Quiz 2: DNA Damage, Repair And Recombination
Section F – DNA damage, repair and recombination F1 Mutagenesis F2 DNA damage F3 DNA Repair F4 Recombination ACARA PRESENTASI KELOMPOK, Selasa, 18 Mei 20101. Presenter Kelompok 3 (Penyanggah Kelompok 5): Topik Mutations2. Presenter Kelompok 4 (Penyanggah Kelompok 6): Topik DNA Repair
- 1.Which of the following is TRUE about mutation
- A.
Acceptable variations in the ‘normal’ DNA and protein sequences
- B.
The exchange of DNA between chromosomes during meiosis.
- C.
The movement of a ribosome from one reading frame to another at an internal position within a gene
- D.
A DNA repair process that corrects various types of DNA damage by excising and resynthesizing a region of polynucleotide
- E.
Permanent, heritable alterations in the base sequence of the DNA.
- 2.Mutations arise through spontaneous__________ I. in DNA replication II. in meiotic recombination III. as a consequence of the damaging effects of physical or chemical agents on the DNA
- A.
I only
- B.
II only
- C.
III only
- D.
I and II
- E.
I, II, and III
- 3.An alteration in a nucleotide sequence that changes a triplet coding for an amino acid into a termination codon.
- A.
Nonsense mutation
- B.
Mutation
- C.
Mutagenesis
- D.
Mutagen
- E.
Missense mutation
- 4.A point mutation that replaces a purine with another purine, or a pyrimidine with another pyrimidine.
- A.
Transition
- B.
Transversion
- C.
Nonsense
- D.
Silent mutation
- E.
Missense mutation
- 5.A point mutation that involves a purine being replaced by a pyrimidine, or vice versa.
- A.
Transition
- B.
Transversion
- C.
Nonsense
- D.
Silent mutation
- E.
Missense mutation
- 6.A change in a DNA sequence that has no effect on the expression or functioning of any gene or gene product.
- A.
Transition
- B.
Transversion
- C.
Nonsense
- D.
Silent mutation
- E.
Missense mutation
- 7.An alteration in a nucleotide sequence that converts a codon for one amino acid into a codon for a second amino acid.
- A.
Transition
- B.
Transversion
- C.
Nonsense
- D.
Silent mutation
- E.
Missense mutation
- 8.The frameshift mutations in genes can be produced by _________ I. transition II. deletetion III. insertion
- A.
I only
- B.
II only
- C.
III only
- D.
I and II
- E.
II and III
- 9.An alteration to the normal chemical or physical structure of the DNA.
- A.
Transition
- B.
Transversion
- C.
Nonsense
- D.
Lesion
- E.
Missense mutation
- 10.5-Bromouracil is an analog of ___________ that can react with deoxyribonucleic acid to produce a polymer with increased susceptibility to mutation.
- A.
Thymine
- B.
Guanine
- C.
Cytosine
- D.
Uracil
- E.
Adenine
- 11.Cyclobutane pyrimidine dimers can be monomerized again by ________ in the presence of visible light.
- A.
Exonuclease
- B.
DNA photolyases
- C.
Transposase
- D.
DNA polymerase
- E.
Integrase
- 12.All transposons encode a _________ which catalyzes the insertion.
- A.
DNA glycosylase
- B.
Excisionase
- C.
Transposase
- D.
DNA polymerase
- E.
Integrase
- 13.Small DNA sequences that can move to virtually any position in a cell’s genome.
- A.
Exons
- B.
Introns
- C.
Egulons
- D.
LTRs
- E.
Transposons
- 14.In base excision repair, the lesion is removed by __________
- A.
DNA glycosylase
- B.
Excisionase
- C.
Transposase
- D.
DNA polymerase
- E.
Integrase
- 15.In nucleotide excision repair, an endonuclease makes nicks on either side of the lesion, which is then removed to leave a gap. This gap is filled by __________ to makes the final phosphodiester bond. I.DNA polymerase II.DNA ligase III. DNA glycolase
- A.
I only
- B.
II only
- C.
III only
- D.
I and II
- E.
I, II, and III
- 16.Which of the following common examples of alkylating agents.
- A.
Methylmethane sulfonate (MMS)
- B.
Ethylnitrosourea (ENU)
- C.
Nitrous acid
- D.
A and B
- E.
A, B, and C
- 17.The exchange of nonhomologous regions of DNA at specific sites is independent of _________
- A.
IS elements
- B.
Illegitimate recombination
- C.
Retrotransposons
- D.
RecA
- E.
General recombination
- 18.The dispersed repetitive sequences found in higher eukaryotic DNA (e.g. LINES and SINES) probably spread through the genome by _________
- A.
Transposition
- B.
Homologous recombination
- C.
Site-specific recombination
- D.
Replication
- E.
General recombination
- 19.The enzyme of Escherichia coli is a nuclease that initiates the repair of double-stranded DNA breaks by homologous recombination.
- A.
RNA polymerase
- B.
DNA polymerase
- C.
DNA ligase
- D.
RecBCD
- E.
DNA glycolase
- 20.Which of the following DNA mutation that result in the appearance of a stop codon in the resulting mRNA. synthesis.
- A.
Transition
- B.
Transversion
- C.
Nonsense
- D.
Silent mutation
- E.
Missense mutation
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