Quiz 2: DNA Damage, Repair And Recombination

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Quiz 2: DNA Damage, Repair And Recombination - Quiz

Section F – DNA damage, repair and recombination F1 Mutagenesis F2 DNA damage F3 DNA Repair F4 Recombination ACARA PRESENTASI KELOMPOK, Selasa, 18 Mei 20101. Presenter Kelompok 3 (Penyanggah Kelompok 5): Topik Mutations2. Presenter Kelompok 4 (Penyanggah Kelompok 6): Topik DNA Repair

Questions and Answers

1.

Which of the following is TRUE about mutation
- A.
  
  Acceptable variations in the ‘normal’ DNA and protein sequences
- B.
  
  The exchange of DNA between chromosomes during meiosis.
- C.
  
  The movement of a ribosome from one reading frame to another at an internal position within a gene
- D.
  
  A DNA repair process that corrects various types of DNA damage by excising and resynthesizing a region of polynucleotide
- E.
  
  Permanent, heritable alterations in the base sequence of the DNA.
2.

Mutations arise through spontaneous__________ I. in DNA replication II. in meiotic recombination III. as a consequence of the damaging effects of physical or chemical agents on the DNA
- A.
  
  I only
- B.
  
  II only
- C.
  
  III only
- D.
  
  I and II
- E.
  
  I, II, and III
3.

An alteration in a nucleotide sequence that changes a triplet coding for an amino acid into a termination codon.
- A.
  
  Nonsense mutation
- B.
  
  Mutation
- C.
  
  Mutagenesis
- D.
  
  Mutagen
- E.
  
  Missense mutation
4.

A point mutation that replaces a purine with another purine, or a pyrimidine with another pyrimidine.
- A.
  
  Transition
- B.
  
  Transversion
- C.
  
  Nonsense
- D.
  
  Silent mutation
- E.
  
  Missense mutation
5.

A point mutation that involves a purine being replaced by a pyrimidine, or vice versa.
- A.
  
  Transition
- B.
  
  Transversion
- C.
  
  Nonsense
- D.
  
  Silent mutation
- E.
  
  Missense mutation
6.

A change in a DNA sequence that has no effect on the expression or functioning of any gene or gene product.
- A.
  
  Transition
- B.
  
  Transversion
- C.
  
  Nonsense
- D.
  
  Silent mutation
- E.
  
  Missense mutation
7.

An alteration in a nucleotide sequence that converts a codon for one amino acid into a codon for a second amino acid.
- A.
  
  Transition
- B.
  
  Transversion
- C.
  
  Nonsense
- D.
  
  Silent mutation
- E.
  
  Missense mutation
8.

The frameshift mutations in genes can be produced by _________ I. transition II. deletetion III. insertion
- A.
  
  I only
- B.
  
  II only
- C.
  
  III only
- D.
  
  I and II
- E.
  
  II and III
9.

An alteration to the normal chemical or physical structure of the DNA.
- A.
  
  Transition
- B.
  
  Transversion
- C.
  
  Nonsense
- D.
  
  Lesion
- E.
  
  Missense mutation
10.

5-Bromouracil is an analog of ___________ that can react with deoxyribonucleic acid to produce a polymer with increased susceptibility to mutation.
- A.
  
  Thymine
- B.
  
  Guanine
- C.
  
  Cytosine
- D.
  
  Uracil
- E.
  
  Adenine
11.

Cyclobutane pyrimidine dimers can be monomerized again by ________ in the presence of visible light.
- A.
  
  Exonuclease
- B.
  
  DNA photolyases
- C.
  
  Transposase
- D.
  
  DNA polymerase
- E.
  
  Integrase
12.

All transposons encode a _________ which catalyzes the insertion.
- A.
  
  DNA glycosylase
- B.
  
  Excisionase
- C.
  
  Transposase
- D.
  
  DNA polymerase
- E.
  
  Integrase
13.

Small DNA sequences that can move to virtually any position in a cell’s genome.
- A.
  
  Exons
- B.
  
  Introns
- C.
  
  Egulons
- D.
  
  LTRs
- E.
  
  Transposons
14.

In base excision repair, the lesion is removed by __________
- A.
  
  DNA glycosylase
- B.
  
  Excisionase
- C.
  
  Transposase
- D.
  
  DNA polymerase
- E.
  
  Integrase
15.

In nucleotide excision repair, an endonuclease makes nicks on either side of the lesion, which is then removed to leave a gap. This gap is filled by __________ to makes the final phosphodiester bond. I.DNA polymerase II.DNA ligase III. DNA glycolase
- A.
  
  I only
- B.
  
  II only
- C.
  
  III only
- D.
  
  I and II
- E.
  
  I, II, and III
16.

Which of the following common examples of alkylating agents.
- A.
  
  Methylmethane sulfonate (MMS)
- B.
  
  Ethylnitrosourea (ENU)
- C.
  
  Nitrous acid
- D.
  
  A and B
- E.
  
  A, B, and C
17.

The exchange of nonhomologous regions of DNA at specific sites is independent of _________
- A.
  
  IS elements
- B.
  
  Illegitimate recombination
- C.
  
  Retrotransposons
- D.
  
  RecA
- E.
  
  General recombination
18.

The dispersed repetitive sequences found in higher eukaryotic DNA (e.g. LINES and SINES) probably spread through the genome by _________
- A.
  
  Transposition
- B.
  
  Homologous recombination
- C.
  
  Site-specific recombination
- D.
  
  Replication
- E.
  
  General recombination
19.

The enzyme of Escherichia coli is a nuclease that initiates the repair of double-stranded DNA breaks by homologous recombination.
- A.
  
  RNA polymerase
- B.
  
  DNA polymerase
- C.
  
  DNA ligase
- D.
  
  RecBCD
- E.
  
  DNA glycolase
20.

Which of the following DNA mutation that result in the appearance of a stop codon in the resulting mRNA. synthesis.
- A.
  
  Transition
- B.
  
  Transversion
- C.
  
  Nonsense
- D.
  
  Silent mutation
- E.
  
  Missense mutation