Abo_shousha_cns_quiz_17_antipsychotics

1. Typical antipsychotic drugs:

Strongly block postsynaptic D2 receptor

Stimulate postsynaptic D2 receptor

Block NMDA receptor

2. The major limitation in the use of clozapine for treatment of schizophrenia is:

Production of hyperprolactinemia

Its inability to benefit negative symptoms of schizophrenia

High incidence of extra pyramidal side effects

Its potential to cause agranulocytosis

3. Tardive dyskinesia is the result of:

Degeneration of dopaminergic and cholinergic fibers

Hyperactive dopaminergic state in the presence of dopamine blockers

Degeneration of histaminergic fibers

Supersensitivity of cholinergic receptors in the caudate-putamen

4. Hyperprolactinemia is caused by blockade of dopamine in:

The pituitary

The chemoreceptor trigger zone of the medulla

The extrapiramidal system

The mesolimbic and mesofrontal systems

5. Which of the following antipsychotic agents is used in combination with an opioid drug fentanyl inneuroleptanalgesia?

Haloperidol

Droperidol

Chlorpromazine

Clozapine