Anemias And Hemoglobinopathies

45 Questions | By Bikisoucy | Updated: Mar 21, 2022 | Attempts: 1189

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1.

small size RBC
- A.
  
  Microcytic
- B.
  
  Macrocytic
- C.
  
  Hypochromic
- D.
  
  Hyperchromic
- E.
  
  Normochromic
- F.
  
  Normocytic
2.

Large size RBC
- A.
  
  Microcytic
- B.
  
  Macrocytic
- C.
  
  Hypochromic
- D.
  
  Hyperchromic
- E.
  
  Normochromic
- F.
  
  Normocytic
3.

Less color in RBC
- A.
  
  Microcytic
- B.
  
  Macrocytic
- C.
  
  Hypochromic
- D.
  
  Hyperchromic
- E.
  
  Normochromic
- F.
  
  Normocytic
4.

More color in RBC
- A.
  
  Microcytic
- B.
  
  Macrocytic
- C.
  
  Hypochromic
- D.
  
  Hyperchromic
- E.
  
  Normochromic
- F.
  
  Normocytic
5.

Which of the following is not a cause of anemia?
- A.
  
  Decreased production of RBCs
- B.
  
  Space occupying lesions
- C.
  
  Increased destruction of RBCs
- D.
  
  Overproduction of RBCs
- E.
  
  Bone marrow poisons
- F.
  
  Chronic disease (i.e, uremia)
6.

Pernicious anemia can be caused by which of the following? (check all that apply)
- A.
  
  B12 deficiency
- B.
  
  Lack of intrinsic factor
- C.
  
  Lack of absorption site
- D.
  
  Crohn's disease
- E.
  
  Atrophic gastritis
7.

Macrocytic anemia caused by vitamin B12 and/or folate deficiency; interruption of DNA Synthesis
- A.
  
  Megaloblastic anemia
- B.
  
  Polycythemia
- C.
  
  Anemia of chronic disease
- D.
  
  Sickle cell anemia
8.

The main cause of pernicious anemia is an autoimmune disease associated with decreased intrinsic factor due to autoantibodies (intrinsic factor carries Vitamin B12 to ileum for absorption)
- A.
  
  True
- B.
  
  False
9.

Directed against, and destroys gastric parietal cells, so that they cannot make intrinsic factor
- A.
  
  Anti-parietal cell antibody
- B.
  
  Anti-intrinsic factor antibody
10.

Directed against intrinsic factor
- A.
  
  Anti-parietal cell antibody
- B.
  
  Anti-intrinsic factor antibody
11.

Both autoantibodies (anti-parietal cell antibody and anti-intrinsic factor antibody) cause deficient intrinsic factor, and therefore malabsorption of vitamin B12
- A.
  
  True
- B.
  
  False
12.

Which of the following is NOT a cause of megaloblastic anemia?
- A.
  
  "tea and toast" diet
- B.
  
  Pregnancy
- C.
  
  Chronic hemolytic anemia
- D.
  
  Alcoholism
- E.
  
  All of these cause megaloblastic anemia
13.

Fish tapeworm can lead to competition for B12 and eventually cause megaloblastic anemia
- A.
  
  True
- B.
  
  False
14.

There are neurologic deficits in Vitamin B12 deficiency and not in folate deficiency.
- A.
  
  True
- B.
  
  False
15.

Iron deficiency
- A.
  
  Hypochromic microcytic anemia
- B.
  
  Normochromic normocytic anemia
- C.
  
  Normochromic macrocytic anemia
16.

Anemia of chronic disease
- A.
  
  Hypochromic microcytic anemia
- B.
  
  Normochromic normocytic anemia
- C.
  
  Normochromic macrocytic anemia
17.

In iron deficiency anemia, ferritin will be low and TIBC will be high
- A.
  
  True
- B.
  
  False
18.

In anemia of chronic disease, iron stores may be high or normal, therefore ferritin will be high and TIBC will be low.
- A.
  
  True
- B.
  
  False
19.

Things that occur with LOW IRON (check all that apply)
- A.
  
  Decreased ferritin
- B.
  
  Increased TIBC
- C.
  
  Increased ferritin
- D.
  
  Decreased TIBC
20.

Things that occur with HIGH IRON (check all that apply)
- A.
  
  Decreased ferritin
- B.
  
  Increased TIBC
- C.
  
  Increased ferritin
- D.
  
  Decreased TIBC
21.

For iron deficiency anemia, the most sensitive test is bone marrow iron and the next best is serum ferritin
- A.
  
  True
- B.
  
  False
22.

Which hemoglobin is increased with thalassemia?
- A.
  
  Hgb A
- B.
  
  Hgb F
- C.
  
  Hgb S
- D.
  
  Hgb SC
- E.
  
  Hgb C
23.

Sickle cell - Equatorial Africa, malaria protection
- A.
  
  Hgb A
- B.
  
  Hgb F
- C.
  
  Hgb S
- D.
  
  Hgb SC
- E.
  
  Hgb C
24.

West Africa- Large spleen, many target cells (30%)
- A.
  
  Hgb A
- B.
  
  Hgb F
- C.
  
  Hgb S
- D.
  
  Hgb SC
- E.
  
  Hgb C
25.

90% of cells are target cells
- A.
  
  Hgb A
- B.
  
  Hgb F
- C.
  
  Hgb S
- D.
  
  Hgb SC
- E.
  
  Hgb C