Anemias And Hemoglobinopathies

45 Questions | Total Attempts: 288

Settings
Please wait...
Blood Quizzes & Trivia

Questions and Answers
  • 1. 
     small size RBC
    • A. 

      Microcytic

    • B. 

      Macrocytic

    • C. 

      Hypochromic

    • D. 

      Hyperchromic

    • E. 

      Normochromic

    • F. 

      Normocytic

  • 2. 
    Large size RBC
    • A. 

      Microcytic

    • B. 

      Macrocytic

    • C. 

      Hypochromic

    • D. 

      Hyperchromic

    • E. 

      Normochromic

    • F. 

      Normocytic

  • 3. 
    Less color in RBC
    • A. 

      Microcytic

    • B. 

      Macrocytic

    • C. 

      Hypochromic

    • D. 

      Hyperchromic

    • E. 

      Normochromic

    • F. 

      Normocytic

  • 4. 
    More color in RBC
    • A. 

      Microcytic

    • B. 

      Macrocytic

    • C. 

      Hypochromic

    • D. 

      Hyperchromic

    • E. 

      Normochromic

    • F. 

      Normocytic

  • 5. 
    Which of the following is not a cause of anemia?
    • A. 

      Decreased production of RBCs

    • B. 

      Space occupying lesions

    • C. 

      Increased destruction of RBCs

    • D. 

      Overproduction of RBCs

    • E. 

      Bone marrow poisons

    • F. 

      Chronic disease (i.e, uremia)

  • 6. 
    Pernicious anemia can be caused by which of the following? (check all that apply)
    • A. 

      B12 deficiency

    • B. 

      Lack of intrinsic factor

    • C. 

      Lack of absorption site

    • D. 

      Crohn's disease

    • E. 

      Atrophic gastritis

  • 7. 
    Macrocytic anemia caused by vitamin B12 and/or folate deficiency; interruption of DNA Synthesis
    • A. 

      Megaloblastic anemia

    • B. 

      Polycythemia

    • C. 

      Anemia of chronic disease

    • D. 

      Sickle cell anemia

  • 8. 
    The main cause of pernicious anemia is an autoimmune disease associated with decreased intrinsic factor due to autoantibodies (intrinsic factor carries Vitamin B12 to ileum for absorption)
    • A. 

      True

    • B. 

      False

  • 9. 
    Directed against, and destroys gastric parietal cells, so that they cannot make intrinsic factor
    • A. 

      Anti-parietal cell antibody

    • B. 

      Anti-intrinsic factor antibody

  • 10. 
    Directed against intrinsic factor
    • A. 

      Anti-parietal cell antibody

    • B. 

      Anti-intrinsic factor antibody

  • 11. 
    Both autoantibodies (anti-parietal cell antibody and anti-intrinsic factor antibody)  cause deficient intrinsic factor, and therefore malabsorption of vitamin B12
    • A. 

      True

    • B. 

      False

  • 12. 
    Which of the following is NOT a cause of megaloblastic anemia?
    • A. 

      "tea and toast" diet

    • B. 

      Pregnancy

    • C. 

      Chronic hemolytic anemia

    • D. 

      Alcoholism

    • E. 

      All of these cause megaloblastic anemia

  • 13. 
    Fish tapeworm can lead to competition for B12 and eventually cause megaloblastic anemia
    • A. 

      True

    • B. 

      False

  • 14. 
    There are neurologic deficits in Vitamin B12 deficiency and not in folate deficiency.
    • A. 

      True

    • B. 

      False

  • 15. 
    Iron deficiency
    • A. 

      Hypochromic microcytic anemia

    • B. 

      Normochromic normocytic anemia

    • C. 

      Normochromic macrocytic anemia

  • 16. 
    Anemia of chronic disease
    • A. 

      Hypochromic microcytic anemia

    • B. 

      Normochromic normocytic anemia

    • C. 

      Normochromic macrocytic anemia

  • 17. 
    In iron deficiency anemia, ferritin will be low and TIBC will be high
    • A. 

      True

    • B. 

      False

  • 18. 
    In anemia of chronic disease, iron stores may be high or normal, therefore ferritin will be high and TIBC will be low.
    • A. 

      True

    • B. 

      False

  • 19. 
    Things that occur with LOW IRON (check all that apply)
    • A. 

      Decreased ferritin

    • B. 

      Increased TIBC

    • C. 

      Increased ferritin

    • D. 

      Decreased TIBC

  • 20. 
    Things that occur with HIGH IRON (check all that apply)
    • A. 

      Decreased ferritin

    • B. 

      Increased TIBC

    • C. 

      Increased ferritin

    • D. 

      Decreased TIBC

  • 21. 
    For —iron deficiency anemia, the most sensitive test is bone marrow iron and the next best is serum ferritin
    • A. 

      True

    • B. 

      False

  • 22. 
    Which hemoglobin is increased with thalassemia?
    • A. 

      Hgb A

    • B. 

      Hgb F

    • C. 

      Hgb S

    • D. 

      Hgb SC

    • E. 

      Hgb C

  • 23. 
    Sickle cell - Equatorial Africa, malaria protection
    • A. 

      Hgb A

    • B. 

      Hgb F

    • C. 

      Hgb S

    • D. 

      Hgb SC

    • E. 

      Hgb C

  • 24. 
    West Africa- —Large spleen, many target cells (30%)
    • A. 

      Hgb A

    • B. 

      Hgb F

    • C. 

      Hgb S

    • D. 

      Hgb SC

    • E. 

      Hgb C

  • 25. 
    90% of cells are target cells
    • A. 

      Hgb A

    • B. 

      Hgb F

    • C. 

      Hgb S

    • D. 

      Hgb SC

    • E. 

      Hgb C

  • 26. 
    Causes of Anemia of Chronic Disease include which of the following? (Check all that apply)
    • A. 

      Renal failure

    • B. 

      Subacute bacterial endocarditis

    • C. 

      Malignancy

    • D. 

      Vasculitis

    • E. 

      Inflammatory Bowel Disease

    • F. 

      Autoimmune Diseases

  • 27. 
    Causes of congenital hemolysis include all of the following except:
    • A. 

      Hereditary spherocytosis

    • B. 

      Sickle cell disease

    • C. 

      G6PD deficiency

    • D. 

      Thalassemia

    • E. 

      All of the above are causes of congenital hemolysis

  • 28. 
    Cell missing enzyme to maintain normal shape.  Fragile…life span 3 weeks instead of 4 months. Mild jaundice, gallstones, splenomegaly (10x normal)
    • A. 

      Hereditary spherocytosis

    • B. 

      Sickle cell disease

    • C. 

      G6PD deficiency

  • 29. 
    B—lood smear: microcytic spherocytes.  Retics up to 20%
    • A. 

      Hereditary spherocytosis

    • B. 

      Sickle cell disease

    • C. 

      G6PD deficiency

  • 30. 
    Cannot repair oxidative damage
    • A. 

      Hereditary spherocytosis

    • B. 

      Sickle cell disease

    • C. 

      G6PD deficiency

  • 31. 
    Can be triggered by drugs, especially aspirin and anti-malarial drugs
    • A. 

      Hereditary spherocytosis

    • B. 

      Sickle cell disease

    • C. 

      G6PD deficiency

  • 32. 
    A—utosomal recessive  genetic blood disorder
    • A. 

      Hereditary spherocytosis

    • B. 

      Sickle cell disease

    • C. 

      G6PD deficiency

  • 33. 
    Sickle Cell Disease
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 34. 
    Sickle Cell Trait
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 35. 
    All Hgb is structurally abnormal (due to incorrect amino acid in beta globin chain): called Hgb S
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 36. 
    Substitution of valine for glutamic acid 
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 37. 
    Inherits gene from both parents
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 38. 
    60% of Hgb is normal - enough to prevent complications
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 39. 
    abnormal Hgb S polymerizes ---> RBC has a sticky membrane with decreased deformability, and a sickle shape --->hemolysis in spleen and vessels
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 40. 
    96% patients present by age 8 with: painful crisis; splenic sequestration
    • A. 

      Homozygotes

    • B. 

      Heterozygotes

  • 41. 
    Presents with intense ischemic pain in chest, back, abdomen, and bones due to occlusion of small vessels; fever; nausea and vomiting
    • A. 

      Sickle Cell Anemia

    • B. 

      Vitamin B12 Deficiency Anemia

    • C. 

      Folate Deficiency Anemia

    • D. 

      Sequestration

  • 42. 
    Presents with glossitis and/or diarrhea
    • A. 

      Sickle Cell Anemia

    • B. 

      Vitamin B12 Deficiency Anemia

    • C. 

      Folate Deficiency Anemia

    • D. 

      Sequestration

  • 43. 
    Can present with glossitis, diarrhea, peripheral neuropathy (numbness and tingling in extremities), subacute combined degeneration of spinal cord (loss of position and vibration sense), positive Romberg test, ataxia, motor weakness, hyperreflexia, dementia, or psychiatric problems
    • A. 

      Sickle Cell Anemia

    • B. 

      Vitamin B12 Deficiency Anemia

    • C. 

      Folate Deficiency Anemia

    • D. 

      Sequestration

  • 44. 
    Can present with —hypersplenism (large spleen traps all three cell lines) and/or third space (oozing of blood into chest or abdominal cavities)
    • A. 

      Sickle Cell Anemia

    • B. 

      Vitamin B12 Deficiency Anemia

    • C. 

      Folate Deficiency Anemia

    • D. 

      Sequestration

  • 45. 
    Which of the following is NOT true of sickle cell anemia?
    • A. 

      Can present with intense ischemic pain in chest, back, abdomen, and bones due to occlusion of small vessels by sticky, sickled RBCs in different tissues; fever; nausea and vomiting

    • B. 

      Precipitated by deoxygenation; infection; dehydration; often no identifiable reason

    • C. 

      Can result in multiorgan tissue death and complications in many organs

    • D. 

      Presents with a normal Hgb S band with hemoglobin electrophoresis

    • E. 

      All of these things are true of sickle cell anemia