s)
    neostigmine
    Explanation
    Neostigmine is a medication that is commonly used to treat myasthenia gravis. Myasthenia gravis is a neuromuscular disorder that causes muscle weakness and fatigue. Neostigmine works by inhibiting the enzyme acetylcholinesterase, which increases the levels of acetylcholine in the body. Acetylcholine is a neurotransmitter that is responsible for transmitting signals between nerve cells and muscles. By increasing acetylcholine levels, neostigmine helps to improve muscle strength and function in individuals with myasthenia gravis. Therefore, neostigmine is the correct answer for this question.

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  • 25. 

    What are the six factors affecting the pharmacokinetics of an ocular drug?

    Correct Answer(s)
    administration, surface drainage and retention, vascular absorption, tear layer, corneal penetration, excretion
    Explanation
    The six factors that affect the pharmacokinetics of an ocular drug are administration, surface drainage and retention, vascular absorption, tear layer, corneal penetration, and excretion. Administration refers to the method of delivering the drug to the eye, while surface drainage and retention relate to the movement of the drug on the ocular surface. Vascular absorption refers to the drug's absorption into the blood vessels of the eye, while tear layer refers to the tears present on the ocular surface. Corneal penetration refers to the drug's ability to penetrate the cornea, and excretion refers to the elimination of the drug from the eye.

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  • 26. 

    What are 8 additional factors that may effect drug absorption?

    Correct Answer(s)
    age, body-weight, gender, time of administration, tolerance, drug interaction, genetic factors, pathology
    Explanation
    The absorption of a drug can be influenced by various factors. Age plays a role as the metabolic rate and organ function may change with age. Body weight can affect drug distribution as some drugs may be stored in fat tissues. Gender differences in physiology can also impact drug absorption. The time of administration can influence absorption rates due to circadian rhythms. Tolerance to a drug can develop over time, affecting absorption. Drug interactions with other medications can alter absorption rates. Genetic factors can affect drug metabolism and absorption. Lastly, underlying pathologies or diseases can impact drug absorption due to changes in organ function or blood flow.

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  • 27. 

    How can the efficacy of administration of drug be maximized (4)

    Correct Answer(s)
    instillation technique, pH (reflex tearing), viscosity, dosage
    Explanation
    To maximize the efficacy of drug administration, several factors need to be considered. The instillation technique is crucial as it ensures that the drug is properly delivered to the intended site. The pH of the drug can affect reflex tearing, which can further enhance drug absorption. Viscosity plays a role in the drug's ability to spread and penetrate the target area effectively. Lastly, the dosage needs to be carefully determined to ensure that it is neither too low to be ineffective nor too high to cause adverse effects. By considering these factors, the administration of the drug can be optimized for maximum efficacy.

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  • 28. 

    What affects the surface drainage and retention of a drug? (4)

    Correct Answer(s)
    small capacity of palpebral aperture, tear secretion rate, blink rate, nasal punctal occlusion
    Explanation
    The surface drainage and retention of a drug can be affected by several factors. One of these factors is the small capacity of the palpebral aperture, which refers to the size of the opening between the eyelids. A smaller aperture may limit the amount of drug that can be drained from the surface of the eye. Tear secretion rate is another important factor, as tears help to flush out foreign substances from the eye. A higher tear secretion rate may result in faster drainage of the drug. Blink rate also plays a role, as blinking helps to distribute tears and promote drainage. Finally, nasal punctal occlusion, which refers to the blockage of the tear drainage system, can affect the retention of the drug on the eye's surface.

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  • 29. 

    What 6 components are incorporated into a multipurpose CL's?

    Correct Answer(s)
    biocides, surfactants, chelating agents, demulcents, propylene glycol, buffering agents.
  • 30. 

    CLP's (contact lens products) are designed to aid in what?

    Correct Answer(s)
    antibacterial, insertion and removal of lens, maintenance of optical properties of lens
    Explanation
    CLP's (contact lens products) are designed to aid in maintaining the cleanliness and hygiene of contact lenses by providing antibacterial properties. They also assist in the proper insertion and removal of lenses, ensuring ease and comfort for the wearer. Additionally, CLP's help in maintaining the optical properties of the lens, ensuring clear vision and optimal performance.

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  • 31. 

    What are some tonicity and buffering agents?

    Correct Answer(s)
    borates, citrates, phosphates
    Explanation
    Borates, citrates, and phosphates are commonly used as tonicity and buffering agents. Tonicity agents help maintain the osmotic pressure and stability of a solution, while buffering agents help maintain the pH level of a solution. Borates, citrates, and phosphates are effective in controlling the pH and tonicity of various solutions, making them suitable for a wide range of applications such as pharmaceuticals, cosmetics, and food products.

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  • 32. 

    What drugs are commonly used in an emergencies?

    Correct Answer(s)
    fluorecein, saline, anaesthetic, artificial tears, AS agents
    Explanation
    These drugs are commonly used in emergencies for different purposes. Fluorescein is a dye used to diagnose corneal injuries or foreign bodies. Saline is a sterile solution used for various purposes like wound cleansing or rehydrating patients. Anesthetics are used to numb an area or provide pain relief during procedures. Artificial tears are used to lubricate the eyes and relieve dryness or irritation. AS agents refer to antiseptic agents used for disinfection purposes. Overall, these drugs are essential in emergency situations to diagnose, treat, and provide relief to patients.

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  • 33. 

    What must be included on a record for a patient in an emergency?

    Correct Answer(s)
    name, address, date, corrected and uncorrected vision, procedure carried out, advice given to patient, refer if serious and inform GP
    Explanation
    In an emergency, it is important to have a comprehensive record for a patient. This includes their name, address, and the date of the emergency. Additionally, the record should include information about the patient's corrected and uncorrected vision, as this can be crucial for medical professionals to understand the patient's condition. The procedure carried out during the emergency should also be documented, along with any advice given to the patient. If the situation is serious, it is necessary to refer the patient to appropriate specialists and inform their general practitioner (GP) for further follow-up.

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  • 34. 

    What are the emergency situations?

    Correct Answer(s)
    acute ocular pathology, adverse response to drug instillation, harmful chemical agents, superficial foreign bodies
    Explanation
    The correct answer includes a list of emergency situations related to eye health. These situations include acute ocular pathology, which refers to sudden and severe eye conditions such as infections or injuries. Adverse response to drug instillation refers to unexpected reactions or complications that can occur after applying medication to the eye. Harmful chemical agents can cause eye injuries or burns, and superficial foreign bodies are objects that get stuck on the surface of the eye. These emergency situations require immediate medical attention to prevent further damage or complications.

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  • 35. 

    What are some types of syncope?

    Correct Answer(s)
    neurally mediated (reflex), orthostatic hypotension, cardiac
    Explanation
    The correct answer lists three types of syncope: neurally mediated (reflex), orthostatic hypotension, and cardiac. Neurally mediated syncope refers to fainting caused by an abnormal reflex response in the nervous system. Orthostatic hypotension occurs when there is a sudden drop in blood pressure upon standing up. Cardiac syncope is caused by a heart condition that disrupts the normal blood flow to the brain. These three types represent different underlying causes of syncope, highlighting the importance of identifying the specific type in order to provide appropriate treatment and management.

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  • 36. 

    Dry eye can be caused by what ocular abnormalities? and what other factors?

    Correct Answer(s)
    aqueous, mucin, lipid deficiences, epitheliopathy, impaired lid function, adverse reaction to systemic medication, secondary to systemic or dermatological disease
    Explanation
    Dry eye can be caused by various ocular abnormalities such as aqueous, mucin, and lipid deficiencies, as well as epitheliopathy and impaired lid function. Additionally, an adverse reaction to systemic medication or secondary to systemic or dermatological disease can also contribute to dry eye symptoms. These factors can all disrupt the normal tear film and lead to dryness and discomfort in the eyes.

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  • 37. 

    What methods can be used to assess quality and quantity of tears?

    Correct Answer(s)
    see second year lecture notes
  • 38. 

    What are some alternatives to artificial tears?

    Correct Answer(s)
    horomone therapy, corticosteroids, NSAID's, diet
    Explanation
    The question asks for alternatives to artificial tears. The correct answer includes hormone therapy, corticosteroids, NSAIDs, and diet. These alternatives suggest different approaches to address dry eyes. Hormone therapy can help balance hormonal levels that may be causing dryness. Corticosteroids can reduce inflammation in the eyes, relieving dryness. NSAIDs can also help reduce inflammation and provide relief. Finally, diet changes, such as increasing omega-3 fatty acids, can improve tear production and reduce dryness. These alternatives offer different options for managing dry eyes beyond artificial tears.

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  • 39. 

    What precautions must be taken prior to dilation?

    Correct Answer(s)
    advise px, check: angle, iop, iol, sx, va, miotic on hand
    Explanation
    Prior to dilation, it is important to advise the patient about the procedure and its potential effects. Additionally, the healthcare provider should check the angle of the patient's eye, intraocular pressure (IOP), intraocular lens (IOL), any previous eye surgeries (sx), visual acuity (VA), and have a miotic agent on hand. These precautions are necessary to ensure the safety and effectiveness of the dilation procedure.

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  • 40. 

    What are some types of medications that cannot be used with phenylephrine? (also, have a think about contraindications for mydriasis in general).

    Correct Answer(s)
    cardiovascular medication, depression medication, pilocarpine (pupil block)
    Explanation
    Phenylephrine is a medication commonly used as a decongestant and to dilate the pupils. It works by constricting blood vessels and can potentially interact with other medications. Cardiovascular medications, such as beta-blockers or alpha-blockers, may have conflicting effects with phenylephrine and can lead to increased blood pressure or heart rate. Depression medications, such as monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, can also interact with phenylephrine and cause a dangerous increase in blood pressure. Pilocarpine, a medication used to constrict the pupils, can block the effects of phenylephrine and reduce its effectiveness in dilating the pupils.

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  • 41. 

    When can topical anaesthetics be used (9)?

    Correct Answer(s)
    CL's, contact tonometry, contact ultrasound, cycloplegic refraction, gonioscopy, punctal plug fitting, SFB's, sustained fixation, tear assessment
    Explanation
    Topical anaesthetics can be used in various procedures and assessments such as contact lens fitting (CL's), contact tonometry, contact ultrasound, cycloplegic refraction, gonioscopy, punctal plug fitting, sustained fixation, and tear assessment. These procedures often involve direct contact with the eye or its surrounding structures, which can cause discomfort or pain. Topical anaesthetics are applied to numb the surface of the eye, providing temporary relief and ensuring a more comfortable experience for the patient during these procedures.

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  • 42. 

    Other than cycloplegic refraction, what can cycloplegics be used for?

    Correct Answer(s)
    amblyopia, corneal abrasion, postoperative use, uveitis
    Explanation
    Cycloplegics can be used for various purposes other than cycloplegic refraction. They can be used in the treatment of amblyopia, which is a condition where one eye has significantly reduced vision. Cycloplegics can also be used for corneal abrasion, which is a scratch or injury to the cornea. Additionally, they can be used postoperatively to prevent or reduce inflammation and pain. Uveitis, which is inflammation of the uvea (middle layer of the eye), can also be treated using cycloplegics.

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  • 43. 

    What information is needed for a signed order (SO's  needed for all EL and AS drugs). Hint: optom, patient, drug.

    Correct Answer(s)
    optom: name, address, GOC number signature, patient: date, name, address, Drug: name, quantity, concentration, labelling directions
    Explanation
    A signed order (SO) for EL and AS drugs requires the following information: optometrist's name, address, GOC number, and signature; patient's date, name, and address; and drug information including name, quantity, concentration, and labeling directions.

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  • 44. 

    In what ways do antibacterials work?

    Correct Answer(s)
    cell wall (penicillins) , bacterial genome (quinolones), nucleotide metabolism (sulphonamides), plasma membrane (polymyxins), protein synthesis (aminoglycosides)
    Explanation
    Antibacterials work in various ways to combat bacterial infections. Penicillins target the cell wall of bacteria, preventing its synthesis and leading to cell lysis. Quinolones act on the bacterial genome by inhibiting DNA replication and repair enzymes, thereby preventing bacterial growth. Sulphonamides interfere with nucleotide metabolism, inhibiting the synthesis of essential components like DNA and RNA. Polymyxins target the plasma membrane of bacteria, disrupting its integrity and causing leakage of cellular contents. Aminoglycosides inhibit bacterial protein synthesis by binding to the bacterial ribosomes, leading to the production of non-functional proteins and ultimately bacterial death.

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  • 45. 

    1st when should propamidine isetionate be used 2nd when should it NOT be used?

    Correct Answer(s)
    indications: acanthamoeba, contraindications: cl problems, hypersensitivity, viral infections
    Explanation
    Propamidine isetionate should be used when treating acanthamoeba infections. It should not be used in cases where there are contact lens problems, hypersensitivity to the medication, or viral infections present.

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  • 46. 

    Azoles inhibit what enzyme?

    Correct Answer(s)
    fungal p450
    Explanation
    Azoles are a class of antifungal medications that work by inhibiting the fungal P450 enzyme. This enzyme is responsible for the synthesis of ergosterol, an essential component of the fungal cell membrane. By inhibiting this enzyme, azoles disrupt the production of ergosterol, leading to the weakening and death of the fungal cells. Therefore, the correct answer is fungal P450.

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  • 47. 

    List the 5 types of designer "biocides"

    Correct Answer(s)
    alexidine, amidoamine, hydrogen peroxide, PHMB, polyquternium-1
    Explanation
    The given answer correctly lists the 5 types of designer "biocides" as alexidine, amidoamine, hydrogen peroxide, PHMB, and polyquternium-1.

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