Otterbein/Grant CRNA Diuretics Review

Both thiazide and loop diuretics mechanism of action are based upon inhibiting the reabsorption of Na+ and Cl- ions.

Osmotic diuretics work by _________ osmolarity, preventing water reabsorption, causing a loss of water, Na+, Cl-, and HCO3.

K+ sparing diuretics inhibit Na+, Cl-, and HCO3 reabsorption and K+ secretion in the distal convoluted tubules.

_________ antagonists bind to cytoplasmic mineralocorticoid receptors on collecting ducts, inhibiting the reabsorption of Na+ and Cl-, preventing the secretion of K+.

Carbonic anhydrase inhibitors bind to carbonic anhydrase in the proximal tubules, retaining H+ ions while excreting HCO3+ ions.  K+ is also excreted in exchange for Na+.  HCO3 excretion causes alkaline urine, the body enters a metabolic acidosis.

Renal dopamine-1 receptors mediate vasodilation, _________ RBF and GFR while inhibiting Na+ reabsorption.