PHR 241 Exam 3 Histamines

29 Questions

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Chemical Compound Quizzes & Trivia

In the study of medicine, histamine is an organic nitrogenous compound which is involved in local immune responses. It also regulates physiological function in the gut and acts as a neurotransmitter for the brain, spinal cord and uterus.


Questions and Answers
  • 1. 
    Which of the following is/are not true regarding histamines?
    • A. 

      They are autocoids

    • B. 

      They are distantly acting hormones

    • C. 

      They mediate immediate allergic reactions

    • D. 

      They function as a neurotransmitter

    • E. 

      They regulate gastric acid secretions

  • 2. 
    WHich of teh following cuases a release of histamine?
    • A. 

      Type II Allergic reactions

    • B. 

      Venoms

    • C. 

      Toxins

    • D. 

      Radiation

    • E. 

      Warm temperatures

    • F. 

      Some drugs

    • G. 

      Mechanical injury

  • 3. 
    Histamine receptors are what type of receptors?
    • A. 

      Ligand-gated ion channels

    • B. 

      GPCR

    • C. 

      Channel-linked receptors

  • 4. 
    Histamine is found is which of the following location(s)?
    • A. 

      Vesicular granules of mast cells or basophils

    • B. 

      Neuronal tissue in the brain

    • C. 

      Enterochromaffin-like cells in teh fundus of the stomach

    • D. 

      Venoms

  • 5. 
    Which of the following is/are not true regarding H1 histamine receptors?
    • A. 

      They are found in smooth muscle

    • B. 

      They are Gs coupled

    • C. 

      They cause elevation in IP3, Ca2+, and diacylglycerol

  • 6. 
    Which histamine receptor-has an effect on gastric parietiel cells, cardiac muscle, and some smooth muscle-is Gs coupled-causes an elevation in cAMP
    • A. 

      H1

    • B. 

      H2

    • C. 

      H3

    • D. 

      H4

  • 7. 
    Which histamine receptor regulates the release of neurotransmitters in the brain and myenteric plexus?
    • A. 

      H1

    • B. 

      H2

    • C. 

      H3

    • D. 

      H4

  • 8. 
    Which histamine receptor is the main receptor that causes a direct decrease in blood pressure?
    • A. 

      H1

    • B. 

      H2

    • C. 

      H3

    • D. 

      H4

  • 9. 
    Edema is mediated by which histamine receptor?
    • A. 

      H1

    • B. 

      H2

    • C. 

      H3

    • D. 

      H4

  • 10. 
    Which of the followingcardiovascular effects of histamine is/are indicative of histamine release in the skin?
    • A. 

      Decrease in BP

    • B. 

      Headache

    • C. 

      Edema

    • D. 

      Heat, redness and local swelling

    • E. 

      Urticaria or hives

  • 11. 
    The axon relfex is the direct action on ______ receptors on sensory nerve endings and/or depolariztion of efferent axons.
    • A. 

      H1

    • B. 

      H2

    • C. 

      H3

    • D. 

      H4

  • 12. 
    Histamine has clinical applications
    • A. 

      True

    • B. 

      False

  • 13. 
    Histamine is a majore player in human asthmas.
    • A. 

      True

    • B. 

      False

  • 14. 
    Antagonists of histamine's actions have important clinical uses.
    • A. 

      True

    • B. 

      False

  • 15. 
    H2 receptors mediate contraction of intestinal smooth muscle
    • A. 

      True

    • B. 

      False

  • 16. 
    Which of the following is/are true about physiological antagonists of histamine.
    • A. 

      They bind to the same receptor as histamine

    • B. 

      They are bronchoconstrictors

    • C. 

      They are vasodilators

    • D. 

      They are inhibitors of degranulation

    • E. 

      None of the above are true

  • 17. 
    Physiological antagonists bind to the receptor.
    • A. 

      True

    • B. 

      False

  • 18. 
    Antihistamines are physiological antagonists of histamine
    • A. 

      True

    • B. 

      False

  • 19. 
    2nd generation antihistamines blcok muscarinic receptors.
    • A. 

      True

    • B. 

      False

  • 20. 
    First generation antihistamines possess anti-cholinergic activity.
    • A. 

      True

    • B. 

      False

  • 21. 
    2nd generation drugs have an extended duration of actoin
    • A. 

      True

    • B. 

      False

  • 22. 
    Whcih of the following is/are not second generation antihistamines?
    • A. 

      Diphenhydramine

    • B. 

      Fexofenadine

    • C. 

      Loratidine

    • D. 

      Pyrilamine

    • E. 

      Cetirizine

    • F. 

      Promethazine

  • 23. 
    Which of the following are major pharmacological effects fo antihistamines?
    • A. 

      Sedation

    • B. 

      Increased and thickened secretions

    • C. 

      Increased heart rate

    • D. 

      Reversal of histamine-induced vasodilation

  • 24. 
    2nd generation antihistamines are more effective than 1st generation ones.
    • A. 

      True

    • B. 

      False

  • 25. 
    Antihistamines are an effective treatment in bronchial asthma
    • A. 

      True

    • B. 

      False

  • 26. 
    Which of the following is/are adverse effects of antihistamines?
    • A. 

      Sedation

    • B. 

      Dry mouth

    • C. 

      Blurred vision

    • D. 

      Urinary excretion

    • E. 

      Increased GI motility

  • 27. 
    Antihistamines can have a paradoxical effect on children. (ie. insomnia, nervousness, tremors)
    • A. 

      True

    • B. 

      False

  • 28. 
    Antihistamines are good decongestants
    • A. 

      True

    • B. 

      False

  • 29. 
    Which of the following are effective decongestants?
    • A. 

      Antihistamines

    • B. 

      Phenylephrine

    • C. 

      Pseudoephedrine

    • D. 

      Oxymetazoline